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Protein

WD repeat-containing protein 1

Gene

Wdr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • positive regulation of actin filament depolymerization Source: MGI
  • regulation of oligodendrocyte differentiation Source: MGI
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  • sarcomere organization Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
Gene namesi
Name:Wdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1337100. Wdr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 606605WD repeat-containing protein 1PRO_0000051342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei81 – 811N6-acetyllysineBy similarity
Modified residuei95 – 951N6-acetyllysineCombined sources
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei238 – 2381PhosphotyrosineCombined sources
Modified residuei480 – 4801N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88342.
PaxDbiO88342.
PRIDEiO88342.

2D gel databases

REPRODUCTION-2DPAGEIPI00314748.
O88342.
UCD-2DPAGEO88342.

PTM databases

iPTMnetiO88342.
PhosphoSiteiO88342.
SwissPalmiO88342.

Expressioni

Gene expression databases

BgeeiO88342.
CleanExiMM_WDR1.
ExpressionAtlasiO88342. baseline and differential.
GenevisibleiO88342. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204554. 7 interactions.
IntActiO88342. 10 interactions.
MINTiMINT-1866496.
STRINGi10090.ENSMUSP00000005234.

Structurei

3D structure databases

ProteinModelPortaliO88342.
SMRiO88342. Positions 8-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati56 – 9540WD 1Add
BLAST
Repeati100 – 14344WD 2Add
BLAST
Repeati144 – 18441WD 3Add
BLAST
Repeati187 – 22640WD 4Add
BLAST
Repeati232 – 27140WD 5Add
BLAST
Repeati318 – 35942WD 6Add
BLAST
Repeati363 – 40139WD 7Add
BLAST
Repeati443 – 48240WD 8Add
BLAST
Repeati487 – 52640WD 9Add
BLAST
Repeati530 – 56940WD 10Add
BLAST
Repeati574 – 60532WD 11Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOVERGENiHBG000780.
InParanoidiO88342.
OMAiWDVGANS.
OrthoDBiEOG7TXKG1.
PhylomeDBiO88342.
TreeFamiTF300821.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KILGGDPKGD HFLYTNGKCV ILRNIDNPAI
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDTGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQTRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGES KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHR NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFS GKGHTNQVSR MTVNESEQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AVGGTDGNVR VYSILASTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,407
Last modified:January 23, 2007 - v3
Checksum:i573CEA1DCD7CA80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020055 mRNA. Translation: AAD05043.1.
CCDSiCCDS51485.1.
RefSeqiNP_035845.1. NM_011715.2.
UniGeneiMm.2654.
Mm.393965.
Mm.406120.

Genome annotation databases

EnsembliENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103.
GeneIDi22388.
KEGGimmu:22388.
UCSCiuc033ije.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020055 mRNA. Translation: AAD05043.1.
CCDSiCCDS51485.1.
RefSeqiNP_035845.1. NM_011715.2.
UniGeneiMm.2654.
Mm.393965.
Mm.406120.

3D structure databases

ProteinModelPortaliO88342.
SMRiO88342. Positions 8-606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204554. 7 interactions.
IntActiO88342. 10 interactions.
MINTiMINT-1866496.
STRINGi10090.ENSMUSP00000005234.

PTM databases

iPTMnetiO88342.
PhosphoSiteiO88342.
SwissPalmiO88342.

2D gel databases

REPRODUCTION-2DPAGEIPI00314748.
O88342.
UCD-2DPAGEO88342.

Proteomic databases

EPDiO88342.
PaxDbiO88342.
PRIDEiO88342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103.
GeneIDi22388.
KEGGimmu:22388.
UCSCiuc033ije.1. mouse.

Organism-specific databases

CTDi9948.
MGIiMGI:1337100. Wdr1.

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOVERGENiHBG000780.
InParanoidiO88342.
OMAiWDVGANS.
OrthoDBiEOG7TXKG1.
PhylomeDBiO88342.
TreeFamiTF300821.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiWdr1. mouse.
PROiO88342.
SOURCEiSearch...

Gene expression databases

BgeeiO88342.
CleanExiMM_WDR1.
ExpressionAtlasiO88342. baseline and differential.
GenevisibleiO88342. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein."
    Adler H.J., Winnicki R.S., Gong T.-W.L., Lomax M.I.
    Genomics 56:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 44-65 AND 162-180, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-95 AND LYS-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiWDR1_MOUSE
AccessioniPrimary (citable) accession number: O88342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.