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Protein

Transforming growth factor beta receptor type 3

Gene

Tgfbr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity).By similarity

GO - Molecular functioni

  • coreceptor activity Source: MGI
  • glycosaminoglycan binding Source: BHF-UCL
  • PDZ domain binding Source: BHF-UCL
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta-activated receptor activity Source: MGI
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type III Source: MGI
  • type II transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  • blastocyst development Source: MGI
  • blood vessel development Source: MGI
  • blood vessel remodeling Source: MGI
  • BMP signaling pathway Source: MGI
  • cardiac epithelial to mesenchymal transition Source: MGI
  • cardiac muscle cell proliferation Source: BHF-UCL
  • collagen metabolic process Source: BHF-UCL
  • coronary vasculature development Source: DFLAT
  • coronary vasculature morphogenesis Source: DFLAT
  • definitive erythrocyte differentiation Source: BHF-UCL
  • definitive hemopoiesis Source: BHF-UCL
  • embryo development Source: DFLAT
  • epicardial cell to mesenchymal cell transition Source: DFLAT
  • epicardium-derived cardiac fibroblast cell development Source: BHF-UCL
  • epithelial to mesenchymal transition Source: MGI
  • heart trabecula formation Source: BHF-UCL
  • heart trabecula morphogenesis Source: BHF-UCL
  • immune response Source: MGI
  • intracellular signal transduction Source: MGI
  • in utero embryonic development Source: MGI
  • liver development Source: BHF-UCL
  • muscular septum morphogenesis Source: BHF-UCL
  • negative regulation of apoptotic process involved in morphogenesis Source: MGI
  • negative regulation of cellular component movement Source: MGI
  • negative regulation of epithelial cell migration Source: MGI
  • negative regulation of epithelial cell proliferation Source: BHF-UCL
  • negative regulation of epithelial to mesenchymal transition Source: MGI
  • negative regulation of gene expression Source: BHF-UCL
  • osteoblast differentiation Source: MGI
  • outflow tract morphogenesis Source: BHF-UCL
  • palate development Source: BHF-UCL
  • pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • positive regulation of BMP signaling pathway Source: MGI
  • positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • regulation of blood vessel size Source: DFLAT
  • response to follicle-stimulating hormone Source: MGI
  • response to luteinizing hormone Source: MGI
  • response to prostaglandin E Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • vasculogenesis Source: MGI
  • vasculogenesis involved in coronary vascular morphogenesis Source: BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
  • ventricular compact myocardium morphogenesis Source: BHF-UCL
  • ventricular septum morphogenesis Source: BHF-UCL
  • visceral serous pericardium development Source: DFLAT
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:Tgfbr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104637. Tgfbr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 785ExtracellularSequence analysisAdd BLAST763
Transmembranei786 – 808HelicalSequence analysisAdd BLAST23
Topological domaini809 – 850CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasm Source: MGI
  • endoplasmic reticulum Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • inhibin-betaglycan-ActRII complex Source: MGI
  • integral component of plasma membrane Source: DFLAT
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi533S → A: Loss of glycosaminoglycan chains; when associated with A-544. 1 Publication1
Mutagenesisi544S → A: Loss of glycosaminoglycan chains; when associated with A-533. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004166423 – 850Transforming growth factor beta receptor type 3Add BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Glycosylationi533O-linked (Xyl...) (glycosaminoglycan)1 Publication1
Glycosylationi544O-linked (Xyl...) (glycosaminoglycan)1 Publication1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Glycosylationi589N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi638 ↔ 7041 Publication
Disulfide bondi659 ↔ 7281 Publication
Glycosylationi696N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi709 ↔ 7211 Publication

Post-translational modificationi

Extensively modified by glycosaminoglycan (GAG), either chondroitin sulfate or heparan sulfate depending upon the tissue of origin.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiO88393.
PaxDbiO88393.
PeptideAtlasiO88393.
PRIDEiO88393.

PTM databases

iPTMnetiO88393.
PhosphoSitePlusiO88393.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029287.
CleanExiMM_TGFBR3.

Interactioni

Subunit structurei

Interacts with TCTEX1D4.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: BHF-UCL
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: MGI

Protein-protein interaction databases

BioGridi204165. 1 interactor.
STRINGi10090.ENSMUSP00000031224.

