##gff-version 3 O88420 UniProtKB Chain 1 1978 . . . ID=PRO_0000390890;Note=Sodium channel protein type 8 subunit alpha O88420 UniProtKB Topological domain 1 132 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 133 151 . . . Note=Helical%3B Name%3DS1 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 152 158 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 159 179 . . . Note=Helical%3B Name%3DS2 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 180 193 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 194 211 . . . Note=Helical%3B Name%3DS3 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 212 217 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 218 234 . . . Note=Helical%3B Name%3DS4 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 235 253 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 254 273 . . . Note=Helical%3B Name%3DS5 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 274 355 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Intramembrane 356 380 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 381 387 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 388 408 . . . Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 409 751 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 752 770 . . . Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 771 781 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 782 801 . . . Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 802 815 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 816 835 . . . Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 836 837 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 838 855 . . . Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 856 871 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 872 890 . . . Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 891 919 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Intramembrane 920 940 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 941 953 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 954 974 . . . Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 975 1197 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1198 1215 . . . Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1216 1228 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1229 1247 . . . Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1248 1261 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1262 1280 . . . Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1281 1288 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1289 1307 . . . Note=Helical%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1308 1324 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1325 1344 . . . Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1345 1397 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Intramembrane 1398 1419 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1420 1436 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1437 1458 . . . Note=Helical%3B Name%3DS6 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1459 1521 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1522 1539 . . . Note=Helical%3B Name%3DS1 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1540 1550 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1551 1569 . . . Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1570 1581 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1582 1599 . . . Note=Helical%3B Name%3DS3 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1600 1612 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1613 1629 . . . Note=Helical%3B Name%3DS4 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1630 1648 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1649 1666 . . . Note=Helical%3B Name%3DS5 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1667 1688 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Intramembrane 1689 1711 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1712 1740 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Transmembrane 1741 1763 . . . Note=Helical%3B Name%3DS6 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Topological domain 1764 1978 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Repeat 114 442 . . . Note=I;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Repeat 733 1005 . . . Note=II;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Repeat 1178 1493 . . . Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Repeat 1502 1799 . . . Note=IV;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88420 UniProtKB Domain 1893 1922 . . . Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116 O88420 UniProtKB Region 1 20 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Region 28 62 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Region 446 530 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Region 576 597 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Region 1105 1146 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Region 1923 1978 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Compositional bias 28 57 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Compositional bias 500 530 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Compositional bias 1114 1129 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Compositional bias 1948 1978 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88420 UniProtKB Binding site 371 371 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Binding site 373 373 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Binding site 891 898 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Binding site 937 937 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Binding site 1411 1411 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Modified residue 518 518 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 O88420 UniProtKB Modified residue 520 520 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 O88420 UniProtKB Modified residue 1495 1495 . . . Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15858 O88420 UniProtKB Glycosylation 215 215 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 289 289 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 295 295 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 308 308 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 326 326 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 1356 1356 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 1370 1370 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Glycosylation 1381 1381 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O88420 UniProtKB Disulfide bond 281 333 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Disulfide bond 902 902 . . . Note=Interchain%3B with SCN2B or SCN4B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04775 O88420 UniProtKB Disulfide bond 902 902 . . . Note=Interchain%3B with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B%3B the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04775 O88420 UniProtKB Disulfide bond 904 910 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Disulfide bond 942 951 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 O88420 UniProtKB Disulfide bond 1354 1374 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Disulfide bond 1719 1734 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UQD0 O88420 UniProtKB Alternative sequence 664 664 . . . ID=VSP_038652;Note=In isoform 2. E->EVKIDKAATDS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9603190;Dbxref=PMID:9603190