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O88407

- LFG2_RAT

UniProt

O88407 - LFG2_RAT

Protein

Protein lifeguard 2

Gene

Faim2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. central nervous system development Source: RGD
    3. cerebellar granular layer development Source: UniProtKB
    4. cerebellar Purkinje cell differentiation Source: UniProtKB
    5. cerebellar Purkinje cell layer development Source: UniProtKB
    6. cerebellum development Source: UniProtKB
    7. regulation of neuron apoptotic process Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 2
    Alternative name(s):
    Fas apoptotic inhibitory molecule 2
    Neural membrane protein 35
    Gene namesi
    Name:Faim2
    Synonyms:Lfg, Lfg2, Nmp35
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi628744. Faim2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Membrane raft By similarity. Cell junctionsynapsepostsynaptic cell membrane 1 Publication

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: UniProtKB
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Protein lifeguard 2PRO_0000179089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO88407.

    PTM databases

    PhosphoSiteiO88407.

    Expressioni

    Tissue specificityi

    Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain.1 Publication

    Developmental stagei

    Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60).1 Publication

    Gene expression databases

    GenevestigatoriO88407.

    Interactioni

    Subunit structurei

    Interacts with FAS/TNFRSF6 and BAX.By similarity

    Protein-protein interaction databases

    BioGridi251568. 1 interaction.
    STRINGi10116.ENSRNOP00000039775.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    GeneTreeiENSGT00500000044791.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    InParanoidiO88407.
    OMAiSCQGVIF.
    OrthoDBiEOG7VB2G8.
    PhylomeDBiO88407.
    TreeFamiTF319996.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG    50
    AFPQGPTAVP LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ 100
    LFIRKVYTIL LVQLLVTLAV VALFTFCDVV KDYVQANPGW YWASYAVFFA 150
    TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLG 200
    ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL LAILLPFQYV 250
    PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI 300
    IYIFTFFLQL FGTNRE 316
    Length:316
    Mass (Da):35,036
    Last modified:November 1, 1998 - v1
    Checksum:i8A0FA4E4312A14F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044201 mRNA. Translation: AAC32463.1.
    BC087606 mRNA. Translation: AAH87606.1.
    RefSeqiNP_653357.1. NM_144756.2.
    UniGeneiRn.162026.

    Genome annotation databases

    EnsembliENSRNOT00000048934; ENSRNOP00000039775; ENSRNOG00000029015.
    GeneIDi246274.
    KEGGirno:246274.
    UCSCiRGD:628744. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044201 mRNA. Translation: AAC32463.1 .
    BC087606 mRNA. Translation: AAH87606.1 .
    RefSeqi NP_653357.1. NM_144756.2.
    UniGenei Rn.162026.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 251568. 1 interaction.
    STRINGi 10116.ENSRNOP00000039775.

    PTM databases

    PhosphoSitei O88407.

    Proteomic databases

    PRIDEi O88407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000048934 ; ENSRNOP00000039775 ; ENSRNOG00000029015 .
    GeneIDi 246274.
    KEGGi rno:246274.
    UCSCi RGD:628744. rat.

    Organism-specific databases

    CTDi 23017.
    RGDi 628744. Faim2.

    Phylogenomic databases

    eggNOGi COG0670.
    GeneTreei ENSGT00500000044791.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    InParanoidi O88407.
    OMAi SCQGVIF.
    OrthoDBi EOG7VB2G8.
    PhylomeDBi O88407.
    TreeFami TF319996.

    Miscellaneous databases

    NextBioi 623649.
    PROi O88407.

    Gene expression databases

    Genevestigatori O88407.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system."
      Schweitzer B., Taylor V., Welcher A.A., McClelland M., Suter U.
      Mol. Cell. Neurosci. 11:260-273(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites."
      Schweitzer B., Suter U., Taylor V.
      Brain Res. Mol. Brain Res. 107:47-56(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLFG2_RAT
    AccessioniPrimary (citable) accession number: O88407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3