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Protein

Unconventional myosin-Ia

Gene

Myo1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in directing the movement of organelles along actin filaments.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 108ATPBy similarity8

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro

GO - Biological processi

  • cell projection organization Source: MGI
  • microvillus assembly Source: MGI
  • sensory perception of sound Source: UniProtKB
  • vesicle localization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ia
Alternative name(s):
Brush border myosin I
Short name:
BBM-I
Short name:
BBMI
Myosin I heavy chain
Short name:
MIHC
Gene namesi
Name:Myo1a
Synonyms:Bbmi, Myhl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107732. Myo1a.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basal plasma membrane Source: MGI
  • basolateral plasma membrane Source: UniProtKB
  • brush border Source: UniProtKB
  • cortical actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • filamentous actin Source: UniProtKB
  • lateral plasma membrane Source: UniProtKB
  • microvillus Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
  • plasma membrane raft Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234391 – 1043Unconventional myosin-IaAdd BLAST1043

Proteomic databases

MaxQBiO88329.
PaxDbiO88329.
PeptideAtlasiO88329.
PRIDEiO88329.

PTM databases

iPTMnetiO88329.
PhosphoSitePlusiO88329.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025401.
CleanExiMM_MYO1A.
GenevisibleiO88329. MM.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

IntActiO88329. 1 interactor.
STRINGi10090.ENSMUSP00000078540.

Structurei

3D structure databases

ProteinModelPortaliO88329.
SMRiO88329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 694Myosin motorAdd BLAST687
Domaini697 – 719IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini720 – 742IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini743 – 772IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini858 – 1042TH1PROSITE-ProRule annotationAdd BLAST185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni571 – 593Actin-bindingSequence analysisAdd BLAST23

Sequence similaritiesi

Contains 3 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO88329.
KOiK10356.
OMAiNTANHEL.
OrthoDBiEOG091G0136.
PhylomeDBiO88329.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLEGPVGV EDLILLEPLD EESLIKNLQL RYENKEIYTY IGNVVISMNP
60 70 80 90 100
YEQLPIYGPE FIAKYRDYTF YELKPHIYAL ANVAYQSLKD RDRDQCILIT
110 120 130 140 150
GESGAGKTEA SKLVMSYVAA VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT
160 170 180 190 200
IRNNNSSRFG KYMDIEFDFK GSPLGGVITN YLLEKSRVVK QLKGERNFHI
210 220 230 240 250
FYQLLAGADA QLLKALKLEE DTSVYGYLNG EVSKVNGMDD ASNFRAVQHA
260 270 280 290 300
MSVIGFSEEE IRQVLEVTAL VLKLGNVKLT DEFQANGIPA SGICDGKGIQ
310 320 330 340 350
EIGEMMGLNS TELERALCSR TMETGKEKVV TVLNVTQAQY ARDALAKNIY
360 370 380 390 400
SRLFDWIVKR INESIKVGTG EKKKVMGVLD IYGFEILEDN SFEQFVINYC
410 420 430 440 450
NERLQQVFIE LTLKEEQEEY KREGIPWTKV EYFDNGIICN LIEHSQRGIL
460 470 480 490 500
AMLDEECLRP GVVSDSTFLA KLNQLFSKHS HYESKVSQNA QRQYDRTMGL
510 520 530 540 550
SCFRISHYAG KVTYNVTGFI DKNNDLLFRD LSQTMWKAQH PLLKSLFPEG
560 570 580 590 600
NPKEASLKRP PTAGTQFKNS VAVLMKNLYS KNPNYIRCIK PNDQQQKGRF
610 620 630 640 650
TSEMVMVQAR YLGLLENVRV RRAGYAFRQG YKPFLERYRL LSRSTWPRWN
660 670 680 690 700
GDDREGVEKV LGSLTLSSEE LAYGKTKIFI RSPKTLFYLE EQRRLRLQQL
710 720 730 740 750
ATLIQKVYRG WRCRTHYQQM RKSQILISAW FRGNKQKKHY GKIRSSVLLI
760 770 780 790 800
QAFVRGWRAR KNYRKYFRSG AALTLANFIY QSMAQKFLLN LKKNLPSTKV
810 820 830 840 850
LDNTWPAAPY RCFNTANQEL QRLFYQWKCK KFRDQLSPKQ VQTLREKLCA
860 870 880 890 900
SELFKGKKAS YPQSVPIPFR GDYIGLQGNP KLQRLKGREE GPVLVADTVK
910 920 930 940 950
KVNRGNGKTS ARILLLTKGH VILTDAKKSQ AQIVIGLEDV AGVSVSSLQD
960 970 980 990 1000
GLFSLHLSEM SSAVSKGDIL LVSDHVVELL TKMYQAVLDA TQRQLSVTVT
1010 1020 1030 1040
EKFSVRFKEG SVAVKVIQGP EGGGNRKLIC KKKGSNAMEV TVR
Length:1,043
Mass (Da):118,695
Last modified:July 10, 2007 - v2
Checksum:iD66000A9E6FFF17E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397I → L in AAC28397 (PubMed:9933937).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160970 Genomic DNA. No translation available.
BC147605 mRNA. Translation: AAI47606.1.
BC147612 mRNA. Translation: AAI47613.1.
AF009960 mRNA. Translation: AAC28397.1.
CCDSiCCDS36083.1.
RefSeqiNP_001074688.1. NM_001081219.2.
XP_006513922.1. XM_006513859.3.
XP_006513923.1. XM_006513860.3.
UniGeneiMm.90450.

Genome annotation databases

EnsembliENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401.
GeneIDi432516.
KEGGimmu:432516.
UCSCiuc007hkh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160970 Genomic DNA. No translation available.
BC147605 mRNA. Translation: AAI47606.1.
BC147612 mRNA. Translation: AAI47613.1.
AF009960 mRNA. Translation: AAC28397.1.
CCDSiCCDS36083.1.
RefSeqiNP_001074688.1. NM_001081219.2.
XP_006513922.1. XM_006513859.3.
XP_006513923.1. XM_006513860.3.
UniGeneiMm.90450.

3D structure databases

ProteinModelPortaliO88329.
SMRiO88329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88329. 1 interactor.
STRINGi10090.ENSMUSP00000078540.

PTM databases

iPTMnetiO88329.
PhosphoSitePlusiO88329.

Proteomic databases

MaxQBiO88329.
PaxDbiO88329.
PeptideAtlasiO88329.
PRIDEiO88329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401.
GeneIDi432516.
KEGGimmu:432516.
UCSCiuc007hkh.2. mouse.

Organism-specific databases

CTDi4640.
MGIiMGI:107732. Myo1a.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO88329.
KOiK10356.
OMAiNTANHEL.
OrthoDBiEOG091G0136.
PhylomeDBiO88329.
TreeFamiTF312960.

Miscellaneous databases

PROiO88329.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025401.
CleanExiMM_MYO1A.
GenevisibleiO88329. MM.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1A_MOUSE
AccessioniPrimary (citable) accession number: O88329
Secondary accession number(s): B2RW65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.