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Protein

Paired box protein Pax-4

Gene

Pax4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi170 – 229HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • circadian rhythm Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • pancreas development Source: InterPro
  • positive regulation of cell differentiation Source: Ensembl
  • response to cAMP Source: RGD
  • response to drug Source: RGD
  • retina development in camera-type eye Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-4
Gene namesi
Name:Pax4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620433. Pax4.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501821 – 349Paired box protein Pax-4Add BLAST349

Proteomic databases

PaxDbiO88436.
PRIDEiO88436.

Expressioni

Tissue specificityi

Specifically expressed in pancreatic islets.

Gene expression databases

BgeeiENSRNOG00000008020.
GenevisibleiO88436. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010658.

Structurei

3D structure databases

ProteinModelPortaliO88436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 131PairedPROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni278 – 349Transcription repressionAdd BLAST72

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiO88436.
KOiK08032.
OMAiESLGPSC.
OrthoDBiEOG091G0S4E.
PhylomeDBiO88436.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033559. Pax-4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF14. PTHR24329:SF14. 2 hits.
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: O88436-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQDGLSSVN QLGGLFVNGR PLPLDTRQQI VQLAIRGMRP CDISRSLKVS
60 70 80 90 100
NGCVSKILGR YYRTGVLEPK GIGGSKPRLA TPAVVARIAQ LKDEYPALFA
110 120 130 140 150
WEIQRQLCAE GLCTQDKAPS VSSINRVLRA LQEDQRLHWT QLRSPAVLAP
160 170 180 190 200
ALPSPHSNCE APRGPHPGTS HRNRTIFSPG QAEALEKEFQ RGQYPDSVVR
210 220 230 240 250
GKLAAATSLP EDTVRVWFSN RRAKWRRQEK LKWETQMPGA SQDLMVPKDS
260 270 280 290 300
PGIISAQQSP GSVPSAALPV LEQLNPSFCQ LCWGAVPDRC SSDTTSQACL
310 320 330 340
QPYWECHSLL PVASSSYMEF AWPCLTTHPV HHLIGGPGQA PSTYYLHWP
Length:349
Mass (Da):38,485
Last modified:November 1, 1998 - v1
Checksum:iA383009DBB0C0F8D
GO
Isoform B (identifier: O88436-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-187: Missing.

Show »
Length:307
Mass (Da):34,103
Checksum:i434BA394DDA47E3F
GO
Isoform C (identifier: O88436-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-223: WFSNRRA → SELWNTV
     224-349: Missing.

Show »
Length:223
Mass (Da):24,451
Checksum:i31194FF27A13644B
GO
Isoform D (identifier: O88436-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-187: Missing.
     217-223: WFSNRRA → SELWNTV
     224-349: Missing.

Show »
Length:181
Mass (Da):20,069
Checksum:iDF6B000D9EF62422
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002363146 – 187Missing in isoform B and isoform D. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_002364217 – 223WFSNRRA → SELWNTV in isoform C and isoform D. 2 Publications7
Alternative sequenceiVSP_002365224 – 349Missing in isoform C and isoform D. 2 PublicationsAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053100 mRNA. Translation: AAC40195.1.
AF053101 mRNA. Translation: AAC40196.1.
AF053102 mRNA. Translation: AAC40197.1.
AF053103 mRNA. Translation: AAC40198.1.
AF198155 mRNA. Translation: AAF04858.1.
AF198156 mRNA. Translation: AAF04859.1.
PIRiJE0202.
RefSeqiNP_113987.1. NM_031799.1. [O88436-1]
XP_006236294.1. XM_006236232.3. [O88436-1]
XP_006236295.1. XM_006236233.3. [O88436-1]
XP_017448403.1. XM_017592914.1. [O88436-1]
XP_017448405.1. XM_017592916.1. [O88436-2]
UniGeneiRn.14531.

Genome annotation databases

EnsembliENSRNOT00000010658; ENSRNOP00000010658; ENSRNOG00000008020. [O88436-1]
GeneIDi83630.
KEGGirno:83630.
UCSCiRGD:620433. rat. [O88436-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053100 mRNA. Translation: AAC40195.1.
AF053101 mRNA. Translation: AAC40196.1.
AF053102 mRNA. Translation: AAC40197.1.
AF053103 mRNA. Translation: AAC40198.1.
AF198155 mRNA. Translation: AAF04858.1.
AF198156 mRNA. Translation: AAF04859.1.
PIRiJE0202.
RefSeqiNP_113987.1. NM_031799.1. [O88436-1]
XP_006236294.1. XM_006236232.3. [O88436-1]
XP_006236295.1. XM_006236233.3. [O88436-1]
XP_017448403.1. XM_017592914.1. [O88436-1]
XP_017448405.1. XM_017592916.1. [O88436-2]
UniGeneiRn.14531.

3D structure databases

ProteinModelPortaliO88436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010658.

Proteomic databases

PaxDbiO88436.
PRIDEiO88436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010658; ENSRNOP00000010658; ENSRNOG00000008020. [O88436-1]
GeneIDi83630.
KEGGirno:83630.
UCSCiRGD:620433. rat. [O88436-1]

Organism-specific databases

CTDi5078.
RGDi620433. Pax4.

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiO88436.
KOiK08032.
OMAiESLGPSC.
OrthoDBiEOG091G0S4E.
PhylomeDBiO88436.

Enzyme and pathway databases

ReactomeiR-RNO-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Miscellaneous databases

PROiO88436.

Gene expression databases

BgeeiENSRNOG00000008020.
GenevisibleiO88436. RN.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033559. Pax-4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF14. PTHR24329:SF14. 2 hits.
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAX4_RAT
AccessioniPrimary (citable) accession number: O88436
Secondary accession number(s): O88437, O88438, O88439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.