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O88430

- CCL22_MOUSE

UniProt

O88430 - CCL22_MOUSE

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Protein
C-C motif chemokine 22
Gene
Ccl22, Abcd1, Scya22
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 22
Alternative name(s):
Activated B and dendritic cell-derived
CC chemokine ABCD-1
Small-inducible cytokine A22
Gene namesi
Name:Ccl22
Synonyms:Abcd1, Scya22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1306779. Ccl22.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 9268C-C motif chemokine 22
PRO_0000005228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 60 By similarity
Disulfide bondi37 ↔ 76 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO88430.

Expressioni

Tissue specificityi

Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.

Gene expression databases

ArrayExpressiO88430.
BgeeiO88430.
CleanExiMM_CCL22.
GenevestigatoriO88430.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034231.

Structurei

3D structure databases

ProteinModelPortaliO88430.
SMRiO88430. Positions 34-91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41373.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO88430.
KOiK05514.
OMAiVKNRDIC.
OrthoDBiEOG7M3J34.
PhylomeDBiO88430.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88430-1 [UniParc]FASTAAdd to Basket

« Hide

MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV   50
KEFFWTSKSC RKPGVVLITV KNRDICADPR QVWVKKLLHK LS 92
Length:92
Mass (Da):10,302
Last modified:November 1, 1998 - v1
Checksum:i39859881CDAE07CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052505 mRNA. Translation: AAC40200.1.
BC012658 mRNA. Translation: AAH12658.1.
CCDSiCCDS40441.1.
RefSeqiNP_033163.1. NM_009137.2.
UniGeneiMm.12895.

Genome annotation databases

EnsembliENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
GeneIDi20299.
KEGGimmu:20299.
UCSCiuc009mww.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052505 mRNA. Translation: AAC40200.1 .
BC012658 mRNA. Translation: AAH12658.1 .
CCDSi CCDS40441.1.
RefSeqi NP_033163.1. NM_009137.2.
UniGenei Mm.12895.

3D structure databases

ProteinModelPortali O88430.
SMRi O88430. Positions 34-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034231.

Proteomic databases

PRIDEi O88430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034231 ; ENSMUSP00000034231 ; ENSMUSG00000031779 .
GeneIDi 20299.
KEGGi mmu:20299.
UCSCi uc009mww.1. mouse.

Organism-specific databases

CTDi 6367.
MGIi MGI:1306779. Ccl22.

Phylogenomic databases

eggNOGi NOG41373.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi O88430.
KOi K05514.
OMAi VKNRDIC.
OrthoDBi EOG7M3J34.
PhylomeDBi O88430.
TreeFami TF334888.

Miscellaneous databases

NextBioi 298033.
PROi O88430.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88430.
Bgeei O88430.
CleanExi MM_CCL22.
Genevestigatori O88430.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells."
    Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.
    J. Exp. Med. 188:451-463(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiCCL22_MOUSE
AccessioniPrimary (citable) accession number: O88430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi