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O88338 (CAD16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name=Ksp-cadherin
Gene names
Name:Cdh16
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length830 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Kidney specific.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 830809Cadherin-16
PRO_0000003810

Regions

Topological domain22 – 788767Extracellular Potential
Transmembrane789 – 80921Helical; Potential
Topological domain810 – 83021Cytoplasmic Potential
Domain27 – 128102Cadherin 1
Domain133 – 237105Cadherin 2
Domain244 – 33895Cadherin 3
Domain343 – 451109Cadherin 4
Domain457 – 566110Cadherin 5
Domain571 – 66797Cadherin 6
Region668 – 788121Ectodomain G

Amino acid modifications

Glycosylation5191N-linked (GlcNAc...) Potential
Glycosylation6041N-linked (GlcNAc...) Potential
Glycosylation7241N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O88338 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 5EB1F06B5B7C2F25

FASTA83089,860
        10         20         30         40         50         60 
MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL GRDEGHIVLS 

        70         80         90        100        110        120 
GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL ESEDGRILWG PQLVTVHVKD 

       130        140        150        160        170        180 
ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL EASDGDAPGT ANSDLRFHIL SQSPPQPLPD 

       190        200        210        220        230        240 
MFQLDPHLGA LALSPSGSTS LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW 

       250        260        270        280        290        300 
APLEPVHLAE NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA 

       310        320        330        340        350        360 
QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL SPPGTEIARL 

       370        380        390        400        410        420 
SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG SVTLGTAPLH AGQSILLQVL 

       430        440        450        460        470        480 
AVDLAGSESG LSSTCEVTVM VTDVNNHAPE FINSQIGPVT LPEDVKPGAL VATLMATDAD 

       490        500        510        520        530        540 
LEPAFRLMDF AIEEGDPEGI FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL 

       550        560        570        580        590        600 
VGPGPGPAAT ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF 

       610        620        630        640        650        660 
SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST SATVVIHFLK 

       670        680        690        700        710        720 
ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR NGPYSFALGP NPTVQRDWRL 

       730        740        750        760        770        780 
QPLNDSHAYL TLALHWVEPG EYMVPVVVHH DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK 

       790        800        810        820        830 
GMPTKLSAVG VLLGTLAAIG FILILVFTHL ALARKDLDQP ADSVPLKAAV 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin."
Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S.
Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity."
Whyte D.A., Li C., Thomson R.B., Nix S.L., Zanjani R., Karp S.L., Aronson P.S., Igarashi P.
Am. J. Physiol. 277:F587-F598(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-25.
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016271 mRNA. Translation: AAC34254.1.
BC015251 mRNA. Translation: AAH15251.1.
AF118228 Genomic DNA. Translation: AAF28836.1.
CCDSCCDS22583.1.
RefSeqNP_031689.1. NM_007663.3.
UniGeneMm.19423.

3D structure databases

ProteinModelPortalO88338.
SMRO88338. Positions 31-748.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88338. 3 interactions.
MINTMINT-4089683.

PTM databases

PhosphoSiteO88338.

Proteomic databases

MaxQBO88338.
PaxDbO88338.
PRIDEO88338.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000163783; ENSMUSP00000129663; ENSMUSG00000031881.
GeneID12556.
KEGGmmu:12556.
UCSCuc009nax.2. mouse.

Organism-specific databases

CTD1014.
MGIMGI:106671. Cdh16.

Phylogenomic databases

eggNOGNOG259000.
HOGENOMHOG000231613.
HOVERGENHBG050766.
InParanoidO88338.
KOK06810.
OMARLMDFAI.
OrthoDBEOG7Z3F4D.
PhylomeDBO88338.
TreeFamTF316817.

Gene expression databases

BgeeO88338.
CleanExMM_CDH16.
GenevestigatorO88338.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio281614.
PROO88338.
SOURCESearch...

Entry information

Entry nameCAD16_MOUSE
AccessionPrimary (citable) accession number: O88338
Secondary accession number(s): Q9JLZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot