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O88393

- TGBR3_MOUSE

UniProt

O88393 - TGBR3_MOUSE

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Protein

Transforming growth factor beta receptor type 3

Gene

Tgfbr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity).By similarity

GO - Molecular functioni

  1. coreceptor activity Source: Ensembl
  2. glycosaminoglycan binding Source: BHF-UCL
  3. heparin binding Source: Ensembl
  4. PDZ domain binding Source: BHF-UCL
  5. SMAD binding Source: BHF-UCL
  6. transforming growth factor beta-activated receptor activity Source: MGI
  7. transforming growth factor beta binding Source: BHF-UCL
  8. transforming growth factor beta receptor activity, type III Source: Ensembl

GO - Biological processi

  1. blastocyst development Source: MGI
  2. blood vessel development Source: MGI
  3. BMP signaling pathway Source: Ensembl
  4. cardiac epithelial to mesenchymal transition Source: Ensembl
  5. cardiac muscle cell proliferation Source: BHF-UCL
  6. cell growth Source: Ensembl
  7. coronary vasculature development Source: DFLAT
  8. coronary vasculature morphogenesis Source: DFLAT
  9. definitive erythrocyte differentiation Source: BHF-UCL
  10. definitive hemopoiesis Source: BHF-UCL
  11. embryo development Source: DFLAT
  12. epicardial cell to mesenchymal cell transition Source: DFLAT
  13. heart trabecula formation Source: BHF-UCL
  14. immune response Source: Ensembl
  15. intracellular signal transduction Source: Ensembl
  16. in utero embryonic development Source: MGI
  17. liver development Source: BHF-UCL
  18. negative regulation of epithelial cell migration Source: MGI
  19. negative regulation of epithelial cell proliferation Source: BHF-UCL
  20. negative regulation of epithelial to mesenchymal transition Source: MGI
  21. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  22. organ regeneration Source: Ensembl
  23. palate development Source: BHF-UCL
  24. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  25. positive regulation of NF-kappaB transcription factor activity Source: MGI
  26. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  27. regulation of blood vessel size Source: DFLAT
  28. regulation of protein binding Source: Ensembl
  29. response to follicle-stimulating hormone Source: Ensembl
  30. response to hypoxia Source: Ensembl
  31. response to luteinizing hormone Source: Ensembl
  32. response to prostaglandin E Source: Ensembl
  33. transforming growth factor beta receptor complex assembly Source: Ensembl
  34. transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  35. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
  36. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
  37. visceral serous pericardium development Source: DFLAT
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:Tgfbr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:104637. Tgfbr3.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Secreted By similarity. Secretedextracellular spaceextracellular matrix By similarity
Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.By similarity

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. cytoplasm Source: MGI
  3. endoplasmic reticulum Source: MGI
  4. external side of plasma membrane Source: Ensembl
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. inhibin-betaglycan-ActRII complex Source: Ensembl
  8. integral component of plasma membrane Source: DFLAT
  9. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi533 – 5331S → A: Loss of glycosaminoglycan chains; when associated with A-544. 1 Publication
Mutagenesisi544 – 5441S → A: Loss of glycosaminoglycan chains; when associated with A-533. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 850828Transforming growth factor beta receptor type 3PRO_0000041664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi533 – 5331O-linked (Xyl...) (glycosaminoglycan)1 Publication
Glycosylationi544 – 5441O-linked (Xyl...) (glycosaminoglycan)1 Publication
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi638 ↔ 7041 Publication
Disulfide bondi659 ↔ 7281 Publication
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi709 ↔ 7211 Publication

Post-translational modificationi

Extensively modified by glycosaminoglycan (GAG), either chondroitin sulfate or heparan sulfate depending upon the tissue of origin.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PRIDEiO88393.

PTM databases

PhosphoSiteiO88393.

Expressioni

Gene expression databases

BgeeiO88393.
CleanExiMM_TGFBR3.
GenevestigatoriO88393.

Interactioni

Subunit structurei

Interacts with TCTEX1D4.By similarity

Protein-protein interaction databases

BioGridi204165. 1 interaction.

