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Protein

Nucleoside diphosphate kinase 6

Gene

Nme6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.PROSITE-ProRule annotation

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191ATPBy similarity
Binding sitei68 – 681ATPBy similarity
Binding sitei96 – 961ATPBy similarity
Binding sitei102 – 1021ATPBy similarity
Binding sitei116 – 1161ATPBy similarity
Binding sitei126 – 1261ATPBy similarity
Active sitei129 – 1291Pros-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 6 (EC:2.7.4.6)
Short name:
NDK 6
Short name:
NDP kinase 6
Alternative name(s):
nm23-M6
Gene namesi
Name:Nme6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1861676. Nme6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Nucleoside diphosphate kinase 6PRO_0000137128Add
BLAST

Proteomic databases

EPDiO88425.
MaxQBiO88425.
PaxDbiO88425.
PeptideAtlasiO88425.
PRIDEiO88425.

Expressioni

Gene expression databases

BgeeiO88425.
ExpressionAtlasiO88425. baseline and differential.
GenevisibleiO88425. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035053.

Structurei

3D structure databases

ProteinModelPortaliO88425.
SMRiO88425. Positions 10-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
HOVERGENiHBG001619.
InParanoidiO88425.
KOiK00940.
OMAiGKFFYHR.
PhylomeDBiO88425.
TreeFamiTF354225.

Family and domain databases

InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRTRELQ
60 70 80 90 100
WKLEDCRRFY REHEGRFFYQ RLVEFMTSGP IRAYILAHKD AIQLWRTLMG
110 120 130 140 150
PTRVFRARYI APDSIRGSLG LTDTRNTTHG SDSVVSASRE IAAFFPDFSE
160 170 180
QRWYEEEEPQ LRCGPVHYSP EEGIHCAAET GGHKQPNKT
Length:189
Mass (Da):21,778
Last modified:November 1, 1998 - v1
Checksum:i47D830A249902ECD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791E → G in AAH02007 (PubMed:15489334).Curated
Sequence conflicti189 – 1891T → A in AAH02007 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051942 mRNA. Translation: AAC78464.1.
BC002007 mRNA. Translation: AAH02007.1.
CCDSiCCDS23558.1.
RefSeqiNP_061227.1. NM_018757.1.
XP_006512260.1. XM_006512197.1.
XP_006512261.1. XM_006512198.2.
XP_006512262.1. XM_006512199.2.
UniGeneiMm.12951.

Genome annotation databases

EnsembliENSMUST00000035053; ENSMUSP00000035053; ENSMUSG00000032478.
ENSMUST00000200468; ENSMUSP00000143021; ENSMUSG00000032478.
GeneIDi54369.
KEGGimmu:54369.
UCSCiuc009rst.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051942 mRNA. Translation: AAC78464.1.
BC002007 mRNA. Translation: AAH02007.1.
CCDSiCCDS23558.1.
RefSeqiNP_061227.1. NM_018757.1.
XP_006512260.1. XM_006512197.1.
XP_006512261.1. XM_006512198.2.
XP_006512262.1. XM_006512199.2.
UniGeneiMm.12951.

3D structure databases

ProteinModelPortaliO88425.
SMRiO88425. Positions 10-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035053.

Proteomic databases

EPDiO88425.
MaxQBiO88425.
PaxDbiO88425.
PeptideAtlasiO88425.
PRIDEiO88425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035053; ENSMUSP00000035053; ENSMUSG00000032478.
ENSMUST00000200468; ENSMUSP00000143021; ENSMUSG00000032478.
GeneIDi54369.
KEGGimmu:54369.
UCSCiuc009rst.1. mouse.

Organism-specific databases

CTDi10201.
MGIiMGI:1861676. Nme6.

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
HOVERGENiHBG001619.
InParanoidiO88425.
KOiK00940.
OMAiGKFFYHR.
PhylomeDBiO88425.
TreeFamiTF354225.

Miscellaneous databases

PROiO88425.
SOURCEiSearch...

Gene expression databases

BgeeiO88425.
ExpressionAtlasiO88425. baseline and differential.
GenevisibleiO88425. MM.

Family and domain databases

InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3."
    Mehus J.G., Deloukas P., Lambeth D.O.
    Hum. Genet. 104:454-459(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNDK6_MOUSE
AccessioniPrimary (citable) accession number: O88425
Secondary accession number(s): Q99M53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.