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O88329

- MYO1A_MOUSE

UniProt

O88329 - MYO1A_MOUSE

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Protein
Unconventional myosin-Ia
Gene
Myo1a, Bbmi, Myhl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in directing the movement of organelles along actin filaments Reviewed prediction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. cell projection organization Source: MGI
  2. microvillus assembly Source: MGI
  3. sensory perception of sound Source: UniProtKB
  4. vesicle localization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ia
Alternative name(s):
Brush border myosin I
Short name:
BBM-I
Short name:
BBMI
Myosin I heavy chain
Short name:
MIHC
Gene namesi
Name:Myo1a
Synonyms:Bbmi, Myhl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:107732. Myo1a.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basal plasma membrane Source: MGI
  3. basolateral plasma membrane Source: UniProtKB
  4. brush border Source: UniProtKB
  5. cortical actin cytoskeleton Source: UniProtKB
  6. cytoplasm Source: UniProtKB
  7. filamentous actin Source: UniProtKB
  8. lateral plasma membrane Source: UniProtKB
  9. microvillus Source: UniProtKB
  10. myosin complex Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10431043Unconventional myosin-Ia
PRO_0000123439Add
BLAST

Proteomic databases

MaxQBiO88329.
PaxDbiO88329.
PRIDEiO88329.

PTM databases

PhosphoSiteiO88329.

Expressioni

Gene expression databases

BgeeiO88329.
CleanExiMM_MYO1A.
GenevestigatoriO88329.

Interactioni

Protein-protein interaction databases

IntActiO88329. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO88329.
SMRiO88329. Positions 3-807.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 694687Myosin motor
Add
BLAST
Domaini697 – 71923IQ 1
Add
BLAST
Domaini720 – 74223IQ 2
Add
BLAST
Domaini743 – 77230IQ 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni571 – 59323Actin-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 3 IQ domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00750000117344.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiB2RW65.
KOiK10356.
OMAiKCKRFRD.
OrthoDBiEOG7V49XQ.
PhylomeDBiO88329.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88329-1 [UniParc]FASTAAdd to Basket

« Hide

MPLLEGPVGV EDLILLEPLD EESLIKNLQL RYENKEIYTY IGNVVISMNP     50
YEQLPIYGPE FIAKYRDYTF YELKPHIYAL ANVAYQSLKD RDRDQCILIT 100
GESGAGKTEA SKLVMSYVAA VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT 150
IRNNNSSRFG KYMDIEFDFK GSPLGGVITN YLLEKSRVVK QLKGERNFHI 200
FYQLLAGADA QLLKALKLEE DTSVYGYLNG EVSKVNGMDD ASNFRAVQHA 250
MSVIGFSEEE IRQVLEVTAL VLKLGNVKLT DEFQANGIPA SGICDGKGIQ 300
EIGEMMGLNS TELERALCSR TMETGKEKVV TVLNVTQAQY ARDALAKNIY 350
SRLFDWIVKR INESIKVGTG EKKKVMGVLD IYGFEILEDN SFEQFVINYC 400
NERLQQVFIE LTLKEEQEEY KREGIPWTKV EYFDNGIICN LIEHSQRGIL 450
AMLDEECLRP GVVSDSTFLA KLNQLFSKHS HYESKVSQNA QRQYDRTMGL 500
SCFRISHYAG KVTYNVTGFI DKNNDLLFRD LSQTMWKAQH PLLKSLFPEG 550
NPKEASLKRP PTAGTQFKNS VAVLMKNLYS KNPNYIRCIK PNDQQQKGRF 600
TSEMVMVQAR YLGLLENVRV RRAGYAFRQG YKPFLERYRL LSRSTWPRWN 650
GDDREGVEKV LGSLTLSSEE LAYGKTKIFI RSPKTLFYLE EQRRLRLQQL 700
ATLIQKVYRG WRCRTHYQQM RKSQILISAW FRGNKQKKHY GKIRSSVLLI 750
QAFVRGWRAR KNYRKYFRSG AALTLANFIY QSMAQKFLLN LKKNLPSTKV 800
LDNTWPAAPY RCFNTANQEL QRLFYQWKCK KFRDQLSPKQ VQTLREKLCA 850
SELFKGKKAS YPQSVPIPFR GDYIGLQGNP KLQRLKGREE GPVLVADTVK 900
KVNRGNGKTS ARILLLTKGH VILTDAKKSQ AQIVIGLEDV AGVSVSSLQD 950
GLFSLHLSEM SSAVSKGDIL LVSDHVVELL TKMYQAVLDA TQRQLSVTVT 1000
EKFSVRFKEG SVAVKVIQGP EGGGNRKLIC KKKGSNAMEV TVR 1043
Length:1,043
Mass (Da):118,695
Last modified:July 10, 2007 - v2
Checksum:iD66000A9E6FFF17E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti397 – 3971I → L in AAC28397. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC160970 Genomic DNA. No translation available.
BC147605 mRNA. Translation: AAI47606.1.
BC147612 mRNA. Translation: AAI47613.1.
AF009960 mRNA. Translation: AAC28397.1.
CCDSiCCDS36083.1.
RefSeqiNP_001074688.1. NM_001081219.2.
XP_006513922.1. XM_006513859.1.
XP_006513923.1. XM_006513860.1.
UniGeneiMm.90450.

Genome annotation databases

EnsembliENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401.
GeneIDi432516.
KEGGimmu:432516.
UCSCiuc007hkh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC160970 Genomic DNA. No translation available.
BC147605 mRNA. Translation: AAI47606.1 .
BC147612 mRNA. Translation: AAI47613.1 .
AF009960 mRNA. Translation: AAC28397.1 .
CCDSi CCDS36083.1.
RefSeqi NP_001074688.1. NM_001081219.2.
XP_006513922.1. XM_006513859.1.
XP_006513923.1. XM_006513860.1.
UniGenei Mm.90450.

3D structure databases

ProteinModelPortali O88329.
SMRi O88329. Positions 3-807.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88329. 1 interaction.

PTM databases

PhosphoSitei O88329.

Proteomic databases

MaxQBi O88329.
PaxDbi O88329.
PRIDEi O88329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079590 ; ENSMUSP00000078540 ; ENSMUSG00000025401 .
GeneIDi 432516.
KEGGi mmu:432516.
UCSCi uc007hkh.2. mouse.

Organism-specific databases

CTDi 4640.
MGIi MGI:107732. Myo1a.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00750000117344.
HOGENOMi HOG000260264.
HOVERGENi HBG062373.
InParanoidi B2RW65.
KOi K10356.
OMAi KCKRFRD.
OrthoDBi EOG7V49XQ.
PhylomeDBi O88329.
TreeFami TF312960.

Miscellaneous databases

NextBioi 407734.
PROi O88329.
SOURCEi Search...

Gene expression databases

Bgeei O88329.
CleanExi MM_MYO1A.
Genevestigatori O88329.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Cloning and characterization of mouse brush border myosin-I in adult and embryonic intestine."
    Skowron J.F., Mooseker M.S.
    J. Exp. Zool. 283:242-257(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-909.

Entry informationi

Entry nameiMYO1A_MOUSE
AccessioniPrimary (citable) accession number: O88329
Secondary accession number(s): B2RW65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi