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Protein

Intelectin-1a

Gene

Itln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism (By similarity).By similarity1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Intelectin-1a
Alternative name(s):
Galactofuranose-binding lectin
Intestinal lactoferrin receptor
Gene namesi
Name:Itln1
Synonyms:Intl, Itln, Itln1a, Itlna
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1333831. Itln1.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity
  • Secreted By similarity

  • Note: Enriched in lipid rafts.1 Publication

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • brush border membrane Source: UniProtKB
  • extracellular exosome Source: MGI
  • membrane raft Source: UniProtKB
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 298279Intelectin-1aPRO_0000009145Add
BLAST
Propeptidei299 – 31315Sequence analysisPRO_0000009146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi298 – 2981GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO88310.
PaxDbiO88310.
PRIDEiO88310.

PTM databases

iPTMnetiO88310.
PhosphoSiteiO88310.

Expressioni

Tissue specificityi

Expressed in small intestinal Paneth cells in uninfected mice. Expression also detected in various other tissues including stomach, kidney, ovary and brain.5 Publications

Developmental stagei

In the embryo, levels are highest at day 7, decrease by mid-embryogenesis at day 11 and increase again in late embryogenesis at day 17.1 Publication

Inductioni

By infection with the helminth parasite N.brasiliensis.1 Publication

Gene expression databases

BgeeiO88310.
CleanExiMM_ITLN1.
ExpressionAtlasiO88310. baseline and differential.
GenevisibleiO88310. MM.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043837.

Structurei

3D structure databases

ProteinModelPortaliO88310.
SMRiO88310. Positions 36-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 251220Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGEB. Eukaryota.
ENOG4110R6N. LUCA.
GeneTreeiENSGT00390000008567.
HOGENOMiHOG000026788.
HOVERGENiHBG052157.
InParanoidiO88310.
KOiK17527.
OMAiTHVKSSC.
OrthoDBiEOG76739X.
PhylomeDBiO88310.
TreeFamiTF328530.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLGFLLFI MVATRGCSAA EENLDTNRWG NSFFSSLPRS CKEIKQEHTK
60 70 80 90 100
AQDGLYFLRT KNGVIYQTFC DMTTAGGGWT LVASVHENNM RGKCTVGDRW
110 120 130 140 150
SSQQGNRADY PEGDGNWANY NTFGSAEAAT SDDYKNPGYF DIQAENLGIW
160 170 180 190 200
HVPNKSPLHN WRKSSLLRYR TFTGFLQHLG HNLFGLYKKY PVKYGEGKCW
210 220 230 240 250
TDNGPALPVV YDFGDARKTA SYYSPSGQRE FTAGYVQFRV FNNERAASAL
260 270 280 290 300
CAGVRVTGCN TEHHCIGGGG FFPEGNPVQC GDFASFDWDG YGTHNGYSSS
310
RKITEAAVLL FYR
Length:313
Mass (Da):34,953
Last modified:November 1, 1998 - v1
Checksum:iD2FA447D3D8547A4
GO

Mass spectrometryi

Molecular mass is 34000 Da from positions 20 - 298. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016496 mRNA. Translation: BAA31992.1.
AY157363 mRNA. Translation: AAO17802.1.
AY157364 mRNA. Translation: AAO17803.1.
AY619693 mRNA. Translation: AAU88049.1.
AK007447 mRNA. Translation: BAB25043.1.
CCDSiCCDS35777.1.
PIRiJE0328.
RefSeqiNP_034714.1. NM_010584.3.
UniGeneiMm.247426.

Genome annotation databases

EnsembliENSMUST00000043094; ENSMUSP00000043837; ENSMUSG00000038209.
GeneIDi16429.
KEGGimmu:16429.
UCSCiuc007doq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016496 mRNA. Translation: BAA31992.1.
AY157363 mRNA. Translation: AAO17802.1.
AY157364 mRNA. Translation: AAO17803.1.
AY619693 mRNA. Translation: AAU88049.1.
AK007447 mRNA. Translation: BAB25043.1.
CCDSiCCDS35777.1.
PIRiJE0328.
RefSeqiNP_034714.1. NM_010584.3.
UniGeneiMm.247426.

3D structure databases

ProteinModelPortaliO88310.
SMRiO88310. Positions 36-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043837.

PTM databases

iPTMnetiO88310.
PhosphoSiteiO88310.

Proteomic databases

MaxQBiO88310.
PaxDbiO88310.
PRIDEiO88310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043094; ENSMUSP00000043837; ENSMUSG00000038209.
GeneIDi16429.
KEGGimmu:16429.
UCSCiuc007doq.2. mouse.

Organism-specific databases

CTDi55600.
MGIiMGI:1333831. Itln1.

Phylogenomic databases

eggNOGiENOG410IGEB. Eukaryota.
ENOG4110R6N. LUCA.
GeneTreeiENSGT00390000008567.
HOGENOMiHOG000026788.
HOVERGENiHBG052157.
InParanoidiO88310.
KOiK17527.
OMAiTHVKSSC.
OrthoDBiEOG76739X.
PhylomeDBiO88310.
TreeFamiTF328530.

Miscellaneous databases

NextBioi289657.
PROiO88310.
SOURCEiSearch...

Gene expression databases

BgeeiO88310.
CleanExiMM_ITLN1.
ExpressionAtlasiO88310. baseline and differential.
GenevisibleiO88310. MM.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the novel gene intelectin, which is expressed in intestinal Paneth cells in mice."
    Komiya T., Tanigawa Y., Hirohashi S.
    Biochem. Biophys. Res. Commun. 251:759-762(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Intestine.
  2. "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins."
    Chang B.Y., Peavy T.R., Wardrip N.J., Hedrick J.L.
    Comp. Biochem. Physiol. 137A:115-129(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Intestine and Thymus.
  3. "Mouse homolog of the Xenopus laevis egg cortical granule lectin."
    Peavy T.R., Hedrick J.L.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Ovary.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse."
    Suzuki Y.A., Lonnerdal B.
    BioMetals 17:301-309(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice."
    Pemberton A.D., Knight P.A., Gamble J., Colledge W.H., Lee J.K., Pierce M., Miller H.R.
    J. Immunol. 173:1894-1901(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Intestine.
  7. "Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life."
    Lopez V., Suzuki Y.A., Loennerdal B.
    Biochem. Cell Biol. 84:337-344(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Intelectin: a novel lipid raft-associated protein in the enterocyte brush border."
    Wrackmeyer U., Hansen G.H., Seya T., Danielsen E.M.
    Biochemistry 45:9188-9197(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection."
    Voehringer D., Stanley S.A., Cox J.S., Completo G.C., Lowary T.L., Locksley R.M.
    Exp. Parasitol. 116:458-466(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  10. "Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer."
    Tsuji S., Yamashita M., Nishiyama A., Shinohara T., Li Z., Myrvik Q.N., Hoffman D.R., Henriksen R.A., Shibata Y.
    Glycobiology 17:1045-1051(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, MASS SPECTROMETRY.

Entry informationi

Entry nameiITL1A_MOUSE
AccessioniPrimary (citable) accession number: O88310
Secondary accession number(s): Q5IWS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Constitutive expression does not lead to enhanced immunity to N.brasiliensis or M.tuberculosis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.