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O88338

- CAD16_MOUSE

UniProt

O88338 - CAD16_MOUSE

Protein

Cadherin-16

Gene

Cdh16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. calcium-dependent cell-cell adhesion Source: MGI
    2. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-16
    Alternative name(s):
    Kidney-specific cadherin
    Short name:
    Ksp-cadherin
    Gene namesi
    Name:Cdh16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:106671. Cdh16.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 830809Cadherin-16PRO_0000003810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO88338.
    PaxDbiO88338.
    PRIDEiO88338.

    PTM databases

    PhosphoSiteiO88338.

    Expressioni

    Tissue specificityi

    Kidney specific.

    Gene expression databases

    BgeeiO88338.
    CleanExiMM_CDH16.
    GenevestigatoriO88338.

    Interactioni

    Protein-protein interaction databases

    IntActiO88338. 3 interactions.
    MINTiMINT-4089683.

    Structurei

    3D structure databases

    ProteinModelPortaliO88338.
    SMRiO88338. Positions 31-748.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 788767ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini810 – 83021CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei789 – 80921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 128102Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 237105Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 33895Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini343 – 451109Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini457 – 566110Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini571 – 66797Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni668 – 788121Ectodomain GAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259000.
    HOGENOMiHOG000231613.
    HOVERGENiHBG050766.
    InParanoidiO88338.
    KOiK06810.
    OMAiRLMDFAI.
    OrthoDBiEOG7Z3F4D.
    PhylomeDBiO88338.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    [Graphical view]
    PfamiPF00028. Cadherin. 4 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 1 hit.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88338-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL    50
    GRDEGHIVLS GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL 100
    ESEDGRILWG PQLVTVHVKD ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL 150
    EASDGDAPGT ANSDLRFHIL SQSPPQPLPD MFQLDPHLGA LALSPSGSTS 200
    LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW APLEPVHLAE 250
    NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA 300
    QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL 350
    SPPGTEIARL SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG 400
    SVTLGTAPLH AGQSILLQVL AVDLAGSESG LSSTCEVTVM VTDVNNHAPE 450
    FINSQIGPVT LPEDVKPGAL VATLMATDAD LEPAFRLMDF AIEEGDPEGI 500
    FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL VGPGPGPAAT 550
    ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF 600
    SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST 650
    SATVVIHFLK ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR 700
    NGPYSFALGP NPTVQRDWRL QPLNDSHAYL TLALHWVEPG EYMVPVVVHH 750
    DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK GMPTKLSAVG VLLGTLAAIG 800
    FILILVFTHL ALARKDLDQP ADSVPLKAAV 830
    Length:830
    Mass (Da):89,860
    Last modified:November 1, 1998 - v1
    Checksum:i5EB1F06B5B7C2F25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016271 mRNA. Translation: AAC34254.1.
    BC015251 mRNA. Translation: AAH15251.1.
    AF118228 Genomic DNA. Translation: AAF28836.1.
    CCDSiCCDS22583.1.
    RefSeqiNP_031689.1. NM_007663.3.
    UniGeneiMm.19423.

    Genome annotation databases

    EnsembliENSMUST00000163783; ENSMUSP00000129663; ENSMUSG00000031881.
    GeneIDi12556.
    KEGGimmu:12556.
    UCSCiuc009nax.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016271 mRNA. Translation: AAC34254.1 .
    BC015251 mRNA. Translation: AAH15251.1 .
    AF118228 Genomic DNA. Translation: AAF28836.1 .
    CCDSi CCDS22583.1.
    RefSeqi NP_031689.1. NM_007663.3.
    UniGenei Mm.19423.

    3D structure databases

    ProteinModelPortali O88338.
    SMRi O88338. Positions 31-748.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88338. 3 interactions.
    MINTi MINT-4089683.

    PTM databases

    PhosphoSitei O88338.

    Proteomic databases

    MaxQBi O88338.
    PaxDbi O88338.
    PRIDEi O88338.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000163783 ; ENSMUSP00000129663 ; ENSMUSG00000031881 .
    GeneIDi 12556.
    KEGGi mmu:12556.
    UCSCi uc009nax.2. mouse.

    Organism-specific databases

    CTDi 1014.
    MGIi MGI:106671. Cdh16.

    Phylogenomic databases

    eggNOGi NOG259000.
    HOGENOMi HOG000231613.
    HOVERGENi HBG050766.
    InParanoidi O88338.
    KOi K06810.
    OMAi RLMDFAI.
    OrthoDBi EOG7Z3F4D.
    PhylomeDBi O88338.
    TreeFami TF316817.

    Miscellaneous databases

    NextBioi 281614.
    PROi O88338.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88338.
    CleanExi MM_CDH16.
    Genevestigatori O88338.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    [Graphical view ]
    Pfami PF00028. Cadherin. 4 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 1 hit.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin."
      Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S.
      Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity."
      Whyte D.A., Li C., Thomson R.B., Nix S.L., Zanjani R., Karp S.L., Aronson P.S., Igarashi P.
      Am. J. Physiol. 277:F587-F598(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-25.
      Strain: 129/Sv.

    Entry informationi

    Entry nameiCAD16_MOUSE
    AccessioniPrimary (citable) accession number: O88338
    Secondary accession number(s): Q9JLZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3