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Protein

Putative hydrolase RBBP9

Gene

Rbbp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemSequence analysis1
Active sitei138Charge relay systemSequence analysis1
Active sitei165Charge relay systemSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • regulation of cell proliferation Source: RGD

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERiratno-rbbp9 Hydrolase_RBBP9_YdeN

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydrolase RBBP9 (EC:3.-.-.-)
Alternative name(s):
B5T-overexpressed gene protein
Short name:
Protein BOG
Retinoblastoma-binding protein 9
Short name:
RBBP-9
Gene namesi
Name:Rbbp9
Synonyms:Bog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3542 Rbbp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971821 – 186Putative hydrolase RBBP9Add BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Phosphothreonine; by CK2Sequence analysis1
Modified residuei135Phosphoserine; by CK2Sequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88350
PRIDEiO88350

PTM databases

iPTMnetiO88350
PhosphoSitePlusiO88350

Expressioni

Tissue specificityi

Highly expressed in the spleen, testis and kidney. Also found in the heart, liver, lung and brain.

Gene expression databases

BgeeiENSRNOG00000007972
GenevisibleiO88350 RN

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rb1P335684EBI-1211014,EBI-1162932

Protein-protein interaction databases

IntActiO88350, 3 interactors
STRINGi10116.ENSRNOP00000010678

Structurei

3D structure databases

ProteinModelPortaliO88350
SMRiO88350
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 70Retinoblastoma protein bindingSequence analysisAdd BLAST15

Sequence similaritiesi

Belongs to the RBBP9 family.Curated

Phylogenomic databases

eggNOGiENOG410IK06 Eukaryota
ENOG411109T LUCA
GeneTreeiENSGT00390000014861
HOGENOMiHOG000231689
HOVERGENiHBG056175
InParanoidiO88350
KOiK07002
OMAiANWYGWL
OrthoDBiEOG091G0MJ3
PhylomeDBiO88350
TreeFamiTF106470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR010662 Hydrolase_RBBP9/YdeN
PfamiView protein in Pfam
PF06821 Ser_hydrolase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

O88350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPTKAVIV PGNGGGDVAT HGWYGWVRKG LEQIPGFQCL AKNMPDPITA
60 70 80 90 100
RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHQV YALILVSAYT
110 120 130 140 150
SDLGDENERA SGYFSRPWQW EKIKANCPHI IQFGSTDDPF LPWKEQQEVA
160 170 180
DRLDAKLYKF TDRGHFQNTE FHELIRVVKS MLTPAL
Length:186
Mass (Da):20,995
Last modified:October 1, 2000 - v2
Checksum:i41EC9779708E5E19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025819 mRNA Translation: AAC40205.2
BC101915 mRNA Translation: AAI01916.1
RefSeqiNP_062092.2, NM_019219.2
UniGeneiRn.162693

Genome annotation databases

EnsembliENSRNOT00000010678; ENSRNOP00000010678; ENSRNOG00000007972
GeneIDi29459
KEGGirno:29459
UCSCiRGD:3542 rat

Similar proteinsi

Entry informationi

Entry nameiRBBP9_RAT
AccessioniPrimary (citable) accession number: O88350
Secondary accession number(s): Q3T1H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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