ID   CCL22_MOUSE             Reviewed;          92 AA.
AC   O88430;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-NOV-2011, entry version 94.
DE   RecName: Full=C-C motif chemokine 22;
DE   AltName: Full=Activated B and dendritic cell-derived;
DE   AltName: Full=CC chemokine ABCD-1;
DE   AltName: Full=Small-inducible cytokine A22;
DE   Flags: Precursor;
GN   Name=Ccl22; Synonyms=Abcd1, Scya22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=98353531; PubMed=9687523; DOI=10.1084/jem.188.3.451;
RA   Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C.,
RA   Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G.,
RA   Sideras P.;
RT   "Activated murine B lymphocytes and dendritic cells produce a novel CC
RT   chemokine which acts selectively on activated T cells.";
RL   J. Exp. Med. 188:451-463(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Chemotactic for activated T-lymphocytes. May play an
CC       important role in the collaboration of dendritic cells and B-
CC       lymphocytes with T-cells in immune responses.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by activated splenic B-lymphocytes
CC       and dendritic cells. Low expression in lung, thymocytes, lymph
CC       node, and unstimulated splenic cells.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
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DR   EMBL; AF052505; AAC40200.1; -; mRNA.
DR   EMBL; BC012658; AAH12658.1; -; mRNA.
DR   IPI; IPI00130912; -.
DR   RefSeq; NP_033163.1; NM_009137.2.
DR   UniGene; Mm.12895; -.
DR   ProteinModelPortal; O88430; -.
DR   SMR; O88430; 31-92.
DR   STRING; O88430; -.
DR   PRIDE; O88430; -.
DR   Ensembl; ENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
DR   GeneID; 20299; -.
DR   KEGG; mmu:20299; -.
DR   CTD; 6367; -.
DR   MGI; MGI:1306779; Ccl22.
DR   eggNOG; roNOG17917; -.
DR   HOGENOM; HBG505826; -.
DR   HOVERGEN; HBG017871; -.
DR   InParanoid; O88430; -.
DR   OMA; VEDSICC; -.
DR   OrthoDB; EOG4BCDPM; -.
DR   PhylomeDB; O88430; -.
DR   NextBio; 298033; -.
DR   ArrayExpress; O88430; -.
DR   Bgee; O88430; -.
DR   CleanEx; MM_CCL22; -.
DR   Genevestigator; O88430; -.
DR   GermOnline; ENSMUSG00000031779; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR002473; Chemokine_CXCL8/IL8.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   KO; K05514; -.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00436; INTERLEUKIN8.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Chemokine_IL8; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Complete proteome; Cytokine; Disulfide bond;
KW   Inflammatory response; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25     92       C-C motif chemokine 22.
FT                                /FTId=PRO_0000005228.
FT   DISULFID     36     60       By similarity.
FT   DISULFID     37     76       By similarity.
SQ   SEQUENCE   92 AA;  10302 MW;  39859881CDAE07CA CRC64;
     MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC
     RKPGVVLITV KNRDICADPR QVWVKKLLHK LS
//