O88430 (CCL22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 22

Alternative name(s):
Activated B and dendritic cell-derived
CC chemokine ABCD-1
Small-inducible cytokine A22

Gene names

Name:	Ccl22
Synonyms:	Abcd1, Scya22

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.
Subcellular location	Secreted.
Tissue specificity	Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chemokine activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 92	68	C-C motif chemokine 22		PRO_0000005228
Amino acid modifications
	Disulfide bond	36 ↔ 60		By similarity
	Disulfide bond	37 ↔ 76		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O88430 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 39859881CDAE07CA	FASTA	92	10,302
	10 20 30 40 50 60 MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC 70 80 90 RKPGVVLITV KNRDICADPR QVWVKKLLHK LS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells." Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P. J. Exp. Med. 188:451-463(1998) [PubMed: 9687523] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF052505 mRNA. Translation: AAC40200.1. BC012658 mRNA. Translation: AAH12658.1.
IPI	IPI00130912.
RefSeq	NP_033163.1. NM_009137.2.
UniGene	Mm.12895.
3D structure databases
ProteinModelPortal	O88430.
SMR	O88430. Positions 31-92.
ModBase	Search...
Protein-protein interaction databases
STRING	O88430.
Proteomic databases
PRIDE	O88430.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
GeneID	20299.
KEGG	mmu:20299.
Organism-specific databases
CTD	6367.
MGI	MGI:1306779. Ccl22.
Phylogenomic databases
eggNOG	roNOG17917.
HOGENOM	HBG505826.
HOVERGEN	HBG017871.
InParanoid	O88430.
OMA	VEDSICC.
OrthoDB	EOG4BCDPM.
PhylomeDB	O88430.
Gene expression databases
ArrayExpress	O88430.
Bgee	O88430.
CleanEx	MM_CCL22.
Genevestigator	O88430.
GermOnline	ENSMUSG00000031779. Mus musculus.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR002473. Chemokine_CXCL8/IL8. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
KO	K05514.
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR00436. INTERLEUKIN8.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298033.
SOURCE	Search...

Entry information

Entry name

CCL22_MOUSE

Accession

Primary (citable) accession number: O88430

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program