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O88343

- S4A4_MOUSE

UniProt

O88343 - S4A4_MOUSE

Protein

Electrogenic sodium bicarbonate cotransporter 1

Gene

Slc4a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.

    Enzyme regulationi

    Inhibited by stilbene derivatives and regulated by cyclic AMP.

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro
    2. protein binding Source: IntAct
    3. sodium:bicarbonate symporter activity Source: MGI

    GO - Biological processi

    1. bicarbonate transport Source: MGI
    2. regulation of pH Source: MGI
    3. sodium ion transmembrane transport Source: GOC
    4. sodium ion transport Source: MGI

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Electrogenic sodium bicarbonate cotransporter 1
    Short name:
    Sodium bicarbonate cotransporter
    Alternative name(s):
    Na(+)/HCO3(-) cotransporter
    Solute carrier family 4 member 4
    Gene namesi
    Name:Slc4a4
    Synonyms:Nbc1, Nbce1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1927555. Slc4a4.

    Subcellular locationi

    Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10791079Electrogenic sodium bicarbonate cotransporter 1PRO_0000079228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301Phosphotyrosine1 Publication
    Modified residuei254 – 2541Phosphothreonine1 Publication
    Modified residuei257 – 2571Phosphoserine1 Publication
    Modified residuei262 – 2621Phosphoserine1 Publication
    Glycosylationi641 – 6411N-linked (GlcNAc...)By similarity
    Glycosylationi661 – 6611N-linked (GlcNAc...)By similarity
    Modified residuei1026 – 10261Phosphoserine; by PKABy similarity
    Modified residuei1029 – 10291Phosphoserine1 Publication
    Modified residuei1034 – 10341Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na+:HCO3- stoichiometry of the transporter from 3:1 to 2:1.By similarity
    N-glycosylated. May not be necessary for the transporter basic functions.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO88343.
    PaxDbiO88343.
    PRIDEiO88343.

    PTM databases

    PhosphoSiteiO88343.

    Expressioni

    Tissue specificityi

    Isoform 1 is specifically expressed in pancreatic ducts and acini. Also expressed in parotid acinar cells and in the colonic crypts.4 Publications

    Gene expression databases

    ArrayExpressiO88343.
    BgeeiO88343.
    GenevestigatoriO88343.

    Interactioni

    Subunit structurei

    Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ca4Q644442EBI-771342,EBI-6859308

    Protein-protein interaction databases

    IntActiO88343. 6 interactions.
    MINTiMINT-4130871.
    STRINGi10090.ENSMUSP00000121744.

    Structurei

    3D structure databases

    ProteinModelPortaliO88343.
    SMRiO88343. Positions 107-382, 453-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 468468CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini489 – 50416ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini527 – 55428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini581 – 691111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini711 – 72515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini749 – 77729ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini798 – 82225CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini848 – 88134ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini902 – 94948CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini968 – 9703ExtracellularSequence Analysis
    Topological domaini987 – 107993CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei469 – 48820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei505 – 52622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 58026HelicalSequence AnalysisAdd
    BLAST
    Transmembranei692 – 71019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei726 – 74823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei778 – 79720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei823 – 84725HelicalSequence AnalysisAdd
    BLAST
    Transmembranei882 – 90120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei950 – 96718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei971 – 98616HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni748 – 77932Interaction with CA4By similarityAdd
    BLAST
    Regioni1002 – 10043CA2-bindingBy similarity
    Regioni1030 – 10334CA2-bindingBy similarity
    Regioni1057 – 10593Required for basolateral targetingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1009 – 102416Lys-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251607.
    GeneTreeiENSGT00560000076851.
    HOGENOMiHOG000280684.
    HOVERGENiHBG004326.
    InParanoidiO88343.
    KOiK13575.
    OrthoDBiEOG7TMZR0.
    PhylomeDBiO88343.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMiSSF55804. SSF55804. 1 hit.
    TIGRFAMsiTIGR00834. ae. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88343-1) [UniParc]FASTAAdd to Basket

