Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Unconventional myosin-Ia

Gene

Myo1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in directing the movement of organelles along actin filaments.Curated

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 108ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

  • cell projection organization Source: MGI
  • microtubule-based movement Source: InterPro
  • microvillus assembly Source: MGI
  • sensory perception of sound Source: UniProtKB
  • vesicle localization Source: UniProtKB

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ia
Alternative name(s):
Brush border myosin I
Short name:
BBM-I
Short name:
BBMI
Myosin I heavy chain
Short name:
MIHC
Gene namesi
Name:Myo1a
Synonyms:Bbmi, Myhl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107732 Myo1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234391 – 1043Unconventional myosin-IaAdd BLAST1043

Proteomic databases

MaxQBiO88329
PaxDbiO88329
PeptideAtlasiO88329
PRIDEiO88329

PTM databases

iPTMnetiO88329
PhosphoSitePlusiO88329

Expressioni

Gene expression databases

BgeeiENSMUSG00000025401
CleanExiMM_MYO1A
GenevisibleiO88329 MM

Interactioni

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB-KW
  • microtubule binding Source: InterPro

Protein-protein interaction databases

BioGridi240656, 1 interactor
IntActiO88329, 1 interactor
STRINGi10090.ENSMUSP00000078540

Structurei

3D structure databases

ProteinModelPortaliO88329
SMRiO88329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 694Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini697 – 719IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini720 – 742IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini743 – 772IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini858 – 1042TH1PROSITE-ProRule annotationAdd BLAST185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni571 – 593Actin-bindingSequence analysisAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiO88329
KOiK10356
OMAiMWKAQHP
OrthoDBiEOG091G0136
PhylomeDBiO88329
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequencei

Sequence statusi: Complete.

O88329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLEGPVGV EDLILLEPLD EESLIKNLQL RYENKEIYTY IGNVVISMNP
60 70 80 90 100
YEQLPIYGPE FIAKYRDYTF YELKPHIYAL ANVAYQSLKD RDRDQCILIT
110 120 130 140 150
GESGAGKTEA SKLVMSYVAA VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT
160 170 180 190 200
IRNNNSSRFG KYMDIEFDFK GSPLGGVITN YLLEKSRVVK QLKGERNFHI
210 220 230 240 250
FYQLLAGADA QLLKALKLEE DTSVYGYLNG EVSKVNGMDD ASNFRAVQHA
260 270 280 290 300
MSVIGFSEEE IRQVLEVTAL VLKLGNVKLT DEFQANGIPA SGICDGKGIQ
310 320 330 340 350
EIGEMMGLNS TELERALCSR TMETGKEKVV TVLNVTQAQY ARDALAKNIY
360 370 380 390 400
SRLFDWIVKR INESIKVGTG EKKKVMGVLD IYGFEILEDN SFEQFVINYC
410 420 430 440 450
NERLQQVFIE LTLKEEQEEY KREGIPWTKV EYFDNGIICN LIEHSQRGIL
460 470 480 490 500
AMLDEECLRP GVVSDSTFLA KLNQLFSKHS HYESKVSQNA QRQYDRTMGL
510 520 530 540 550
SCFRISHYAG KVTYNVTGFI DKNNDLLFRD LSQTMWKAQH PLLKSLFPEG
560 570 580 590 600
NPKEASLKRP PTAGTQFKNS VAVLMKNLYS KNPNYIRCIK PNDQQQKGRF
610 620 630 640 650
TSEMVMVQAR YLGLLENVRV RRAGYAFRQG YKPFLERYRL LSRSTWPRWN
660 670 680 690 700
GDDREGVEKV LGSLTLSSEE LAYGKTKIFI RSPKTLFYLE EQRRLRLQQL
710 720 730 740 750
ATLIQKVYRG WRCRTHYQQM RKSQILISAW FRGNKQKKHY GKIRSSVLLI
760 770 780 790 800
QAFVRGWRAR KNYRKYFRSG AALTLANFIY QSMAQKFLLN LKKNLPSTKV
810 820 830 840 850
LDNTWPAAPY RCFNTANQEL QRLFYQWKCK KFRDQLSPKQ VQTLREKLCA
860 870 880 890 900
SELFKGKKAS YPQSVPIPFR GDYIGLQGNP KLQRLKGREE GPVLVADTVK
910 920 930 940 950
KVNRGNGKTS ARILLLTKGH VILTDAKKSQ AQIVIGLEDV AGVSVSSLQD
960 970 980 990 1000
GLFSLHLSEM SSAVSKGDIL LVSDHVVELL TKMYQAVLDA TQRQLSVTVT
1010 1020 1030 1040
EKFSVRFKEG SVAVKVIQGP EGGGNRKLIC KKKGSNAMEV TVR
Length:1,043
Mass (Da):118,695
Last modified:July 10, 2007 - v2
Checksum:iD66000A9E6FFF17E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397I → L in AAC28397 (PubMed:9933937).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160970 Genomic DNA No translation available.
BC147605 mRNA Translation: AAI47606.1
BC147612 mRNA Translation: AAI47613.1
AF009960 mRNA Translation: AAC28397.1
CCDSiCCDS36083.1
RefSeqiNP_001074688.1, NM_001081219.2
XP_006513922.1, XM_006513859.3
XP_006513923.1, XM_006513860.3
UniGeneiMm.90450

Genome annotation databases

EnsembliENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401
GeneIDi432516
KEGGimmu:432516
UCSCiuc007hkh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMYO1A_MOUSE
AccessioniPrimary (citable) accession number: O88329
Secondary accession number(s): B2RW65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health