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Protein

CD83 antigen

Gene

Cd83

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.By similarity

GO - Biological processi

  • defense response Source: GO_Central
  • humoral immune response Source: GO_Central
  • negative regulation of interleukin-4 production Source: MGI
  • positive regulation of CD4-positive, alpha-beta T cell differentiation Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • response to organic cyclic compound Source: MGI
  • signal transduction Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD83 antigen
Short name:
mCD83
Alternative name(s):
CD_antigen: CD83
Gene namesi
Name:Cd83
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1328316. Cd83.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 133ExtracellularSequence analysisAdd BLAST112
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 196CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000037845122 – 196CD83 antigenAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 98PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88324.
PRIDEiO88324.

PTM databases

iPTMnetiO88324.
PhosphoSitePlusiO88324.

Expressioni

Tissue specificityi

Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed.1 Publication

Gene expression databases

BgeeiENSMUSG00000015396.
GenevisibleiO88324. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015540.

Structurei

3D structure databases

ProteinModelPortaliO88324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 110Ig-like V-typeAdd BLAST89

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKX7. Eukaryota.
ENOG410ZACF. LUCA.
GeneTreeiENSGT00390000007302.
HOGENOMiHOG000057288.
InParanoidiO88324.
KOiK06510.
OMAiEVKVACS.
OrthoDBiEOG091G0OEV.
PhylomeDBiO88324.
TreeFamiTF337861.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGLQLLFL GCACSLAPAM AMREVTVACS ETADLPCTAP WDPQLSYAVS
60 70 80 90 100
WAKVSESGTE SVELPESKQN SSFEAPRRRA YSLTIQNTTI CSSGTYRCAL
110 120 130 140 150
QELGGQRNLS GTVVLKVTGC PKEATESTFR KYRAEAVLLF SLVVFYLTLI
160 170 180 190
IFTCKFARLQ SIFPDISKPG TEQAFLPVTS PSKHLGPVTL PKTETV
Length:196
Mass (Da):21,313
Last modified:November 1, 1998 - v1
Checksum:i026C1007BD7ABD1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001036 mRNA. Translation: AAC83185.1.
AF001041
, AF001037, AF001038, AF001039, AF001040 Genomic DNA. Translation: AAC83186.1.
AJ245551 mRNA. Translation: CAB63843.1.
AK075888 mRNA. Translation: BAC36032.1.
AK139410 mRNA. Translation: BAE23999.1.
AK154862 mRNA. Translation: BAE32886.1.
AK156386 mRNA. Translation: BAE33694.1.
AK171716 mRNA. Translation: BAE42629.1.
AK172396 mRNA. Translation: BAE42984.1.
AK172449 mRNA. Translation: BAE43011.1.
AK172466 mRNA. Translation: BAE43020.1.
CH466546 Genomic DNA. Translation: EDL41001.1.
BC107344 mRNA. Translation: AAI07345.1.
BC107345 mRNA. Translation: AAI07346.1.
CCDSiCCDS26481.1.
RefSeqiNP_033986.1. NM_009856.3.
UniGeneiMm.57175.

Genome annotation databases

EnsembliENSMUST00000015540; ENSMUSP00000015540; ENSMUSG00000015396.
GeneIDi12522.
KEGGimmu:12522.
UCSCiuc007qgj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001036 mRNA. Translation: AAC83185.1.
AF001041
, AF001037, AF001038, AF001039, AF001040 Genomic DNA. Translation: AAC83186.1.
AJ245551 mRNA. Translation: CAB63843.1.
AK075888 mRNA. Translation: BAC36032.1.
AK139410 mRNA. Translation: BAE23999.1.
AK154862 mRNA. Translation: BAE32886.1.
AK156386 mRNA. Translation: BAE33694.1.
AK171716 mRNA. Translation: BAE42629.1.
AK172396 mRNA. Translation: BAE42984.1.
AK172449 mRNA. Translation: BAE43011.1.
AK172466 mRNA. Translation: BAE43020.1.
CH466546 Genomic DNA. Translation: EDL41001.1.
BC107344 mRNA. Translation: AAI07345.1.
BC107345 mRNA. Translation: AAI07346.1.
CCDSiCCDS26481.1.
RefSeqiNP_033986.1. NM_009856.3.
UniGeneiMm.57175.

3D structure databases

ProteinModelPortaliO88324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015540.

PTM databases

iPTMnetiO88324.
PhosphoSitePlusiO88324.

Proteomic databases

PaxDbiO88324.
PRIDEiO88324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015540; ENSMUSP00000015540; ENSMUSG00000015396.
GeneIDi12522.
KEGGimmu:12522.
UCSCiuc007qgj.2. mouse.

Organism-specific databases

CTDi9308.
MGIiMGI:1328316. Cd83.

Phylogenomic databases

eggNOGiENOG410IKX7. Eukaryota.
ENOG410ZACF. LUCA.
GeneTreeiENSGT00390000007302.
HOGENOMiHOG000057288.
InParanoidiO88324.
KOiK06510.
OMAiEVKVACS.
OrthoDBiEOG091G0OEV.
PhylomeDBiO88324.
TreeFamiTF337861.

Miscellaneous databases

PROiO88324.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015396.
GenevisibleiO88324. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD83_MOUSE
AccessioniPrimary (citable) accession number: O88324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.