O88426 (NDK6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate kinase 6
Short name=NDK 6
Short name=NDP kinase 6
EC=2.7.4.6

Alternative name(s):
nm23-R6

Gene names

Name:

Nme6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	175 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 175	›175	Nucleoside diphosphate kinase 6		PRO_0000137129
Sites
	Active site	118	1	Pros-phosphohistidine intermediate By similarity
	Binding site	8	1	ATP By similarity
	Binding site	57	1	ATP By similarity
	Binding site	85	1	ATP By similarity
	Binding site	91	1	ATP By similarity
	Binding site	105	1	ATP By similarity
	Binding site	115	1	ATP By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	O88426 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E75F77C698639878	FASTA	175	20,112
	10 20 30 40 50 60 QLTLALIKPD AVAHPLILEA VHQQILSNKF LIVRMRELLW KPEDCRRFYR EHEGRFFYQR 70 80 90 100 110 120 LVEFMTSGPI RAYILAHKDA IQLWRTLMGP TRVFRARHIA PDSIRGSLGL TDTRNTTHGS 130 140 150 160 170 DSVVSASREI AAFFPDFSEQ RWYEEEEPQL RCGPVHYSPE EGIHCAAETG GPKPA

References

[1]	"NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3." Mehus J.G., Deloukas P., Lambeth D.O. Hum. Genet. 104:454-459(1999) [PubMed: 10453732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF051943 mRNA. Translation: AAC78465.1.
IPI	IPI00366726.
UniGene	Rn.36170.
3D structure databases
ProteinModelPortal	O88426.
ModBase	Search...
Protein-protein interaction databases
STRING	O88426.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000028125; ENSRNOP00000028125; ENSRNOG00000020721.
Organism-specific databases
RGD	61896. Nme6.
Phylogenomic databases
eggNOG	roNOG10242.
GeneTree	ENSGT00550000074206.
HOVERGEN	HBG001619.
InParanoid	O88426.
Gene expression databases
ArrayExpress	O88426.
Genevestigator	O88426.
GermOnline	ENSRNOG00000020721. Rattus norvegicus.
Family and domain databases
InterPro	IPR001564. Nucleoside_diP_kinase. IPR023005. Nucleoside_diP_kinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
SUPFAM	SSF54919. NDK. 1 hit.
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK6_RAT

Accession

Primary (citable) accession number: O88426

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1998
Last modified:	September 21, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program