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O88444

- ADCY1_MOUSE

UniProt

O88444 - ADCY1_MOUSE

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Protein
Adenylate cyclase type 1
Gene
Adcy1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina.1 Publication

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulationi

Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi307 – 3071Magnesium 1 By similarity
Metal bindingi307 – 3071Magnesium 2 By similarity
Metal bindingi308 – 3081Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi351 – 3511Magnesium 1 By similarity
Metal bindingi351 – 3511Magnesium 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: MGI
  3. calcium- and calmodulin-responsive adenylate cyclase activity Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. axonogenesis Source: MGI
  3. cAMP biosynthetic process Source: MGI
  4. circadian rhythm Source: Ensembl
  5. intracellular signal transduction Source: InterPro
  6. long-term memory Source: MGI
  7. regulation of circadian rhythm Source: UniProtKB
  8. response to drug Source: Ensembl
  9. response to lithium ion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Biological rhythms, cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 1 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 1
Adenylate cyclase type I
Adenylyl cyclase 1
Ca(2+)/calmodulin-activated adenylyl cyclase
Gene namesi
Name:Adcy1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:99677. Adcy1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Topological domaini234 – 609376Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei610 – 63021Helical; Reviewed prediction
Add
BLAST
Transmembranei634 – 65421Helical; Reviewed prediction
Add
BLAST
Transmembranei673 – 69321Helical; Reviewed prediction
Add
BLAST
Transmembranei724 – 74421Helical; Reviewed prediction
Add
BLAST
Transmembranei752 – 77221Helical; Reviewed prediction
Add
BLAST
Transmembranei774 – 79320Helical; Reviewed prediction
Add
BLAST
Topological domaini794 – 1118325Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: Ensembl
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show a significant reduction in daytime contrast sensitivity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11181118Adenylate cyclase type 1
PRO_0000195683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi703 – 7031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88444.
PRIDEiO88444.

PTM databases

PhosphoSiteiO88444.

Expressioni

Inductioni

Expression in the retina oscillates in a circadian manner.1 Publication

Gene expression databases

BgeeiO88444.
CleanExiMM_ADCY1.
GenevestigatoriO88444.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020706.

Structurei

3D structure databases

ProteinModelPortaliO88444.
SMRiO88444. Positions 289-476, 859-1053.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni492 – 51928Interaction with calmodulin By similarity
Add
BLAST
Regioni1023 – 104624Interaction with calmodulin By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00680000099709.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiO88444.
KOiK08041.
OMAiCLPWAWS.
OrthoDBiEOG7B8S30.
PhylomeDBiO88444.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88444-1 [UniParc]FASTAAdd to Basket

