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O88329 (MYO1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-Ia
Alternative name(s):
Brush border myosin I
Short name=BBM-I
Short name=BBMI
Myosin I heavy chain
Short name=MIHC
Gene names
Name:Myo1a
Synonyms:Bbmi, Myhl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1043 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in directing the movement of organelles along actin filaments Potential.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Contains 3 IQ domains.

Contains 1 myosin motor domain.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

Ontologies

Keywords
   DomainRepeat
   LigandActin-binding
ATP-binding
Calmodulin-binding
Nucleotide-binding
   Molecular functionMotor protein
Myosin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell projection organization

Inferred from mutant phenotype PubMed 15758024. Source: MGI

microvillus assembly

Inferred from mutant phenotype PubMed 15758024. Source: MGI

sensory perception of sound

Inferred from sequence or structural similarity. Source: UniProtKB

vesicle localization

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentapical plasma membrane

Inferred from direct assay Ref.3. Source: MGI

basal plasma membrane

Inferred from direct assay Ref.3. Source: MGI

basolateral plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

brush border

Inferred from sequence or structural similarity. Source: UniProtKB

cortical actin cytoskeleton

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

filamentous actin

Inferred from sequence or structural similarity. Source: UniProtKB

lateral plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

microvillus

Inferred from sequence or structural similarity. Source: UniProtKB

myosin complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10431043Unconventional myosin-Ia
PRO_0000123439

Regions

Domain8 – 694687Myosin motor
Domain697 – 71923IQ 1
Domain720 – 74223IQ 2
Domain743 – 77230IQ 3
Nucleotide binding101 – 1088ATP By similarity
Region571 – 59323Actin-binding Potential

Experimental info

Sequence conflict3971I → L in AAC28397. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O88329 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: D66000A9E6FFF17E

FASTA1,043118,695
        10         20         30         40         50         60 
MPLLEGPVGV EDLILLEPLD EESLIKNLQL RYENKEIYTY IGNVVISMNP YEQLPIYGPE 

        70         80         90        100        110        120 
FIAKYRDYTF YELKPHIYAL ANVAYQSLKD RDRDQCILIT GESGAGKTEA SKLVMSYVAA 

       130        140        150        160        170        180 
VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT IRNNNSSRFG KYMDIEFDFK GSPLGGVITN 

       190        200        210        220        230        240 
YLLEKSRVVK QLKGERNFHI FYQLLAGADA QLLKALKLEE DTSVYGYLNG EVSKVNGMDD 

       250        260        270        280        290        300 
ASNFRAVQHA MSVIGFSEEE IRQVLEVTAL VLKLGNVKLT DEFQANGIPA SGICDGKGIQ 

       310        320        330        340        350        360 
EIGEMMGLNS TELERALCSR TMETGKEKVV TVLNVTQAQY ARDALAKNIY SRLFDWIVKR 

       370        380        390        400        410        420 
INESIKVGTG EKKKVMGVLD IYGFEILEDN SFEQFVINYC NERLQQVFIE LTLKEEQEEY 

       430        440        450        460        470        480 
KREGIPWTKV EYFDNGIICN LIEHSQRGIL AMLDEECLRP GVVSDSTFLA KLNQLFSKHS 

       490        500        510        520        530        540 
HYESKVSQNA QRQYDRTMGL SCFRISHYAG KVTYNVTGFI DKNNDLLFRD LSQTMWKAQH 

       550        560        570        580        590        600 
PLLKSLFPEG NPKEASLKRP PTAGTQFKNS VAVLMKNLYS KNPNYIRCIK PNDQQQKGRF 

       610        620        630        640        650        660 
TSEMVMVQAR YLGLLENVRV RRAGYAFRQG YKPFLERYRL LSRSTWPRWN GDDREGVEKV 

       670        680        690        700        710        720 
LGSLTLSSEE LAYGKTKIFI RSPKTLFYLE EQRRLRLQQL ATLIQKVYRG WRCRTHYQQM 

       730        740        750        760        770        780 
RKSQILISAW FRGNKQKKHY GKIRSSVLLI QAFVRGWRAR KNYRKYFRSG AALTLANFIY 

       790        800        810        820        830        840 
QSMAQKFLLN LKKNLPSTKV LDNTWPAAPY RCFNTANQEL QRLFYQWKCK KFRDQLSPKQ 

       850        860        870        880        890        900 
VQTLREKLCA SELFKGKKAS YPQSVPIPFR GDYIGLQGNP KLQRLKGREE GPVLVADTVK 

       910        920        930        940        950        960 
KVNRGNGKTS ARILLLTKGH VILTDAKKSQ AQIVIGLEDV AGVSVSSLQD GLFSLHLSEM 

       970        980        990       1000       1010       1020 
SSAVSKGDIL LVSDHVVELL TKMYQAVLDA TQRQLSVTVT EKFSVRFKEG SVAVKVIQGP 

      1030       1040 
EGGGNRKLIC KKKGSNAMEV TVR 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Cloning and characterization of mouse brush border myosin-I in adult and embryonic intestine."
Skowron J.F., Mooseker M.S.
J. Exp. Zool. 283:242-257(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-909.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC160970 Genomic DNA. No translation available.
BC147605 mRNA. Translation: AAI47606.1.
BC147612 mRNA. Translation: AAI47613.1.
AF009960 mRNA. Translation: AAC28397.1.
CCDSCCDS36083.1.
RefSeqNP_001074688.1. NM_001081219.2.
XP_006513922.1. XM_006513859.1.
XP_006513923.1. XM_006513860.1.
UniGeneMm.90450.

3D structure databases

ProteinModelPortalO88329.
SMRO88329. Positions 3-807.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88329. 1 interaction.

PTM databases

PhosphoSiteO88329.

Proteomic databases

MaxQBO88329.
PaxDbO88329.
PRIDEO88329.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401.
GeneID432516.
KEGGmmu:432516.
UCSCuc007hkh.2. mouse.

Organism-specific databases

CTD4640.
MGIMGI:107732. Myo1a.

Phylogenomic databases

eggNOGCOG5022.
GeneTreeENSGT00750000117344.
HOGENOMHOG000260264.
HOVERGENHBG062373.
InParanoidB2RW65.
KOK10356.
OMAKCKRFRD.
OrthoDBEOG7V49XQ.
PhylomeDBO88329.
TreeFamTF312960.

Gene expression databases

BgeeO88329.
CleanExMM_MYO1A.
GenevestigatorO88329.

Family and domain databases

InterProIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio407734.
PROO88329.
SOURCESearch...

Entry information

Entry nameMYO1A_MOUSE
AccessionPrimary (citable) accession number: O88329
Secondary accession number(s): B2RW65
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot