ID   CCL22_MOUSE             Reviewed;          92 AA.
AC   O88430;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 167.
DE   RecName: Full=C-C motif chemokine 22;
DE   AltName: Full=Activated B and dendritic cell-derived;
DE   AltName: Full=CC chemokine ABCD-1;
DE   AltName: Full=Small-inducible cytokine A22;
DE   Flags: Precursor;
GN   Name=Ccl22; Synonyms=Abcd1, Scya22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=9687523; DOI=10.1084/jem.188.3.451;
RA   Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T.,
RA   Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.;
RT   "Activated murine B lymphocytes and dendritic cells produce a novel CC
RT   chemokine which acts selectively on activated T cells.";
RL   J. Exp. Med. 188:451-463(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Chemotactic for activated T-lymphocytes. May play an
CC       important role in the collaboration of dendritic cells and B-
CC       lymphocytes with T-cells in immune responses.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by activated splenic B-lymphocytes and
CC       dendritic cells. Low expression in lung, thymocytes, lymph node, and
CC       unstimulated splenic cells.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF052505; AAC40200.1; -; mRNA.
DR   EMBL; BC012658; AAH12658.1; -; mRNA.
DR   CCDS; CCDS40441.1; -.
DR   RefSeq; NP_033163.1; NM_009137.2.
DR   AlphaFoldDB; O88430; -.
DR   SMR; O88430; -.
DR   STRING; 10090.ENSMUSP00000034231; -.
DR   PhosphoSitePlus; O88430; -.
DR   PaxDb; 10090-ENSMUSP00000034231; -.
DR   Antibodypedia; 15019; 575 antibodies from 33 providers.
DR   DNASU; 20299; -.
DR   Ensembl; ENSMUST00000034231.4; ENSMUSP00000034231.4; ENSMUSG00000031779.4.
DR   GeneID; 20299; -.
DR   KEGG; mmu:20299; -.
DR   UCSC; uc009mww.1; mouse.
DR   AGR; MGI:1306779; -.
DR   CTD; 6367; -.
DR   MGI; MGI:1306779; Ccl22.
DR   VEuPathDB; HostDB:ENSMUSG00000031779; -.
DR   eggNOG; ENOG502SWZ0; Eukaryota.
DR   GeneTree; ENSGT01100000263482; -.
DR   HOGENOM; CLU_141716_4_2_1; -.
DR   InParanoid; O88430; -.
DR   OMA; RDYIRHP; -.
DR   OrthoDB; 4265193at2759; -.
DR   PhylomeDB; O88430; -.
DR   TreeFam; TF334888; -.
DR   Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR   BioGRID-ORCS; 20299; 1 hit in 77 CRISPR screens.
DR   PRO; PR:O88430; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; O88430; Protein.
DR   Bgee; ENSMUSG00000031779; Expressed in peripheral lymph node and 25 other cell types or tissues.
DR   ExpressionAtlas; O88430; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF102; C-C MOTIF CHEMOKINE 22; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00436; INTERLEUKIN8.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
DR   Genevisible; O88430; MM.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..92
FT                   /note="C-C motif chemokine 22"
FT                   /id="PRO_0000005228"
FT   DISULFID        36..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10302 MW;  39859881CDAE07CA CRC64;
     MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC
     RKPGVVLITV KNRDICADPR QVWVKKLLHK LS
//