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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

Pip4k2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: RGD

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1660499 Synthesis of PIPs at the plasma membrane
R-RNO-6811555 PI5P Regulates TP53 Acetylation
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8847453 Synthesis of PIPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
Gene namesi
Name:Pip4k2c
Synonyms:Pip5k2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621711 Pip4k2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002857532 – 420Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO88370
PRIDEiO88370

PTM databases

iPTMnetiO88370
PhosphoSitePlusiO88370

Expressioni

Tissue specificityi

Widely expressed, with the most abundant expression in kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000005138
ExpressionAtlasiO88370 baseline and differential
GenevisibleiO88370 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061758

Structurei

3D structure databases

ProteinModelPortaliO88370
SMRiO88370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 419PIPKPROSITE-ProRule annotationAdd BLAST377

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiO88370
KOiK00920
PhylomeDBiO88370

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSVPPAT APAAAGGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
60 70 80 90 100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF
110 120 130 140 150
KEYCPQVFRN LRDRFAIDDH DYLVSLTRSP PSETEGSDGR FLISYDRTLV
160 170 180 190 200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVENEDSYM
210 220 230 240 250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
260 270 280 290 300
KVYIGEEEKK VFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG
310 320 330 340 350
PVREEESEWD GDCNLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
360 370 380 390 400
IDVYAIRSAE GAPEGGVFHG LIDILTQYDA KKKAAHAAKT VKHGAGAEIS
410 420
TVHPEQYAKR FLDFISNIFA
Length:420
Mass (Da):47,049
Last modified:November 1, 1998 - v1
Checksum:iBDB07F67FA81E943
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030558 mRNA Translation: AAC40202.1
RefSeqiNP_536728.2, NM_080480.2
UniGeneiRn.94783

Genome annotation databases

EnsembliENSRNOT00000079327; ENSRNOP00000075530; ENSRNOG00000005138
GeneIDi140607
KEGGirno:140607
UCSCiRGD:621711 rat

Similar proteinsi

Entry informationi

Entry nameiPI42C_RAT
AccessioniPrimary (citable) accession number: O88370
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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