Adenylate cyclase type 1 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot O88444 (ADCY1_MOUSE)

Last modified January 19, 2010. Version 78. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 1
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type I
    ATP pyrophosphate-lyase 1
    Adenylyl cyclase 1
    Ca(2+)/calmodulin-activated adenylyl cyclase

Gene names

Name:

Adcy1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	1118 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning By similarity.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

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Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity Ref.2 Traceable author statement. Source: MGI cAMP biosynthetic process Ref.2 Traceable author statement. Source: MGI intracellular signaling cascade Inferred from electronic annotation. Source: InterPro long-term memory Inferred from genetic interaction. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.2 Traceable author statement. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Ref.2 Inferred from genetic interaction. Source: MGI calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1118

1118

Adenylate cyclase type 1

PRO_0000195683

Regions

Topological domain

1 – 62

Cytoplasmic Potential

Transmembrane

63 – 83

Potential

Transmembrane

87 – 107

Potential

Transmembrane

124 – 144

Potential

Transmembrane

157 – 177

Potential

Transmembrane

182 – 202

Potential

Transmembrane

213 – 233

Potential

Topological domain

234 – 609

376

Cytoplasmic Potential

Transmembrane

610 – 630

Potential

Transmembrane

634 – 654

Potential

Transmembrane

673 – 693

Potential

Transmembrane

724 – 744

Potential

Transmembrane

752 – 772

Potential

Transmembrane

774 – 793

Potential

Topological domain

794 – 1118

325

Cytoplasmic Potential

Region

492 – 519

Interaction with calmodulin By similarity

Region

1023 – 1046

Interaction with calmodulin By similarity

Sites

Metal binding

307

Magnesium 1 By similarity

Metal binding

307

Magnesium 2 By similarity

Metal binding

308

Magnesium 2; via carbonyl oxygen By similarity

Metal binding

351

Magnesium 1 By similarity

Metal binding

351

Magnesium 2 By similarity

Amino acid modifications

Glycosylation

703

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

147 – 155

SSAGGAMGS → ALQEAQWAR in AAC29478. Ref.2

Sequence conflict

234

T → A in AAC29478. Ref.2

Sequence conflict

270

L → M in AAC29478. Ref.2

Sequence conflict

319

T → K in AAC29478. Ref.2

Sequence conflict

466

R → K in AAC29478. Ref.2

Sequence conflict

523

F → I in AAC29478. Ref.2

Sequence conflict

542

S → T in AAC29478. Ref.2

Sequence conflict

549

S → T in AAC29478. Ref.2

Sequence conflict

570

R → L in AAC29478. Ref.2

Sequence conflict

598

Q → R in AAC29478. Ref.2

Sequence conflict

692

G → V in AAC29478. Ref.2

Sequence conflict

697

A → S in AAC29478. Ref.2

Sequence conflict

707

V → L in AAC29478. Ref.2

Sequence conflict

713

G → C in AAC29478. Ref.2

Sequence conflict

720 – 721

AL → GP in AAC29478. Ref.2

Sequence conflict

774 – 776

VGG → AMGA in AAC29478. Ref.2

Sequence conflict

867 – 869

GVM → AVL in AAC29478. Ref.2

Sequence conflict

938

R → K in AAC29478. Ref.2

Sequence conflict

991

R → C in AAC29478. Ref.2

Sequence conflict

1020

T → I in AAC29478. Ref.2

Sequence conflict

1030

C → S in AAC29478. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

O88444-1 [UniParc].

Last modified April 12, 2005. Version 2.
Checksum: CEFAFF3940B22277
Show »

FASTA

1,118

123,373

        10         20         30         40         50         60 
MAGAPRGQGG GGGAGEPGGA ERAAGPGGRR GFRACGEEFA CPELEALFRG YTLRLEQAAT 

        70         80         90        100        110        120 
LKALAVLSLL AGALALAELL GAPGPAPGLA KGSHPVHCIL FLALFVVTNV RSLQVSQLQQ 

       130        140        150        160        170        180 
VGQLALFFSL TFALLCCPFA LGGPARSSAG GAMGSTVAEQ GVWQLLLVTF VSYALLPVRS 

       190        200        210        220        230        240 
LLAIGFGLVV AASHLLVTAA LVPAKRPRLW RTLGANALLF FGVNMYGVFV RILTERSQRK 

       250        260        270        280        290        300 
AFLQARNCIE DRLRLEDENE KQERLLMSLL PRNVAMEMKE DFLKPPERIF HKIYIQRHDN 