« Hide

MAGAPRGQGG GGGAGEPGGA ERAAGPGGRR GFRACGEEFA CPELEALFRG     50
YTLRLEQAAT LKALAVLSLL AGALALAELL GAPGPAPGLA KGSHPVHCIL 100
FLALFVVTNV RSLQVSQLQQ VGQLALFFSL TFALLCCPFA LGGPARSSAG 150
GAMGSTVAEQ GVWQLLLVTF VSYALLPVRS LLAIGFGLVV AASHLLVTAA 200
LVPAKRPRLW RTLGANALLF FGVNMYGVFV RILTERSQRK AFLQARNCIE 250
DRLRLEDENE KQERLLMSLL PRNVAMEMKE DFLKPPERIF HKIYIQRHDN 300
VSILFADIVG FTGLASQCTA QELVKLLNEL FGKFDELATE NHCRRIKILG 350
DCYYCVSGLT QPKTDHAHCC VEMGLDMIDT ITSVAEATEV DLNMRVGLHT 400
GRVLCGVLGL RKWQYDVWSN DVTLANVMEA AGLPGKVHIT KTTLACLNGD 450
YEVEPGHGHE RNTFLRTHNI ETFFIVPSHR RKIFPGLILS DIKPAKRMKF 500
KTVCYLLVQL MHCRKMFKAE IPFSNVMTCE DDDKRRALRT ASEKLRNRSS 550
FSTNVVYTTP GTRVNRYISR LLEARQTELE MADLNFFTLK YKHVEREQKY 600
HQLQDEYFTS AVVLALILAA LFGLIYLLVI PQSVAVLLLL VFSICFLVAC 650
TLYLHITRVQ CFPGCLTIQI RTALCVFIVV LIYSVAQGCV VGCLPWAWSS 700
QSNSSLVVLA AGGRRTVLPA LPCESAHHAL LCCLVGTLPL AIFLRVSSLP 750
KMILLSGLTT SYILVLELSG YTKVGGGALS GRSYEPIMAI LLFSCTLALH 800
ARQVDVRLRL DYLWAAQAEE ERDDMERVKL DNKRILFNLL PAHVAQHFLM 850
SNPRNMDLYY QSYSQVGVMF ASIPNFNDFY IELDGNNMGV ECLRLLNEII 900
ADFDELMDKD FYKDLEKIKT IGSTYMAAVG LAPTAGTRAK KSISSHLCTL 950
ADFAIDMFDV LDEINYQSYN DFVLRVGINV GPVVAGVIGA RRPQYDIWGN 1000
TVNVASRMDS TGVQGRIQVT EEVHRLLKRC SYQFVCRGKV SVKGKGEMLT 1050
YFLEGRTDGN SSHGRTFRLE RRMCPYGRGG GQARRPPLCP AAGPPVRPGL 1100
PPAPTSQYLS STAAGKEA 1118
Length:1,118
Mass (Da):123,373
Last modified:April 12, 2005 - v2
Checksum:iCEFAFF3940B22277
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1559SSAGGAMGS → ALQEAQWAR in AAC29478. 1 Publication
Sequence conflicti234 – 2341T → A in AAC29478. 1 Publication
Sequence conflicti270 – 2701L → M in AAC29478. 1 Publication
Sequence conflicti319 – 3191T → K in AAC29478. 1 Publication
Sequence conflicti466 – 4661R → K in AAC29478. 1 Publication
Sequence conflicti523 – 5231F → I in AAC29478. 1 Publication
Sequence conflicti542 – 5421S → T in AAC29478. 1 Publication
Sequence conflicti549 – 5491S → T in AAC29478. 1 Publication
Sequence conflicti570 – 5701R → L in AAC29478. 1 Publication
Sequence conflicti598 – 5981Q → R in AAC29478. 1 Publication
Sequence conflicti692 – 6921G → V in AAC29478. 1 Publication
Sequence conflicti697 – 6971A → S in AAC29478. 1 Publication
Sequence conflicti707 – 7071V → L in AAC29478. 1 Publication
Sequence conflicti713 – 7131G → C in AAC29478. 1 Publication
Sequence conflicti720 – 7212AL → GP in AAC29478. 1 Publication
Sequence conflicti774 – 7763VGG → AMGA in AAC29478. 1 Publication
Sequence conflicti867 – 8693GVM → AVL in AAC29478. 1 Publication
Sequence conflicti938 – 9381R → K in AAC29478. 1 Publication
Sequence conflicti991 – 9911R → C in AAC29478. 1 Publication
Sequence conflicti1020 – 10201T → I in AAC29478. 1 Publication
Sequence conflicti1030 – 10301C → S in AAC29478. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL669838 Genomic DNA. Translation: CAI25155.1.
AF053980 mRNA. Translation: AAC29478.1.
CCDSiCCDS24426.1.
RefSeqiNP_033752.1. NM_009622.1.
UniGeneiMm.259733.

Genome annotation databases

EnsembliENSMUST00000020706; ENSMUSP00000020706; ENSMUSG00000020431.
GeneIDi432530.
KEGGimmu:432530.
UCSCiuc007hzf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL669838 Genomic DNA. Translation: CAI25155.1 .
AF053980 mRNA. Translation: AAC29478.1 .
CCDSi CCDS24426.1.
RefSeqi NP_033752.1. NM_009622.1.
UniGenei Mm.259733.

3D structure databases

ProteinModelPortali O88444.
SMRi O88444. Positions 289-476, 859-1053.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020706.

Chemistry

BindingDBi O88444.

PTM databases

PhosphoSitei O88444.

Proteomic databases

PaxDbi O88444.
PRIDEi O88444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020706 ; ENSMUSP00000020706 ; ENSMUSG00000020431 .
GeneIDi 432530.
KEGGi mmu:432530.
UCSCi uc007hzf.1. mouse.

Organism-specific databases

CTDi 107.
MGIi MGI:99677. Adcy1.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00680000099709.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi O88444.
KOi K08041.
OMAi CLPWAWS.
OrthoDBi EOG7B8S30.
PhylomeDBi O88444.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

ChiTaRSi ADCY1. mouse.
NextBioi 407738.
PROi O88444.
SOURCEi Search...

Gene expression databases

Bgeei O88444.
CleanExi MM_ADCY1.
Genevestigatori O88444.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex."
    Abdel-Majid R.M., Leong W.L., Schalkwyk L.C., Smallman D.S., Wong S.T., Storm D.R., Fine A., Dobson M.J., Guernsey D.L., Neumann P.E.
    Nat. Genet. 19:289-291(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-1050.
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells."
    Hwang C.K., Chaurasia S.S., Jackson C.R., Chan G.C., Storm D.R., Iuvone P.M.
    J. Neurosci. 33:14989-14997(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiADCY1_MOUSE
AccessioniPrimary (citable) accession number: O88444
Secondary accession number(s): Q5SS89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: April 12, 2005
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi