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Protein

Putative hydrolase RBBP9

Gene

Rbbp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemSequence analysis
Active sitei138 – 1381Charge relay systemSequence analysis
Active sitei165 – 1651Charge relay systemSequence analysis

GO - Molecular functioni

GO - Biological processi

  • regulation of cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERiratno-rbbp9. Duf_1234.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydrolase RBBP9 (EC:3.-.-.-)
Alternative name(s):
B5T-overexpressed gene protein
Short name:
Protein BOG
Retinoblastoma-binding protein 9
Short name:
RBBP-9
Gene namesi
Name:Rbbp9
Synonyms:Bog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3542. Rbbp9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Putative hydrolase RBBP9PRO_0000097182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphothreonine; by CK2Sequence analysis
Modified residuei135 – 1351Phosphoserine; by CK2Sequence analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88350.
PRIDEiO88350.

PTM databases

iPTMnetiO88350.

Expressioni

Tissue specificityi

Highly expressed in the spleen, testis and kidney. Also found in the heart, liver, lung and brain.

Gene expression databases

GenevisibleiO88350. RN.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rb1P335684EBI-1211014,EBI-1162932

Protein-protein interaction databases

IntActiO88350. 3 interactions.
STRINGi10116.ENSRNOP00000010678.

Structurei

3D structure databases

ProteinModelPortaliO88350.
SMRiO88350. Positions 3-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 7015Retinoblastoma protein bindingSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the RBBP9 family.Curated

Phylogenomic databases

eggNOGiENOG410IK06. Eukaryota.
ENOG411109T. LUCA.
GeneTreeiENSGT00390000014861.
HOGENOMiHOG000231689.
HOVERGENiHBG056175.
InParanoidiO88350.
KOiK07002.
OMAiIVPGNGC.
OrthoDBiEOG7XWPPP.
PhylomeDBiO88350.
TreeFamiTF106470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR010662. Hydrolase_RBBP9/YdeN.
[Graphical view]
PfamiPF06821. Ser_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O88350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPTKAVIV PGNGGGDVAT HGWYGWVRKG LEQIPGFQCL AKNMPDPITA
60 70 80 90 100
RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHQV YALILVSAYT
110 120 130 140 150
SDLGDENERA SGYFSRPWQW EKIKANCPHI IQFGSTDDPF LPWKEQQEVA
160 170 180
DRLDAKLYKF TDRGHFQNTE FHELIRVVKS MLTPAL
Length:186
Mass (Da):20,995
Last modified:October 1, 2000 - v2
Checksum:i41EC9779708E5E19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025819 mRNA. Translation: AAC40205.2.
BC101915 mRNA. Translation: AAI01916.1.
RefSeqiNP_062092.2. NM_019219.2.
UniGeneiRn.162693.

Genome annotation databases

EnsembliENSRNOT00000010678; ENSRNOP00000010678; ENSRNOG00000007972.
GeneIDi29459.
KEGGirno:29459.
UCSCiRGD:3542. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025819 mRNA. Translation: AAC40205.2.
BC101915 mRNA. Translation: AAI01916.1.
RefSeqiNP_062092.2. NM_019219.2.
UniGeneiRn.162693.

3D structure databases

ProteinModelPortaliO88350.
SMRiO88350. Positions 3-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88350. 3 interactions.
STRINGi10116.ENSRNOP00000010678.

Protein family/group databases

ESTHERiratno-rbbp9. Duf_1234.

PTM databases

iPTMnetiO88350.

Proteomic databases

PaxDbiO88350.
PRIDEiO88350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010678; ENSRNOP00000010678; ENSRNOG00000007972.
GeneIDi29459.
KEGGirno:29459.
UCSCiRGD:3542. rat.

Organism-specific databases

CTDi10741.
RGDi3542. Rbbp9.

Phylogenomic databases

eggNOGiENOG410IK06. Eukaryota.
ENOG411109T. LUCA.
GeneTreeiENSGT00390000014861.
HOGENOMiHOG000231689.
HOVERGENiHBG056175.
InParanoidiO88350.
KOiK07002.
OMAiIVPGNGC.
OrthoDBiEOG7XWPPP.
PhylomeDBiO88350.
TreeFamiTF106470.

Miscellaneous databases

PROiO88350.

Gene expression databases

GenevisibleiO88350. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR010662. Hydrolase_RBBP9/YdeN.
[Graphical view]
PfamiPF06821. Ser_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability."
    Woitach J.T., Zhang M., Niu C.-H., Thorgeirsson S.S.
    Nat. Genet. 19:371-374(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiRBBP9_RAT
AccessioniPrimary (citable) accession number: O88350
Secondary accession number(s): Q3T1H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.