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O88393 (TGBR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transforming growth factor beta receptor type 3

Short name=TGF-beta receptor type 3
Short name=TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name=TGF-beta receptor type III
Gene names
Name:Tgfbr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length850 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors By similarity.

Subunit structure

Interacts with TCTEX1D4 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Secreted By similarity. Secretedextracellular spaceextracellular matrix By similarity. Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix By similarity.

Post-translational modification

Extensively modified by glycosaminoglycan (GAG), either chondroitin sulfate or heparan sulfate depending upon the tissue of origin.

Sequence similarities

Contains 1 ZP domain.

Ontologies

Keywords
   Cellular componentCell membrane
Extracellular matrix
Membrane
Secreted
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Proteoglycan
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

blastocyst development

Inferred from direct assay PubMed 9921650. Source: MGI

blood vessel development

Inferred from mutant phenotype PubMed 17704211. Source: MGI

cardiac epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

cardiac muscle cell proliferation

Inferred from mutant phenotype PubMed 12773577. Source: BHF-UCL

cell growth

Inferred from electronic annotation. Source: Ensembl

coronary vasculature development

Traceable author statement PubMed 20299672. Source: DFLAT

coronary vasculature morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

definitive erythrocyte differentiation

Inferred from mutant phenotype PubMed 12773577. Source: BHF-UCL

definitive hemopoiesis

Inferred from mutant phenotype PubMed 12773577. Source: BHF-UCL

embryo development

Traceable author statement PubMed 20299672. Source: DFLAT

epicardial cell to mesenchymal cell transition

Traceable author statement PubMed 20299672. Source: DFLAT

heart trabecula formation

Inferred from mutant phenotype PubMed 12773577. Source: BHF-UCL

immune response

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from mutant phenotype PubMed 17704211. Source: MGI

liver development

Inferred from mutant phenotype PubMed 12773577. Source: BHF-UCL

negative regulation of epithelial cell migration

Inferred from mutant phenotype PubMed 17823118. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 17295310. Source: BHF-UCL

negative regulation of epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 17823118. Source: MGI

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from mutant phenotype PubMed 17295310. Source: BHF-UCL

pathway-restricted SMAD protein phosphorylation

Inferred from mutant phenotype PubMed 17295310. Source: BHF-UCL

positive regulation of NF-kappaB transcription factor activity

Inferred from mutant phenotype PubMed 17823118. Source: MGI

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of blood vessel size

Traceable author statement PubMed 20299672. Source: DFLAT

regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

response to follicle-stimulating hormone

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to luteinizing hormone

Inferred from electronic annotation. Source: Ensembl

response to prostaglandin E

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor complex assembly

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 11546783PubMed 17295310. Source: BHF-UCL

vasculogenesis involved in coronary vascular morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

ventricular cardiac muscle tissue morphogenesis

Inferred from mutant phenotype PubMed 12773577. Source: BHF-UCL

visceral serous pericardium development

Traceable author statement PubMed 20299672. Source: DFLAT

   Cellular_componentcell surface

Inferred from direct assay PubMed 11546783. Source: BHF-UCL

cytoplasm

Inferred from direct assay PubMed 18236212PubMed 9921650. Source: MGI

endoplasmic reticulum

Inferred from direct assay PubMed 9921650. Source: MGI

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

inhibin-betaglycan-ActRII complex

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement PubMed 20299672. Source: DFLAT

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionPDZ domain binding

Inferred from physical interaction PubMed 11546783. Source: BHF-UCL

SMAD binding

Inferred from mutant phenotype PubMed 17295310. Source: BHF-UCL

coreceptor activity

Inferred from electronic annotation. Source: Ensembl

glycosaminoglycan binding

Inferred from direct assay PubMed 12773577. Source: BHF-UCL

heparin binding

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta binding

Inferred from direct assay PubMed 17295310. Source: BHF-UCL

transforming growth factor beta receptor activity, type III

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta-activated receptor activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 850828Transforming growth factor beta receptor type 3
PRO_0000041664

Regions

Topological domain23 – 785763Extracellular Potential
Transmembrane786 – 80823Helical; Potential
Topological domain809 – 85042Cytoplasmic Potential
Domain454 – 728275ZP

