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O88430 (CCL22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 22
Alternative name(s):
Activated B and dendritic cell-derived
CC chemokine ABCD-1
Small-inducible cytokine A22
Gene names
Name:Ccl22
Synonyms:Abcd1, Scya22
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.

Subcellular location

Secreted.

Tissue specificity

Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from direct assay PubMed 23460747. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 9268C-C motif chemokine 22
PRO_0000005228

Amino acid modifications

Disulfide bond36 ↔ 60 By similarity
Disulfide bond37 ↔ 76 By similarity

Sequences

Sequence LengthMass (Da)Tools
O88430 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 39859881CDAE07CA

FASTA9210,302
        10         20         30         40         50         60 
MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC 

        70         80         90 
RKPGVVLITV KNRDICADPR QVWVKKLLHK LS 

« Hide

References

« Hide 'large scale' references
[1]"Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells."
Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.
J. Exp. Med. 188:451-463(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF052505 mRNA. Translation: AAC40200.1.
BC012658 mRNA. Translation: AAH12658.1.
CCDSCCDS40441.1.
RefSeqNP_033163.1. NM_009137.2.
UniGeneMm.12895.

3D structure databases

ProteinModelPortalO88430.
SMRO88430. Positions 34-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000034231.

Proteomic databases

PRIDEO88430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
GeneID20299.
KEGGmmu:20299.
UCSCuc009mww.1. mouse.

Organism-specific databases

CTD6367.
MGIMGI:1306779. Ccl22.

Phylogenomic databases

eggNOGNOG41373.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidO88430.
KOK05514.
OMAVKNRDIC.
OrthoDBEOG7M3J34.
PhylomeDBO88430.
TreeFamTF334888.

Gene expression databases

ArrayExpressO88430.
BgeeO88430.
CleanExMM_CCL22.
GenevestigatorO88430.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298033.
PROO88430.
SOURCESearch...

Entry information

Entry nameCCL22_MOUSE
AccessionPrimary (citable) accession number: O88430
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot