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O88397 (SO1A5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name=OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene names
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7, Slco1a2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in the kidney and moderately abundant in the retina.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Solute carrier organic anion transporter family member 1A5
PRO_0000191044

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4020Helical; Name=1; Potential
Topological domain41 – 5919Extracellular Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 866Cytoplasmic Potential
Transmembrane87 – 11125Helical; Name=3; Potential
Topological domain112 – 15544Extracellular Potential
Transmembrane156 – 18429Helical; Name=4; Potential
Topological domain185 – 20319Cytoplasmic Potential
Transmembrane204 – 22421Helical; Name=5; Potential
Topological domain225 – 24218Extracellular Potential
Transmembrane243 – 26725Helical; Name=6; Potential
Topological domain268 – 31144Cytoplasmic Potential
Transmembrane312 – 33322Helical; Name=7; Potential
Topological domain334 – 35320Extracellular Potential
Transmembrane354 – 37724Helical; Name=8; Potential
Topological domain378 – 3814Cytoplasmic Potential
Transmembrane382 – 40524Helical; Name=9; Potential
Topological domain406 – 513108Extracellular Potential
Transmembrane514 – 53623Helical; Name=10; Potential
Topological domain537 – 5459Cytoplasmic Potential
Transmembrane546 – 57126Helical; Name=11; Potential
Topological domain572 – 60534Extracellular Potential
Transmembrane606 – 62318Helical; Name=12; Potential
Topological domain624 – 67047Cytoplasmic Potential
Domain433 – 48856Kazal-like

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential
Disulfide bond439 ↔ 465 By similarity
Disulfide bond443 ↔ 454 By similarity
Disulfide bond445 ↔ 469 By similarity

Experimental info

Sequence conflict331K → Q in AAC32804. Ref.1
Sequence conflict551T → I in AAC32804. Ref.1
Sequence conflict701L → F in AAC32804. Ref.1
Sequence conflict4211S → L in AAC32804. Ref.1
Sequence conflict5431E → K in AAC32804. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O88397 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: 17BA60B86E0B567A

FASTA67074,577
        10         20         30         40         50         60 
MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ FDIPTSIVGF 

        70         80         90        100        110        120 
INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC FLMSLPHFLM GRYEYETTIS 

       130        140        150        160        170        180 
PTSNLSSNSF LCMENRSQTL KPTQDPAECI KEMKSLMWIY VLVGNIIRGI GETPIMPLGI 

       190        200        210        220        230        240 
SYIEDFAKSE NSPLYIGILE TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR 

       250        260        270        280        290        300 
WVGAWWIGFL ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG 

       310        320        330        340        350        360 
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TAEVVLLIGV 

       370        380        390        400        410        420 
YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL LYFLHFMITC DNFPVAGLTA 

       430        440        450        460        470        480 
SYEGVHHPLY VENKVLADCN RGCSCSTNSW DPVCGDNGLA YMSACLAGCK KSVGTGTNMV 

       490        500        510        520        530        540 
FQNCSCIRSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK 

       550        560        570        580        590        600 
PEEKSLGIGL HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI 

       610        620        630        640        650        660 
YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE CTDVHGSPQV 

       670 
ENDGELKTRL 

« Hide

References

[1]"Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2."
Abe T., Kakyo M., Sakagami H., Tokui T., Nishio T., Tanemoto M., Nomura H., Hebert S.C., Matsuno S., Kondo H., Yawo H.
J. Biol. Chem. 273:22395-22401(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Ileum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041105 mRNA. Translation: AAC32804.1.
AF083469 mRNA. Translation: AAG36719.1.
RefSeqNP_110465.1. NM_030838.1.
XP_006237703.1. XM_006237641.1.
XP_006237704.1. XM_006237642.1.
XP_006237705.1. XM_006237643.1.
XP_006237706.1. XM_006237644.1.
XP_006237707.1. XM_006237645.1.
XP_006237708.1. XM_006237646.1.
XP_006237709.1. XM_006237647.1.
UniGeneRn.9912.

3D structure databases

ProteinModelPortalO88397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000040752.

Chemistry

ChEMBLCHEMBL2073692.

Protein family/group databases

TCDB2.A.60.1.3. the organo anion transporter (oat) family.

Proteomic databases

PaxDbO88397.
PRIDEO88397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000049569; ENSRNOP00000048288; ENSRNOG00000031249.
GeneID80900.
KEGGrno:80900.
UCSCRGD:70985. rat.

Organism-specific databases

CTD108096.
RGD70985. Slco1a5.

Phylogenomic databases

eggNOGNOG256971.
GeneTreeENSGT00740000115555.
HOGENOMHOG000231269.
HOVERGENHBG063896.
InParanoidO88397.
KOK03460.
OMAHENDDIM.
OrthoDBEOG7GFB4C.
PhylomeDBO88397.
TreeFamTF317540.

Gene expression databases

GenevestigatorO88397.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614919.

Entry information

Entry nameSO1A5_RAT
AccessionPrimary (citable) accession number: O88397
Secondary accession number(s): Q9EQR8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 10, 2003
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families