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O88319

- NTR1_MOUSE

UniProt

O88319 - NTR1_MOUSE

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Protein

Neurotensin receptor type 1

Gene

Ntsr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis By similarity.By similarity

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: UniProtKB
  2. neuropeptide receptor activity Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. negative regulation of apoptotic process Source: UniProtKB
  3. neuropeptide signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 1
Short name:
NT-R-1
Short name:
NTR1
Gene namesi
Name:Ntsr1
Synonyms:Ntsr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:97386. Ntsr1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Membrane raft By similarity
Note: Palmitoylation is required for localization at CAV1-enriched membrane rafts.By similarity

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane raft Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Neurotensin receptor type 1PRO_0000069947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 224PROSITE-ProRule annotation
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
Lipidationi386 – 3861S-palmitoyl cysteineBy similarity
Lipidationi388 – 3881S-palmitoyl cysteineBy similarity

Post-translational modificationi

N-gycosylated.By similarity
Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88319.
PRIDEiO88319.

PTM databases

PhosphoSiteiO88319.

Expressioni

Gene expression databases

BgeeiO88319.
CleanExiMM_NTSR1.
ExpressionAtlasiO88319. baseline and differential.
GenevestigatoriO88319.

Interactioni

Subunit structurei

Interacts (palmitoylated form) with GNA11.By similarity

Structurei

3D structure databases

ProteinModelPortaliO88319.
SMRiO88319. Positions 50-386.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767ExtracellularBy similarityAdd
BLAST
Topological domaini89 – 10214CytoplasmicBy similarityAdd
BLAST
Topological domaini123 – 14220ExtracellularBy similarityAdd
BLAST
Topological domaini165 – 18723CytoplasmicBy similarityAdd
BLAST
Topological domaini210 – 23425ExtracellularBy similarityAdd
BLAST
Topological domaini260 – 30849CytoplasmicBy similarityAdd
BLAST
Topological domaini331 – 34818ExtracellularBy similarityAdd
BLAST
Topological domaini370 – 42455CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821Helical; Name=1By similarityAdd
BLAST
Transmembranei103 – 12220Helical; Name=2By similarityAdd
BLAST
Transmembranei143 – 16422Helical; Name=3By similarityAdd
BLAST
Transmembranei188 – 20922Helical; Name=4By similarityAdd
BLAST
Transmembranei235 – 25925Helical; Name=5By similarityAdd
BLAST
Transmembranei309 – 33022Helical; Name=6By similarityAdd
BLAST
Transmembranei349 – 36921Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni326 – 34924Neurotensin bindingBy similarityAdd
BLAST

Domaini

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303702.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO88319.
KOiK04211.
OMAiTVMVRQA.
OrthoDBiEOG75F4DR.
PhylomeDBiO88319.
TreeFamiTF337167.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88319-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP
60 70 80 90 100
NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST
110 120 130 140 150
VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA
160 170 180 190 200
CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA
210 220 230 240 250
VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML
260 270 280 290 300
IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV
310 320 330 340 350
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF
360 370 380 390 400
YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT
410 420
FSRKPNSMSS NHAFSTSATR ETLY
Length:424
Mass (Da):47,217
Last modified:November 1, 1998 - v1
Checksum:i8E9A723171A48711
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017027 mRNA. Translation: BAA33013.1.
CCDSiCCDS17177.1.
RefSeqiNP_061236.1. NM_018766.2.
UniGeneiMm.301712.

Genome annotation databases

EnsembliENSMUST00000029084; ENSMUSP00000029084; ENSMUSG00000027568.
ENSMUST00000170448; ENSMUSP00000127548; ENSMUSG00000027568.
GeneIDi18216.
KEGGimmu:18216.
UCSCiuc008ojg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017027 mRNA. Translation: BAA33013.1 .
CCDSi CCDS17177.1.
RefSeqi NP_061236.1. NM_018766.2.
UniGenei Mm.301712.

3D structure databases

ProteinModelPortali O88319.
SMRi O88319. Positions 50-386.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O88319.
ChEMBLi CHEMBL3570.
GuidetoPHARMACOLOGYi 309.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O88319.

Proteomic databases

PaxDbi O88319.
PRIDEi O88319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029084 ; ENSMUSP00000029084 ; ENSMUSG00000027568 .
ENSMUST00000170448 ; ENSMUSP00000127548 ; ENSMUSG00000027568 .
GeneIDi 18216.
KEGGi mmu:18216.
UCSCi uc008ojg.1. mouse.

Organism-specific databases

CTDi 4923.
MGIi MGI:97386. Ntsr1.

Phylogenomic databases

eggNOGi NOG303702.
GeneTreei ENSGT00700000104070.
HOGENOMi HOG000231271.
HOVERGENi HBG098285.
InParanoidi O88319.
KOi K04211.
OMAi TVMVRQA.
OrthoDBi EOG75F4DR.
PhylomeDBi O88319.
TreeFami TF337167.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 293624.
PROi O88319.
SOURCEi Search...

Gene expression databases

Bgeei O88319.
CleanExi MM_NTSR1.
ExpressionAtlasi O88319. baseline and differential.
Genevestigatori O88319.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Neurotensin receptor type 1."
    Snider J., Sano H., Ohta M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNTR1_MOUSE
AccessioniPrimary (citable) accession number: O88319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3