O88338 (CAD16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-16

Alternative name(s):
Kidney-specific cadherin
Short name=Ksp-cadherin

Gene names

Name:

Cdh16

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	830 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein Probable.
Tissue specificity	Kidney specific.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 830	809	Cadherin-16		PRO_0000003810
Regions
	Topological domain	22 – 788	767	Extracellular Potential
	Transmembrane	789 – 809	21	Helical; Potential
	Topological domain	810 – 830	21	Cytoplasmic Potential
	Domain	27 – 128	102	Cadherin 1
	Domain	133 – 237	105	Cadherin 2
	Domain	244 – 338	95	Cadherin 3
	Domain	343 – 451	109	Cadherin 4
	Domain	457 – 566	110	Cadherin 5
	Domain	571 – 667	97	Cadherin 6
	Region	668 – 788	121	Ectodomain G
Amino acid modifications
	Glycosylation	519	1	N-linked (GlcNAc...) Potential
	Glycosylation	604	1	N-linked (GlcNAc...) Potential
	Glycosylation	724	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O88338 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 5EB1F06B5B7C2F25	FASTA	830	89,860
	10 20 30 40 50 60 MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL GRDEGHIVLS 70 80 90 100 110 120 GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL ESEDGRILWG PQLVTVHVKD 130 140 150 160 170 180 ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL EASDGDAPGT ANSDLRFHIL SQSPPQPLPD 190 200 210 220 230 240 MFQLDPHLGA LALSPSGSTS LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW 250 260 270 280 290 300 APLEPVHLAE NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA 310 320 330 340 350 360 QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL SPPGTEIARL 370 380 390 400 410 420 SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG SVTLGTAPLH AGQSILLQVL 430 440 450 460 470 480 AVDLAGSESG LSSTCEVTVM VTDVNNHAPE FINSQIGPVT LPEDVKPGAL VATLMATDAD 490 500 510 520 530 540 LEPAFRLMDF AIEEGDPEGI FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL 550 560 570 580 590 600 VGPGPGPAAT ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF 610 620 630 640 650 660 SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST SATVVIHFLK 670 680 690 700 710 720 ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR NGPYSFALGP NPTVQRDWRL 730 740 750 760 770 780 QPLNDSHAYL TLALHWVEPG EYMVPVVVHH DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK 790 800 810 820 830 GMPTKLSAVG VLLGTLAAIG FILILVFTHL ALARKDLDQP ADSVPLKAAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin." Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S. Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity." Whyte D.A., Li C., Thomson R.B., Nix S.L., Zanjani R., Karp S.L., Aronson P.S., Igarashi P. Am. J. Physiol. 277:F587-F598(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-25. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF016271 mRNA. Translation: AAC34254.1. BC015251 mRNA. Translation: AAH15251.1. AF118228 Genomic DNA. Translation: AAF28836.1.
IPI	IPI00129960.
RefSeq	NP_031689.1. NM_007663.3.
UniGene	Mm.19423.
3D structure databases
ProteinModelPortal	O88338.
SMR	O88338. Positions 31-748.
ModBase	Search...
PTM databases
PhosphoSite	O88338.
Proteomic databases
PaxDb	O88338.
PRIDE	O88338.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000163783; ENSMUSP00000129663; ENSMUSG00000031881.
GeneID	12556.
KEGG	mmu:12556.
Organism-specific databases
CTD	1014.
MGI	MGI:106671. Cdh16.
Phylogenomic databases
eggNOG	NOG259000.
HOGENOM	HOG000231613.
HOVERGEN	HBG050766.
InParanoid	O88338.
KO	K06810.
OMA	DENDQVP.
OrthoDB	EOG4DJJVT.
Gene expression databases
ArrayExpress	O88338.
Bgee	O88338.
CleanEx	MM_CDH16.
Genevestigator	O88338.
GermOnline	ENSMUSG00000031881. Mus musculus.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. [Graphical view]
Pfam	PF00028. Cadherin. 4 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 1 hit. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	281614.
SOURCE	Search...

Entry information

Entry name

CAD16_MOUSE

Accession

Primary (citable) accession number: O88338
Secondary accession number(s): Q9JLZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program