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Protein

Tubby-related protein 3

Gene

Tulp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • bone development Source: MGI
  • brain development Source: MGI
  • bronchus morphogenesis Source: MGI
  • central nervous system neuron differentiation Source: MGI
  • dorsal/ventral neural tube patterning Source: MGI
  • embryonic camera-type eye development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic neurocranium morphogenesis Source: MGI
  • ganglion development Source: MGI
  • limb development Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
  • negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Source: MGI
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • neural tube formation Source: MGI
  • protein localization to photoreceptor outer segment Source: GO_Central
  • receptor localization to non-motile cilium Source: GO_Central
  • regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  • regulation of smoothened signaling pathway Source: MGI
  • smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-related protein 3
Alternative name(s):
Tubby-like protein 3
Gene namesi
Name:Tulp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1329045 Tulp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Membrane, Nucleus, Secreted

Pathology & Biotechi

Disruption phenotypei

Failure of neural tube closure and death by embryonic day 14.5. Failure of cranial neural tube closure coincident with increased neuroepithelial apoptosis specifically in the hindbrain and the caudal neural tube. In addition, the number of tubulin beta-3 positive cells is significantly decreased in the embryonic hindbrain. Morphological defects in the embryonic craniofacial regions, the spinal neural tube and the limbs.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864711 – 460Tubby-related protein 3Add BLAST460

Proteomic databases

EPDiO88413
MaxQBiO88413
PaxDbiO88413
PeptideAtlasiO88413
PRIDEiO88413

PTM databases

iPTMnetiO88413
PhosphoSitePlusiO88413

Expressioni

Tissue specificityi

Widely expressed including eyes and adipose depots.1 Publication

Developmental stagei

Ubiquitously expressed during development.1 Publication

Gene expression databases

BgeeiENSMUSG00000001521
CleanExiMM_TULP3
ExpressionAtlasiO88413 baseline and differential
GenevisibleiO88413 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204384, 1 interactor
STRINGi10090.ENSMUSP00000001562

Structurei

3D structure databases

ProteinModelPortaliO88413
SMRiO88413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiKOG2502 Eukaryota
ENOG410XQFT LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000016044
HOVERGENiHBG018010
InParanoidiO88413
OMAiYDHGVSP
OrthoDBiEOG091G04TF
PhylomeDBiO88413
TreeFamiTF314076

Family and domain databases

Gene3Di3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR018066 Tubby_C_CS
IPR005398 Tubby_N
PfamiView protein in Pfam
PF01167 Tub, 1 hit
PF16322 Tub_N, 2 hits
PRINTSiPR01573 SUPERTUBBY
PR01574 TUBBYPROTEIN
SUPFAMiSSF54518 SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS01200 TUB_1, 1 hit
PS01201 TUB_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAARCAPGP RGDSAFDDET LRLRQLKLDN QRALLEKKQR KKRLEPLMVQ
60 70 80 90 100
PNPEARLRRL KPRGSEEHTP LVDPQMPRSD VILHGIDGPA AFLKPEAQDL
110 120 130 140 150
ESKPQVLSVG SPAPEEGTEG SADGESPEET APKPDLQEIL QKHGILSSVN
160 170 180 190 200
YDEEPDKEED EGGNLSSPSA RSEESAAASQ KAASETGASG VTAQQGDAQL
210 220 230 240 250
GEVENLEDFA YSPAPRGVTV KCKVTRDKKG MDRGLFPTYY MHLEREENRK
260 270 280 290 300
IFLLAGRKRK KSKTSNYLVS TDPTDLSREG ESYIGKLRSN LMGTKFTVYD
310 320 330 340 350
HGVNPVKAQG LVEKAHTRQE LAAICYETNV LGFKGPRKMS VIIPGMNMNH
360 370 380 390 400
ERIPFRPRNE HESLLSKWQN KSMENLIELH NKAPVWNDDT QSYVLNFHGR
410 420 430 440 450
VTQASVKNFQ IVHGNDPDYI VMQFGRVADD VFTLDYNYPL CALQAFAIGL
460
SSFDSKLACE
Length:460
Mass (Da):51,231
Last modified:November 1, 1998 - v1
Checksum:i02EBC62899BB8B3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045582 mRNA Translation: AAC95430.1
AB016963 mRNA Translation: BAA74752.1
BC060068 mRNA Translation: AAH60068.1
CCDSiCCDS39647.1
RefSeqiNP_035787.1, NM_011657.2
UniGeneiMm.291783
Mm.439490

Genome annotation databases

EnsembliENSMUST00000001562; ENSMUSP00000001562; ENSMUSG00000001521
GeneIDi22158
KEGGimmu:22158
UCSCiuc009edh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTULP3_MOUSE
AccessioniPrimary (citable) accession number: O88413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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