Structurei

Secondary structure

1
850
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi592 – 5998
Beta strandi607 – 6126
Beta strandi617 – 62711
Beta strandi629 – 64416
Beta strandi646 – 6483
Beta strandi653 – 6564
Beta strandi666 – 67510
Turni676 – 6794
Beta strandi680 – 69011
Beta strandi695 – 71420
Turni724 – 7285
Beta strandi747 – 75610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AJVX-ray2.70A591-757[»]
ProteinModelPortaliO88393.
SMRiO88393. Positions 587-755.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 785763ExtracellularSequence AnalysisAdd
BLAST
Topological domaini809 – 85042CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei786 – 80823HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini454 – 728275ZPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni735 – 74915Interaction with TGF-beta ligandAdd
BLAST

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40778.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiO88393.
KOiK05843.
OrthoDBiEOG72ZCDK.
PhylomeDBiO88393.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88393-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV
60 70 80 90 100
LSGCASRGTT GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK
110 120 130 140 150
PVVFLLNSPQ PLVWHVKTER LAAGVPRLFL VSEGSVVQFS SGNFSLTAET
160 170 180 190 200
EERSFPQENE HLLHWAQKEY GAVTSFTELK IARNIYIKVG EDQVFPPTCN
210 220 230 240 250
IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI SPNSNPYSTF
260 270 280 290 300
QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD
310 320 330 340 350
SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA
360 370 380 390 400
NRFHLRLENN EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG
410 420 430 440 450
FPFPFPDIPR RGWKEGEDRI PRPKEPIIPR VQLLPDHREP EEVQGGVNIA
460 470 480 490 500
LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT LLDPSCKAKM NGTHFVLESP
510 520 530 540 550
LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE DLESGDNGFP
560 570 580 590 600
GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD
610 620 630 640 650
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS
660 670 680 690 700
DYTIIENICP KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL
710 720 730 740 750
FLHCELTLCS RNKGSQKLPK CVTPDDACTS LDATMIWTMM QNKKTFTKPL
760 770 780 790 800
AVVLQVDYKE NVPNMKESSP VPPPPQIFHG LDTLTVMGIA FAAFVIGALL
810 820 830 840 850
TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ STPCSSSSTA
Length:850
Mass (Da):93,829
Last modified:November 1, 1998 - v1
Checksum:i4154D034C7307C86
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti322 – 3221Y → I in AAH70428. (PubMed:15489334)Curated
Sequence conflicti391 – 3911P → S in AAH70428. (PubMed:15489334)Curated
Sequence conflicti712 – 7121N → K in AAH70428. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039601 mRNA. Translation: AAC28564.1.
BC070428 mRNA. Translation: AAH70428.1.
CCDSiCCDS19499.1.
RefSeqiNP_035708.2. NM_011578.3.
UniGeneiMm.200775.

Genome annotation databases

EnsembliENSMUST00000031224; ENSMUSP00000031224; ENSMUSG00000029287.
GeneIDi21814.
KEGGimmu:21814.
UCSCiuc008ylz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039601 mRNA. Translation: AAC28564.1 .
BC070428 mRNA. Translation: AAH70428.1 .
CCDSi CCDS19499.1.
RefSeqi NP_035708.2. NM_011578.3.
UniGenei Mm.200775.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AJV X-ray 2.70 A 591-757 [» ]
ProteinModelPortali O88393.
SMRi O88393. Positions 587-755.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204165. 1 interaction.

PTM databases

PhosphoSitei O88393.

Proteomic databases

PRIDEi O88393.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031224 ; ENSMUSP00000031224 ; ENSMUSG00000029287 .
GeneIDi 21814.
KEGGi mmu:21814.
UCSCi uc008ylz.2. mouse.

Organism-specific databases

CTDi 7049.
MGIi MGI:104637. Tgfbr3.

Phylogenomic databases

eggNOGi NOG40778.
GeneTreei ENSGT00530000063861.
HOGENOMi HOG000090193.
HOVERGENi HBG057515.
InParanoidi O88393.
KOi K05843.
OrthoDBi EOG72ZCDK.
PhylomeDBi O88393.
TreeFami TF337375.

Miscellaneous databases

NextBioi 301212.
PROi O88393.
SOURCEi Search...

Gene expression databases

Bgeei O88393.
CleanExi MM_TGFBR3.
Genevestigatori O88393.

Family and domain databases

InterProi IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
PROSITEi PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites."
    Ponce-Castaneda M.V., Esparza-Lopez J., Vilchis-Landeros M.M., Mendoza V., Lopez-Casillas F.
    Biochim. Biophys. Acta 1384:189-196(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT SER-533 AND SER-544, MUTAGENESIS OF SER-533 AND SER-544.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Identification of a novel TGF-beta-binding site in the zona pellucida C-terminal (ZP-C) domain of TGF-beta-receptor-3 (TGFR-3)."
    Diestel U., Resch M., Meinhardt K., Weiler S., Hellmann T.V., Mueller T.D., Nickel J., Eichler J., Muller Y.A.
    PLoS ONE 8:E67214-E67214(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 591-757, DISULFIDE BONDS, INTERACTION WITH TGF-BETA.

Entry informationi

Entry nameiTGBR3_MOUSE
AccessioniPrimary (citable) accession number: O88393
Secondary accession number(s): Q6NS72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3