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Protein

Putative hydrolase RBBP9

Gene

Rbbp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemSequence analysis1
Active sitei138Charge relay systemSequence analysis1
Active sitei165Charge relay systemSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • regulation of cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERiratno-rbbp9. Duf_1234.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydrolase RBBP9 (EC:3.-.-.-)
Alternative name(s):
B5T-overexpressed gene protein
Short name:
Protein BOG
Retinoblastoma-binding protein 9
Short name:
RBBP-9
Gene namesi
Name:Rbbp9
Synonyms:Bog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3542. Rbbp9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971821 – 186Putative hydrolase RBBP9Add BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Phosphothreonine; by CK2Sequence analysis1
Modified residuei135Phosphoserine; by CK2Sequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88350.
PRIDEiO88350.

PTM databases

iPTMnetiO88350.
PhosphoSitePlusiO88350.

Expressioni

Tissue specificityi

Highly expressed in the spleen, testis and kidney. Also found in the heart, liver, lung and brain.

Gene expression databases

BgeeiENSRNOG00000007972.
GenevisibleiO88350. RN.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rb1P335684EBI-1211014,EBI-1162932

Protein-protein interaction databases

IntActiO88350. 3 interactors.
STRINGi10116.ENSRNOP00000010678.

Structurei

3D structure databases

ProteinModelPortaliO88350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 70Retinoblastoma protein bindingSequence analysisAdd BLAST15

Sequence similaritiesi

Belongs to the RBBP9 family.Curated

Phylogenomic databases

eggNOGiENOG410IK06. Eukaryota.
ENOG411109T. LUCA.
GeneTreeiENSGT00390000014861.
HOGENOMiHOG000231689.
HOVERGENiHBG056175.
InParanoidiO88350.
KOiK07002.
OMAiIVPGNGC.
OrthoDBiEOG091G0MJ3.
PhylomeDBiO88350.
TreeFamiTF106470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR010662. Hydrolase_RBBP9/YdeN.
[Graphical view]
PfamiPF06821. Ser_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O88350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPTKAVIV PGNGGGDVAT HGWYGWVRKG LEQIPGFQCL AKNMPDPITA
60 70 80 90 100
RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHQV YALILVSAYT
110 120 130 140 150
SDLGDENERA SGYFSRPWQW EKIKANCPHI IQFGSTDDPF LPWKEQQEVA
160 170 180
DRLDAKLYKF TDRGHFQNTE FHELIRVVKS MLTPAL
Length:186
Mass (Da):20,995
Last modified:October 1, 2000 - v2
Checksum:i41EC9779708E5E19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025819 mRNA. Translation: AAC40205.2.
BC101915 mRNA. Translation: AAI01916.1.
RefSeqiNP_062092.2. NM_019219.2.
UniGeneiRn.162693.

Genome annotation databases

EnsembliENSRNOT00000010678; ENSRNOP00000010678; ENSRNOG00000007972.
GeneIDi29459.
KEGGirno:29459.
UCSCiRGD:3542. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025819 mRNA. Translation: AAC40205.2.
BC101915 mRNA. Translation: AAI01916.1.
RefSeqiNP_062092.2. NM_019219.2.
UniGeneiRn.162693.

3D structure databases

ProteinModelPortaliO88350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88350. 3 interactors.
STRINGi10116.ENSRNOP00000010678.

Protein family/group databases

ESTHERiratno-rbbp9. Duf_1234.

PTM databases

iPTMnetiO88350.
PhosphoSitePlusiO88350.

Proteomic databases

PaxDbiO88350.
PRIDEiO88350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010678; ENSRNOP00000010678; ENSRNOG00000007972.
GeneIDi29459.
KEGGirno:29459.
UCSCiRGD:3542. rat.

Organism-specific databases

CTDi10741.
RGDi3542. Rbbp9.

Phylogenomic databases

eggNOGiENOG410IK06. Eukaryota.
ENOG411109T. LUCA.
GeneTreeiENSGT00390000014861.
HOGENOMiHOG000231689.
HOVERGENiHBG056175.
InParanoidiO88350.
KOiK07002.
OMAiIVPGNGC.
OrthoDBiEOG091G0MJ3.
PhylomeDBiO88350.
TreeFamiTF106470.

Miscellaneous databases

PROiO88350.

Gene expression databases

BgeeiENSRNOG00000007972.
GenevisibleiO88350. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR010662. Hydrolase_RBBP9/YdeN.
[Graphical view]
PfamiPF06821. Ser_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRBBP9_RAT
AccessioniPrimary (citable) accession number: O88350
Secondary accession number(s): Q3T1H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.