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O88397

- SO1A5_RAT

UniProt

O88397 - SO1A5_RAT

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Protein
Solute carrier organic anion transporter family member 1A5
Gene
Slco1a5, Oatp1a5, Oatp3, Slc21a7, Slco1a2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.

GO - Molecular functioni

  1. bile acid transmembrane transporter activity Source: RGD
  2. monocarboxylic acid transmembrane transporter activity Source: RGD
  3. organic anion transmembrane transporter activity Source: RGD
  4. thyroid hormone transmembrane transporter activity Source: RGD

GO - Biological processi

  1. bile acid and bile salt transport Source: RGD
  2. intestinal absorption Source: RGD
  3. monocarboxylic acid transport Source: RGD
  4. organ regeneration Source: RGD
  5. organic anion transport Source: RGD
  6. thyroid hormone transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.60.1.3. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name:
OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene namesi
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7, Slco1a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi70985. Slco1a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei21 – 4020Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini41 – 5919Extracellular Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 866Cytoplasmic Reviewed prediction
Transmembranei87 – 11125Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini112 – 15544Extracellular Reviewed prediction
Add
BLAST
Transmembranei156 – 18429Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini185 – 20319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini225 – 24218Extracellular Reviewed prediction
Add
BLAST
Transmembranei243 – 26725Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini268 – 31144Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei312 – 33322Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini334 – 35320Extracellular Reviewed prediction
Add
BLAST
Transmembranei354 – 37724Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini378 – 3814Cytoplasmic Reviewed prediction
Transmembranei382 – 40524Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini406 – 513108Extracellular Reviewed prediction
Add
BLAST
Transmembranei514 – 53623Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini537 – 5459Cytoplasmic Reviewed prediction
Transmembranei546 – 57126Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini572 – 60534Extracellular Reviewed prediction
Add
BLAST
Transmembranei606 – 62318Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini624 – 67047Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. brush border membrane Source: RGD
  2. integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Solute carrier organic anion transporter family member 1A5
PRO_0000191044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi439 ↔ 465 By similarity
Disulfide bondi443 ↔ 454 By similarity
Disulfide bondi445 ↔ 469 By similarity
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88397.
PRIDEiO88397.

Expressioni

Tissue specificityi

Highly expressed in the kidney and moderately abundant in the retina.

Gene expression databases

GenevestigatoriO88397.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040752.

Structurei

3D structure databases

ProteinModelPortaliO88397.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 48856Kazal-like
Add
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256971.
GeneTreeiENSGT00740000115555.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiO88397.
KOiK03460.
OMAiMYVENNI.
OrthoDBiEOG7GFB4C.
PhylomeDBiO88397.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88397-1 [UniParc]FASTAAdd to Basket

« Hide

MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ    50
FDIPTSIVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC 100
FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRSQTL KPTQDPAECI 150
KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE 200
TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL 250
ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG 300
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS 350
TAEVVLLIGV YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL 400
LYFLHFMITC DNFPVAGLTA SYEGVHHPLY VENKVLADCN RGCSCSTNSW 450
DPVCGDNGLA YMSACLAGCK KSVGTGTNMV FQNCSCIRSS GNSSAVLGLC 500
KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK PEEKSLGIGL 550
HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI 600
YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE 650
CTDVHGSPQV ENDGELKTRL 670
Length:670
Mass (Da):74,577
Last modified:January 10, 2003 - v2
Checksum:i17BA60B86E0B567A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331K → Q in AAC32804. 1 Publication
Sequence conflicti55 – 551T → I in AAC32804. 1 Publication
Sequence conflicti70 – 701L → F in AAC32804. 1 Publication
Sequence conflicti421 – 4211S → L in AAC32804. 1 Publication
Sequence conflicti543 – 5431E → K in AAC32804. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041105 mRNA. Translation: AAC32804.1.
AF083469 mRNA. Translation: AAG36719.1.
RefSeqiNP_110465.1. NM_030838.1.
XP_006237703.1. XM_006237641.1.
XP_006237704.1. XM_006237642.1.
XP_006237705.1. XM_006237643.1.
XP_006237706.1. XM_006237644.1.
XP_006237707.1. XM_006237645.1.
XP_006237708.1. XM_006237646.1.
XP_006237709.1. XM_006237647.1.
UniGeneiRn.9912.

Genome annotation databases

EnsembliENSRNOT00000049569; ENSRNOP00000048288; ENSRNOG00000031249.
GeneIDi80900.
KEGGirno:80900.
UCSCiRGD:70985. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041105 mRNA. Translation: AAC32804.1 .
AF083469 mRNA. Translation: AAG36719.1 .
RefSeqi NP_110465.1. NM_030838.1.
XP_006237703.1. XM_006237641.1.
XP_006237704.1. XM_006237642.1.
XP_006237705.1. XM_006237643.1.
XP_006237706.1. XM_006237644.1.
XP_006237707.1. XM_006237645.1.
XP_006237708.1. XM_006237646.1.
XP_006237709.1. XM_006237647.1.
UniGenei Rn.9912.

3D structure databases

ProteinModelPortali O88397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000040752.

Chemistry

ChEMBLi CHEMBL2073692.

Protein family/group databases

TCDBi 2.A.60.1.3. the organo anion transporter (oat) family.

Proteomic databases

PaxDbi O88397.
PRIDEi O88397.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000049569 ; ENSRNOP00000048288 ; ENSRNOG00000031249 .
GeneIDi 80900.
KEGGi rno:80900.
UCSCi RGD:70985. rat.

Organism-specific databases

CTDi 108096.
RGDi 70985. Slco1a5.

Phylogenomic databases

eggNOGi NOG256971.
GeneTreei ENSGT00740000115555.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi O88397.
KOi K03460.
OMAi MYVENNI.
OrthoDBi EOG7GFB4C.
PhylomeDBi O88397.
TreeFami TF317540.

Miscellaneous databases

NextBioi 614919.

Gene expression databases

Genevestigatori O88397.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2."
    Abe T., Kakyo M., Sakagami H., Tokui T., Nishio T., Tanemoto M., Nomura H., Hebert S.C., Matsuno S., Kondo H., Yawo H.
    J. Biol. Chem. 273:22395-22401(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
    Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
    Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ileum.

Entry informationi

Entry nameiSO1A5_RAT
AccessioniPrimary (citable) accession number: O88397
Secondary accession number(s): Q9EQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 10, 2003
Last modified: May 14, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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