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O88329

- MYO1A_MOUSE

UniProt

O88329 - MYO1A_MOUSE

Protein

Unconventional myosin-Ia

Gene

Myo1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Involved in directing the movement of organelles along actin filaments.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 1088ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    GO - Biological processi

    1. cell projection organization Source: MGI
    2. microvillus assembly Source: MGI
    3. sensory perception of sound Source: UniProtKB
    4. vesicle localization Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-Ia
    Alternative name(s):
    Brush border myosin I
    Short name:
    BBM-I
    Short name:
    BBMI
    Myosin I heavy chain
    Short name:
    MIHC
    Gene namesi
    Name:Myo1a
    Synonyms:Bbmi, Myhl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:107732. Myo1a.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. basal plasma membrane Source: MGI
    3. basolateral plasma membrane Source: UniProtKB
    4. brush border Source: UniProtKB
    5. cortical actin cytoskeleton Source: UniProtKB
    6. cytoplasm Source: UniProtKB
    7. filamentous actin Source: UniProtKB
    8. lateral plasma membrane Source: UniProtKB
    9. microvillus Source: UniProtKB
    10. myosin complex Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10431043Unconventional myosin-IaPRO_0000123439Add
    BLAST

    Proteomic databases

    MaxQBiO88329.
    PaxDbiO88329.
    PRIDEiO88329.

    PTM databases

    PhosphoSiteiO88329.

    Expressioni

    Gene expression databases

    BgeeiO88329.
    CleanExiMM_MYO1A.
    GenevestigatoriO88329.

    Interactioni

    Protein-protein interaction databases

    IntActiO88329. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO88329.
    SMRiO88329. Positions 3-807.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 694687Myosin motorAdd
    BLAST
    Domaini697 – 71923IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini720 – 74223IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini743 – 77230IQ 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni571 – 59323Actin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 3 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5022.
    GeneTreeiENSGT00750000117344.
    HOGENOMiHOG000260264.
    HOVERGENiHBG062373.
    InParanoidiB2RW65.
    KOiK10356.
    OMAiKCKRFRD.
    OrthoDBiEOG7V49XQ.
    PhylomeDBiO88329.
    TreeFamiTF312960.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00612. IQ. 2 hits.
    PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 3 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 2 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88329-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLEGPVGV EDLILLEPLD EESLIKNLQL RYENKEIYTY IGNVVISMNP     50
    YEQLPIYGPE FIAKYRDYTF YELKPHIYAL ANVAYQSLKD RDRDQCILIT 100
    GESGAGKTEA SKLVMSYVAA VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT 150
    IRNNNSSRFG KYMDIEFDFK GSPLGGVITN YLLEKSRVVK QLKGERNFHI 200
    FYQLLAGADA QLLKALKLEE DTSVYGYLNG EVSKVNGMDD ASNFRAVQHA 250
    MSVIGFSEEE IRQVLEVTAL VLKLGNVKLT DEFQANGIPA SGICDGKGIQ 300
    EIGEMMGLNS TELERALCSR TMETGKEKVV TVLNVTQAQY ARDALAKNIY 350
    SRLFDWIVKR INESIKVGTG EKKKVMGVLD IYGFEILEDN SFEQFVINYC 400
    NERLQQVFIE LTLKEEQEEY KREGIPWTKV EYFDNGIICN LIEHSQRGIL 450
    AMLDEECLRP GVVSDSTFLA KLNQLFSKHS HYESKVSQNA QRQYDRTMGL 500
    SCFRISHYAG KVTYNVTGFI DKNNDLLFRD LSQTMWKAQH PLLKSLFPEG 550
    NPKEASLKRP PTAGTQFKNS VAVLMKNLYS KNPNYIRCIK PNDQQQKGRF 600
    TSEMVMVQAR YLGLLENVRV RRAGYAFRQG YKPFLERYRL LSRSTWPRWN 650
    GDDREGVEKV LGSLTLSSEE LAYGKTKIFI RSPKTLFYLE EQRRLRLQQL 700
    ATLIQKVYRG WRCRTHYQQM RKSQILISAW FRGNKQKKHY GKIRSSVLLI 750
    QAFVRGWRAR KNYRKYFRSG AALTLANFIY QSMAQKFLLN LKKNLPSTKV 800
    LDNTWPAAPY RCFNTANQEL QRLFYQWKCK KFRDQLSPKQ VQTLREKLCA 850
    SELFKGKKAS YPQSVPIPFR GDYIGLQGNP KLQRLKGREE GPVLVADTVK 900
    KVNRGNGKTS ARILLLTKGH VILTDAKKSQ AQIVIGLEDV AGVSVSSLQD 950
    GLFSLHLSEM SSAVSKGDIL LVSDHVVELL TKMYQAVLDA TQRQLSVTVT 1000
    EKFSVRFKEG SVAVKVIQGP EGGGNRKLIC KKKGSNAMEV TVR 1043
    Length:1,043
    Mass (Da):118,695
    Last modified:July 10, 2007 - v2
    Checksum:iD66000A9E6FFF17E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti397 – 3971I → L in AAC28397. (PubMed:9933937)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC160970 Genomic DNA. No translation available.
    BC147605 mRNA. Translation: AAI47606.1.
    BC147612 mRNA. Translation: AAI47613.1.
    AF009960 mRNA. Translation: AAC28397.1.
    CCDSiCCDS36083.1.
    RefSeqiNP_001074688.1. NM_001081219.2.
    XP_006513922.1. XM_006513859.1.
    XP_006513923.1. XM_006513860.1.
    UniGeneiMm.90450.