Amino acid modifications

Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Glycosylation5331O-linked (Xyl...) (glycosaminoglycan) Ref.1
Glycosylation5441O-linked (Xyl...) (glycosaminoglycan) Ref.1
Glycosylation5701N-linked (GlcNAc...) Potential
Glycosylation5891N-linked (GlcNAc...) Potential
Glycosylation6961N-linked (GlcNAc...) Potential
Disulfide bond638 ↔ 704 By similarity
Disulfide bond659 ↔ 728 By similarity

Experimental info

Mutagenesis5331S → A: Loss of glycosaminoglycan chains; when associated with A-544. Ref.1
Mutagenesis5441S → A: Loss of glycosaminoglycan chains; when associated with A-533. Ref.1
Sequence conflict3221Y → I in AAH70428. Ref.2
Sequence conflict3911P → S in AAH70428. Ref.2
Sequence conflict7121N → K in AAH70428. Ref.2

Secondary structure

....................... 850
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O88393 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 4154D034C7307C86

FASTA85093,829
        10         20         30         40         50         60 
MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV LSGCASRGTT 

        70         80         90        100        110        120 
GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK PVVFLLNSPQ PLVWHVKTER 

       130        140        150        160        170        180 
LAAGVPRLFL VSEGSVVQFS SGNFSLTAET EERSFPQENE HLLHWAQKEY GAVTSFTELK 

       190        200        210        220        230        240 
IARNIYIKVG EDQVFPPTCN IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI 

       250        260        270        280        290        300 
SPNSNPYSTF QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD 

       310        320        330        340        350        360 
SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA NRFHLRLENN 

       370        380        390        400        410        420 
EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG FPFPFPDIPR RGWKEGEDRI 

       430        440        450        460        470        480 
PRPKEPIIPR VQLLPDHREP EEVQGGVNIA LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT 

       490        500        510        520        530        540 
LLDPSCKAKM NGTHFVLESP LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE 

       550        560        570        580        590        600 
DLESGDNGFP GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD 

       610        620        630        640        650        660 
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS DYTIIENICP 

       670        680        690        700        710        720 
KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL FLHCELTLCS RNKGSQKLPK 

       730        740        750        760        770        780 
CVTPDDACTS LDATMIWTMM QNKKTFTKPL AVVLQVDYKE NVPNMKESSP VPPPPQIFHG 

       790        800        810        820        830        840 
LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ 

       850 
STPCSSSSTA 

« Hide

References

« Hide 'large scale' references
[1]"Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites."
Ponce-Castaneda M.V., Esparza-Lopez J., Vilchis-Landeros M.M., Mendoza V., Lopez-Casillas F.
Biochim. Biophys. Acta 1384:189-196(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT SER-533 AND SER-544, MUTAGENESIS OF SER-533 AND SER-544.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF039601 mRNA. Translation: AAC28564.1.
BC070428 mRNA. Translation: AAH70428.1.
RefSeqNP_035708.2. NM_011578.3.
UniGeneMm.200775.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AJVX-ray2.70A591-757[»]
ProteinModelPortalO88393.
SMRO88393. Positions 587-755.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204165. 1 interaction.

PTM databases

PhosphoSiteO88393.

Proteomic databases

PRIDEO88393.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031224; ENSMUSP00000031224; ENSMUSG00000029287.
GeneID21814.
KEGGmmu:21814.
UCSCuc008ylz.2. mouse.

Organism-specific databases

CTD7049.
MGIMGI:104637. Tgfbr3.

Phylogenomic databases

eggNOGNOG40778.
GeneTreeENSGT00530000063861.
HOGENOMHOG000090193.
HOVERGENHBG057515.
InParanoidO88393.
KOK05843.
OrthoDBEOG72ZCDK.
PhylomeDBO88393.
TreeFamTF337375.

Gene expression databases

BgeeO88393.
CleanExMM_TGFBR3.
GenevestigatorO88393.

Family and domain databases

InterProIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSPR00023. ZPELLUCIDA.
SMARTSM00241. ZP. 1 hit.
[Graphical view]
PROSITEPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301212.
PROO88393.
SOURCESearch...

Entry information

Entry nameTGBR3_MOUSE
AccessionPrimary (citable) accession number: O88393
Secondary accession number(s): Q6NS72
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot