Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

Pip4k2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: RGD
  2. 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol biosynthetic process Source: RGD
  2. phosphatidylinositol phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
Gene namesi
Name:Pip4k2c
Synonyms:Pip5k2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621711. Pip4k2c.

Subcellular locationi

  1. Cytoplasm
  2. Membrane

  3. Note: Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis.

GO - Cellular componenti

  1. endoplasmic reticulum Source: RGD
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 420419Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaPRO_0000285753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei26 – 261PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiO88370.

PTM databases

PhosphoSiteiO88370.

Expressioni

Tissue specificityi

Widely expressed, with the most abundant expression in kidney.1 Publication

Gene expression databases

GenevestigatoriO88370.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061758.

Structurei

3D structure databases

ProteinModelPortaliO88370.
SMRiO88370. Positions 39-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 419377PIPKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000007832.
HOVERGENiHBG000072.
InParanoidiO88370.
KOiK00920.
PhylomeDBiO88370.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSVPPAT APAAAGGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
60 70 80 90 100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF
110 120 130 140 150
KEYCPQVFRN LRDRFAIDDH DYLVSLTRSP PSETEGSDGR FLISYDRTLV
160 170 180 190 200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVENEDSYM
210 220 230 240 250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
260 270 280 290 300
KVYIGEEEKK VFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG
310 320 330 340 350
PVREEESEWD GDCNLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
360 370 380 390 400
IDVYAIRSAE GAPEGGVFHG LIDILTQYDA KKKAAHAAKT VKHGAGAEIS
410 420
TVHPEQYAKR FLDFISNIFA
Length:420
Mass (Da):47,049
Last modified:November 1, 1998 - v1
Checksum:iBDB07F67FA81E943
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030558 mRNA. Translation: AAC40202.1.
RefSeqiNP_536728.2. NM_080480.2.
UniGeneiRn.94783.

Genome annotation databases

GeneIDi140607.
KEGGirno:140607.
UCSCiRGD:621711. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030558 mRNA. Translation: AAC40202.1.
RefSeqiNP_536728.2. NM_080480.2.
UniGeneiRn.94783.

3D structure databases

ProteinModelPortaliO88370.
SMRiO88370. Positions 39-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061758.

PTM databases

PhosphoSiteiO88370.

Proteomic databases

PRIDEiO88370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140607.
KEGGirno:140607.
UCSCiRGD:621711. rat.

Organism-specific databases

CTDi79837.
RGDi621711. Pip4k2c.

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000007832.
HOVERGENiHBG000072.
InParanoidiO88370.
KOiK00920.
PhylomeDBiO88370.

Miscellaneous databases

NextBioi620578.
PROiO88370.

Gene expression databases

GenevestigatoriO88370.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals."
    Itoh T., Ijuin T., Takenawa T.
    J. Biol. Chem. 273:20292-20299(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiPI42C_RAT
AccessioniPrimary (citable) accession number: O88370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 1, 1998
Last modified: April 29, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.