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O88397

- SO1A5_RAT

UniProt

O88397 - SO1A5_RAT

Protein

Solute carrier organic anion transporter family member 1A5

Gene

Slco1a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.

    GO - Molecular functioni

    1. bile acid transmembrane transporter activity Source: RGD
    2. monocarboxylic acid transmembrane transporter activity Source: RGD
    3. organic anion transmembrane transporter activity Source: RGD
    4. thyroid hormone transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. bile acid and bile salt transport Source: RGD
    2. intestinal absorption Source: RGD
    3. monocarboxylic acid transport Source: RGD
    4. organic anion transport Source: RGD
    5. organ regeneration Source: RGD
    6. thyroid hormone transport Source: GOC

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi2.A.60.1.3. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1A5
    Alternative name(s):
    Organic anion-transporting polypeptide 3
    Short name:
    OATP-3
    Sodium-independent organic anion transporter 3
    Solute carrier family 21 member 7
    Gene namesi
    Name:Slco1a5
    Synonyms:Oatp1a5, Oatp3, Slc21a7, Slco1a2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi70985. Slco1a5.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: RGD
    2. integral component of plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Solute carrier organic anion transporter family member 1A5PRO_0000191044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
    Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
    Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO88397.
    PRIDEiO88397.

    Expressioni

    Tissue specificityi

    Highly expressed in the kidney and moderately abundant in the retina.

    Gene expression databases

    GenevestigatoriO88397.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000040752.

    Structurei

    3D structure databases

    ProteinModelPortaliO88397.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 866CytoplasmicSequence Analysis
    Topological domaini112 – 15544ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 20319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 31144CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini334 – 35320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini378 – 3814CytoplasmicSequence Analysis
    Topological domaini406 – 513108ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini537 – 5459CytoplasmicSequence Analysis
    Topological domaini572 – 60534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini624 – 67047CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 11125Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 18429Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33322Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei354 – 37724Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40524Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei514 – 53623Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei546 – 57126Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei606 – 62318Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256971.
    GeneTreeiENSGT00740000115555.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiO88397.
    KOiK03460.
    OMAiMYVENNI.
    OrthoDBiEOG7GFB4C.
    PhylomeDBiO88397.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88397-1 [UniParc]FASTAAdd to Basket

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    MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ    50
    FDIPTSIVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC 100
    FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRSQTL KPTQDPAECI 150
    KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE 200
    TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL 250
    ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG 300
    ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS 350
    TAEVVLLIGV YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL 400
    LYFLHFMITC DNFPVAGLTA SYEGVHHPLY VENKVLADCN RGCSCSTNSW 450
    DPVCGDNGLA YMSACLAGCK KSVGTGTNMV FQNCSCIRSS GNSSAVLGLC 500
    KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK PEEKSLGIGL 550
    HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI 600
    YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE 650
    CTDVHGSPQV ENDGELKTRL 670
    Length:670
    Mass (Da):74,577
    Last modified:January 10, 2003 - v2
    Checksum:i17BA60B86E0B567A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331K → Q in AAC32804. (PubMed:9712861)Curated
    Sequence conflicti55 – 551T → I in AAC32804. (PubMed:9712861)Curated
    Sequence conflicti70 – 701L → F in AAC32804. (PubMed:9712861)Curated
    Sequence conflicti421 – 4211S → L in AAC32804. (PubMed:9712861)Curated
    Sequence conflicti543 – 5431E → K in AAC32804. (PubMed:9712861)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041105 mRNA. Translation: AAC32804.1.
    AF083469 mRNA. Translation: AAG36719.1.
    RefSeqiNP_110465.1. NM_030838.1.
    XP_006237703.1. XM_006237641.1.
    XP_006237704.1. XM_006237642.1.
    XP_006237705.1. XM_006237643.1.
    XP_006237706.1. XM_006237644.1.
    XP_006237707.1. XM_006237645.1.
    XP_006237708.1. XM_006237646.1.
    XP_006237709.1. XM_006237647.1.
    UniGeneiRn.9912.

    Genome annotation databases

    EnsembliENSRNOT00000049569; ENSRNOP00000048288; ENSRNOG00000031249.
    GeneIDi80900.
    KEGGirno:80900.
    UCSCiRGD:70985. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041105 mRNA. Translation: AAC32804.1 .
    AF083469 mRNA. Translation: AAG36719.1 .
    RefSeqi NP_110465.1. NM_030838.1.
    XP_006237703.1. XM_006237641.1.
    XP_006237704.1. XM_006237642.1.
    XP_006237705.1. XM_006237643.1.
    XP_006237706.1. XM_006237644.1.
    XP_006237707.1. XM_006237645.1.
    XP_006237708.1. XM_006237646.1.
    XP_006237709.1. XM_006237647.1.
    UniGenei Rn.9912.

    3D structure databases

    ProteinModelPortali O88397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000040752.

    Chemistry

    ChEMBLi CHEMBL2073692.

    Protein family/group databases

    TCDBi 2.A.60.1.3. the organo anion transporter (oat) family.

    Proteomic databases

    PaxDbi O88397.
    PRIDEi O88397.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000049569 ; ENSRNOP00000048288 ; ENSRNOG00000031249 .
    GeneIDi 80900.
    KEGGi rno:80900.
    UCSCi RGD:70985. rat.

    Organism-specific databases

    CTDi 108096.
    RGDi 70985. Slco1a5.

    Phylogenomic databases

    eggNOGi NOG256971.
    GeneTreei ENSGT00740000115555.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi O88397.
    KOi K03460.
    OMAi MYVENNI.
    OrthoDBi EOG7GFB4C.
    PhylomeDBi O88397.
    TreeFami TF317540.

    Miscellaneous databases

    NextBioi 614919.

    Gene expression databases

    Genevestigatori O88397.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2."
      Abe T., Kakyo M., Sakagami H., Tokui T., Nishio T., Tanemoto M., Nomura H., Hebert S.C., Matsuno S., Kondo H., Yawo H.
      J. Biol. Chem. 273:22395-22401(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
      Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
      Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Ileum.

    Entry informationi

    Entry nameiSO1A5_RAT
    AccessioniPrimary (citable) accession number: O88397
    Secondary accession number(s): Q9EQR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3