    Also known as: pNBC

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKAG     50
    HKEKKEKERI SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED 100
    DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV 150
    ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIADHQ IETGLLKPDL 200
    KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFSN PDNGSPAMTH 250
    RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI 300
    AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD 350
    EVFHDIAYKA KDRHDLIAGI DEFLDEVIVL PPGEWDPTIR IEPPKSLPSS 400
    DKRKNMYSGG ENVQMNGDTP HDGGHGGGGH GDCEELQRTG RFCGGLIKDI 450
    KRKAPFFASD FYDALNIQAL SAILFIYLAT VTNAITFGGL LGDATDNMQG 500
    VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF NFSKDHNFDY 550
    LEFRLWIGLW SAFMCLVLVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA 600
    FKKMIKLADY YPINSDFKVG YNTHFSCACL PPDPVNLSVS NDTTLAPEDL 650
    PTISSTDMYH NVTFDWAYLS KKECVKYGGK LVGNNCDFVP DITLMSFILF 700
    LGTYTSSMAM KKFKTSRYFP TTARKLISDF AIILSILIFC VIDALVGVDT 750
    PKLIVPSEFK PTSPNRGWFV PPFGGNPWWV CLAAAIPALL VTILIFMDQQ 800
    ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VVCSFMALPW YVAATVISIA 850
    HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI 900
    PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV 950
    HLFTFLQVLC LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS 1000
    FLDDVIPEKD KKKKEDEKKK KKKKGSLDSD NDDSDCPYSE KVPSIKIPMD 1050
    IMEQQPFLSD NKPLDRERSS TFLERHTSC 1079
    Length:1,079
    Mass (Da):121,484
    Last modified:December 20, 2005 - v2
    Checksum:iDBC7C3DEBE10BE97
    GO
    Isoform 2 (identifier: O88343-2) [UniParc]FASTAAdd to Basket

    Also known as: kNBC

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: Missing.
         45-85: HKRKAGHKEK...SSSSILKPLI → MSTENVEGKP...FNHSIFTSAV

    Show »
    Length:1,035
    Mass (Da):116,182
    Checksum:i75CD2F7008D52ADE
    GO
    Isoform 3 (identifier: O88343-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: Missing.
         45-85: HKRKAGHKEK...SSSSILKPLI → MSTENVEGKP...FNHSIFTSAV
         185-201: MIADHQIETGLLKPDLK → LLGESRKVIRPAGFIRP
         202-1079: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:157
    Mass (Da):17,829
    Checksum:i95E7EA3165687E5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti388 – 3881T → A in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti546 – 5461H → N in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti560 – 5601W → R in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti564 – 5641M → L in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti567 – 5671V → I in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti589 – 5891S → P in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti740 – 7401C → G in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti775 – 7751G → E in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti814 – 8141K → Q in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti832 – 8321V → I in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti835 – 8351F → L in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti848 – 8481S → F in AAD31036. (PubMed:11171615)Curated
    Sequence conflicti876 – 8761Q → P in AAD31036. (PubMed:11171615)Curated
    Sequence conflicti884 – 8841F → L in AAC40160. (PubMed:9651366)Curated
    Sequence conflicti901 – 9011P → R in AAD31036. (PubMed:11171615)Curated
    Sequence conflicti909 – 9102FL → SW in AAD31036. (PubMed:11171615)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4444Missing in isoform 2 and isoform 3. 2 PublicationsVSP_016709Add
    BLAST
    Alternative sequencei45 – 8541HKRKA…LKPLI → MSTENVEGKPNNLGERGRAR SSTFLRVFQPMFNHSIFTSA V in isoform 2 and isoform 3. 2 PublicationsVSP_016710Add
    BLAST
    Alternative sequencei185 – 20117MIADH…KPDLK → LLGESRKVIRPAGFIRP in isoform 3. 1 PublicationVSP_016711Add
    BLAST
    Alternative sequencei202 – 1079878Missing in isoform 3. 1 PublicationVSP_016712Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020195 mRNA. Translation: AAC40160.1.
    AF141934 mRNA. Translation: AAD31036.3.
    AK085387 mRNA. Translation: BAC39437.1.
    AK140443 mRNA. Translation: BAE24389.1.
    BC026592 mRNA. Translation: AAH26592.1.
    CCDSiCCDS19406.1. [O88343-1]
    PIRiT14031.
    RefSeqiNP_001129732.1. NM_001136260.1.
    NP_061230.2. NM_018760.2. [O88343-1]
    UniGeneiMm.41044.

    Genome annotation databases

    EnsembliENSMUST00000113216; ENSMUSP00000108842; ENSMUSG00000060961. [O88343-3]
    ENSMUST00000130041; ENSMUSP00000118413; ENSMUSG00000060961. [O88343-2]
    ENSMUST00000148750; ENSMUSP00000119325; ENSMUSG00000060961. [O88343-1]
    GeneIDi54403.
    KEGGimmu:54403.
    UCSCiuc008yak.1. mouse. [O88343-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020195 mRNA. Translation: AAC40160.1 .
    AF141934 mRNA. Translation: AAD31036.3 .
    AK085387 mRNA. Translation: BAC39437.1 .
    AK140443 mRNA. Translation: BAE24389.1 .
    BC026592 mRNA. Translation: AAH26592.1 .
    CCDSi CCDS19406.1. [O88343-1 ]
    PIRi T14031.
    RefSeqi NP_001129732.1. NM_001136260.1.
    NP_061230.2. NM_018760.2. [O88343-1 ]
    UniGenei Mm.41044.

