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Protein

Anterior gradient protein 2 homolog

Gene

Agr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 2 homolog
Short name:
AG-2
Short name:
mAG-2
Alternative name(s):
Protein Gob-4
Secreted cement gland protein XAG-2 homolog
Gene namesi
Name:Agr2
Synonyms:Gob4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1344405. Agr2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • extracellular space Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable but display altered production of mucus with loss of production of MUC2 despite expression of its mRNA. They also display an increase in mast cells in the intestine, an increased expression of inflammation-specific genes, and frequent rectal prolapse. This is associated with a higher susceptibility to colitis.1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 175155Anterior gradient protein 2 homologPRO_0000001038Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO88312.
PaxDbiO88312.
PeptideAtlasiO88312.
PRIDEiO88312.

PTM databases

PhosphoSiteiO88312.

Expressioni

Tissue specificityi

Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach.2 Publications

Developmental stagei

Expressed in embryo at 15 dpc onwards.

Gene expression databases

BgeeiENSMUSG00000020581.
CleanExiMM_AGR2.
GenevisibleiO88312. MM.

Interactioni

Subunit structurei

Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88312. 2 interactions.
MINTiMINT-4105490.
STRINGi10090.ENSMUSP00000020898.

Structurei

3D structure databases

ProteinModelPortaliO88312.
SMRiO88312. Positions 38-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVR8. Eukaryota.
ENOG4111K70. LUCA.
GeneTreeiENSGT00530000063273.
HOGENOMiHOG000231100.
HOVERGENiHBG006516.
InParanoidiO88312.
OMAiYSNMQKA.
OrthoDBiEOG091G0RHV.
PhylomeDBiO88312.
TreeFamiTF321449.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFSVSAIL LLVAISGTLA KDTTVKSGAK KDPKDSRPKL PQTLSRGWGD
60 70 80 90 100
QLIWTQTYEE ALYRSKTSNR PLMVIHHLDE CPHSQALKKV FAEHKEIQKL
110 120 130 140 150
AEQFVLLNLV YETTDKHLSP DGQYVPRIVF VDPSLTVRAD ITGRYSNRLY
160 170
AYEPSDTALL YDNMKKALKL LKTEL
Length:175
Mass (Da):19,920
Last modified:November 1, 1998 - v1
Checksum:iACC3CFE429B668CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044262 mRNA. Translation: AAC72705.1.
AB016592 mRNA. Translation: BAA32044.1.
AK007677 mRNA. Translation: BAB25181.1.
CT030196 Genomic DNA. Translation: CAM19620.1.
BC013334 mRNA. Translation: AAH13334.1.
CCDSiCCDS25881.1.
RefSeqiNP_035913.1. NM_011783.2.
UniGeneiMm.7244.

Genome annotation databases

EnsembliENSMUST00000020898; ENSMUSP00000020898; ENSMUSG00000020581.
GeneIDi23795.
KEGGimmu:23795.
UCSCiuc007njm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044262 mRNA. Translation: AAC72705.1.
AB016592 mRNA. Translation: BAA32044.1.
AK007677 mRNA. Translation: BAB25181.1.
CT030196 Genomic DNA. Translation: CAM19620.1.
BC013334 mRNA. Translation: AAH13334.1.
CCDSiCCDS25881.1.
RefSeqiNP_035913.1. NM_011783.2.
UniGeneiMm.7244.

3D structure databases

ProteinModelPortaliO88312.
SMRiO88312. Positions 38-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88312. 2 interactions.
MINTiMINT-4105490.
STRINGi10090.ENSMUSP00000020898.

PTM databases

PhosphoSiteiO88312.

Proteomic databases

MaxQBiO88312.
PaxDbiO88312.
PeptideAtlasiO88312.
PRIDEiO88312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020898; ENSMUSP00000020898; ENSMUSG00000020581.
GeneIDi23795.
KEGGimmu:23795.
UCSCiuc007njm.1. mouse.

Organism-specific databases

CTDi10551.
MGIiMGI:1344405. Agr2.

Phylogenomic databases

eggNOGiENOG410IVR8. Eukaryota.
ENOG4111K70. LUCA.
GeneTreeiENSGT00530000063273.
HOGENOMiHOG000231100.
HOVERGENiHBG006516.
InParanoidiO88312.
OMAiYSNMQKA.
OrthoDBiEOG091G0RHV.
PhylomeDBiO88312.
TreeFamiTF321449.

Miscellaneous databases

PROiO88312.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020581.
CleanExiMM_AGR2.
GenevisibleiO88312. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGR2_MOUSE
AccessioniPrimary (citable) accession number: O88312
Secondary accession number(s): A2CGA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.