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Protein

GrpE protein homolog 2, mitochondrial

Gene

Grpel2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70.

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: InterPro
  • unfolded protein binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 2, mitochondrial
Alternative name(s):
Mt-GrpE#2
Gene namesi
Name:Grpel2
Synonyms:Mt-grpel2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1334416. Grpel2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionBy similarityAdd
BLAST
Chaini32 – 224193GrpE protein homolog 2, mitochondrialPRO_0000013053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO88396.
PaxDbiO88396.
PRIDEiO88396.

PTM databases

PhosphoSiteiO88396.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO88396.
CleanExiMM_GRPEL2.
ExpressionAtlasiO88396. baseline and differential.
GenevisibleiO88396. MM.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.By similarity

GO - Molecular functioni

  • unfolded protein binding Source: MGI

Protein-protein interaction databases

BioGridi201546. 2 interactions.
STRINGi10090.ENSMUSP00000053440.

Structurei

3D structure databases

ProteinModelPortaliO88396.
SMRiO88396. Positions 64-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiO88396.
KOiK03687.
OMAiVPAEGMQ.
OrthoDBiEOG718KDB.
PhylomeDBiO88396.
TreeFamiTF105284.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSLWAVQ RLQRLLASGA MSESRGWLHP FSTATQRTAG EDCSSEDPPD
60 70 80 90 100
GLGPSLAEQA LRLKAVKLEK EVQDLTLRYQ RAVADCENIR RRTQRCVEDA
110 120 130 140 150
KIFGIQSFCK DLVEVADILE KTAKCCSEGA EPEDHRRTLE KVFQGLSLLE
160 170 180 190 200
ARLKSVFTKH GLEKMTPIGD KYDPHEHELI CHMPAGVGVQ PGTVALVRQD
210 220
GYKLHGRTIR LAQVEVAVES QRRL
Length:224
Mass (Da):25,030
Last modified:August 13, 2002 - v2
Checksum:iADCD75FA05C7B892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003011 mRNA. Translation: BAB22511.1.
AK012634 mRNA. Translation: BAB28371.1.
AK082983 mRNA. Translation: BAC38720.1.
AK145493 mRNA. Translation: BAE26470.1.
AF041060 mRNA. Translation: AAC31364.1.
CCDSiCCDS29288.1.
RefSeqiNP_067271.1. NM_021296.2.
UniGeneiMm.269657.

Genome annotation databases

EnsembliENSMUST00000062991; ENSMUSP00000053440; ENSMUSG00000024580.
GeneIDi17714.
KEGGimmu:17714.
UCSCiuc008fco.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003011 mRNA. Translation: BAB22511.1.
AK012634 mRNA. Translation: BAB28371.1.
AK082983 mRNA. Translation: BAC38720.1.
AK145493 mRNA. Translation: BAE26470.1.
AF041060 mRNA. Translation: AAC31364.1.
CCDSiCCDS29288.1.
RefSeqiNP_067271.1. NM_021296.2.
UniGeneiMm.269657.

3D structure databases

ProteinModelPortaliO88396.
SMRiO88396. Positions 64-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201546. 2 interactions.
STRINGi10090.ENSMUSP00000053440.

PTM databases

PhosphoSiteiO88396.

Proteomic databases

EPDiO88396.
PaxDbiO88396.
PRIDEiO88396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062991; ENSMUSP00000053440; ENSMUSG00000024580.
GeneIDi17714.
KEGGimmu:17714.
UCSCiuc008fco.1. mouse.

Organism-specific databases

CTDi134266.
MGIiMGI:1334416. Grpel2.

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiO88396.
KOiK03687.
OMAiVPAEGMQ.
OrthoDBiEOG718KDB.
PhylomeDBiO88396.
TreeFamiTF105284.

Miscellaneous databases

PROiO88396.
SOURCEiSearch...

Gene expression databases

BgeeiO88396.
CleanExiMM_GRPEL2.
ExpressionAtlasiO88396. baseline and differential.
GenevisibleiO88396. MM.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain, Embryo and Spinal cord.
  2. "Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the co-chaperones of specific Hsp70 members."
    Naylor D.J., Stines A.P., Hoogenraad N.J., Hoej P.B.
    J. Biol. Chem. 273:21169-21177(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-224.

Entry informationi

Entry nameiGRPE2_MOUSE
AccessioniPrimary (citable) accession number: O88396
Secondary accession number(s): Q3ULH8, Q9CQ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.