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Protein

Solute carrier organic anion transporter family member 1A5

Gene

Slco1a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.

GO - Molecular functioni

  1. bile acid transmembrane transporter activity Source: RGD
  2. monocarboxylic acid transmembrane transporter activity Source: RGD
  3. organic anion transmembrane transporter activity Source: RGD
  4. thyroid hormone transmembrane transporter activity Source: RGD

GO - Biological processi

  1. bile acid and bile salt transport Source: RGD
  2. intestinal absorption Source: RGD
  3. monocarboxylic acid transport Source: RGD
  4. organic anion transport Source: RGD
  5. organ regeneration Source: RGD
  6. thyroid hormone transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_233958. Recycling of bile acids and salts.
REACT_251660. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.3. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name:
OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene namesi
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7, Slco1a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi70985. Slco1a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence Analysis
Transmembranei87 – 11125Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini112 – 15544ExtracellularSequence AnalysisAdd
BLAST
Transmembranei156 – 18429Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini185 – 20319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 24218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini268 – 31144CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei312 – 33322Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini334 – 35320ExtracellularSequence AnalysisAdd
BLAST
Transmembranei354 – 37724Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini378 – 3814CytoplasmicSequence Analysis
Transmembranei382 – 40524Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini406 – 513108ExtracellularSequence AnalysisAdd
BLAST
Transmembranei514 – 53623Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini537 – 5459CytoplasmicSequence Analysis
Transmembranei546 – 57126Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini572 – 60534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei606 – 62318Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini624 – 67047CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: RGD
  2. integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Solute carrier organic anion transporter family member 1A5PRO_0000191044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88397.
PRIDEiO88397.

Expressioni

Tissue specificityi

Highly expressed in the kidney and moderately abundant in the retina.

Gene expression databases

GenevestigatoriO88397.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040752.

Structurei

3D structure databases

ProteinModelPortaliO88397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256971.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiO88397.
KOiK03460.
OMAiCTRILAG.
OrthoDBiEOG7GFB4C.
PhylomeDBiO88397.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88397-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ
60 70 80 90 100
FDIPTSIVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC
110 120 130 140 150
FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRSQTL KPTQDPAECI
160 170 180 190 200
KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE
210 220 230 240 250
TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL
260 270 280 290 300
ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS
360 370 380 390 400
TAEVVLLIGV YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL
410 420 430 440 450
LYFLHFMITC DNFPVAGLTA SYEGVHHPLY VENKVLADCN RGCSCSTNSW
460 470 480 490 500
DPVCGDNGLA YMSACLAGCK KSVGTGTNMV FQNCSCIRSS GNSSAVLGLC
510 520 530 540 550
KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK PEEKSLGIGL
560 570 580 590 600
HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI
610 620 630 640 650
YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE
660 670
CTDVHGSPQV ENDGELKTRL
Length:670
Mass (Da):74,577
Last modified:January 10, 2003 - v2
Checksum:i17BA60B86E0B567A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331K → Q in AAC32804. (PubMed:9712861)Curated
Sequence conflicti55 – 551T → I in AAC32804. (PubMed:9712861)Curated
Sequence conflicti70 – 701L → F in AAC32804. (PubMed:9712861)Curated
Sequence conflicti421 – 4211S → L in AAC32804. (PubMed:9712861)Curated
Sequence conflicti543 – 5431E → K in AAC32804. (PubMed:9712861)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041105 mRNA. Translation: AAC32804.1.
AF083469 mRNA. Translation: AAG36719.1.
RefSeqiNP_110465.1. NM_030838.1.
XP_006237704.1. XM_006237642.2.
XP_006237705.1. XM_006237643.2.
XP_006237708.1. XM_006237646.2.
XP_008761654.1. XM_008763432.1.
UniGeneiRn.9912.

Genome annotation databases

EnsembliENSRNOT00000049569; ENSRNOP00000048288; ENSRNOG00000031249.
GeneIDi80900.
KEGGirno:80900.
UCSCiRGD:70985. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041105 mRNA. Translation: AAC32804.1.
AF083469 mRNA. Translation: AAG36719.1.
RefSeqiNP_110465.1. NM_030838.1.
XP_006237704.1. XM_006237642.2.
XP_006237705.1. XM_006237643.2.
XP_006237708.1. XM_006237646.2.
XP_008761654.1. XM_008763432.1.
UniGeneiRn.9912.

3D structure databases

ProteinModelPortaliO88397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040752.

Chemistry

ChEMBLiCHEMBL2073692.

Protein family/group databases

TCDBi2.A.60.1.3. the organo anion transporter (oat) family.

Proteomic databases

PaxDbiO88397.
PRIDEiO88397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049569; ENSRNOP00000048288; ENSRNOG00000031249.
GeneIDi80900.
KEGGirno:80900.
UCSCiRGD:70985. rat.

Organism-specific databases

CTDi108096.
RGDi70985. Slco1a5.

Phylogenomic databases

eggNOGiNOG256971.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiO88397.
KOiK03460.
OMAiCTRILAG.
OrthoDBiEOG7GFB4C.
PhylomeDBiO88397.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiREACT_233958. Recycling of bile acids and salts.
REACT_251660. Transport of organic anions.

Miscellaneous databases

NextBioi614919.

Gene expression databases

GenevestigatoriO88397.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2."
    Abe T., Kakyo M., Sakagami H., Tokui T., Nishio T., Tanemoto M., Nomura H., Hebert S.C., Matsuno S., Kondo H., Yawo H.
    J. Biol. Chem. 273:22395-22401(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
    Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
    Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ileum.

Entry informationi

Entry nameiSO1A5_RAT
AccessioniPrimary (citable) accession number: O88397
Secondary accession number(s): Q9EQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 10, 2003
Last modified: January 7, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.