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Protein

Alpha-catulin

Gene

Ctnnal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-catulin
Alternative name(s):
Alpha-catenin-related protein
Short name:
ACRP
Catenin alpha-like protein 1
Gene namesi
Name:Ctnnal1
Synonyms:Catnal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1859649. Ctnnal1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Alpha-catulinPRO_0000064269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei373 – 3731PhosphoserineCombined sources
Modified residuei537 – 5371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88327.
PaxDbiO88327.
PeptideAtlasiO88327.
PRIDEiO88327.

PTM databases

iPTMnetiO88327.
PhosphoSiteiO88327.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038816.
ExpressionAtlasiO88327. baseline and differential.
GenevisibleiO88327. MM.

Interactioni

Subunit structurei

Interacts with ARHGEF1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036487.

Structurei

3D structure databases

ProteinModelPortaliO88327.
SMRiO88327. Positions 30-723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 136Poly-Gly

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000020484.
HOVERGENiHBG051219.
InParanoidiO88327.
OMAiYHADHVV.
OrthoDBiEOG091G0BL2.
PhylomeDBiO88327.
TreeFamiTF313686.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030045. CTNNAL1.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PTHR18914:SF8. PTHR18914:SF8. 1 hit.
PfamiPF01044. Vinculin. 3 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 3 hits.

Sequencei

Sequence statusi: Complete.

O88327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASPVPGGG GAGAVHSSNA AGFTFDSGLE IRTRSVEQTL LPLVSQITTL
60 70 80 90 100
INHKDNTKKS DKTLQAIQRV GQAVNLAVGR FVKVGEAIAN ENWDLKEEIN
110 120 130 140 150
IACIEAKQAG ETIASLTDVT KRSHLESDGQ VTILTDKTGV VQAARLLLSS
160 170 180 190 200
VTKVLLLADR VVIKQIVTSR NKILATMERL EKVNSFQEFV QIFSQFGNEM
210 220 230 240 250
VEFAHLTGDR QNDLKDEKKK ARMAVARAVL EKGTMMLLTA SKTCLRHPSC
260 270 280 290 300
ESAHTNKEGV FDRMRVALEK VTEIVTDCRL SGETDSSSVS IFTGIKELKV
310 320 330 340 350
NIEALRENVC FESKENLSAA LEAVLEHVED FTDSAYTSHE HRERILELSS
360 370 380 390 400
QARTELQQLL SVWMQTQSRK TKSAAEELEL TVLKISHSLD ELRRELHCTA
410 420 430 440 450
MQLAADLLKF HADHVVLKAL KVTGVEGNLE ALAEYACKLS EQKEQLVETC
460 470 480 490 500
RLLRHISGTE PLEITCIHAE ETFQVTGQQI ISAAETLTLH PSSKIAKENL
510 520 530 540 550
DVFCEAWESQ MSDMATLLRE ISDVFEGRRG ERCDHLSLPK PTKNSANLKS
560 570 580 590 600
LKPDKPDSEE QAKIAKLGLK LGLLSSDADC EIEKWEDEEN EIVRHGRNMS
610 620 630 640 650
RMAYSLYLFT RGEGPLKTSQ DLIHFLEVFA AEGLKLTSSV QSFSKQLKDD
660 670 680 690 700
DKLMLLLEIN KLIPLCHQLQ TITKTSLQSK VFLKVDKCIT KIRSMMTLVV
710 720 730
QLLSLCYKLL KKMENNRWGS ATNKDTMDGQ N
Length:731
Mass (Da):81,462
Last modified:November 1, 1998 - v1
Checksum:i36CF25115E3EF1F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621K → R in AAH50070 (PubMed:15489334).Curated
Sequence conflicti135 – 1351T → S in AAH50070 (PubMed:15489334).Curated
Sequence conflicti728 – 7281D → N in AAH50070 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006071 mRNA. Translation: AAC26012.1.
BC050070 mRNA. Translation: AAH50070.1.
CCDSiCCDS18200.1.
RefSeqiNP_061231.3. NM_018761.3.
UniGeneiMm.218891.

Genome annotation databases

EnsembliENSMUST00000045142; ENSMUSP00000036487; ENSMUSG00000038816.
GeneIDi54366.
KEGGimmu:54366.
UCSCiuc008sxu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006071 mRNA. Translation: AAC26012.1.
BC050070 mRNA. Translation: AAH50070.1.
CCDSiCCDS18200.1.
RefSeqiNP_061231.3. NM_018761.3.
UniGeneiMm.218891.

3D structure databases

ProteinModelPortaliO88327.
SMRiO88327. Positions 30-723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036487.

PTM databases

iPTMnetiO88327.
PhosphoSiteiO88327.

Proteomic databases

MaxQBiO88327.
PaxDbiO88327.
PeptideAtlasiO88327.
PRIDEiO88327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045142; ENSMUSP00000036487; ENSMUSG00000038816.
GeneIDi54366.
KEGGimmu:54366.
UCSCiuc008sxu.2. mouse.

Organism-specific databases

CTDi8727.
MGIiMGI:1859649. Ctnnal1.

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000020484.
HOVERGENiHBG051219.
InParanoidiO88327.
OMAiYHADHVV.
OrthoDBiEOG091G0BL2.
PhylomeDBiO88327.
TreeFamiTF313686.

Miscellaneous databases

ChiTaRSiCtnnal1. mouse.
PROiO88327.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038816.
ExpressionAtlasiO88327. baseline and differential.
GenevisibleiO88327. MM.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030045. CTNNAL1.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PTHR18914:SF8. PTHR18914:SF8. 1 hit.
PfamiPF01044. Vinculin. 3 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCTNL1_MOUSE
AccessioniPrimary (citable) accession number: O88327
Secondary accession number(s): Q810J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.