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Protein

Probable G-protein coupled receptor 33

Gene

Gpr33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor; could be a chemoattractant receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 33
Gene namesi
Name:Gpr33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1277106. Gpr33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5323Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6411CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8622Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini87 – 10317ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16522Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 20944ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 24616CytoplasmicSequence analysisAdd
BLAST
Transmembranei247 – 26822Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 28315ExtracellularSequence analysisAdd
BLAST
Transmembranei284 – 30320Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini304 – 33936CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Probable G-protein coupled receptor 33PRO_0000069554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88416.
PRIDEiO88416.

Expressioni

Tissue specificityi

Expressed predominantly in lung, spleen and testis.1 Publication

Gene expression databases

BgeeiO88416.
CleanExiMM_GPR33.
ExpressionAtlasiO88416. baseline and differential.
GenevisibleiO88416. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048059.

Structurei

3D structure databases

ProteinModelPortaliO88416.
SMRiO88416. Positions 42-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKP8. Eukaryota.
ENOG4111ISS. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112790.
HOVERGENiHBG096748.
InParanoidiO88416.
KOiK08382.
OMAiIHVACFI.
OrthoDBiEOG7T7GTK.
PhylomeDBiO88416.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLINSSTHV INVSTSLTNS TGVPTPAPKT IIAASLFMAF IIGVISNGLY
60 70 80 90 100
LWMLQFKMQR TVNTLLFFHL ILSYFISTLI LPFMATSFLQ DNHWVFGSVL
110 120 130 140 150
CKAFNSTLSV SMFASVFFLS AISVARYYLI LHPVWSQQHR TPHWASRIAL
160 170 180 190 200
QIWISATILS IPYLVFRTTH DDHKGRIKCQ NNYIVSTDWE SKEHQTLGQW
210 220 230 240 250
IHAACFVGRF LLGFLLPFLV IIFCYKRVAT KMKEKGLFKS SKPFKVMVTA
260 270 280 290 300
VISFFVCWMP YHVHSGLVLT KSQPLPLHLT LGLAVVTISF NTVVSPVLYL
310 320 330
FTGENFKVFK KSILALFNST FSDISSTERT QTLNSETEI
Length:339
Mass (Da):38,446
Last modified:November 1, 1998 - v1
Checksum:iCCA468A38B55A1FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045766 mRNA. Translation: AAC40152.1.
BC064084 mRNA. Translation: AAH64084.1.
CCDSiCCDS25904.1.
RefSeqiNP_032185.1. NM_008159.2.
UniGeneiMm.12890.

Genome annotation databases

EnsembliENSMUST00000040161; ENSMUSP00000048059; ENSMUSG00000035148.
GeneIDi14762.
KEGGimmu:14762.
UCSCiuc007nnf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045766 mRNA. Translation: AAC40152.1.
BC064084 mRNA. Translation: AAH64084.1.
CCDSiCCDS25904.1.
RefSeqiNP_032185.1. NM_008159.2.
UniGeneiMm.12890.

3D structure databases

ProteinModelPortaliO88416.
SMRiO88416. Positions 42-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048059.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO88416.
PRIDEiO88416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040161; ENSMUSP00000048059; ENSMUSG00000035148.
GeneIDi14762.
KEGGimmu:14762.
UCSCiuc007nnf.1. mouse.

Organism-specific databases

CTDi2856.
MGIiMGI:1277106. Gpr33.

Phylogenomic databases

eggNOGiENOG410IKP8. Eukaryota.
ENOG4111ISS. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112790.
HOVERGENiHBG096748.
InParanoidiO88416.
KOiK08382.
OMAiIHVACFI.
OrthoDBiEOG7T7GTK.
PhylomeDBiO88416.
TreeFamiTF330976.

Miscellaneous databases

NextBioi286839.
PROiO88416.
SOURCEiSearch...

Gene expression databases

BgeeiO88416.
CleanExiMM_GPR33.
ExpressionAtlasiO88416. baseline and differential.
GenevisibleiO88416. MM.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning genes encoding receptors related to chemoattractant receptors."
    Marchese A., Nguyen T., Malik P., Xu S., Cheng R., Xie Z., Heng H.H.Q., George S.R., Kolakowski L.F. Jr., O'Dowd B.F.
    Genomics 50:281-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR33_MOUSE
AccessioniPrimary (citable) accession number: O88416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.