Protein lifeguard 2 - Rattus norvegicus (Rat)

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O88407 (LFG2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein lifeguard 2

Alternative name(s):
Fas apoptotic inhibitory molecule 2
Neural membrane protein 35

Gene names

Name:	Faim2
Synonyms:	Lfg, Lfg2, Nmp35

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.
Subunit structure	Interacts with FAS/TNFRSF6 and BAX By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Membrane raft By similarity. Cell junction › synapse › postsynaptic cell membrane Ref.3.
Tissue specificity	Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain. Ref.3
Developmental stage	Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60). Ref.1
Sequence similarities	Belongs to the BI1 family. LFG subfamily.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cerebellar Purkinje cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB cerebellar granular layer development Inferred from sequence or structural similarity. Source: UniProtKB regulation of neuron apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 316

316

Protein lifeguard 2

PRO_0000179089

Regions

Transmembrane

106 – 126

Helical; Potential

Transmembrane

138 – 158

Helical; Potential

Transmembrane

165 – 185

Helical; Potential

Transmembrane

194 – 214

Helical; Potential

Transmembrane

225 – 245

Helical; Potential

Transmembrane

251 – 271

Helical; Potential

Transmembrane

290 – 310

Helical; Potential

Amino acid modifications

Modified residue

Phosphotyrosine By similarity

Glycosylation

191

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O88407 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8A0FA4E4312A14F7
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FASTA

316

35,036

        10         20         30         40         50         60 
MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG AFPQGPTAVP 

        70         80         90        100        110        120 
LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ LFIRKVYTIL LVQLLVTLAV 

       130        140        150        160        170        180 
VALFTFCDVV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTIFTLSMA 

       190        200        210        220        230        240 
YLTGMLSSYY NTTSVLLCLG ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL 

       250        260        270        280        290        300 
LAILLPFQYV PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI 

       310 
IYIFTFFLQL FGTNRE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system." Schweitzer B., Taylor V., Welcher A.A., McClelland M., Suter U. Mol. Cell. Neurosci. 11:260-273(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites." Schweitzer B., Suter U., Taylor V. Brain Res. Mol. Brain Res. 107:47-56(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044201 mRNA. Translation: AAC32463.1. BC087606 mRNA. Translation: AAH87606.1.
IPI	IPI00207906.
RefSeq	NP_653357.1. NM_144756.2. XP_003752174.1. XM_003752126.1.
UniGene	Rn.162026.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000039775.
PTM databases
PhosphoSite	O88407.
Proteomic databases
PRIDE	O88407.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000048934; ENSRNOP00000039775; ENSRNOG00000029015.
GeneID	100909872. 246274.
KEGG	rno:100909872. rno:246274.
UCSC	RGD:628744. rat.
Organism-specific databases
CTD	23017.
RGD	628744. Faim2.
Phylogenomic databases
eggNOG	COG0670.
GeneTree	ENSGT00500000044791.
HOGENOM	HOG000060393.
HOVERGEN	HBG012084.
InParanoid	O88407.
OrthoDB	EOG43R3N3.
Gene expression databases
Genevestigator	O88407.
GermOnline	ENSRNOG00000029015. Rattus norvegicus.
Family and domain databases
InterPro	IPR006214. Bax_inhibitor_1-related. [Graphical view]
PANTHER	PTHR23291. PTHR23291. 1 hit.
Pfam	PF01027. Bax1-I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	623649.

Entry information

Entry name

LFG2_RAT

Accession

Primary (citable) accession number: O88407

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents