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Protein

WD repeat-containing protein 1

Gene

Wdr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actin filament fragmentation Source: UniProtKB
  • apical junction assembly Source: MGI
  • cortical cytoskeleton organization Source: UniProtKB
  • establishment of planar polarity of follicular epithelium Source: UniProtKB
  • maintenance of epithelial cell apical/basal polarity Source: MGI
  • neutrophil mediated immunity Source: UniProtKB
  • neutrophil migration Source: UniProtKB
  • platelet formation Source: UniProtKB
  • positive regulation of actin filament depolymerization Source: MGI
  • regulation of actin filament depolymerization Source: MGI
  • regulation of cell shape Source: UniProtKB
  • regulation of oligodendrocyte differentiation Source: MGI
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  • sarcomere organization Source: MGI
  • sensory perception of sound Source: MGI

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
Gene namesi
Name:Wdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1337100 Wdr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal. Partial deficiencies disrupt megakaryocyte maturation, platelet shedding and provoke neutrophilic autoinflammatory disease.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513421 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei238PhosphotyrosineCombined sources1
Modified residuei480N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88342
PaxDbiO88342
PeptideAtlasiO88342
PRIDEiO88342

2D gel databases

REPRODUCTION-2DPAGEiIPI00314748
O88342
UCD-2DPAGEiO88342

PTM databases

iPTMnetiO88342
PhosphoSitePlusiO88342
SwissPalmiO88342

Expressioni

Gene expression databases

BgeeiENSMUSG00000005103
CleanExiMM_WDR1
ExpressionAtlasiO88342 baseline and differential
GenevisibleiO88342 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2045548 interactors.
IntActiO88342 11 interactors.
MINTiO88342
STRINGi10090.ENSMUSP00000005234

Structurei

3D structure databases

ProteinModelPortaliO88342
SMRiO88342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 45WD 1Add BLAST42
Repeati48 – 87WD 2Add BLAST40
Repeati93 – 135WD 3Add BLAST43
Repeati138 – 176WD 4Add BLAST39
Repeati180 – 218WD 5Add BLAST39
Repeati224 – 263WD 6Add BLAST40
Repeati270 – 306WD 7Add BLAST37
Repeati311 – 351WD 8Add BLAST41
Repeati358 – 408WD 9Add BLAST51
Repeati432 – 474WD 10Add BLAST43
Repeati480 – 518WD 11Add BLAST39
Repeati523 – 561WD 12Add BLAST39
Repeati566 – 604WD 13Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318 Eukaryota
ENOG410XQN1 LUCA
GeneTreeiENSGT00390000009416
HOVERGENiHBG000780
InParanoidiO88342
OMAiDGHINYW
OrthoDBiEOG091G03SZ
PhylomeDBiO88342
TreeFamiTF300821

Family and domain databases

Gene3Di2.130.10.103 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50974 SSF50974, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O88342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KILGGDPKGD HFLYTNGKCV ILRNIDNPAI
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDTGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQTRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGES KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHR NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFS GKGHTNQVSR MTVNESEQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AVGGTDGNVR VYSILASTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,407
Last modified:January 23, 2007 - v3
Checksum:i573CEA1DCD7CA80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020055 mRNA Translation: AAD05043.1
CCDSiCCDS51485.1
RefSeqiNP_035845.1, NM_011715.2
UniGeneiMm.2654
Mm.393965
Mm.406120

Genome annotation databases

EnsembliENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103
GeneIDi22388
KEGGimmu:22388
UCSCiuc033ije.1 mouse

Similar proteinsi

Entry informationi

Entry nameiWDR1_MOUSE
AccessioniPrimary (citable) accession number: O88342
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome