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O88319

- NTR1_MOUSE

UniProt

O88319 - NTR1_MOUSE

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Protein
Neurotensin receptor type 1
Gene
Ntsr1, Ntsr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: UniProtKB
  2. neuropeptide receptor activity Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. neuropeptide signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 1
Short name:
NT-R-1
Short name:
NTR1
Gene namesi
Name:Ntsr1
Synonyms:Ntsr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:97386. Ntsr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464Extracellular Reviewed prediction
Add
BLAST
Transmembranei65 – 8723Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini88 – 969Cytoplasmic Reviewed prediction
Transmembranei97 – 12125Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini122 – 14322Extracellular Reviewed prediction
Add
BLAST
Transmembranei144 – 16522Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini166 – 18823Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei189 – 21022Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini211 – 23525Extracellular Reviewed prediction
Add
BLAST
Transmembranei236 – 26025Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini261 – 30848Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei309 – 33022Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini331 – 34818Extracellular Reviewed prediction
Add
BLAST
Transmembranei349 – 37224Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini373 – 42452Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Neurotensin receptor type 1
PRO_0000069947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi141 ↔ 224 By similarity
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Lipidationi388 – 3881S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88319.
PRIDEiO88319.

PTM databases

PhosphoSiteiO88319.

Expressioni

Gene expression databases

ArrayExpressiO88319.
BgeeiO88319.
CleanExiMM_NTSR1.
GenevestigatoriO88319.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO88319.
SMRiO88319. Positions 50-386.

Family & Domainsi

Domaini

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7 By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303702.
GeneTreeiENSGT00700000104470.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiO88319.
KOiK04211.
OMAiTVMVRQA.
OrthoDBiEOG75F4DR.
PhylomeDBiO88319.
TreeFamiTF337167.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88319-1 [UniParc]FASTAAdd to Basket

« Hide

MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP    50
NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST 100
VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA 150
CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA 200
VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML 250
IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV 300
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF 350
YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT 400
FSRKPNSMSS NHAFSTSATR ETLY 424
Length:424
Mass (Da):47,217
Last modified:November 1, 1998 - v1
Checksum:i8E9A723171A48711
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017027 mRNA. Translation: BAA33013.1.
CCDSiCCDS17177.1.
RefSeqiNP_061236.1. NM_018766.2.
UniGeneiMm.301712.

Genome annotation databases

EnsembliENSMUST00000029084; ENSMUSP00000029084; ENSMUSG00000027568.
ENSMUST00000170448; ENSMUSP00000127548; ENSMUSG00000027568.
GeneIDi18216.
KEGGimmu:18216.
UCSCiuc008ojg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017027 mRNA. Translation: BAA33013.1 .
CCDSi CCDS17177.1.
RefSeqi NP_061236.1. NM_018766.2.
UniGenei Mm.301712.

3D structure databases

ProteinModelPortali O88319.
SMRi O88319. Positions 50-386.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O88319.
ChEMBLi CHEMBL3570.
GuidetoPHARMACOLOGYi 309.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O88319.

Proteomic databases

PaxDbi O88319.
PRIDEi O88319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029084 ; ENSMUSP00000029084 ; ENSMUSG00000027568 .
ENSMUST00000170448 ; ENSMUSP00000127548 ; ENSMUSG00000027568 .
GeneIDi 18216.
KEGGi mmu:18216.
UCSCi uc008ojg.1. mouse.

Organism-specific databases

CTDi 4923.
MGIi MGI:97386. Ntsr1.

Phylogenomic databases

eggNOGi NOG303702.
GeneTreei ENSGT00700000104470.
HOGENOMi HOG000231271.
HOVERGENi HBG098285.
InParanoidi O88319.
KOi K04211.
OMAi TVMVRQA.
OrthoDBi EOG75F4DR.
PhylomeDBi O88319.
TreeFami TF337167.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 293624.
PROi O88319.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88319.
Bgeei O88319.
CleanExi MM_NTSR1.
Genevestigatori O88319.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Neurotensin receptor type 1."
    Snider J., Sano H., Ohta M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNTR1_MOUSE
AccessioniPrimary (citable) accession number: O88319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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