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Protein

Protein lifeguard 2

Gene

Faim2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity).By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. central nervous system development Source: RGD
  3. cerebellar granular layer development Source: UniProtKB
  4. cerebellar Purkinje cell differentiation Source: UniProtKB
  5. cerebellar Purkinje cell layer development Source: UniProtKB
  6. cerebellum development Source: UniProtKB
  7. regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 2
Alternative name(s):
Fas apoptotic inhibitory molecule 2
Neural membrane protein 35
Gene namesi
Name:Faim2
Synonyms:Lfg, Lfg2, Nmp35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi628744. Faim2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Membrane raft By similarity. Cell junctionsynapsepostsynaptic cell membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProtKB
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Protein lifeguard 2PRO_0000179089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO88407.

PTM databases

PhosphoSiteiO88407.

Expressioni

Tissue specificityi

Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain.1 Publication

Developmental stagei

Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60).1 Publication

Gene expression databases

ExpressionAtlasiO88407. baseline and differential.
GenevestigatoriO88407.

Interactioni

Subunit structurei

Interacts with FAS/TNFRSF6 and BAX.By similarity

Protein-protein interaction databases

BioGridi251568. 1 interaction.
STRINGi10116.ENSRNOP00000039775.

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiO88407.
OMAiSCQGVIF.
OrthoDBiEOG7VB2G8.
PhylomeDBiO88407.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88407-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG
60 70 80 90 100
AFPQGPTAVP LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ
110 120 130 140 150
LFIRKVYTIL LVQLLVTLAV VALFTFCDVV KDYVQANPGW YWASYAVFFA
160 170 180 190 200
TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLG
210 220 230 240 250
ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL LAILLPFQYV
260 270 280 290 300
PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI
310
IYIFTFFLQL FGTNRE
Length:316
Mass (Da):35,036
Last modified:November 1, 1998 - v1
Checksum:i8A0FA4E4312A14F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044201 mRNA. Translation: AAC32463.1.
BC087606 mRNA. Translation: AAH87606.1.
RefSeqiNP_653357.1. NM_144756.2.
UniGeneiRn.162026.

Genome annotation databases

EnsembliENSRNOT00000048934; ENSRNOP00000039775; ENSRNOG00000029015.
GeneIDi246274.
KEGGirno:246274.
UCSCiRGD:628744. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044201 mRNA. Translation: AAC32463.1.
BC087606 mRNA. Translation: AAH87606.1.
RefSeqiNP_653357.1. NM_144756.2.
UniGeneiRn.162026.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251568. 1 interaction.
STRINGi10116.ENSRNOP00000039775.

PTM databases

PhosphoSiteiO88407.

Proteomic databases

PRIDEiO88407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048934; ENSRNOP00000039775; ENSRNOG00000029015.
GeneIDi246274.
KEGGirno:246274.
UCSCiRGD:628744. rat.

Organism-specific databases

CTDi23017.
RGDi628744. Faim2.

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiO88407.
OMAiSCQGVIF.
OrthoDBiEOG7VB2G8.
PhylomeDBiO88407.
TreeFamiTF319996.

Miscellaneous databases

NextBioi623649.
PROiO88407.

Gene expression databases

ExpressionAtlasiO88407. baseline and differential.
GenevestigatoriO88407.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system."
    Schweitzer B., Taylor V., Welcher A.A., McClelland M., Suter U.
    Mol. Cell. Neurosci. 11:260-273(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites."
    Schweitzer B., Suter U., Taylor V.
    Brain Res. Mol. Brain Res. 107:47-56(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLFG2_RAT
AccessioniPrimary (citable) accession number: O88407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.