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O88430

- CCL22_MOUSE

UniProt

O88430 - CCL22_MOUSE

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Protein

C-C motif chemokine 22

Gene

Ccl22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 22
Alternative name(s):
Activated B and dendritic cell-derived
CC chemokine ABCD-1
Small-inducible cytokine A22
Gene namesi
Name:Ccl22
Synonyms:Abcd1, Scya22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1306779. Ccl22.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 9268C-C motif chemokine 22PRO_0000005228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 60By similarity
Disulfide bondi37 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO88430.

Expressioni

Tissue specificityi

Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.

Gene expression databases

BgeeiO88430.
CleanExiMM_CCL22.
ExpressionAtlasiO88430. baseline and differential.
GenevestigatoriO88430.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034231.

Structurei

3D structure databases

ProteinModelPortaliO88430.
SMRiO88430. Positions 36-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41373.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO88430.
KOiK05514.
OMAiVKNRDIC.
OrthoDBiEOG7M3J34.
PhylomeDBiO88430.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV
60 70 80 90
KEFFWTSKSC RKPGVVLITV KNRDICADPR QVWVKKLLHK LS
Length:92
Mass (Da):10,302
Last modified:November 1, 1998 - v1
Checksum:i39859881CDAE07CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052505 mRNA. Translation: AAC40200.1.
BC012658 mRNA. Translation: AAH12658.1.
CCDSiCCDS40441.1.
RefSeqiNP_033163.1. NM_009137.2.
UniGeneiMm.12895.

Genome annotation databases

EnsembliENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
GeneIDi20299.
KEGGimmu:20299.
UCSCiuc009mww.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052505 mRNA. Translation: AAC40200.1 .
BC012658 mRNA. Translation: AAH12658.1 .
CCDSi CCDS40441.1.
RefSeqi NP_033163.1. NM_009137.2.
UniGenei Mm.12895.

3D structure databases

ProteinModelPortali O88430.
SMRi O88430. Positions 36-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034231.

Proteomic databases

PRIDEi O88430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034231 ; ENSMUSP00000034231 ; ENSMUSG00000031779 .
GeneIDi 20299.
KEGGi mmu:20299.
UCSCi uc009mww.1. mouse.

Organism-specific databases

CTDi 6367.
MGIi MGI:1306779. Ccl22.

Phylogenomic databases

eggNOGi NOG41373.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi O88430.
KOi K05514.
OMAi VKNRDIC.
OrthoDBi EOG7M3J34.
PhylomeDBi O88430.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_230248. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 298033.
PROi O88430.
SOURCEi Search...

Gene expression databases

Bgeei O88430.
CleanExi MM_CCL22.
ExpressionAtlasi O88430. baseline and differential.
Genevestigatori O88430.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells."
    Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.
    J. Exp. Med. 188:451-463(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiCCL22_MOUSE
AccessioniPrimary (citable) accession number: O88430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3