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Protein

Nucleoside diphosphate kinase 6

Gene

Nme6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.PROSITE-ProRule annotation

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19ATPBy similarity1
Binding sitei68ATPBy similarity1
Binding sitei96ATPBy similarity1
Binding sitei102ATPBy similarity1
Binding sitei116ATPBy similarity1
Binding sitei126ATPBy similarity1
Active sitei129Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 6 (EC:2.7.4.6)
Short name:
NDK 6
Short name:
NDP kinase 6
Alternative name(s):
nm23-M6
Gene namesi
Name:Nme6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1861676 Nme6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371281 – 189Nucleoside diphosphate kinase 6Add BLAST189

Proteomic databases

EPDiO88425
MaxQBiO88425
PaxDbiO88425
PeptideAtlasiO88425
PRIDEiO88425

PTM databases

PhosphoSitePlusiO88425

Expressioni

Gene expression databases

BgeeiENSMUSG00000032478
ExpressionAtlasiO88425 baseline and differential
GenevisibleiO88425 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035053

Structurei

3D structure databases

ProteinModelPortaliO88425
SMRiO88425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00760000119146
HOGENOMiHOG000224565
HOVERGENiHBG001619
InParanoidiO88425
KOiK00940
OMAiGKFFYHR
OrthoDBiEOG091G0FHI
PhylomeDBiO88425
TreeFamiTF354225

Family and domain databases

CDDicd04414 NDPk6, 1 hit
Gene3Di3.30.70.141, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR037994 NDPk6
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

O88425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRTRELQ
60 70 80 90 100
WKLEDCRRFY REHEGRFFYQ RLVEFMTSGP IRAYILAHKD AIQLWRTLMG
110 120 130 140 150
PTRVFRARYI APDSIRGSLG LTDTRNTTHG SDSVVSASRE IAAFFPDFSE
160 170 180
QRWYEEEEPQ LRCGPVHYSP EEGIHCAAET GGHKQPNKT
Length:189
Mass (Da):21,778
Last modified:November 1, 1998 - v1
Checksum:i47D830A249902ECD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179E → G in AAH02007 (PubMed:15489334).Curated1
Sequence conflicti189T → A in AAH02007 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051942 mRNA Translation: AAC78464.1
BC002007 mRNA Translation: AAH02007.1
CCDSiCCDS23558.1
RefSeqiNP_061227.1, NM_018757.1
XP_006512260.1, XM_006512197.1
XP_006512261.1, XM_006512198.3
XP_006512262.1, XM_006512199.3
UniGeneiMm.12951

Genome annotation databases

EnsembliENSMUST00000035053; ENSMUSP00000035053; ENSMUSG00000032478
ENSMUST00000200468; ENSMUSP00000143021; ENSMUSG00000032478
GeneIDi54369
KEGGimmu:54369
UCSCiuc009rst.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDK6_MOUSE
AccessioniPrimary (citable) accession number: O88425
Secondary accession number(s): Q99M53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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