       310        320        330        340        350        360 
VSILFADIVG FTGLASQCTA QELVKLLNEL FGKFDELATE NHCRRIKILG DCYYCVSGLT 

       370        380        390        400        410        420 
QPKTDHAHCC VEMGLDMIDT ITSVAEATEV DLNMRVGLHT GRVLCGVLGL RKWQYDVWSN 

       430        440        450        460        470        480 
DVTLANVMEA AGLPGKVHIT KTTLACLNGD YEVEPGHGHE RNTFLRTHNI ETFFIVPSHR 

       490        500        510        520        530        540 
RKIFPGLILS DIKPAKRMKF KTVCYLLVQL MHCRKMFKAE IPFSNVMTCE DDDKRRALRT 

       550        560        570        580        590        600 
ASEKLRNRSS FSTNVVYTTP GTRVNRYISR LLEARQTELE MADLNFFTLK YKHVEREQKY 

       610        620        630        640        650        660 
HQLQDEYFTS AVVLALILAA LFGLIYLLVI PQSVAVLLLL VFSICFLVAC TLYLHITRVQ 

       670        680        690        700        710        720 
CFPGCLTIQI RTALCVFIVV LIYSVAQGCV VGCLPWAWSS QSNSSLVVLA AGGRRTVLPA 

       730        740        750        760        770        780 
LPCESAHHAL LCCLVGTLPL AIFLRVSSLP KMILLSGLTT SYILVLELSG YTKVGGGALS 

       790        800        810        820        830        840 
GRSYEPIMAI LLFSCTLALH ARQVDVRLRL DYLWAAQAEE ERDDMERVKL DNKRILFNLL 

       850        860        870        880        890        900 
PAHVAQHFLM SNPRNMDLYY QSYSQVGVMF ASIPNFNDFY IELDGNNMGV ECLRLLNEII 

       910        920        930        940        950        960 
ADFDELMDKD FYKDLEKIKT IGSTYMAAVG LAPTAGTRAK KSISSHLCTL ADFAIDMFDV 

       970        980        990       1000       1010       1020 
LDEINYQSYN DFVLRVGINV GPVVAGVIGA RRPQYDIWGN TVNVASRMDS TGVQGRIQVT 

      1030       1040       1050       1060       1070       1080 
EEVHRLLKRC SYQFVCRGKV SVKGKGEMLT YFLEGRTDGN SSHGRTFRLE RRMCPYGRGG 

      1090       1100       1110 
GQARRPPLCP AAGPPVRPGL PPAPTSQYLS STAAGKEA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex." Abdel-Majid R.M., Leong W.L., Schalkwyk L.C., Smallman D.S., Wong S.T., Storm D.R., Fine A., Dobson M.J., Guernsey D.L., Neumann P.E. Nat. Genet. 19:289-291(1998) [PubMed: 9662407] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-1050. Strain: C57BL/6J. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AL669838 Genomic DNA. Translation: CAI25155.1. AF053980 mRNA. Translation: AAC29478.1.
IPI	IPI00130949.
RefSeq	NP_033752.1.
UniGene	Mm.259733
3D structure databases
SMR	O88444. Positions 287-476, 858-1053.
ModBase	Search...
Protein-protein interaction databases
STRING	O88444.
PTM databases
PhosphoSite	O88444.
Proteomic databases
PRIDE	O88444.
Genome annotation databases
Ensembl	ENSMUST00000020706; ENSMUSP00000020706; ENSMUSG00000020431; Mus musculus. [Genome view]
GeneID	432530.
KEGG	mmu:432530.
UCSC	uc007hzf.1. mouse.
Organism-specific databases
CTD	432530.
MGI	MGI:99677. Adcy1.
Phylogenomic databases
eggNOG	roNOG09082.
HOGENOM	HBG445220.
HOVERGEN	O88444.
InParanoid	O88444.
OMA	KCISSHL.
OrthoDB	EOG99PDHQ.
PhylomeDB	O88444.
Enzyme and pathway databases
BRENDA	4.6.1.1. 244.
Gene expression databases
ArrayExpress	O88444.
Bgee	O88444.
CleanEx	MM_ADCY1.
Genevestigator	O88444.
GermOnline	ENSMUSG00000020431. Mus musculus.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	407738.
SOURCE	Search...

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Entry information

Entry name

ADCY1_MOUSE

Accession

Primary (citable) accession number: O88444
Secondary accession number(s): Q5SS89

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	April 12, 2005
Last modified:	January 19, 2010
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents