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O88377

- PI42B_RAT

UniProt

O88377 - PI42B_RAT

Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Gene

Pip4k2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.1 Publication

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: Ensembl
    2. 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
    3. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC:2.7.1.149)
    Alternative name(s):
    1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
    Diphosphoinositide kinase 2-beta
    Phosphatidylinositol 5-phosphate 4-kinase type II beta
    Short name:
    PI(5)P 4-kinase type II beta
    Short name:
    PIP4KII-beta
    Phosphatidylinositol-phosphate kinase IIgamma
    Short name:
    PIPKIIgamma
    PtdIns(5)P-4-kinase isoform 2-beta
    Gene namesi
    Name:Pip4k2b
    Synonyms:Pip5k2b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi621710. Pip4k2b.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Nucleus By similarity. Cytoplasm By similarity
    Note: Associated with the plasma membrane and the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 416415Phosphatidylinositol 5-phosphate 4-kinase type-2 betaPRO_0000185472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei150 – 1501N6-acetyllysineBy similarity
    Modified residuei326 – 3261PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on serine residues. Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO88377.
    PRIDEiO88377.

    Expressioni

    Gene expression databases

    GenevestigatoriO88377.

    Interactioni

    Subunit structurei

    Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex By similarity.By similarity

    Protein-protein interaction databases

    IntActiO88377. 1 interaction.
    STRINGi10116.ENSRNOP00000017989.

    Structurei

    3D structure databases

    ProteinModelPortaliO88377.
    SMRiO88377. Positions 34-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 415378PIPKPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi303 – 3086Poly-Glu

    Sequence similaritiesi

    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5253.
    GeneTreeiENSGT00690000102069.
    HOGENOMiHOG000007832.
    HOVERGENiHBG000072.
    InParanoidiO88377.
    KOiK00920.
    OMAiECENDGL.
    OrthoDBiEOG708VZZ.
    PhylomeDBiO88377.
    TreeFamiTF354315.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88377-1 [UniParc]FASTAAdd to Basket

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    MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV    50
    NHTINELSNV PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP 100
    MVFRNLRERF GIDDQDYQNS VTRSAPINSD SQGRCGTRFL TTYDRRFVIK 150
    TVSSEDVAEM HNILKKYHQF IVECHGNTLL PQFLGMYRLT VDGVETYMVV 200
    TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD NDFLNEGQKL 250
    RVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEETEVED 300
    RAEEEECEND GVGGGLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA 350
    MKSHESAPKK EVYFMAIIDI LTPYDAKKKA AHAAKTVKHG AGAEISTVNP 400
    EQYSKRFNEF MSNILT 416
    Length:416
    Mass (Da):47,264
    Last modified:November 1, 1998 - v1
    Checksum:i9481AC50CBB6C196
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033355 mRNA. Translation: AAC40203.1.
    RefSeqiNP_446002.1. NM_053550.1.
    UniGeneiRn.30025.

    Genome annotation databases

    EnsembliENSRNOT00000017989; ENSRNOP00000017989; ENSRNOG00000013030.
    GeneIDi89812.
    KEGGirno:89812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033355 mRNA. Translation: AAC40203.1 .
    RefSeqi NP_446002.1. NM_053550.1.
    UniGenei Rn.30025.

    3D structure databases

    ProteinModelPortali O88377.
    SMRi O88377. Positions 34-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88377. 1 interaction.
    STRINGi 10116.ENSRNOP00000017989.

    Proteomic databases

    PaxDbi O88377.
    PRIDEi O88377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017989 ; ENSRNOP00000017989 ; ENSRNOG00000013030 .
    GeneIDi 89812.
    KEGGi rno:89812.

    Organism-specific databases

    CTDi 8396.
    RGDi 621710. Pip4k2b.

    Phylogenomic databases

    eggNOGi COG5253.
    GeneTreei ENSGT00690000102069.
    HOGENOMi HOG000007832.
    HOVERGENi HBG000072.
    InParanoidi O88377.
    KOi K00920.
    OMAi ECENDGL.
    OrthoDBi EOG708VZZ.
    PhylomeDBi O88377.
    TreeFami TF354315.

    Enzyme and pathway databases

    Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    NextBioi 617686.
    PROi O88377.

    Gene expression databases

    Genevestigatori O88377.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals."
      Itoh T., Ijuin T., Takenawa T.
      J. Biol. Chem. 273:20292-20299(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
      Tissue: Brain.

    Entry informationi

    Entry nameiPI42B_RAT
    AccessioniPrimary (citable) accession number: O88377
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3