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Protein

Kinesin light chain 1

Gene

Klc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

GO - Molecular functioni

GO - Biological processi

  • axo-dendritic transport Source: MGI
  • microtubule-based movement Source: HGNC
  • stress granule disassembly Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 1
Short name:
KLC 1
Gene namesi
Name:Klc1
Synonyms:Kns2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107978. Klc1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • ciliary rootlet Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytoplasmic vesicle Source: MGI
  • cytosol Source: HGNC
  • growth cone Source: UniProtKB
  • kinesin complex Source: HGNC
  • membrane Source: MGI
  • membrane-bounded organelle Source: MGI
  • microtubule Source: UniProtKB-KW
  • neuron projection Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150931 – 541Kinesin light chain 1Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1
Modified residuei448PhosphotyrosineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei520Phosphoserine; by AMPKCombined sourcesCurated1
Modified residuei523Phosphoserine; by AMPKCombined sourcesCurated1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88447.
MaxQBiO88447.
PaxDbiO88447.
PeptideAtlasiO88447.
PRIDEiO88447.

PTM databases

iPTMnetiO88447.
PhosphoSitePlusiO88447.
SwissPalmiO88447.

Expressioni

Gene expression databases

CleanExiMM_KLC1.

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with BORCS5 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Hspa8P630173EBI-301550,EBI-433443
Mapk8ip3Q9ESN99EBI-301550,EBI-301496
VACWR159P686192EBI-301550,EBI-7133540From a different organism.

Protein-protein interaction databases

DIPiDIP-31520N.
IntActiO88447. 15 interactors.
MINTiMINT-1351315.
STRINGi10090.ENSMUSP00000082004.

Structurei

3D structure databases

ProteinModelPortaliO88447.
SMRiO88447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati211 – 244TPR 1Add BLAST34
Repeati253 – 286TPR 2Add BLAST34
Repeati295 – 328TPR 3Add BLAST34
Repeati337 – 370TPR 4Add BLAST34
Repeati380 – 413TPR 5Add BLAST34
Repeati463 – 496TPR 6Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 156Add BLAST130

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOVERGENiHBG006217.
InParanoidiO88447.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDNMSTMVY IKEEKLENVT QDEIISKTKQ VIQGLEALKN EHNSILQSLL
60 70 80 90 100
ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE
110 120 130 140 150
SEKQNVRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF
160 170 180 190 200
MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDEPGQG IQHSDSSAAA
210 220 230 240 250
ARQGYEIPAR LRTLHNLVIQ YASQGRYEVA VPSCKQALED LEKTSGHDHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK DAANLLNDAL AIREKTLGRD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCKR ALEIREKVLG KDHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEEVEYYY QRALGIYQTK LGPDRTPNVA KTKNNLASCY LKQGKFKQAE
410 420 430 440 450
TLYKEILTRA HEAEFGSVDD ENKPIWMHAE EREECKGKQK DGSAFGEYGG
460 470 480 490 500
WYKACKVDSP TVTTTLKNLG ALYRRQGKFE AAETLEEAAM RSRKQGLDNV
510 520 530 540
HKQRVAEVLN DPESMEKRRS RESLNMDVVK YESGPDGGEE A
Length:541
Mass (Da):61,450
Last modified:November 25, 2008 - v3
Checksum:i550F23AB36049C03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055665 mRNA. Translation: AAC27740.1.
UniGeneiMm.278357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055665 mRNA. Translation: AAC27740.1.
UniGeneiMm.278357.

3D structure databases

ProteinModelPortaliO88447.
SMRiO88447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-31520N.
IntActiO88447. 15 interactors.
MINTiMINT-1351315.
STRINGi10090.ENSMUSP00000082004.

PTM databases

iPTMnetiO88447.
PhosphoSitePlusiO88447.
SwissPalmiO88447.

Proteomic databases

EPDiO88447.
MaxQBiO88447.
PaxDbiO88447.
PeptideAtlasiO88447.
PRIDEiO88447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107978. Klc1.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOVERGENiHBG006217.
InParanoidiO88447.

Miscellaneous databases

ChiTaRSiKlc1. mouse.
PROiO88447.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KLC1.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC1_MOUSE
AccessioniPrimary (citable) accession number: O88447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.