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O88319 (NTR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin receptor type 1

Short name=NT-R-1
Short name=NTR1
Gene names
Name:Ntsr1
Synonyms:Ntsr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Neurotensin receptor type 1
PRO_0000069947

Regions

Topological domain1 – 6464Extracellular Potential
Transmembrane65 – 8723Helical; Name=1; Potential
Topological domain88 – 969Cytoplasmic Potential
Transmembrane97 – 12125Helical; Name=2; Potential
Topological domain122 – 14322Extracellular Potential
Transmembrane144 – 16522Helical; Name=3; Potential
Topological domain166 – 18823Cytoplasmic Potential
Transmembrane189 – 21022Helical; Name=4; Potential
Topological domain211 – 23525Extracellular Potential
Transmembrane236 – 26025Helical; Name=5; Potential
Topological domain261 – 30848Cytoplasmic Potential
Transmembrane309 – 33022Helical; Name=6; Potential
Topological domain331 – 34818Extracellular Potential
Transmembrane349 – 37224Helical; Name=7; Potential
Topological domain373 – 42452Cytoplasmic Potential

Amino acid modifications

Lipidation3881S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Disulfide bond141 ↔ 224 By similarity

Sequences

Sequence LengthMass (Da)Tools
O88319 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8E9A723171A48711

FASTA42447,217
        10         20         30         40         50         60 
MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP NSNLDVNTDI 

        70         80         90        100        110        120 
YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLILLLAM 

       130        140        150        160        170        180 
PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM 

       190        200        210        220        230        240 
SRSRTKKFIS AIWLASALLA VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN 

       250        260        270        280        290        300 
TFMSFLFPML IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV 

       310        320        330        340        350        360 
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF YMLTNALFYV 

       370        380        390        400        410        420 
SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT FSRKPNSMSS NHAFSTSATR 


ETLY 

« Hide

References

[1]"Neurotensin receptor type 1."
Snider J., Sano H., Ohta M.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB017027 mRNA. Translation: BAA33013.1.
RefSeqNP_061236.1. NM_018766.2.
UniGeneMm.301712.

3D structure databases

ProteinModelPortalO88319.
SMRO88319. Positions 51-268, 298-379.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBO88319.
ChEMBLCHEMBL3570.
GuidetoPHARMACOLOGY309.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO88319.

Proteomic databases

PaxDbO88319.
PRIDEO88319.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029084; ENSMUSP00000029084; ENSMUSG00000027568.
ENSMUST00000170448; ENSMUSP00000127548; ENSMUSG00000027568.
GeneID18216.
KEGGmmu:18216.
UCSCuc008ojg.1. mouse.

Organism-specific databases

CTD4923.
MGIMGI:97386. Ntsr1.

Phylogenomic databases

eggNOGNOG303702.
GeneTreeENSGT00700000104470.
HOGENOMHOG000231271.
HOVERGENHBG098285.
InParanoidO88319.
KOK04211.
OMATVMVRQA.
OrthoDBEOG75F4DR.
PhylomeDBO88319.
TreeFamTF337167.

Gene expression databases

ArrayExpressO88319.
BgeeO88319.
CleanExMM_NTSR1.
GenevestigatorO88319.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293624.
PROO88319.
SOURCESearch...

Entry information

Entry nameNTR1_MOUSE
AccessionPrimary (citable) accession number: O88319
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries