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Protein

Bromodomain adjacent to zinc finger domain protein 1A

Gene

Baz1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression (By similarity).By similarity
Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1149 – 119951PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 1A
Alternative name(s):
Cbp146
Gene namesi
Name:Baz1a
Synonyms:Cbp146
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1309478. Baz1a.

Subcellular locationi

  • Nucleus

  • Note: Concentrated in pericentric to heterochromatin.

GO - Cellular componenti

  • CHRAC Source: MGI
  • nuclear chromosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15551555Bromodomain adjacent to zinc finger domain protein 1APRO_0000211168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphoserineBy similarity
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei732 – 7321PhosphothreonineCombined sources
Modified residuei962 – 9621PhosphoserineCombined sources
Modified residuei963 – 9631PhosphoserineCombined sources
Modified residuei1282 – 12821PhosphoserineBy similarity
Modified residuei1320 – 13201PhosphoserineBy similarity
Modified residuei1339 – 13391PhosphoserineCombined sources
Modified residuei1352 – 13521PhosphoserineCombined sources
Modified residuei1370 – 13701PhosphoserineBy similarity
Modified residuei1401 – 14011PhosphoserineBy similarity
Modified residuei1412 – 14121PhosphoserineCombined sources
Modified residuei1416 – 14161PhosphoserineBy similarity
Modified residuei1546 – 15461PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88379.
MaxQBiO88379.
PaxDbiO88379.
PeptideAtlasiO88379.
PRIDEiO88379.

PTM databases

iPTMnetiO88379.
PhosphoSiteiO88379.

Expressioni

Gene expression databases

BgeeiO88379.
CleanExiMM_BAZ1A.
ExpressionAtlasiO88379. baseline and differential.
GenevisibleiO88379. MM.

Interactioni

Subunit structurei

Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes (By similarity).By similarity

Protein-protein interaction databases

IntActiO88379. 2 interactions.
MINTiMINT-4084348.
STRINGi10090.ENSMUSP00000133478.

Structurei

3D structure databases

ProteinModelPortaliO88379.
SMRiO88379. Positions 1152-1196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 128107WACPROSITE-ProRule annotationAdd
BLAST
Domaini422 – 48867DDTPROSITE-ProRule annotationAdd
BLAST
Domaini1445 – 151571BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 133133Required for interaction with NCOR1By similarityAdd
BLAST
Regioni1 – 128128Required for association with the CHRAC1/POLE3 complexBy similarityAdd
BLAST
Regioni668 – 935268Interaction with SMARCA5By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili635 – 70167Sequence analysisAdd
BLAST
Coiled coili773 – 79826Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi315 – 496182Glu-richAdd
BLAST
Compositional biasi1214 – 125138Glu-richAdd
BLAST
Compositional biasi1225 – 125632Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the WAL family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 DDT domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 WAC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1149 – 119951PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1245. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119099.
HOGENOMiHOG000095179.
HOVERGENiHBG080889.
InParanoidiO88379.
OMAiEVSLMES.
TreeFamiTF316326.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR018501. DDT_dom.
IPR028942. WHIM1_dom.
IPR028941. WHIM2_dom.
IPR013136. WSTF_Acf1_Cbp146.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF00628. PHD. 1 hit.
PF10537. WAC_Acf1_DNA_bd. 1 hit.
PF15612. WHIM1. 1 hit.
PF15613. WSD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS51136. WAC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLHRKPFV RQKPPGDLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL
60 70 80 90 100
VWSCAVTGRP GLTYQEALES ERKARQNLQS FPEPLIIPVL YLTNLTRRSR
110 120 130 140 150
LHEICDDIFA YVKDRYFVEE TVEVIRNNGT RLQCRILEVL PPLHQNGFAN
160 170 180 190 200
GHLSSADGET IVISDSDDSE TQSSSFHHGK KKDAIDPLLF RYRVQPTKKE
210 220 230 240 250
MYESAVVKAT QISRRKHLFS RDKLKLFLKQ HCEAQDGVIK IKASSFSAYN
260 270 280 290 300
IAEQDFSYFF PDDPPTFIFS PANRRRGRPP KRISFGQEDS IASKQTAARY
310 320 330 340 350
RNKAIKERDK LLKQEEMRAL AFEKAKLKRE RADALEARKR EKEDKEKKRE
360 370 380 390 400
ELKKMVEEER LKKKEEKERL KIEREKEREK LREEKRKYME YLKQWSKPRE
410 420 430 440 450
DMECDDLKEL PEPTPVKTRL PPEVFGDALM VLEFLNAFGE LFDLQDEFPE
460 470 480 490 500
GVTLAEVLEE ALVGNDSEGP LCELLFFFLT AIFQAMAEEE EEVAKEQITD
510 520 530 540 550
ADTKDLTEAL DEDADPTKSA LSAVAALAAA WPQLHQGCSL KSLDLDSCTL
560 570 580 590 600
SEILRLHILA SGADVTSANA KYRYQKRGGF DATDDACMEL RLSNPSLVKK
610 620 630 640 650
LSSTSVYDLT PGEKMKILHA LCGKLLTLVS TRDFIEDYVD VLRQAKQEFR
660 670 680 690 700
ELKAEQHRKE REATAARIRR RKEEKLKEQE QKMKEKQEKL KEDEQRNSAA
710 720 730 740 750
VPGYGEEERE DFDTSTENKN IEQKDLDPDV VTEDEDDPGS HKRSRRGKVG
760 770 780 790 800
QTAVKQCIKQ EEMNYCIKQE PLSADAEEAL RQEQQQKEKE LLDKIQSAIA
810 820 830 840 850
CTNIFPLGRD RLYRRYWIFP SIPGLFIEED YSGLTEDMLL PRPSSFHNNA
860 870 880 890 900
QPRDPQVSIK TEESFLSEST SSLDQGPFDD SVLLPKPVHK PNRWCFYSSC
910 920 930 940 950
AQLDQLIDAL NSRGHRESAL KETLLQEKSR ICAQLAHFSE EKFHFSDKPQ
960 970 980 990 1000
ADSKPVSSRG RSSGACDISQ MSAERQLELR LRDFLLDIED RIYQGTLGAI
1010 1020 1030 1040 1050
KVTDRQVWRS ALENGRYELL SEESKENGVI KTVNEDVEEM EMEQARVIVR
1060 1070 1080 1090 1100
DRLLGIKTET PSTISTSAST PQSVSNVVHY LALALFQIEQ GIERRFLKAP
1110 1120 1130 1140 1150
LDGNDSGRSY KTVLDRWRES LLSSASLSQV FLHLSTLDRS VMWSKSILNA
1160 1170 1180 1190 1200
RCKICRKKGD AENMVLCDGC DRGHHTYCVR PKLKAVPDGD WFCPECRPKQ
1210 1220 1230 1240 1250
RSRRLSSRQR PSLESDEEME EGMEDDDDEV DDDDEEGQSE EEEYEVEQDE
1260 1270 1280 1290 1300
EDSDDDEALS PPKRGRPQVR LPIKTKGRFG PSFPSRSQRQ DPGRYPSRSQ
1310 1320 1330 1340 1350
QSTPKNTAKS ASKNLRKTRS APPTETRSLR VGSRSTRHSP SALQDVFVEL
1360 1370 1380 1390 1400
LSPHSKRRGR KGADHTPEHS PSFTNFRVST SRSSRQLIPL NTAESLSLQH
1410 1420 1430 1440 1450
SESKRRGRKR QSTESSPVPL NRRSSGRQGG VHELSAFEQL VVELVRHDDS
1460 1470 1480 1490 1500
WPFLKLVSKI QVPDYYDIIK KPIALNIIRE KVNKCEYKLA SEFIDDIELM
1510 1520 1530 1540 1550
FSNCFEYNPR NTSEAKAGTR LQAFFHIQAQ KLGLHVSPST VDQVSTPLAA

