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O88407

- LFG2_RAT

UniProt

O88407 - LFG2_RAT

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Protein
Protein lifeguard 2
Gene
Faim2, Lfg, Lfg2, Nmp35
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. central nervous system development Source: RGD
  3. cerebellar Purkinje cell differentiation Source: UniProtKB
  4. cerebellar Purkinje cell layer development Source: UniProtKB
  5. cerebellar granular layer development Source: UniProtKB
  6. cerebellum development Source: UniProtKB
  7. regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 2
Alternative name(s):
Fas apoptotic inhibitory molecule 2
Neural membrane protein 35
Gene namesi
Name:Faim2
Synonyms:Lfg, Lfg2, Nmp35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi628744. Faim2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Membrane raft By similarity. Cell junctionsynapsepostsynaptic cell membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Transmembranei138 – 15821Helical; Reviewed prediction
Add
BLAST
Transmembranei165 – 18521Helical; Reviewed prediction
Add
BLAST
Transmembranei194 – 21421Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProtKB
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Protein lifeguard 2
PRO_0000179089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO88407.

PTM databases

PhosphoSiteiO88407.

Expressioni

Tissue specificityi

Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain.1 Publication

Developmental stagei

Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60).1 Publication

Gene expression databases

GenevestigatoriO88407.

Interactioni

Subunit structurei

Interacts with FAS/TNFRSF6 and BAX By similarity.

Protein-protein interaction databases

BioGridi251568. 1 interaction.
STRINGi10116.ENSRNOP00000039775.

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiO88407.
OMAiSCQGVIF.
OrthoDBiEOG7VB2G8.
PhylomeDBiO88407.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88407-1 [UniParc]FASTAAdd to Basket

« Hide

MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG    50
AFPQGPTAVP LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ 100
LFIRKVYTIL LVQLLVTLAV VALFTFCDVV KDYVQANPGW YWASYAVFFA 150
TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLG 200
ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL LAILLPFQYV 250
PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI 300
IYIFTFFLQL FGTNRE 316
Length:316
Mass (Da):35,036
Last modified:November 1, 1998 - v1
Checksum:i8A0FA4E4312A14F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044201 mRNA. Translation: AAC32463.1.
BC087606 mRNA. Translation: AAH87606.1.
RefSeqiNP_653357.1. NM_144756.2.
UniGeneiRn.162026.

Genome annotation databases

EnsembliENSRNOT00000048934; ENSRNOP00000039775; ENSRNOG00000029015.
GeneIDi246274.
KEGGirno:246274.
UCSCiRGD:628744. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044201 mRNA. Translation: AAC32463.1 .
BC087606 mRNA. Translation: AAH87606.1 .
RefSeqi NP_653357.1. NM_144756.2.
UniGenei Rn.162026.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251568. 1 interaction.
STRINGi 10116.ENSRNOP00000039775.

PTM databases

PhosphoSitei O88407.

Proteomic databases

PRIDEi O88407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000048934 ; ENSRNOP00000039775 ; ENSRNOG00000029015 .
GeneIDi 246274.
KEGGi rno:246274.
UCSCi RGD:628744. rat.

Organism-specific databases

CTDi 23017.
RGDi 628744. Faim2.

Phylogenomic databases

eggNOGi COG0670.
GeneTreei ENSGT00500000044791.
HOGENOMi HOG000060393.
HOVERGENi HBG012084.
InParanoidi O88407.
OMAi SCQGVIF.
OrthoDBi EOG7VB2G8.
PhylomeDBi O88407.
TreeFami TF319996.

Miscellaneous databases

NextBioi 623649.
PROi O88407.

Gene expression databases

Genevestigatori O88407.

Family and domain databases

InterProi IPR006214. Bax_inhibitor_1-related.
[Graphical view ]
PANTHERi PTHR23291. PTHR23291. 1 hit.
Pfami PF01027. Bax1-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system."
    Schweitzer B., Taylor V., Welcher A.A., McClelland M., Suter U.
    Mol. Cell. Neurosci. 11:260-273(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites."
    Schweitzer B., Suter U., Taylor V.
    Brain Res. Mol. Brain Res. 107:47-56(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLFG2_RAT
AccessioniPrimary (citable) accession number: O88407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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