    Genome annotation databases

    EnsembliENSMUST00000079590; ENSMUSP00000078540; ENSMUSG00000025401.
    GeneIDi432516.
    KEGGimmu:432516.
    UCSCiuc007hkh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC160970 Genomic DNA. No translation available.
    BC147605 mRNA. Translation: AAI47606.1 .
    BC147612 mRNA. Translation: AAI47613.1 .
    AF009960 mRNA. Translation: AAC28397.1 .
    CCDSi CCDS36083.1.
    RefSeqi NP_001074688.1. NM_001081219.2.
    XP_006513922.1. XM_006513859.1.
    XP_006513923.1. XM_006513860.1.
    UniGenei Mm.90450.

    3D structure databases

    ProteinModelPortali O88329.
    SMRi O88329. Positions 3-807.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88329. 1 interaction.

    PTM databases

    PhosphoSitei O88329.

    Proteomic databases

    MaxQBi O88329.
    PaxDbi O88329.
    PRIDEi O88329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079590 ; ENSMUSP00000078540 ; ENSMUSG00000025401 .
    GeneIDi 432516.
    KEGGi mmu:432516.
    UCSCi uc007hkh.2. mouse.

    Organism-specific databases

    CTDi 4640.
    MGIi MGI:107732. Myo1a.

    Phylogenomic databases

    eggNOGi COG5022.
    GeneTreei ENSGT00750000117344.
    HOGENOMi HOG000260264.
    HOVERGENi HBG062373.
    InParanoidi B2RW65.
    KOi K10356.
    OMAi KCKRFRD.
    OrthoDBi EOG7V49XQ.
    PhylomeDBi O88329.
    TreeFami TF312960.

    Miscellaneous databases

    NextBioi 407734.
    PROi O88329.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88329.
    CleanExi MM_MYO1A.
    Genevestigatori O88329.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00612. IQ. 2 hits.
    PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 3 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 2 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Cloning and characterization of mouse brush border myosin-I in adult and embryonic intestine."
      Skowron J.F., Mooseker M.S.
      J. Exp. Zool. 283:242-257(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-909.

    Entry informationi

    Entry nameiMYO1A_MOUSE
    AccessioniPrimary (citable) accession number: O88329
    Secondary accession number(s): B2RW65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3