Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-16

Gene

Cdh16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:Cdh16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106671. Cdh16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 788ExtracellularSequence analysisAdd BLAST767
Transmembranei789 – 809HelicalSequence analysisAdd BLAST21
Topological domaini810 – 830CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000381022 – 830Cadherin-16Add BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi519N-linked (GlcNAc...)Sequence analysis1
Glycosylationi604N-linked (GlcNAc...)Sequence analysis1
Glycosylationi724N-linked (GlcNAc...)Sequence analysis1
Modified residuei823PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO88338.
PeptideAtlasiO88338.
PRIDEiO88338.

PTM databases

iPTMnetiO88338.
PhosphoSitePlusiO88338.

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiENSMUSG00000031881.
CleanExiMM_CDH16.
ExpressionAtlasiO88338. baseline and differential.
GenevisibleiO88338. MM.

Interactioni

Protein-protein interaction databases

IntActiO88338. 3 interactors.
MINTiMINT-4089683.
STRINGi10090.ENSMUSP00000129663.

Structurei

3D structure databases

ProteinModelPortaliO88338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 128Cadherin 1PROSITE-ProRule annotationAdd BLAST102
Domaini133 – 237Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini244 – 338Cadherin 3PROSITE-ProRule annotationAdd BLAST95
Domaini343 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini457 – 566Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini571 – 667Cadherin 6PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni668 – 788Ectodomain GAdd BLAST121

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO88338.
KOiK06810.
OMAiHWVEPRE.
OrthoDBiEOG091G03CL.
PhylomeDBiO88338.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL
60 70 80 90 100
GRDEGHIVLS GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL
110 120 130 140 150
ESEDGRILWG PQLVTVHVKD ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL
160 170 180 190 200
EASDGDAPGT ANSDLRFHIL SQSPPQPLPD MFQLDPHLGA LALSPSGSTS
210 220 230 240 250
LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW APLEPVHLAE
260 270 280 290 300
NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA
310 320 330 340 350
QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL
360 370 380 390 400
SPPGTEIARL SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG
410 420 430 440 450
SVTLGTAPLH AGQSILLQVL AVDLAGSESG LSSTCEVTVM VTDVNNHAPE
460 470 480 490 500
FINSQIGPVT LPEDVKPGAL VATLMATDAD LEPAFRLMDF AIEEGDPEGI
510 520 530 540 550
FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL VGPGPGPAAT
560 570 580 590 600
ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF
610 620 630 640 650
SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST
660 670 680 690 700
SATVVIHFLK ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR
710 720 730 740 750
NGPYSFALGP NPTVQRDWRL QPLNDSHAYL TLALHWVEPG EYMVPVVVHH
760 770 780 790 800
DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK GMPTKLSAVG VLLGTLAAIG
810 820 830
FILILVFTHL ALARKDLDQP ADSVPLKAAV
Length:830
Mass (Da):89,860
Last modified:November 1, 1998 - v1
Checksum:i5EB1F06B5B7C2F25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016271 mRNA. Translation: AAC34254.1.
BC015251 mRNA. Translation: AAH15251.1.
AF118228 Genomic DNA. Translation: AAF28836.1.
CCDSiCCDS22583.1.
RefSeqiNP_031689.1. NM_007663.3.
UniGeneiMm.19423.

Genome annotation databases

EnsembliENSMUST00000211903; ENSMUSP00000148478; ENSMUSG00000031881.
GeneIDi12556.
KEGGimmu:12556.
UCSCiuc009nax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016271 mRNA. Translation: AAC34254.1.
BC015251 mRNA. Translation: AAH15251.1.
AF118228 Genomic DNA. Translation: AAF28836.1.
CCDSiCCDS22583.1.
RefSeqiNP_031689.1. NM_007663.3.
UniGeneiMm.19423.

3D structure databases

ProteinModelPortaliO88338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88338. 3 interactors.
MINTiMINT-4089683.
STRINGi10090.ENSMUSP00000129663.

PTM databases

iPTMnetiO88338.
PhosphoSitePlusiO88338.

Proteomic databases

PaxDbiO88338.
PeptideAtlasiO88338.
PRIDEiO88338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000211903; ENSMUSP00000148478; ENSMUSG00000031881.
GeneIDi12556.
KEGGimmu:12556.
UCSCiuc009nax.2. mouse.

Organism-specific databases

CTDi1014.
MGIiMGI:106671. Cdh16.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO88338.
KOiK06810.
OMAiHWVEPRE.
OrthoDBiEOG091G03CL.
PhylomeDBiO88338.
TreeFamiTF316817.

Miscellaneous databases

PROiO88338.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031881.
CleanExiMM_CDH16.
ExpressionAtlasiO88338. baseline and differential.
GenevisibleiO88338. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD16_MOUSE
AccessioniPrimary (citable) accession number: O88338
Secondary accession number(s): Q9JLZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.