    3D structure databases

    ProteinModelPortali O88343.
    SMRi O88343. Positions 107-382, 453-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88343. 6 interactions.
    MINTi MINT-4130871.
    STRINGi 10090.ENSMUSP00000121744.

    PTM databases

    PhosphoSitei O88343.

    Proteomic databases

    MaxQBi O88343.
    PaxDbi O88343.
    PRIDEi O88343.

    Protocols and materials databases

    DNASUi 54403.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113216 ; ENSMUSP00000108842 ; ENSMUSG00000060961 . [O88343-3 ]
    ENSMUST00000130041 ; ENSMUSP00000118413 ; ENSMUSG00000060961 . [O88343-2 ]
    ENSMUST00000148750 ; ENSMUSP00000119325 ; ENSMUSG00000060961 . [O88343-1 ]
    GeneIDi 54403.
    KEGGi mmu:54403.
    UCSCi uc008yak.1. mouse. [O88343-1 ]

    Organism-specific databases

    CTDi 8671.
    MGIi MGI:1927555. Slc4a4.

    Phylogenomic databases

    eggNOGi NOG251607.
    GeneTreei ENSGT00560000076851.
    HOGENOMi HOG000280684.
    HOVERGENi HBG004326.
    InParanoidi O88343.
    KOi K13575.
    OrthoDBi EOG7TMZR0.
    PhylomeDBi O88343.

    Miscellaneous databases

    ChiTaRSi SLC4A4. mouse.
    NextBioi 311268.
    PROi O88343.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88343.
    Bgeei O88343.
    Genevestigatori O88343.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMi SSF55804. SSF55804. 1 hit.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter."
      Abuladze N., Lee I., Newman D., Hwang J., Boorer K., Pushkin A., Kurtz I.
      J. Biol. Chem. 273:17689-17695(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Pancreas.
    2. "Molecular and functional evidence for electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters in murine duodenum."
      Praetorius J., Hager H., Nielsen S., Aalkjaer C., Friis U.G., Ainsworth M.A., Johansen T.
      Am. J. Physiol. 280:G332-G343(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Strain: C57BL/6.
      Tissue: Duodenum.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-400 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Kidney and Medulla oblongata.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-9; 60-67; 168-174; 323-331; 343-359; 607-618; 753-766; 857-869 AND 935-943, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-1079.
      Strain: FVB/N.
      Tissue: Kidney.
    6. "Role of glycosylation in the renal electrogenic Na+-HCO3-cotransporter (NBCe1)."
      Choi I., Hu L., Rojas J.D., Schmitt B.M., Boron W.F.
      Am. J. Physiol. 284:F1199-F1206(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION.
    7. "cAMP-mediated regulation of murine intestinal/pancreatic Na+/HCO3-cotransporter subtype pNBC1."
      Bachmann O., Rossmann H., Berger U.V., Colledge W.H., Ratcliff R., Evans M.J., Gregor M., Seidler U.
      Am. J. Physiol. 284:G37-G45(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGULATION BY CAMP, TISSUE SPECIFICITY.
    8. "Expression of Na+/HCO3- cotransporter and its role in pH regulation in mouse parotid acinar cells."
      Kim Y.-B., Yang B.H., Piao Z.G., Oh S.B., Kim J.S., Park K.
      Biochem. Biophys. Res. Commun. 304:593-598(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter."
      Alvarez B.V., Loiselle F.B., Supuran C.T., Schwartz G.J., Casey J.R.
      Biochemistry 42:12321-12329(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CA4.
    10. "Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells."
      Pushkin A., Abuladze N., Gross E., Newman D., Tatishchev S., Lee I., Fedotoff O., Bondar G., Azimov R., Ngyuen M., Kurtz I.
      J. Physiol. (Lond.) 559:55-65(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CA2.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; SER-257; SER-262; SER-1029 AND SER-1034, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    12. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    13. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiS4A4_MOUSE
    AccessioniPrimary (citable) accession number: O88343
    Secondary accession number(s): Q3USE4
    , Q8BUG0, Q8QZR9, Q9R1C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3