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Protein

WD repeat-containing protein 1

Gene

Wdr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actin filament fragmentation Source: UniProtKB
  • apical junction assembly Source: MGI
  • cortical cytoskeleton organization Source: UniProtKB
  • establishment of planar polarity of follicular epithelium Source: UniProtKB
  • maintenance of epithelial cell apical/basal polarity Source: MGI
  • neutrophil mediated immunity Source: UniProtKB
  • neutrophil migration Source: UniProtKB
  • platelet formation Source: UniProtKB
  • positive regulation of actin filament depolymerization Source: MGI
  • regulation of actin filament depolymerization Source: MGI
  • regulation of cell shape Source: UniProtKB
  • regulation of oligodendrocyte differentiation Source: MGI
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  • sarcomere organization Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
Gene namesi
Name:Wdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1337100. Wdr1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectionpodosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal. Partial deficiencies disrupt megakaryocyte maturation, platelet shedding and provoke neutrophilic autoinflammatory disease.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513421 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei238PhosphotyrosineCombined sources1
Modified residuei480N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88342.
PaxDbiO88342.
PeptideAtlasiO88342.
PRIDEiO88342.

2D gel databases

REPRODUCTION-2DPAGEIPI00314748.
O88342.
UCD-2DPAGEO88342.

PTM databases

iPTMnetiO88342.
PhosphoSitePlusiO88342.
SwissPalmiO88342.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005103.
CleanExiMM_WDR1.
ExpressionAtlasiO88342. baseline and differential.
GenevisibleiO88342. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204554. 7 interactors.
IntActiO88342. 10 interactors.
MINTiMINT-1866496.
STRINGi10090.ENSMUSP00000005234.

Structurei

3D structure databases

ProteinModelPortaliO88342.
SMRiO88342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 95WD 1Add BLAST40
Repeati100 – 143WD 2Add BLAST44
Repeati144 – 184WD 3Add BLAST41
Repeati187 – 226WD 4Add BLAST40
Repeati232 – 271WD 5Add BLAST40
Repeati318 – 359WD 6Add BLAST42
Repeati363 – 401WD 7Add BLAST39
Repeati443 – 482WD 8Add BLAST40
Repeati487 – 526WD 9Add BLAST40
Repeati530 – 569WD 10Add BLAST40
Repeati574 – 605WD 11Add BLAST32

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO88342.
OMAiWDVGANS.
OrthoDBiEOG091G03SZ.
PhylomeDBiO88342.
TreeFamiTF300821.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KILGGDPKGD HFLYTNGKCV ILRNIDNPAI
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDTGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQTRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGES KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHR NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFS GKGHTNQVSR MTVNESEQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AVGGTDGNVR VYSILASTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,407
Last modified:January 23, 2007 - v3
Checksum:i573CEA1DCD7CA80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020055 mRNA. Translation: AAD05043.1.
CCDSiCCDS51485.1.
RefSeqiNP_035845.1. NM_011715.2.
UniGeneiMm.2654.
Mm.393965.
Mm.406120.

Genome annotation databases

EnsembliENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103.
GeneIDi22388.
KEGGimmu:22388.
UCSCiuc033ije.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020055 mRNA. Translation: AAD05043.1.
CCDSiCCDS51485.1.
RefSeqiNP_035845.1. NM_011715.2.
UniGeneiMm.2654.
Mm.393965.
Mm.406120.

3D structure databases

ProteinModelPortaliO88342.
SMRiO88342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204554. 7 interactors.
IntActiO88342. 10 interactors.
MINTiMINT-1866496.
STRINGi10090.ENSMUSP00000005234.

PTM databases

iPTMnetiO88342.
PhosphoSitePlusiO88342.
SwissPalmiO88342.

2D gel databases

REPRODUCTION-2DPAGEIPI00314748.
O88342.
UCD-2DPAGEO88342.

Proteomic databases

EPDiO88342.
PaxDbiO88342.
PeptideAtlasiO88342.
PRIDEiO88342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103.
GeneIDi22388.
KEGGimmu:22388.
UCSCiuc033ije.1. mouse.

Organism-specific databases

CTDi9948.
MGIiMGI:1337100. Wdr1.

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO88342.
OMAiWDVGANS.
OrthoDBiEOG091G03SZ.
PhylomeDBiO88342.
TreeFamiTF300821.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiWdr1. mouse.
PROiO88342.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005103.
CleanExiMM_WDR1.
ExpressionAtlasiO88342. baseline and differential.
GenevisibleiO88342. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR1_MOUSE
AccessioniPrimary (citable) accession number: O88342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.