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Protein

Vesicle transport through interaction with t-SNAREs homolog 1B

Gene

Vti1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1B
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 1
Vti1-rp1
Gene namesi
Name:Vti1b
Synonyms:Vti1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1855688. Vti1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 208CytoplasmicSequence analysisAdd BLAST207
Transmembranei209 – 229Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini230 – 232VesicularSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002182292 – 232Vesicle transport through interaction with t-SNAREs homolog 1BAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei107Omega-N-methylarginineBy similarity1
Modified residuei138PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO88384.
MaxQBiO88384.
PaxDbiO88384.
PeptideAtlasiO88384.
PRIDEiO88384.

PTM databases

iPTMnetiO88384.
PhosphoSitePlusiO88384.
SwissPalmiO88384.

Expressioni

Tissue specificityi

Broadly expressed.

Interactioni

Subunit structurei

May interact with STX17 (By similarity). Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-32212N.
IntActiO88384. 7 interactors.
STRINGi10090.ENSMUSP00000057462.

Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 33Combined sources32
Helixi39 – 67Combined sources29
Helixi71 – 95Combined sources25
Helixi141 – 196Combined sources56

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90C140-200[»]
2QYWX-ray2.00A1-96[»]
ProteinModelPortaliO88384.
SMRiO88384.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88384.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 98Sequence analysisAdd BLAST63
Coiled coili160 – 201Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1666. Eukaryota.
ENOG4111J90. LUCA.
HOGENOMiHOG000116573.
HOVERGENiHBG058837.
InParanoidiO88384.
PhylomeDBiO88384.

Family and domain databases

InterProiIPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view]
PfamiPF05008. V-SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAASSEH FEKLHEIFRG LLEDLQGVPE RLLGTAGTEE KKKLVRDFDE
60 70 80 90 100
NQQEANETLA EMEEELRYAP LTFRNPMMSK LRNYRKDLAK LHREVRSTPL
110 120 130 140 150
TAAPGGRGDL KYGTYTLENE HLNRLQSQRA LLLQGTESLN RATQSIERSH
160 170 180 190 200
RIATETDQIG TEIIEELGEQ RDQLERTKSR LVNTNENLSK SRKILRSMSR
210 220 230
KVITNKLLLS VIILLELAIL VGLVYYKFFR HH
Length:232
Mass (Da):26,713
Last modified:November 1, 1998 - v1
Checksum:i6827DCAF9650DFC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035208 mRNA. Translation: AAC23483.1.
CCDSiCCDS26008.1.
UniGeneiMm.265929.

Genome annotation databases

UCSCiuc007nzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035208 mRNA. Translation: AAC23483.1.
CCDSiCCDS26008.1.
UniGeneiMm.265929.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90C140-200[»]
2QYWX-ray2.00A1-96[»]
ProteinModelPortaliO88384.
SMRiO88384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-32212N.
IntActiO88384. 7 interactors.
STRINGi10090.ENSMUSP00000057462.

PTM databases

iPTMnetiO88384.
PhosphoSitePlusiO88384.
SwissPalmiO88384.

Proteomic databases

EPDiO88384.
MaxQBiO88384.
PaxDbiO88384.
PeptideAtlasiO88384.
PRIDEiO88384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007nzy.2. mouse.

Organism-specific databases

MGIiMGI:1855688. Vti1b.

Phylogenomic databases

eggNOGiKOG1666. Eukaryota.
ENOG4111J90. LUCA.
HOGENOMiHOG000116573.
HOVERGENiHBG058837.
InParanoidiO88384.
PhylomeDBiO88384.

Miscellaneous databases

ChiTaRSiVti1b. mouse.
EvolutionaryTraceiO88384.
PROiO88384.
SOURCEiSearch...

Family and domain databases

InterProiIPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view]
PfamiPF05008. V-SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVTI1B_MOUSE
AccessioniPrimary (citable) accession number: O88384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.