Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O88407 (LFG2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lifeguard 2
Alternative name(s):
Fas apoptotic inhibitory molecule 2
Neural membrane protein 35
Gene names
Name:Faim2
Synonyms:Lfg, Lfg2, Nmp35
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.

Subunit structure

Interacts with FAS/TNFRSF6 and BAX By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Membrane raft By similarity. Cell junctionsynapsepostsynaptic cell membrane Ref.3.

Tissue specificity

Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain. Ref.3

Developmental stage

Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60). Ref.1

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Protein lifeguard 2
PRO_0000179089

Regions

Transmembrane106 – 12621Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane290 – 31021Helical; Potential

Amino acid modifications

Glycosylation1911N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O88407 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8A0FA4E4312A14F7

FASTA31635,036
        10         20         30         40         50         60 
MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG AFPQGPTAVP 

        70         80         90        100        110        120 
LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ LFIRKVYTIL LVQLLVTLAV 

       130        140        150        160        170        180 
VALFTFCDVV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTIFTLSMA 

       190        200        210        220        230        240 
YLTGMLSSYY NTTSVLLCLG ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL 

       250        260        270        280        290        300 
LAILLPFQYV PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI 

       310 
IYIFTFFLQL FGTNRE 

« Hide

References

« Hide 'large scale' references
[1]"Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system."
Schweitzer B., Taylor V., Welcher A.A., McClelland M., Suter U.
Mol. Cell. Neurosci. 11:260-273(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites."
Schweitzer B., Suter U., Taylor V.
Brain Res. Mol. Brain Res. 107:47-56(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF044201 mRNA. Translation: AAC32463.1.
BC087606 mRNA. Translation: AAH87606.1.
RefSeqNP_653357.1. NM_144756.2.
UniGeneRn.162026.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid251568. 1 interaction.
STRING10116.ENSRNOP00000039775.

PTM databases

PhosphoSiteO88407.

Proteomic databases

PRIDEO88407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000048934; ENSRNOP00000039775; ENSRNOG00000029015.
GeneID246274.
KEGGrno:100909872.
rno:246274.
UCSCRGD:628744. rat.

Organism-specific databases

CTD23017.
RGD628744. Faim2.

Phylogenomic databases

eggNOGCOG0670.
GeneTreeENSGT00500000044791.
HOGENOMHOG000060393.
HOVERGENHBG012084.
InParanoidO88407.
OMASCQGVIF.
OrthoDBEOG7VB2G8.
PhylomeDBO88407.
TreeFamTF319996.

Gene expression databases

GenevestigatorO88407.

Family and domain databases

InterProIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERPTHR23291. PTHR23291. 1 hit.
PfamPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623649.
PROO88407.

Entry information

Entry nameLFG2_RAT
AccessionPrimary (citable) accession number: O88407
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families