KKSRI
Length:1,555
Mass (Da):178,459
Last modified:July 27, 2011 - v3
Checksum:iF7BE6227A420A842
GO

Sequence cautioni

The sequence BAE22607.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 203LRP → EFR in AAC32043 (PubMed:9701556).Curated
Sequence conflicti148 – 1492FA → LL in BAE22607 (PubMed:16141072).Curated
Sequence conflicti342 – 36120KEDKE…EEERL → AGILTPDQLVMVATGAQLEF in AAC32043 (PubMed:9701556).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138767 Genomic DNA. No translation available.
AC154732 Genomic DNA. No translation available.
CT030142 Genomic DNA. No translation available.
AK135668 mRNA. Translation: BAE22607.1. Different initiation.
AK166955 mRNA. Translation: BAE39138.1.
AF033664 mRNA. Translation: AAC32043.1.
UniGeneiMm.479583.

Genome annotation databases

EnsembliENSMUST00000038926; ENSMUSP00000039757; ENSMUSG00000035021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138767 Genomic DNA. No translation available.
AC154732 Genomic DNA. No translation available.
CT030142 Genomic DNA. No translation available.
AK135668 mRNA. Translation: BAE22607.1. Different initiation.
AK166955 mRNA. Translation: BAE39138.1.
AF033664 mRNA. Translation: AAC32043.1.
UniGeneiMm.479583.

3D structure databases

ProteinModelPortaliO88379.
SMRiO88379. Positions 1152-1196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88379. 2 interactions.
MINTiMINT-4084348.
STRINGi10090.ENSMUSP00000133478.

PTM databases

iPTMnetiO88379.
PhosphoSiteiO88379.

Proteomic databases

EPDiO88379.
MaxQBiO88379.
PaxDbiO88379.
PeptideAtlasiO88379.
PRIDEiO88379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038926; ENSMUSP00000039757; ENSMUSG00000035021.

Organism-specific databases

MGIiMGI:1309478. Baz1a.

Phylogenomic databases

eggNOGiKOG1245. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119099.
HOGENOMiHOG000095179.
HOVERGENiHBG080889.
InParanoidiO88379.
OMAiEVSLMES.
TreeFamiTF316326.

Miscellaneous databases

PROiO88379.
SOURCEiSearch...

Gene expression databases

BgeeiO88379.
CleanExiMM_BAZ1A.
ExpressionAtlasiO88379. baseline and differential.
GenevisibleiO88379. MM.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR018501. DDT_dom.
IPR028942. WHIM1_dom.
IPR028941. WHIM2_dom.
IPR013136. WSTF_Acf1_Cbp146.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF02791. DDT. 1 hit.
PF00628. PHD. 1 hit.
PF10537. WAC_Acf1_DNA_bd. 1 hit.
PF15612. WHIM1. 1 hit.
PF15613. WSD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00571. DDT. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50827. DDT. 1 hit.
PS51136. WAC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-382.
    Strain: C57BL/6J.
    Tissue: Blastocyst and Egg.
  3. "Capturing novel mouse genes encoding chromosomal and other nuclear proteins."
    Tate P., Lee M., Tweedie S., Skarnes W.C., Bickmore W.A.
    J. Cell Sci. 111:2575-2585(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-361.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-732, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284; THR-732; SER-962; SER-963; SER-1339; SER-1352 AND SER-1412, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiBAZ1A_MOUSE
AccessioniPrimary (citable) accession number: O88379
Secondary accession number(s): Q3TKK7, Q3UXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.