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Protein

Metaxin-2

Gene

Mtx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport of proteins into the mitochondrion.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Metaxin-2
Alternative name(s):
Mitochondrial outer membrane import complex protein 2
Gene namesi
Name:Mtx2
ORF Names:MNCb-0780
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859652. Mtx2.

Subcellular locationi

  • Mitochondrion outer membrane 1 Publication
  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 263262Metaxin-2PRO_0000220996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO88441.
MaxQBiO88441.
PaxDbiO88441.
PRIDEiO88441.
TopDownProteomicsiO88441.

PTM databases

iPTMnetiO88441.
PhosphoSiteiO88441.

Expressioni

Gene expression databases

BgeeiO88441.
CleanExiMM_MTX2.
GenevisibleiO88441. MM.

Interactioni

Subunit structurei

Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi207298. 22 interactions.
IntActiO88441. 27 interactions.
MINTiMINT-1860963.
STRINGi10090.ENSMUSP00000028511.

Structurei

3D structure databases

ProteinModelPortaliO88441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metaxin family.Curated

Phylogenomic databases

eggNOGiKOG3027. Eukaryota.
ENOG410XY7W. LUCA.
GeneTreeiENSGT00530000063166.
HOGENOMiHOG000231908.
HOVERGENiHBG003471.
InParanoidiO88441.
KOiK17776.
OMAiPWPENAA.
OrthoDBiEOG7SFHX6.
PhylomeDBiO88441.
TreeFamiTF313422.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR033468. Metaxin_GST.
IPR019564. Sam37/metaxin_N.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF10568. Tom37. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVAEAFVS QIAATEPWPE NATLYQQLRG EQILLSDNAA SLAVQAFLQM
60 70 80 90 100
CNLPVKVVCR ANAEYMSPSG KVPFIHVGNQ VVSELGPIVQ FVKAKGHSLS
110 120 130 140 150
DGLDEVQKAE MKAYMELVNN MLLTAELYLQ WCDEATVGEI TIARYGSPYP
160 170 180 190 200
WPLNHILAYQ KQWEVKRKMK AIGWGNKTLD QVLEDVDQCC QALSQRLGTQ
210 220 230 240 250
PYFFNKQPTE LDALVFGHLY TILTTQLTSD ELSEKVKNYS NLLAFCRRIE
260
QHYFEDWGKG RLS
Length:263
Mass (Da):29,758
Last modified:November 1, 1998 - v1
Checksum:iD77DE08F05DF7C11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053550 mRNA. Translation: AAC25104.1.
AB041562 mRNA. Translation: BAA95046.1.
AK087933 mRNA. Translation: BAC40046.1.
AK168000 mRNA. Translation: BAE39989.1.
AK169048 mRNA. Translation: BAE40836.1.
BC006641 mRNA. Translation: AAH06641.1.
CCDSiCCDS16148.1.
RefSeqiNP_058084.3. NM_016804.4.
UniGeneiMm.292613.
Mm.478750.

Genome annotation databases

EnsembliENSMUST00000028511; ENSMUSP00000028511; ENSMUSG00000027099.
GeneIDi53375.
KEGGimmu:53375.
UCSCiuc008kej.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053550 mRNA. Translation: AAC25104.1.
AB041562 mRNA. Translation: BAA95046.1.
AK087933 mRNA. Translation: BAC40046.1.
AK168000 mRNA. Translation: BAE39989.1.
AK169048 mRNA. Translation: BAE40836.1.
BC006641 mRNA. Translation: AAH06641.1.
CCDSiCCDS16148.1.
RefSeqiNP_058084.3. NM_016804.4.
UniGeneiMm.292613.
Mm.478750.

3D structure databases

ProteinModelPortaliO88441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207298. 22 interactions.
IntActiO88441. 27 interactions.
MINTiMINT-1860963.
STRINGi10090.ENSMUSP00000028511.

PTM databases

iPTMnetiO88441.
PhosphoSiteiO88441.

Proteomic databases

EPDiO88441.
MaxQBiO88441.
PaxDbiO88441.
PRIDEiO88441.
TopDownProteomicsiO88441.

Protocols and materials databases

DNASUi53375.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028511; ENSMUSP00000028511; ENSMUSG00000027099.
GeneIDi53375.
KEGGimmu:53375.
UCSCiuc008kej.2. mouse.

Organism-specific databases

CTDi10651.
MGIiMGI:1859652. Mtx2.

Phylogenomic databases

eggNOGiKOG3027. Eukaryota.
ENOG410XY7W. LUCA.
GeneTreeiENSGT00530000063166.
HOGENOMiHOG000231908.
HOVERGENiHBG003471.
InParanoidiO88441.
KOiK17776.
OMAiPWPENAA.
OrthoDBiEOG7SFHX6.
PhylomeDBiO88441.
TreeFamiTF313422.

Miscellaneous databases

PROiO88441.
SOURCEiSearch...

Gene expression databases

BgeeiO88441.
CleanExiMM_MTX2.
GenevisibleiO88441. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR033468. Metaxin_GST.
IPR019564. Sam37/metaxin_N.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF10568. Tom37. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane."
    Armstrong L.C., Saenz A.J., Bornstein P.
    J. Cell. Biochem. 74:11-22(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MTX1, SUBCELLULAR LOCATION, FUNCTION.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ, C57BL/6J and NOD.
    Tissue: Kidney and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiMTX2_MOUSE
AccessioniPrimary (citable) accession number: O88441
Secondary accession number(s): Q3TFR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.