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O88410 (CXCR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 3

Short name=CXC-R3
Short name=CXCR-3
Alternative name(s):
Interferon-inducible protein 10 receptor
Short name=IP-10 receptor
CD_antigen=CD183
Gene names
Name:Cxcr3
Synonyms:Cmkar3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response By similarity. Binds to CCL21. Ref.1 Ref.2

Subunit structure

Homomer. Forms heteromers with ACKR4 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expresses in lymphoid organs and Th1 cells. Ref.2

Post-translational modification

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding By similarity.

N-glycosylated By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processAngiogenesis
Chemotaxis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

T cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

calcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

chemokine (C-C motif) ligand 11 production

Inferred from sequence or structural similarity. Source: UniProtKB

inflammatory response

Inferred from electronic annotation. Source: InterPro

negative regulation of execution phase of apoptosis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of leukocyte migration

Inferred from electronic annotation. Source: InterPro

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 19008373. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionC-X-C chemokine binding

Inferred from sequence or structural similarity. Source: UniProtKB

C-X-C chemokine receptor activity

Inferred from electronic annotation. Source: Ensembl

receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367C-X-C chemokine receptor type 3
PRO_0000069347

Regions

Topological domain1 – 5252Extracellular Potential
Transmembrane53 – 7927Helical; Name=1; Potential
Topological domain80 – 889Cytoplasmic Potential
Transmembrane89 – 10921Helical; Name=2; Potential
Topological domain110 – 12415Extracellular Potential
Transmembrane125 – 14622Helical; Name=3; Potential
Topological domain147 – 16822Cytoplasmic Potential
Transmembrane169 – 18820Helical; Name=4; Potential
Topological domain189 – 21123Extracellular Potential
Transmembrane212 – 23221Helical; Name=5; Potential
Topological domain233 – 25422Cytoplasmic Potential
Transmembrane255 – 27622Helical; Name=6; Potential
Topological domain277 – 29721Extracellular Potential
Transmembrane298 – 32023Helical; Name=7; Potential
Topological domain321 – 36747Cytoplasmic Potential

Amino acid modifications

Modified residue271Sulfotyrosine By similarity
Modified residue291Sulfotyrosine By similarity
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation321N-linked (GlcNAc...) Potential
Disulfide bond123 ↔ 202 By similarity

Experimental info

Sequence conflict161F → S in AAH96626. Ref.3
Sequence conflict2921E → K in AAC40163. Ref.1
Sequence conflict3271Q → K in AAC40163. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O88410 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: EF0348A8358AD951

FASTA36741,018
        10         20         30         40         50         60 
MYLEVSERQV LDASDFAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF DRTFLPALYS 

        70         80         90        100        110        120 
LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL LVLTLPLWAV DAAVQWVFGP 

       130        140        150        160        170        180 
GLCKVAGALF NINFYAGAFL LACISFDRYL SIVHATQIYR RDPRVRVALT CIVVWGLCLL 

       190        200        210        220        230        240 
FALPDFIYLS ANYDQRLNAT HCQYNFPQVG RTALRVLQLV AGFLLPLLVM AYCYAHILAV 

       250        260        270        280        290        300 
LLVSRGQRRF RAMRLVVVVV AAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS 

       310        320        330        340        350        360 
VTSGMGYMHC CLNPLLYAFV GVKFREQMWM LFTRLGRSDQ RGPQRQPSSS RRESSWSETT 


EASYLGL 

« Hide

References

« Hide 'large scale' references
[1]"The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3."
Soto H., Wang W., Strieter R.M., Copeland N.G., Gilbert D.J., Jenkins N.A., Hedrick J., Zlotnik A.
Proc. Natl. Acad. Sci. U.S.A. 95:8205-8210(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"Cloning of the murine interferon-inducible protein 10 (IP-10) receptor and its specific expression in lymphoid organs."
Tamaru M., Tominaga Y., Yatunami K., Narumi S.
Biochem. Biophys. Res. Commun. 251:41-48(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
Tissue: Blood.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6NCr.
Tissue: Hematopoietic stem cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF045146 mRNA. Translation: AAC40163.1.
AB003174 mRNA. Translation: BAA34045.1.
BC096626 mRNA. Translation: AAH96626.1.
PIRJE0349.
RefSeqNP_034040.1. NM_009910.2.
UniGeneMm.12876.

3D structure databases

ProteinModelPortalO88410.
SMRO88410. Positions 59-325.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBO88410.
ChEMBLCHEMBL5200.
GuidetoPHARMACOLOGY70.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO88410.

Proteomic databases

PRIDEO88410.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232.
GeneID12766.
KEGGmmu:12766.
UCSCuc009tye.1. mouse.

Organism-specific databases

CTD2833.
MGIMGI:1277207. Cxcr3.

Phylogenomic databases

eggNOGNOG150428.
GeneTreeENSGT00730000110292.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidO88410.
KOK04188.
OMAAYCYARI.
OrthoDBEOG7F5126.
PhylomeDBO88410.
TreeFamTF330966.

Gene expression databases

BgeeO88410.
CleanExMM_CXCR3.
GenevestigatorO88410.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF27. PTHR24227:SF27. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282126.
PROO88410.
SOURCESearch...

Entry information

Entry nameCXCR3_MOUSE
AccessionPrimary (citable) accession number: O88410
Secondary accession number(s): Q4V9Y6, Q9QWN6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries