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O88319

- NTR1_MOUSE

UniProt

O88319 - NTR1_MOUSE

Protein

Neurotensin receptor type 1

Gene

Ntsr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled neurotensin receptor activity Source: UniProtKB
    2. neuropeptide receptor activity Source: MGI

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. negative regulation of apoptotic process Source: UniProtKB
    3. neuropeptide signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotensin receptor type 1
    Short name:
    NT-R-1
    Short name:
    NTR1
    Gene namesi
    Name:Ntsr1
    Synonyms:Ntsr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:97386. Ntsr1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Membrane raft By similarity
    Note: Palmitoylation is required for localization at CAV1-enriched membrane rafts.By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. membrane raft Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Neurotensin receptor type 1PRO_0000069947Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi141 ↔ 224PROSITE-ProRule annotation
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Lipidationi386 – 3861S-palmitoyl cysteineBy similarity
    Lipidationi388 – 3881S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    N-gycosylated.By similarity
    Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO88319.
    PRIDEiO88319.

    PTM databases

    PhosphoSiteiO88319.

    Expressioni

    Gene expression databases

    ArrayExpressiO88319.
    BgeeiO88319.
    CleanExiMM_NTSR1.
    GenevestigatoriO88319.

    Interactioni

    Subunit structurei

    Interacts (palmitoylated form) with GNA11.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO88319.
    SMRiO88319. Positions 50-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767ExtracellularBy similarityAdd
    BLAST
    Topological domaini89 – 10214CytoplasmicBy similarityAdd
    BLAST
    Topological domaini123 – 14220ExtracellularBy similarityAdd
    BLAST
    Topological domaini165 – 18723CytoplasmicBy similarityAdd
    BLAST
    Topological domaini210 – 23425ExtracellularBy similarityAdd
    BLAST
    Topological domaini260 – 30849CytoplasmicBy similarityAdd
    BLAST
    Topological domaini331 – 34818ExtracellularBy similarityAdd
    BLAST
    Topological domaini370 – 42455CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821Helical; Name=1By similarityAdd
    BLAST
    Transmembranei103 – 12220Helical; Name=2By similarityAdd
    BLAST
    Transmembranei143 – 16422Helical; Name=3By similarityAdd
    BLAST
    Transmembranei188 – 20922Helical; Name=4By similarityAdd
    BLAST
    Transmembranei235 – 25925Helical; Name=5By similarityAdd
    BLAST
    Transmembranei309 – 33022Helical; Name=6By similarityAdd
    BLAST
    Transmembranei349 – 36921Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni326 – 34924Neurotensin bindingBy similarityAdd
    BLAST

    Domaini

    The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7.By similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303702.
    GeneTreeiENSGT00700000104470.
    HOGENOMiHOG000231271.
    HOVERGENiHBG098285.
    InParanoidiO88319.
    KOiK04211.
    OMAiTVMVRQA.
    OrthoDBiEOG75F4DR.
    PhylomeDBiO88319.
    TreeFamiTF337167.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003985. NT1_rcpt.
    IPR003984. NT_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01479. NEUROTENSINR.
    PR01480. NEUROTENSN1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88319-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP    50
    NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST 100
    VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA 150
    CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA 200
    VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML 250
    IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV 300
    QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF 350
    YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT 400
    FSRKPNSMSS NHAFSTSATR ETLY 424
    Length:424
    Mass (Da):47,217
    Last modified:November 1, 1998 - v1
    Checksum:i8E9A723171A48711
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017027 mRNA. Translation: BAA33013.1.
    CCDSiCCDS17177.1.
    RefSeqiNP_061236.1. NM_018766.2.
    UniGeneiMm.301712.

    Genome annotation databases

    EnsembliENSMUST00000029084; ENSMUSP00000029084; ENSMUSG00000027568.
    ENSMUST00000170448; ENSMUSP00000127548; ENSMUSG00000027568.
    GeneIDi18216.
    KEGGimmu:18216.
    UCSCiuc008ojg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017027 mRNA. Translation: BAA33013.1 .
    CCDSi CCDS17177.1.
    RefSeqi NP_061236.1. NM_018766.2.
    UniGenei Mm.301712.

    3D structure databases

    ProteinModelPortali O88319.
    SMRi O88319. Positions 50-386.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi O88319.
    ChEMBLi CHEMBL3570.
    GuidetoPHARMACOLOGYi 309.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O88319.

    Proteomic databases

    PaxDbi O88319.
    PRIDEi O88319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029084 ; ENSMUSP00000029084 ; ENSMUSG00000027568 .
    ENSMUST00000170448 ; ENSMUSP00000127548 ; ENSMUSG00000027568 .
    GeneIDi 18216.
    KEGGi mmu:18216.
    UCSCi uc008ojg.1. mouse.

    Organism-specific databases

    CTDi 4923.
    MGIi MGI:97386. Ntsr1.

    Phylogenomic databases

    eggNOGi NOG303702.
    GeneTreei ENSGT00700000104470.
    HOGENOMi HOG000231271.
    HOVERGENi HBG098285.
    InParanoidi O88319.
    KOi K04211.
    OMAi TVMVRQA.
    OrthoDBi EOG75F4DR.
    PhylomeDBi O88319.
    TreeFami TF337167.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 293624.
    PROi O88319.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88319.
    Bgeei O88319.
    CleanExi MM_NTSR1.
    Genevestigatori O88319.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003985. NT1_rcpt.
    IPR003984. NT_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01479. NEUROTENSINR.
    PR01480. NEUROTENSN1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neurotensin receptor type 1."
      Snider J., Sano H., Ohta M.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNTR1_MOUSE
    AccessioniPrimary (citable) accession number: O88319
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3