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O88370 (PI42C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

EC=2.7.1.149
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name=PI(5)P 4-kinase type II gamma
Short name=PIP4KII-gamma
Gene names
Name:Pip4k2c
Synonyms:Pip5k2c
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. Ref.1

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

Subcellular location

Cytoplasm. Membrane. Note: Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis.

Tissue specificity

Widely expressed, with the most abundant expression in kidney. Ref.1

Post-translational modification

Phosphorylated By similarity. Ref.1

Sequence similarities

Contains 1 PIPK domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 420419Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PRO_0000285753

Regions

Domain43 – 419377PIPK

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue261Phosphoserine By similarity
Modified residue3491Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O88370 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: BDB07F67FA81E943

FASTA42047,049
        10         20         30         40         50         60 
MASSSVPPAT APAAAGGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV FLWGVAHSIN 

        70         80         90        100        110        120 
ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF KEYCPQVFRN LRDRFAIDDH 

       130        140        150        160        170        180 
DYLVSLTRSP PSETEGSDGR FLISYDRTLV IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT 

       190        200        210        220        230        240 
LLPQFLGMYR VSVENEDSYM LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL 

       250        260        270        280        290        300 
KDMDFLNKNQ KVYIGEEEKK VFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG 

       310        320        330        340        350        360 
PVREEESEWD GDCNLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF IDVYAIRSAE 

       370        380        390        400        410        420 
GAPEGGVFHG LIDILTQYDA KKKAAHAAKT VKHGAGAEIS TVHPEQYAKR FLDFISNIFA 

« Hide

References

[1]"A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals."
Itoh T., Ijuin T., Takenawa T.
J. Biol. Chem. 273:20292-20299(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030558 mRNA. Translation: AAC40202.1.
RefSeqNP_536728.2. NM_080480.2.
UniGeneRn.94783.

3D structure databases

ProteinModelPortalO88370.
SMRO88370. Positions 39-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000061758.

PTM databases

PhosphoSiteO88370.

Proteomic databases

PRIDEO88370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID140607.
KEGGrno:140607.
UCSCRGD:621711. rat.

Organism-specific databases

CTD79837.
RGD621711. Pip4k2c.

Phylogenomic databases

eggNOGCOG5253.
HOGENOMHOG000007832.
HOVERGENHBG000072.
InParanoidO88370.
KOK00920.
PhylomeDBO88370.

Gene expression databases

GenevestigatorO88370.

Family and domain databases

Gene3D3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERPTHR23086. PTHR23086. 1 hit.
PfamPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620578.

Entry information

Entry namePI42C_RAT
AccessionPrimary (citable) accession number: O88370
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families