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Protein

Solute carrier family 22 member 3

Gene

Slc22a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.Curated2 Publications

GO - Molecular functioni

  • dopamine transmembrane transporter activity Source: RGD
  • organic cation transmembrane transporter activity Source: RGD
  • quaternary ammonium group transmembrane transporter activity Source: RGD
  • toxin transporter activity Source: RGD

GO - Biological processi

  • ammonium transmembrane transport Source: GOC
  • dopamine transport Source: RGD
  • histamine uptake Source: Ensembl
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • organic cation transport Source: RGD
  • quaternary ammonium group transport Source: RGD
  • regulation of appetite Source: Ensembl
  • toxin transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-2161517. Abacavir transmembrane transport.
R-RNO-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Organic cation transporter 3
Gene namesi
Name:Slc22a3
Synonyms:Oct3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3701. Slc22a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence analysisAdd
BLAST
Transmembranei463 – 48321HelicalSequence analysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1770033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Solute carrier family 22 member 3PRO_0000220505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88446.

Expressioni

Tissue specificityi

Highly expressed in placenta. Moderate expression in intestine, heart and brain. In the brain, widely expressed, especially in hippocampus, cerebellum and cerebral cortex. Expression is low in kidney and lung and undetectable in liver.Curated2 Publications

Gene expression databases

GenevisibleiO88446. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029748.

Structurei

3D structure databases

ProteinModelPortaliO88446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO88446.
KOiK08200.
OMAiGGWRYAQ.
OrthoDBiEOG78PV8N.
PhylomeDBiO88446.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW
60 70 80 90 100
CRGPRATALA ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEDTNT
110 120 130 140 150
SSELSCDPLA AFPNRSAPLV PCSGDWRYVE THSTIVSQFD LVCGNAWMLD
160 170 180 190 200
LTQAILNLGF LAGAFTLGYA ADRYGRLIVY LISCFGVGIT GVVVAFAPNF
210 220 230 240 250
SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV IQMFFTLGII
260 270 280 290 300
ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL
310 320 330 340 350
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM
360 370 380 390 400
FAWFTSAVVY QGLVMRLGLI GGNLYMDFFI SGLVELPGAL LILLTIERLG
410 420 430 440 450
RRLPFAASNI VAGVSCLVTA FLPEGIPWLR TTVATLGRLG ITMAFEIVYL
460 470 480 490 500
VNSELYPTTL RNFGVSLCSG LCDFGGIIAP FLLFRLAAIW LELPLIIFGI
510 520 530 540 550
LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR KKKTQVSTSN

V
Length:551
Mass (Da):61,050
Last modified:November 1, 1998 - v1
Checksum:i23F0EBC24E4F3DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055286 mRNA. Translation: AAC40150.1.
RefSeqiNP_062103.1. NM_019230.1.
UniGeneiRn.24231.

Genome annotation databases

EnsembliENSRNOT00000037369; ENSRNOP00000029748; ENSRNOG00000022946.
GeneIDi29504.
KEGGirno:29504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055286 mRNA. Translation: AAC40150.1.
RefSeqiNP_062103.1. NM_019230.1.
UniGeneiRn.24231.

3D structure databases

ProteinModelPortaliO88446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029748.

Chemistry

ChEMBLiCHEMBL1770033.

Protein family/group databases

TCDBi2.A.1.19.6. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiO88446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037369; ENSRNOP00000029748; ENSRNOG00000022946.
GeneIDi29504.
KEGGirno:29504.

Organism-specific databases

CTDi6581.
RGDi3701. Slc22a3.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO88446.
KOiK08200.
OMAiGGWRYAQ.
OrthoDBiEOG78PV8N.
PhylomeDBiO88446.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-RNO-2161517. Abacavir transmembrane transport.
R-RNO-549127. Organic cation transport.

Miscellaneous databases

PROiO88446.

Gene expression databases

GenevisibleiO88446. RN.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta."
    Kekuda R., Prasad P.D., Wu X., Wang H., Fei Y.-J., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 273:15971-15979(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain."
    Wu X., Kekuda R., Huang W., Fei Y.-J., Leibach F.H., Chen J., Conway S.J., Ganapathy V.
    J. Biol. Chem. 273:32776-32786(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.

Entry informationi

Entry nameiS22A3_RAT
AccessioniPrimary (citable) accession number: O88446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.