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Protein

CD83 antigen

Gene

Cd83

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.By similarity

GO - Biological processi

  • negative regulation of interleukin-4 production Source: MGI
  • positive regulation of CD4-positive, alpha-beta T cell differentiation Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • response to organic cyclic compound Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD83 antigen
Short name:
mCD83
Alternative name(s):
CD_antigen: CD83
Gene namesi
Name:Cd83
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1328316. Cd83.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 133112ExtracellularSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 19642CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 196175CD83 antigenPRO_0000378451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 98PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88324.
PaxDbiO88324.
PRIDEiO88324.

PTM databases

iPTMnetiO88324.
PhosphoSiteiO88324.

Expressioni

Tissue specificityi

Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed.1 Publication

Gene expression databases

BgeeiO88324.
GenevisibleiO88324. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015540.

Structurei

3D structure databases

ProteinModelPortaliO88324.
SMRiO88324. Positions 23-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11089Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKX7. Eukaryota.
ENOG410ZACF. LUCA.
GeneTreeiENSGT00390000007302.
HOGENOMiHOG000057288.
InParanoidiO88324.
KOiK06510.
OMAiEVKVACS.
OrthoDBiEOG70GMH9.
PhylomeDBiO88324.
TreeFamiTF337861.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGLQLLFL GCACSLAPAM AMREVTVACS ETADLPCTAP WDPQLSYAVS
60 70 80 90 100
WAKVSESGTE SVELPESKQN SSFEAPRRRA YSLTIQNTTI CSSGTYRCAL
110 120 130 140 150
QELGGQRNLS GTVVLKVTGC PKEATESTFR KYRAEAVLLF SLVVFYLTLI
160 170 180 190
IFTCKFARLQ SIFPDISKPG TEQAFLPVTS PSKHLGPVTL PKTETV
Length:196
Mass (Da):21,313
Last modified:November 1, 1998 - v1
Checksum:i026C1007BD7ABD1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001036 mRNA. Translation: AAC83185.1.
AF001041
, AF001037, AF001038, AF001039, AF001040 Genomic DNA. Translation: AAC83186.1.
AJ245551 mRNA. Translation: CAB63843.1.
AK075888 mRNA. Translation: BAC36032.1.
AK139410 mRNA. Translation: BAE23999.1.
AK154862 mRNA. Translation: BAE32886.1.
AK156386 mRNA. Translation: BAE33694.1.
AK171716 mRNA. Translation: BAE42629.1.
AK172396 mRNA. Translation: BAE42984.1.
AK172449 mRNA. Translation: BAE43011.1.
AK172466 mRNA. Translation: BAE43020.1.
CH466546 Genomic DNA. Translation: EDL41001.1.
BC107344 mRNA. Translation: AAI07345.1.
BC107345 mRNA. Translation: AAI07346.1.
CCDSiCCDS26481.1.
RefSeqiNP_033986.1. NM_009856.3.
UniGeneiMm.57175.

Genome annotation databases

EnsembliENSMUST00000015540; ENSMUSP00000015540; ENSMUSG00000015396.
GeneIDi12522.
KEGGimmu:12522.
UCSCiuc007qgj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001036 mRNA. Translation: AAC83185.1.
AF001041
, AF001037, AF001038, AF001039, AF001040 Genomic DNA. Translation: AAC83186.1.
AJ245551 mRNA. Translation: CAB63843.1.
AK075888 mRNA. Translation: BAC36032.1.
AK139410 mRNA. Translation: BAE23999.1.
AK154862 mRNA. Translation: BAE32886.1.
AK156386 mRNA. Translation: BAE33694.1.
AK171716 mRNA. Translation: BAE42629.1.
AK172396 mRNA. Translation: BAE42984.1.
AK172449 mRNA. Translation: BAE43011.1.
AK172466 mRNA. Translation: BAE43020.1.
CH466546 Genomic DNA. Translation: EDL41001.1.
BC107344 mRNA. Translation: AAI07345.1.
BC107345 mRNA. Translation: AAI07346.1.
CCDSiCCDS26481.1.
RefSeqiNP_033986.1. NM_009856.3.
UniGeneiMm.57175.

3D structure databases

ProteinModelPortaliO88324.
SMRiO88324. Positions 23-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015540.

PTM databases

iPTMnetiO88324.
PhosphoSiteiO88324.

Proteomic databases

MaxQBiO88324.
PaxDbiO88324.
PRIDEiO88324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015540; ENSMUSP00000015540; ENSMUSG00000015396.
GeneIDi12522.
KEGGimmu:12522.
UCSCiuc007qgj.2. mouse.

Organism-specific databases

CTDi9308.
MGIiMGI:1328316. Cd83.

Phylogenomic databases

eggNOGiENOG410IKX7. Eukaryota.
ENOG410ZACF. LUCA.
GeneTreeiENSGT00390000007302.
HOGENOMiHOG000057288.
InParanoidiO88324.
KOiK06510.
OMAiEVKVACS.
OrthoDBiEOG70GMH9.
PhylomeDBiO88324.
TreeFamiTF337861.

Miscellaneous databases

PROiO88324.
SOURCEiSearch...

Gene expression databases

BgeeiO88324.
GenevisibleiO88324. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse Cd83 gene: structure, domain organization, and chromosome localization."
    Twist C.J., Beier D.R., Disteche C.M., Edelhoff S., Tedder T.F.
    Immunogenetics 48:383-393(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: 129.
  2. "Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule, which is specifically up-regulated during dendritic cell maturation."
    Berchtold S., Muehl-Zuerbes P., Heufler C., Winklehner P., Schuler G., Steinkasserer A.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Brain cortex, Spleen and Tongue.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCD83_MOUSE
AccessioniPrimary (citable) accession number: O88324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.