Unconventional myosin-Ia - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Unconventional myosin-Ia

Alternative name(s):
Brush border myosin I
Short name=BBM-I
Short name=BBMI
Myosin I heavy chain
Short name=MIHC

Gene names

Name:	Myo1a
Synonyms:	Bbmi, Myhl

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1043 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Involved in directing the movement of organelles along actin filaments Potential.

Sequence similarities

Contains 3 IQ domains.

Contains 1 myosin head-like domain.

Caution

Represents a unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microvillus assembly Inferred from mutant phenotype PubMed 15758024. Source: MGI sensory perception of sound Inferred from sequence or structural similarity. Source: UniProtKB vesicle localization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from direct assay Ref.3. Source: MGI basal plasma membrane Inferred from direct assay Ref.3. Source: MGI brush border Inferred from sequence or structural similarity. Source: UniProtKB cortical actin cytoskeleton Inferred from sequence or structural similarity. Source: UniProtKB filamentous actin Inferred from sequence or structural similarity. Source: UniProtKB lateral plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB microvillus Inferred from sequence or structural similarity. Source: UniProtKB myosin complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1043

1043

Unconventional myosin-Ia

PRO_0000123439

Regions

Domain

1 – 681

681

Myosin head-like

Domain

697 – 719

23

IQ 1

Domain

720 – 742

23

IQ 2

Domain

743 – 772

30

IQ 3

Nucleotide binding

101 – 108

8

ATP By similarity

Region

571 – 593

23

Actin-binding Potential

Experimental info

Sequence conflict

397

1

I → L in AAC28397. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

O88329 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: D66000A9E6FFF17E
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FASTA

1,043

118,695

        10         20         30         40         50         60 
MPLLEGPVGV EDLILLEPLD EESLIKNLQL RYENKEIYTY IGNVVISMNP YEQLPIYGPE 

        70         80         90        100        110        120 
FIAKYRDYTF YELKPHIYAL ANVAYQSLKD RDRDQCILIT GESGAGKTEA SKLVMSYVAA 

       130        140        150        160        170        180 
VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT IRNNNSSRFG KYMDIEFDFK GSPLGGVITN 

       190        200        210        220        230        240 
YLLEKSRVVK QLKGERNFHI FYQLLAGADA QLLKALKLEE DTSVYGYLNG EVSKVNGMDD 

       250        260        270        280        290        300 
ASNFRAVQHA MSVIGFSEEE IRQVLEVTAL VLKLGNVKLT DEFQANGIPA SGICDGKGIQ 

       310        320        330        340        350        360 
EIGEMMGLNS TELERALCSR TMETGKEKVV TVLNVTQAQY ARDALAKNIY SRLFDWIVKR 

       370        380        390        400        410        420 
INESIKVGTG EKKKVMGVLD IYGFEILEDN SFEQFVINYC NERLQQVFIE LTLKEEQEEY 

       430        440        450        460        470        480 
KREGIPWTKV EYFDNGIICN LIEHSQRGIL AMLDEECLRP GVVSDSTFLA KLNQLFSKHS 

       490        500        510        520        530        540 
HYESKVSQNA QRQYDRTMGL SCFRISHYAG KVTYNVTGFI DKNNDLLFRD LSQTMWKAQH 

       550        560        570        580        590        600 
PLLKSLFPEG NPKEASLKRP PTAGTQFKNS VAVLMKNLYS KNPNYIRCIK PNDQQQKGRF 

       610        620        630        640        650        660 
TSEMVMVQAR YLGLLENVRV RRAGYAFRQG YKPFLERYRL LSRSTWPRWN GDDREGVEKV 

       670        680        690        700        710        720 
LGSLTLSSEE LAYGKTKIFI RSPKTLFYLE EQRRLRLQQL ATLIQKVYRG WRCRTHYQQM 

       730        740        750        760        770        780 
RKSQILISAW FRGNKQKKHY GKIRSSVLLI QAFVRGWRAR KNYRKYFRSG AALTLANFIY 

       790        800        810        820        830        840 
QSMAQKFLLN LKKNLPSTKV LDNTWPAAPY RCFNTANQEL QRLFYQWKCK KFRDQLSPKQ 

       850        860        870        880        890        900 
VQTLREKLCA SELFKGKKAS YPQSVPIPFR GDYIGLQGNP KLQRLKGREE GPVLVADTVK 

       910        920        930        940        950        960 
KVNRGNGKTS ARILLLTKGH VILTDAKKSQ AQIVIGLEDV AGVSVSSLQD GLFSLHLSEM 

       970        980        990       1000       1010       1020 
SSAVSKGDIL LVSDHVVELL TKMYQAVLDA TQRQLSVTVT EKFSVRFKEG SVAVKVIQGP 

      1030       1040 
EGGGNRKLIC KKKGSNAMEV TVR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Cloning and characterization of mouse brush border myosin-I in adult and embryonic intestine." Skowron J.F., Mooseker M.S. J. Exp. Zool. 283:242-257(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-909.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC160970 Genomic DNA. No translation available. BC147605 mRNA. Translation: AAI47606.1. BC147612 mRNA. Translation: AAI47613.1. AF009960 mRNA. Translation: AAC28397.1.
IPI	IPI00465712.
RefSeq	NP_001074688.1. NM_001081219.2.
UniGene	Mm.90450.
3D structure databases
ProteinModelPortal	O88329.
SMR	O88329. Positions 9-807.
ModBase	Search...
Protein-protein interaction databases
IntAct	O88329. 1 interaction.
PTM databases
PhosphoSite	O88329.
Proteomic databases
PaxDb	O88329.
PRIDE	O88329.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401.
GeneID	432516.
KEGG	mmu:432516.
UCSC	uc007hkh.2. mouse.
Organism-specific databases
CTD	4640.
MGI	MGI:107732. Myo1a.
Phylogenomic databases
eggNOG	COG5022.
GeneTree	ENSGT00690000101926.
HOGENOM	HOG000260264.
HOVERGEN	HBG062373.
InParanoid	B2RW65.
KO	K10356.
OMA	DNSKLRY.
OrthoDB	EOG4XD3QB.
Gene expression databases
Bgee	O88329.
CleanEx	MM_MYO1A.
Genevestigator	O88329.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR010926. Myosin_tail_2. [Graphical view]
Pfam	PF00612. IQ. 2 hits. PF00063. Myosin_head. 1 hit. PF06017. Myosin_TH1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 3 hits. SM00242. MYSc. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	407734.
SOURCE	Search...

Entry information

Entry name

MYO1A_MOUSE

Accession

Primary (citable) accession number: O88329
Secondary accession number(s): B2RW65

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents