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O88370

- PI42C_RAT

UniProt

O88370 - PI42C_RAT

Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

Pip4k2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.1 Publication

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: RGD
    2. 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
    3. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phosphatidylinositol biosynthetic process Source: RGD
    2. phosphatidylinositol phosphorylation Source: GOC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
    Alternative name(s):
    Phosphatidylinositol 5-phosphate 4-kinase type II gamma
    Short name:
    PI(5)P 4-kinase type II gamma
    Short name:
    PIP4KII-gamma
    Gene namesi
    Name:Pip4k2c
    Synonyms:Pip5k2c
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621711. Pip4k2c.

    Subcellular locationi

    Cytoplasm. Membrane
    Note: Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RGD
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 420419Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaPRO_0000285753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei26 – 261PhosphoserineBy similarity
    Modified residuei349 – 3491PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiO88370.

    PTM databases

    PhosphoSiteiO88370.

    Expressioni

    Tissue specificityi

    Widely expressed, with the most abundant expression in kidney.1 Publication

    Gene expression databases

    GenevestigatoriO88370.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000061758.

    Structurei

    3D structure databases

    ProteinModelPortaliO88370.
    SMRiO88370. Positions 39-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 419377PIPKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5253.
    HOGENOMiHOG000007832.
    HOVERGENiHBG000072.
    InParanoidiO88370.
    KOiK00920.
    PhylomeDBiO88370.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88370-1 [UniParc]FASTAAdd to Basket

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    MASSSVPPAT APAAAGGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV    50
    FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF 100
    KEYCPQVFRN LRDRFAIDDH DYLVSLTRSP PSETEGSDGR FLISYDRTLV 150
    IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVENEDSYM 200
    LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ 250
    KVYIGEEEKK VFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG 300
    PVREEESEWD GDCNLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF 350
    IDVYAIRSAE GAPEGGVFHG LIDILTQYDA KKKAAHAAKT VKHGAGAEIS 400
    TVHPEQYAKR FLDFISNIFA 420
    Length:420
    Mass (Da):47,049
    Last modified:November 1, 1998 - v1
    Checksum:iBDB07F67FA81E943
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030558 mRNA. Translation: AAC40202.1.
    RefSeqiNP_536728.2. NM_080480.2.
    UniGeneiRn.94783.

    Genome annotation databases

    GeneIDi140607.
    KEGGirno:140607.
    UCSCiRGD:621711. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030558 mRNA. Translation: AAC40202.1 .
    RefSeqi NP_536728.2. NM_080480.2.
    UniGenei Rn.94783.

    3D structure databases

    ProteinModelPortali O88370.
    SMRi O88370. Positions 39-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000061758.

    PTM databases

    PhosphoSitei O88370.

    Proteomic databases

    PRIDEi O88370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 140607.
    KEGGi rno:140607.
    UCSCi RGD:621711. rat.

    Organism-specific databases

    CTDi 79837.
    RGDi 621711. Pip4k2c.

    Phylogenomic databases

    eggNOGi COG5253.
    HOGENOMi HOG000007832.
    HOVERGENi HBG000072.
    InParanoidi O88370.
    KOi K00920.
    PhylomeDBi O88370.

    Miscellaneous databases

    NextBioi 620578.

    Gene expression databases

    Genevestigatori O88370.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals."
      Itoh T., Ijuin T., Takenawa T.
      J. Biol. Chem. 273:20292-20299(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, FUNCTION.

    Entry informationi

    Entry nameiPI42C_RAT
    AccessioniPrimary (citable) accession number: O88370
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3