Reviewed, UniProtKB/Swiss-Prot O88425 (NDK6_MOUSE)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 6
      Short name=NDP kinase 6
      Short name=NDK 6
    EC=2.7.4.6
Alternative name(s):
    nm23-M6

Gene names

Name:

Nme6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Nucleoside diphosphate kinase 6		PRO_0000137128
Sites
	Active site	129	1	Pros-phosphohistidine intermediate By similarity
	Binding site	19	1	ATP By similarity
	Binding site	68	1	ATP By similarity
	Binding site	96	1	ATP By similarity
	Binding site	102	1	ATP By similarity
	Binding site	116	1	ATP By similarity
	Binding site	126	1	ATP By similarity
Experimental info
	Sequence conflict	179	1	E → G in AAH02007. Ref.2
	Sequence conflict	189	1	T → A in AAH02007. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O88425-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 47D830A249902ECD	FASTA	189	21,778
	10 20 30 40 50 60 MTSILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRTRELQ WKLEDCRRFY 70 80 90 100 110 120 REHEGRFFYQ RLVEFMTSGP IRAYILAHKD AIQLWRTLMG PTRVFRARYI APDSIRGSLG 130 140 150 160 170 180 LTDTRNTTHG SDSVVSASRE IAAFFPDFSE QRWYEEEEPQ LRCGPVHYSP EEGIHCAAET GGHKQPNKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3." Mehus J.G., Deloukas P., Lambeth D.O. Hum. Genet. 104:454-459(1999) [PubMed: 10453732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF051942 mRNA. Translation: AAC78464.1. BC002007 mRNA. Translation: AAH02007.1.
IPI	IPI00130874.
RefSeq	NP_061227.1.
UniGene	Mm.12951
3D structure databases
SMR	O88425. Positions 11-161.
ModBase	Search...
Protein-protein interaction databases
STRING	O88425.
Proteomic databases
PRIDE	O88425.
Genome annotation databases
Ensembl	ENSMUST00000035053; ENSMUSP00000035053; ENSMUSG00000032478; Mus musculus. [Genome view]
GeneID	54369.
KEGG	mmu:54369.
NMPDR	fig|10090.3.peg.20910.
UCSC	uc009rst.1. mouse.
Organism-specific databases
CTD	54369.
MGI	MGI:1861676. Nme6.
Phylogenomic databases
eggNOG	roNOG10242.
HOGENOM	HBG445152.
HOVERGEN	O88425.
InParanoid	O88425.
OMA	YSPEGGI.
OrthoDB	EOG98PQ55.
PhylomeDB	O88425.
Enzyme and pathway databases
BRENDA	2.7.4.6. 244.
Gene expression databases
ArrayExpress	O88425.
Bgee	O88425.
Genevestigator	O88425.
GermOnline	ENSMUSG00000032478. Mus musculus.
Family and domain databases
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	311170.
SOURCE	Search...

Entry information

Entry name

NDK6_MOUSE

Accession

Primary (citable) accession number: O88425
Secondary accession number(s): Q99M53

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1998
Last modified:	January 19, 2010
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)