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O88338

- CAD16_MOUSE

UniProt

O88338 - CAD16_MOUSE

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Protein
Cadherin-16
Gene
Cdh16
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: MGI
  2. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:Cdh16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:106671. Cdh16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 788767Extracellular Reviewed prediction
Add
BLAST
Transmembranei789 – 80921Helical; Reviewed prediction
Add
BLAST
Topological domaini810 – 83021Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 830809Cadherin-16
PRO_0000003810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi519 – 5191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi604 – 6041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi724 – 7241N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO88338.
PaxDbiO88338.
PRIDEiO88338.

PTM databases

PhosphoSiteiO88338.

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiO88338.
CleanExiMM_CDH16.
GenevestigatoriO88338.

Interactioni

Protein-protein interaction databases

IntActiO88338. 3 interactions.
MINTiMINT-4089683.

Structurei

3D structure databases

ProteinModelPortaliO88338.
SMRiO88338. Positions 31-748.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 128102Cadherin 1
Add
BLAST
Domaini133 – 237105Cadherin 2
Add
BLAST
Domaini244 – 33895Cadherin 3
Add
BLAST
Domaini343 – 451109Cadherin 4
Add
BLAST
Domaini457 – 566110Cadherin 5
Add
BLAST
Domaini571 – 66797Cadherin 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni668 – 788121Ectodomain G
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259000.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO88338.
KOiK06810.
OMAiRLMDFAI.
OrthoDBiEOG7Z3F4D.
PhylomeDBiO88338.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88338-1 [UniParc]FASTAAdd to Basket

« Hide

MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL    50
GRDEGHIVLS GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL 100
ESEDGRILWG PQLVTVHVKD ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL 150
EASDGDAPGT ANSDLRFHIL SQSPPQPLPD MFQLDPHLGA LALSPSGSTS 200
LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW APLEPVHLAE 250
NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA 300
QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL 350
SPPGTEIARL SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG 400
SVTLGTAPLH AGQSILLQVL AVDLAGSESG LSSTCEVTVM VTDVNNHAPE 450
FINSQIGPVT LPEDVKPGAL VATLMATDAD LEPAFRLMDF AIEEGDPEGI 500
FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL VGPGPGPAAT 550
ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF 600
SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST 650
SATVVIHFLK ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR 700
NGPYSFALGP NPTVQRDWRL QPLNDSHAYL TLALHWVEPG EYMVPVVVHH 750
DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK GMPTKLSAVG VLLGTLAAIG 800
FILILVFTHL ALARKDLDQP ADSVPLKAAV 830
Length:830
Mass (Da):89,860
Last modified:November 1, 1998 - v1
Checksum:i5EB1F06B5B7C2F25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016271 mRNA. Translation: AAC34254.1.
BC015251 mRNA. Translation: AAH15251.1.
AF118228 Genomic DNA. Translation: AAF28836.1.
CCDSiCCDS22583.1.
RefSeqiNP_031689.1. NM_007663.3.
UniGeneiMm.19423.

Genome annotation databases

EnsembliENSMUST00000163783; ENSMUSP00000129663; ENSMUSG00000031881.
GeneIDi12556.
KEGGimmu:12556.
UCSCiuc009nax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016271 mRNA. Translation: AAC34254.1 .
BC015251 mRNA. Translation: AAH15251.1 .
AF118228 Genomic DNA. Translation: AAF28836.1 .
CCDSi CCDS22583.1.
RefSeqi NP_031689.1. NM_007663.3.
UniGenei Mm.19423.

3D structure databases

ProteinModelPortali O88338.
SMRi O88338. Positions 31-748.
ModBasei Search...

Protein-protein interaction databases

IntActi O88338. 3 interactions.
MINTi MINT-4089683.

PTM databases

PhosphoSitei O88338.

Proteomic databases

MaxQBi O88338.
PaxDbi O88338.
PRIDEi O88338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000163783 ; ENSMUSP00000129663 ; ENSMUSG00000031881 .
GeneIDi 12556.
KEGGi mmu:12556.
UCSCi uc009nax.2. mouse.

Organism-specific databases

CTDi 1014.
MGIi MGI:106671. Cdh16.

Phylogenomic databases

eggNOGi NOG259000.
HOGENOMi HOG000231613.
HOVERGENi HBG050766.
InParanoidi O88338.
KOi K06810.
OMAi RLMDFAI.
OrthoDBi EOG7Z3F4D.
PhylomeDBi O88338.
TreeFami TF316817.

Miscellaneous databases

NextBioi 281614.
PROi O88338.
SOURCEi Search...

Gene expression databases

Bgeei O88338.
CleanExi MM_CDH16.
Genevestigatori O88338.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin."
    Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S.
    Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity."
    Whyte D.A., Li C., Thomson R.B., Nix S.L., Zanjani R., Karp S.L., Aronson P.S., Igarashi P.
    Am. J. Physiol. 277:F587-F598(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-25.
    Strain: 129/Sv.

Entry informationi

Entry nameiCAD16_MOUSE
AccessioniPrimary (citable) accession number: O88338
Secondary accession number(s): Q9JLZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi