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O88410

- CXCR3_MOUSE

UniProt

O88410 - CXCR3_MOUSE

Protein

C-X-C chemokine receptor type 3

Gene

Cxcr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response By similarity. Binds to CCL21.By similarity2 Publications

    GO - Molecular functioni

    1. C-X-C chemokine binding Source: UniProtKB
    2. C-X-C chemokine receptor activity Source: Ensembl
    3. receptor activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. calcium-mediated signaling Source: Ensembl
    3. chemokine (C-C motif) ligand 11 production Source: UniProtKB
    4. G-protein coupled receptor signaling pathway Source: UniProtKB
    5. inflammatory response Source: InterPro
    6. negative regulation of angiogenesis Source: Ensembl
    7. negative regulation of endothelial cell proliferation Source: Ensembl
    8. negative regulation of execution phase of apoptosis Source: UniProtKB
    9. positive regulation of angiogenesis Source: UniProtKB
    10. positive regulation of cAMP-mediated signaling Source: Ensembl
    11. positive regulation of cAMP metabolic process Source: Ensembl
    12. positive regulation of cell proliferation Source: UniProtKB
    13. positive regulation of chemotaxis Source: UniProtKB
    14. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    15. positive regulation of execution phase of apoptosis Source: Ensembl
    16. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    17. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    18. regulation of leukocyte migration Source: InterPro
    19. T cell chemotaxis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Angiogenesis, Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 3
    Short name:
    CXC-R3
    Short name:
    CXCR-3
    Alternative name(s):
    Interferon-inducible protein 10 receptor
    Short name:
    IP-10 receptor
    CD_antigen: CD183
    Gene namesi
    Name:Cxcr3
    Synonyms:Cmkar3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1277207. Cxcr3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367C-X-C chemokine receptor type 3PRO_0000069347Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Modified residuei27 – 271SulfotyrosineBy similarity
    Modified residuei29 – 291SulfotyrosineBy similarity
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 202PROSITE-ProRule annotation

    Post-translational modificationi

    Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Proteomic databases

    PRIDEiO88410.

    PTM databases

    PhosphoSiteiO88410.

    Expressioni

    Tissue specificityi

    Expresses in lymphoid organs and Th1 cells.1 Publication

    Gene expression databases

    BgeeiO88410.
    CleanExiMM_CXCR3.
    GenevestigatoriO88410.

    Interactioni

    Subunit structurei

    Homomer. Forms heteromers with ACKR4 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO88410.
    SMRiO88410. Positions 59-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 889CytoplasmicSequence Analysis
    Topological domaini110 – 12415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 21123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 25422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini321 – 36747CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7927Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18820Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27622Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 32023Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150428.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO88410.
    KOiK04188.
    OMAiAYCYARI.
    OrthoDBiEOG7F5126.
    PhylomeDBiO88410.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004070. Chemokine_CXCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF27. PTHR24227:SF27. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01532. CXCCHMKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLEVSERQV LDASDFAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF    50
    DRTFLPALYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL 100
    LVLTLPLWAV DAAVQWVFGP GLCKVAGALF NINFYAGAFL LACISFDRYL 150
    SIVHATQIYR RDPRVRVALT CIVVWGLCLL FALPDFIYLS ANYDQRLNAT 200
    HCQYNFPQVG RTALRVLQLV AGFLLPLLVM AYCYAHILAV LLVSRGQRRF 250
    RAMRLVVVVV AAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS 300
    VTSGMGYMHC CLNPLLYAFV GVKFREQMWM LFTRLGRSDQ RGPQRQPSSS 350
    RRESSWSETT EASYLGL 367
    Length:367
    Mass (Da):41,018
    Last modified:September 27, 2005 - v2
    Checksum:iEF0348A8358AD951
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161F → S in AAH96626. (PubMed:15489334)Curated
    Sequence conflicti292 – 2921E → K in AAC40163. (PubMed:9653165)Curated
    Sequence conflicti327 – 3271Q → K in AAC40163. (PubMed:9653165)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045146 mRNA. Translation: AAC40163.1.
    AB003174 mRNA. Translation: BAA34045.1.
    BC096626 mRNA. Translation: AAH96626.1.
    CCDSiCCDS30319.1.
    PIRiJE0349.
    RefSeqiNP_034040.1. NM_009910.2.
    UniGeneiMm.12876.

    Genome annotation databases

    EnsembliENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232.
    GeneIDi12766.
    KEGGimmu:12766.
    UCSCiuc009tye.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045146 mRNA. Translation: AAC40163.1 .
    AB003174 mRNA. Translation: BAA34045.1 .
    BC096626 mRNA. Translation: AAH96626.1 .
    CCDSi CCDS30319.1.
    PIRi JE0349.
    RefSeqi NP_034040.1. NM_009910.2.
    UniGenei Mm.12876.

    3D structure databases

    ProteinModelPortali O88410.
    SMRi O88410. Positions 59-325.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi O88410.
    ChEMBLi CHEMBL5200.
    GuidetoPHARMACOLOGYi 70.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O88410.

    Proteomic databases

    PRIDEi O88410.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056614 ; ENSMUSP00000052444 ; ENSMUSG00000050232 .
    GeneIDi 12766.
    KEGGi mmu:12766.
    UCSCi uc009tye.1. mouse.

    Organism-specific databases

    CTDi 2833.
    MGIi MGI:1277207. Cxcr3.

    Phylogenomic databases

    eggNOGi NOG150428.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O88410.
    KOi K04188.
    OMAi AYCYARI.
    OrthoDBi EOG7F5126.
    PhylomeDBi O88410.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282126.
    PROi O88410.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88410.
    CleanExi MM_CXCR3.
    Genevestigatori O88410.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004070. Chemokine_CXCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF27. PTHR24227:SF27. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01532. CXCCHMKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Cloning of the murine interferon-inducible protein 10 (IP-10) receptor and its specific expression in lymphoid organs."
      Tamaru M., Tominaga Y., Yatunami K., Narumi S.
      Biochem. Biophys. Res. Commun. 251:41-48(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
      Tissue: Blood.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6NCr.
      Tissue: Hematopoietic stem cell.

    Entry informationi

    Entry nameiCXCR3_MOUSE
    AccessioniPrimary (citable) accession number: O88410
    Secondary accession number(s): Q4V9Y6, Q9QWN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3