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O88430

- CCL22_MOUSE

UniProt

O88430 - CCL22_MOUSE

Protein

C-C motif chemokine 22

Gene

Ccl22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 22
    Alternative name(s):
    Activated B and dendritic cell-derived
    CC chemokine ABCD-1
    Small-inducible cytokine A22
    Gene namesi
    Name:Ccl22
    Synonyms:Abcd1, Scya22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1306779. Ccl22.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 9268C-C motif chemokine 22PRO_0000005228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 60By similarity
    Disulfide bondi37 ↔ 76By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO88430.

    Expressioni

    Tissue specificityi

    Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.

    Gene expression databases

    ArrayExpressiO88430.
    BgeeiO88430.
    CleanExiMM_CCL22.
    GenevestigatoriO88430.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034231.

    Structurei

    3D structure databases

    ProteinModelPortaliO88430.
    SMRiO88430. Positions 34-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41373.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiO88430.
    KOiK05514.
    OMAiVKNRDIC.
    OrthoDBiEOG7M3J34.
    PhylomeDBiO88430.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV   50
    KEFFWTSKSC RKPGVVLITV KNRDICADPR QVWVKKLLHK LS 92
    Length:92
    Mass (Da):10,302
    Last modified:November 1, 1998 - v1
    Checksum:i39859881CDAE07CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052505 mRNA. Translation: AAC40200.1.
    BC012658 mRNA. Translation: AAH12658.1.
    CCDSiCCDS40441.1.
    RefSeqiNP_033163.1. NM_009137.2.
    UniGeneiMm.12895.

    Genome annotation databases

    EnsembliENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
    GeneIDi20299.
    KEGGimmu:20299.
    UCSCiuc009mww.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052505 mRNA. Translation: AAC40200.1 .
    BC012658 mRNA. Translation: AAH12658.1 .
    CCDSi CCDS40441.1.
    RefSeqi NP_033163.1. NM_009137.2.
    UniGenei Mm.12895.

    3D structure databases

    ProteinModelPortali O88430.
    SMRi O88430. Positions 34-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034231.

    Proteomic databases

    PRIDEi O88430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034231 ; ENSMUSP00000034231 ; ENSMUSG00000031779 .
    GeneIDi 20299.
    KEGGi mmu:20299.
    UCSCi uc009mww.1. mouse.

    Organism-specific databases

    CTDi 6367.
    MGIi MGI:1306779. Ccl22.

    Phylogenomic databases

    eggNOGi NOG41373.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi O88430.
    KOi K05514.
    OMAi VKNRDIC.
    OrthoDBi EOG7M3J34.
    PhylomeDBi O88430.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298033.
    PROi O88430.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88430.
    Bgeei O88430.
    CleanExi MM_CCL22.
    Genevestigatori O88430.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells."
      Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.
      J. Exp. Med. 188:451-463(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiCCL22_MOUSE
    AccessioniPrimary (citable) accession number: O88430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3