Structurei

Secondary structure

1850
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi592 – 599Combined sources8
Beta strandi607 – 612Combined sources6
Beta strandi617 – 627Combined sources11
Beta strandi629 – 644Combined sources16
Beta strandi646 – 648Combined sources3
Beta strandi653 – 656Combined sources4
Beta strandi666 – 675Combined sources10
Turni676 – 679Combined sources4
Beta strandi680 – 690Combined sources11
Beta strandi695 – 714Combined sources20
Turni724 – 728Combined sources5
Beta strandi747 – 756Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AJVX-ray2.70A591-757[»]
ProteinModelPortaliO88393.
SMRiO88393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini454 – 728ZPPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni735 – 749Interaction with TGF-beta ligandAdd BLAST15

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7K. Eukaryota.
ENOG410XSMK. LUCA.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiO88393.
KOiK05843.
PhylomeDBiO88393.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV
60 70 80 90 100
LSGCASRGTT GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK
110 120 130 140 150
PVVFLLNSPQ PLVWHVKTER LAAGVPRLFL VSEGSVVQFS SGNFSLTAET
160 170 180 190 200
EERSFPQENE HLLHWAQKEY GAVTSFTELK IARNIYIKVG EDQVFPPTCN
210 220 230 240 250
IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI SPNSNPYSTF
260 270 280 290 300
QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD
310 320 330 340 350
SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA
360 370 380 390 400
NRFHLRLENN EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG
410 420 430 440 450
FPFPFPDIPR RGWKEGEDRI PRPKEPIIPR VQLLPDHREP EEVQGGVNIA
460 470 480 490 500
LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT LLDPSCKAKM NGTHFVLESP
510 520 530 540 550
LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE DLESGDNGFP
560 570 580 590 600
GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD
610 620 630 640 650
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS
660 670 680 690 700
DYTIIENICP KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL
710 720 730 740 750
FLHCELTLCS RNKGSQKLPK CVTPDDACTS LDATMIWTMM QNKKTFTKPL
760 770 780 790 800
AVVLQVDYKE NVPNMKESSP VPPPPQIFHG LDTLTVMGIA FAAFVIGALL
810 820 830 840 850
TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ STPCSSSSTA
Length:850
Mass (Da):93,829
Last modified:November 1, 1998 - v1
Checksum:i4154D034C7307C86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti322Y → I in AAH70428 (PubMed:15489334).Curated1
Sequence conflicti391P → S in AAH70428 (PubMed:15489334).Curated1
Sequence conflicti712N → K in AAH70428 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039601 mRNA. Translation: AAC28564.1.
BC070428 mRNA. Translation: AAH70428.1.
CCDSiCCDS19499.1.
RefSeqiNP_035708.2. NM_011578.3.
UniGeneiMm.200775.

Genome annotation databases

GeneIDi21814.
KEGGimmu:21814.
UCSCiuc008ylz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039601 mRNA. Translation: AAC28564.1.
BC070428 mRNA. Translation: AAH70428.1.
CCDSiCCDS19499.1.
RefSeqiNP_035708.2. NM_011578.3.
UniGeneiMm.200775.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AJVX-ray2.70A591-757[»]
ProteinModelPortaliO88393.
SMRiO88393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204165. 1 interactor.
STRINGi10090.ENSMUSP00000031224.

PTM databases

iPTMnetiO88393.
PhosphoSitePlusiO88393.

Proteomic databases

MaxQBiO88393.
PaxDbiO88393.
PeptideAtlasiO88393.
PRIDEiO88393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21814.
KEGGimmu:21814.
UCSCiuc008ylz.2. mouse.

Organism-specific databases

CTDi7049.
MGIiMGI:104637. Tgfbr3.

Phylogenomic databases

eggNOGiENOG410IK7K. Eukaryota.
ENOG410XSMK. LUCA.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiO88393.
KOiK05843.
PhylomeDBiO88393.
TreeFamiTF337375.

Miscellaneous databases

PROiO88393.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029287.
CleanExiMM_TGFBR3.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGBR3_MOUSE
AccessioniPrimary (citable) accession number: O88393
Secondary accession number(s): Q6NS72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.