O88325 (O88325_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alpha-N-acetylglucosaminidase EMBL AAC26842.1

Submitted name:
Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) EMBL AAH55733.1
Submitted name:
Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB), isoform CRA_b EMBL EDL03876.1
Submitted name:
N-acetyl-glucosaminidase EMBL AAM21194.1

Gene names

Name:	Naglu MGI 1351641 EMBL AAH55733.1
ORF Names:	mCG_20229 EMBL EDL03876.1

Organism

Mus musculus (Mouse) EMBL AAC26842.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	739 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	cerebellar Purkinje cell layer development Inferred from mutant phenotype. Source: MGI inner ear receptor cell development Inferred from mutant phenotype. Source: MGI locomotor rhythm Inferred from mutant phenotype. Source: MGI lysosome organization Inferred from mutant phenotype. Source: MGI middle ear morphogenesis Inferred from mutant phenotype. Source: MGI retinal rod cell development Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O88325 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 01C71966557CDE27	FASTA	739	82,596
	10 20 30 40 50 60 MEAAGLAVIL GFLLLAGGSV GDEAREAKAV RELVVRLLGP GPAANFLVSV ERALADESGL 70 80 90 100 110 120 DTYSLSGGGG VPVLVRGSTG VAAAAGLHRY LRDFCGCQVA WSSAQLHLPW PLPAVPDGLT 130 140 150 160 170 180 ETTPNRYRYY QNVCTHSYSF VWWDWARWEQ EIDWMALNGI NLALAWNGQE AIWQRVYLAL 190 200 210 220 230 240 GLTQSEIDTY FTGPAFLAWG RMGNLHTWDG PLPRSWHLSQ VYLQHRILDR MRSFGMIPVL 250 260 270 280 290 300 PAFAGHVPKA ITRVFPQVNV IKLGSWGHFN CSYSCSFLLA PGDPMFPLIG NLFLRELTKE 310 320 330 340 350 360 FGTDHIYGAD TFNEMQPPFS DPSYLAATTA AVYEAMVTVD PDAVWLLQGW LFQHQPQFWG 370 380 390 400 410 420 PSQIRAVLEA VPRGRLLVLD LFAESHPVYM HTASFHGQPF IWCMLHNFGG NHGLFGALED 430 440 450 460 470 480 VNRGPQAARL FPNSTMVGTG IAPEGIGQNE VVYALMAELG WRKDPVPDLM AWVSSFAIRR 490 500 510 520 530 540 YGVSQPDAVA AWKLLLRSVY NCSGEACSGH NRSPLVKRPS LQMSTAVWYN RSDVFEAWRL 550 560 570 580 590 600 LLTAAPNLTT SPAFRYDLLD VTRQAVQELV SLCYEEARTA YLKQELDLLL RAGGLLVYKL 610 620 630 640 650 660 LPTLDELLAS SSHFLLGTWL DQARKAAVSE AEAQFYEQNS RYQITLWGPE GNILDYANKQ 670 680 690 700 710 720 LAGLVADYYQ PRWCLFLGTL AHSLARGVPF QQHEFEKNVF PLEQAFVYNK KRYPSQPRGD 730 TVDLSKKIFL KYHPQPDSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed: 16141073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[2]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed: 11076861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[3]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL03876.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[5]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed: 10349636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[6]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed: 11042159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[7]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[8]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[9]	"Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase." Li H.H., Yu W.H., Rozengurt N., Zhao H.Z., Lyons K.M., Anagnostaras S., Fanselow M.S., Suzuki K., Vanier M.T., Neufeld E.F. Proc. Natl. Acad. Sci. U.S.A. 96:14505-14510(1999) [PubMed: 10588735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129sv EMBL AAC26842.1.
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 EMBL AAH55733.1. Tissue: Brain EMBL AAH55733.1.
[11]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37639.1 and NOD EMBL BAE42009.1. Tissue: Spinal cord EMBL BAE37639.1.
[12]	"Characterization of HSD17B1 gene in mice." Gloeckner C.J., Breitling R., Moeller G., Adamski J. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/SvEvTacfBr EMBL AAM21194.1. Tissue: Spleen EMBL AAM21194.1.
[13]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL03876.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF003255 Genomic DNA. Translation: AAC26842.1. BC055733 mRNA. Translation: AAH55733.1. AF363242 Genomic DNA. Translation: AAM21194.1. AK164125 mRNA. Translation: BAE37639.1. AK170758 mRNA. Translation: BAE42009.1. CH466677 Genomic DNA. Translation: EDL03876.1.
IPI	IPI00314726.
RefSeq	NP_038820.2. NM_013792.2.
UniGene	Mm.95452.
3D structure databases
ProteinModelPortal	O88325.
ModBase	Search...
Protein-protein interaction databases
STRING	O88325.
Protein family/group databases
CAZy	GH89. Glycoside Hydrolase Family 89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	27419.
KEGG	mmu:27419.
UCSC	uc007lna.2. mouse.
Organism-specific databases
CTD	4669.
MGI	MGI:1351641. Naglu.
Phylogenomic databases
GeneTree	ENSGT00390000005900.
HOVERGEN	HBG004225.
InParanoid	O88325.
Gene expression databases
ArrayExpress	O88325.
Genevestigator	O88325.
Family and domain databases
InterPro	IPR007781. NAGLU. IPR024732. NAGLU_C. IPR024240. NAGLU_N. IPR024733. NAGLU_tim-barrel. [Graphical view]
KO	K01205.
PANTHER	PTHR12872. NAGLU. 1 hit.
Pfam	PF05089. NAGLU. 1 hit. PF12972. NAGLU_C. 1 hit. PF12971. NAGLU_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

O88325_MOUSE

Accession

Primary (citable) accession number: O88325

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)