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Protein

Cadherin-16

Gene

Cdh16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:Cdh16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106671. Cdh16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 788767ExtracellularSequence AnalysisAdd
BLAST
Transmembranei789 – 80921HelicalSequence AnalysisAdd
BLAST
Topological domaini810 – 83021CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 830809Cadherin-16PRO_0000003810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO88338.
PaxDbiO88338.
PRIDEiO88338.

PTM databases

PhosphoSiteiO88338.

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiO88338.
CleanExiMM_CDH16.
ExpressionAtlasiO88338. baseline and differential.
GenevisibleiO88338. MM.

Interactioni

Protein-protein interaction databases

IntActiO88338. 3 interactions.
MINTiMINT-4089683.
STRINGi10090.ENSMUSP00000129663.

Structurei

3D structure databases

ProteinModelPortaliO88338.
SMRiO88338. Positions 31-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 128102Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 237105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 33895Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini343 – 451109Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini457 – 566110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini571 – 66797Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni668 – 788121Ectodomain GAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259000.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO88338.
OMAiHWVEPRE.
OrthoDBiEOG7Z3F4D.
PhylomeDBiO88338.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL
60 70 80 90 100
GRDEGHIVLS GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL
110 120 130 140 150
ESEDGRILWG PQLVTVHVKD ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL
160 170 180 190 200
EASDGDAPGT ANSDLRFHIL SQSPPQPLPD MFQLDPHLGA LALSPSGSTS
210 220 230 240 250
LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW APLEPVHLAE
260 270 280 290 300
NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA
310 320 330 340 350
QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL
360 370 380 390 400
SPPGTEIARL SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG
410 420 430 440 450
SVTLGTAPLH AGQSILLQVL AVDLAGSESG LSSTCEVTVM VTDVNNHAPE
460 470 480 490 500
FINSQIGPVT LPEDVKPGAL VATLMATDAD LEPAFRLMDF AIEEGDPEGI
510 520 530 540 550
FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL VGPGPGPAAT
560 570 580 590 600
ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF
610 620 630 640 650
SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST
660 670 680 690 700
SATVVIHFLK ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR
710 720 730 740 750
NGPYSFALGP NPTVQRDWRL QPLNDSHAYL TLALHWVEPG EYMVPVVVHH
760 770 780 790 800
DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK GMPTKLSAVG VLLGTLAAIG
810 820 830
FILILVFTHL ALARKDLDQP ADSVPLKAAV
Length:830
Mass (Da):89,860
Last modified:November 1, 1998 - v1
Checksum:i5EB1F06B5B7C2F25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016271 mRNA. Translation: AAC34254.1.
BC015251 mRNA. Translation: AAH15251.1.
AF118228 Genomic DNA. Translation: AAF28836.1.
CCDSiCCDS22583.1.
RefSeqiNP_031689.1. NM_007663.3.
UniGeneiMm.19423.

Genome annotation databases

EnsembliENSMUST00000163783; ENSMUSP00000129663; ENSMUSG00000031881.
GeneIDi12556.
UCSCiuc009nax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016271 mRNA. Translation: AAC34254.1.
BC015251 mRNA. Translation: AAH15251.1.
AF118228 Genomic DNA. Translation: AAF28836.1.
CCDSiCCDS22583.1.
RefSeqiNP_031689.1. NM_007663.3.
UniGeneiMm.19423.

3D structure databases

ProteinModelPortaliO88338.
SMRiO88338. Positions 31-748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88338. 3 interactions.
MINTiMINT-4089683.
STRINGi10090.ENSMUSP00000129663.

PTM databases

PhosphoSiteiO88338.

Proteomic databases

MaxQBiO88338.
PaxDbiO88338.
PRIDEiO88338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163783; ENSMUSP00000129663; ENSMUSG00000031881.
GeneIDi12556.
UCSCiuc009nax.2. mouse.

Organism-specific databases

CTDi1014.
MGIiMGI:106671. Cdh16.

Phylogenomic databases

eggNOGiNOG259000.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO88338.
OMAiHWVEPRE.
OrthoDBiEOG7Z3F4D.
PhylomeDBiO88338.
TreeFamiTF316817.

Miscellaneous databases

NextBioi281614.
PROiO88338.
SOURCEiSearch...

Gene expression databases

BgeeiO88338.
CleanExiMM_CDH16.
ExpressionAtlasiO88338. baseline and differential.
GenevisibleiO88338. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin."
    Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S.
    Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity."
    Whyte D.A., Li C., Thomson R.B., Nix S.L., Zanjani R., Karp S.L., Aronson P.S., Igarashi P.
    Am. J. Physiol. 277:F587-F598(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-25.
    Strain: 129/Sv.

Entry informationi

Entry nameiCAD16_MOUSE
AccessioniPrimary (citable) accession number: O88338
Secondary accession number(s): Q9JLZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.