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Protein

C-X-C chemokine receptor type 3

Gene

Cxcr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Binds to CCL21.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Angiogenesis, Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 3
Short name:
CXC-R3
Short name:
CXCR-3
Alternative name(s):
Interferon-inducible protein 10 receptor
Short name:
IP-10 receptor
CD_antigen: CD183
Gene namesi
Name:Cxcr3
Synonyms:Cmkar3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1277207. Cxcr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7927Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini80 – 889CytoplasmicSequence Analysis
Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini110 – 12415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei125 – 14622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini147 – 16822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 18820Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini189 – 21123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini233 – 25422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27622Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini277 – 29721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei298 – 32023Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini321 – 36747CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • cytosol Source: GOC
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367C-X-C chemokine receptor type 3PRO_0000069347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Modified residuei27 – 271SulfotyrosineBy similarity
Modified residuei29 – 291SulfotyrosineBy similarity
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 202PROSITE-ProRule annotation

Post-translational modificationi

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PRIDEiO88410.

PTM databases

PhosphoSiteiO88410.

Expressioni

Tissue specificityi

Expresses in lymphoid organs and Th1 cells.1 Publication

Gene expression databases

BgeeiO88410.
CleanExiMM_CXCR3.
GenevisibleiO88410. MM.

Interactioni

Subunit structurei

Homomer. Forms heteromers with ACKR4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052444.

Structurei

3D structure databases

ProteinModelPortaliO88410.
SMRiO88410. Positions 59-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150428.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO88410.
KOiK04188.
OMAiAYCYARI.
OrthoDBiEOG7F5126.
PhylomeDBiO88410.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF27. PTHR24227:SF27. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLEVSERQV LDASDFAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF
60 70 80 90 100
DRTFLPALYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL
110 120 130 140 150
LVLTLPLWAV DAAVQWVFGP GLCKVAGALF NINFYAGAFL LACISFDRYL
160 170 180 190 200
SIVHATQIYR RDPRVRVALT CIVVWGLCLL FALPDFIYLS ANYDQRLNAT
210 220 230 240 250
HCQYNFPQVG RTALRVLQLV AGFLLPLLVM AYCYAHILAV LLVSRGQRRF
260 270 280 290 300
RAMRLVVVVV AAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS
310 320 330 340 350
VTSGMGYMHC CLNPLLYAFV GVKFREQMWM LFTRLGRSDQ RGPQRQPSSS
360
RRESSWSETT EASYLGL
Length:367
Mass (Da):41,018
Last modified:September 27, 2005 - v2
Checksum:iEF0348A8358AD951
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161F → S in AAH96626 (PubMed:15489334).Curated
Sequence conflicti292 – 2921E → K in AAC40163 (PubMed:9653165).Curated
Sequence conflicti327 – 3271Q → K in AAC40163 (PubMed:9653165).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045146 mRNA. Translation: AAC40163.1.
AB003174 mRNA. Translation: BAA34045.1.
BC096626 mRNA. Translation: AAH96626.1.
CCDSiCCDS30319.1.
PIRiJE0349.
RefSeqiNP_034040.1. NM_009910.3.
UniGeneiMm.12876.

Genome annotation databases

EnsembliENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232.
GeneIDi12766.
KEGGimmu:12766.
UCSCiuc009tye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045146 mRNA. Translation: AAC40163.1.
AB003174 mRNA. Translation: BAA34045.1.
BC096626 mRNA. Translation: AAH96626.1.
CCDSiCCDS30319.1.
PIRiJE0349.
RefSeqiNP_034040.1. NM_009910.3.
UniGeneiMm.12876.

3D structure databases

ProteinModelPortaliO88410.
SMRiO88410. Positions 59-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052444.

Chemistry

BindingDBiO88410.
ChEMBLiCHEMBL5200.
GuidetoPHARMACOLOGYi70.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO88410.

Proteomic databases

PRIDEiO88410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232.
GeneIDi12766.
KEGGimmu:12766.
UCSCiuc009tye.1. mouse.

Organism-specific databases

CTDi2833.
MGIiMGI:1277207. Cxcr3.

Phylogenomic databases

eggNOGiNOG150428.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO88410.
KOiK04188.
OMAiAYCYARI.
OrthoDBiEOG7F5126.
PhylomeDBiO88410.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi282126.
PROiO88410.
SOURCEiSearch...

Gene expression databases

BgeeiO88410.
CleanExiMM_CXCR3.
GenevisibleiO88410. MM.

Family and domain databases

InterProiIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF27. PTHR24227:SF27. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Cloning of the murine interferon-inducible protein 10 (IP-10) receptor and its specific expression in lymphoid organs."
    Tamaru M., Tominaga Y., Yatunami K., Narumi S.
    Biochem. Biophys. Res. Commun. 251:41-48(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Blood.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.

Entry informationi

Entry nameiCXCR3_MOUSE
AccessioniPrimary (citable) accession number: O88410
Secondary accession number(s): Q4V9Y6, Q9QWN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 27, 2005
Last modified: July 22, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.