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O88307

- SORL_MOUSE

UniProt

O88307 - SORL_MOUSE

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Protein
Sortilin-related receptor
Gene
Sorl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. Involved in APP trafficking to and from the Golgi apparatus By similarity. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta By similarity. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.1 Publication

GO - Molecular functioni

  1. low-density lipoprotein particle binding Source: Ensembl
  2. protein binding Source: MGI

GO - Biological processi

  1. cell migration Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. cholesterol metabolic process Source: UniProtKB-KW
  4. endocytosis Source: UniProtKB-KW
  5. lipid transport Source: UniProtKB-KW
  6. negative regulation of MAP kinase activity Source: Alzheimers_University_of_Toronto
  7. negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
  8. negative regulation of beta-amyloid formation Source: Alzheimers_University_of_Toronto
  9. negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
  10. negative regulation of neurofibrillary tangle assembly Source: Alzheimers_University_of_Toronto
  11. negative regulation of neurogenesis Source: Alzheimers_University_of_Toronto
  12. negative regulation of neuron death Source: Alzheimers_University_of_Toronto
  13. negative regulation of protein binding Source: Alzheimers_University_of_Toronto
  14. negative regulation of protein oligomerization Source: Alzheimers_University_of_Toronto
  15. negative regulation of tau-protein kinase activity Source: Alzheimers_University_of_Toronto
  16. positive regulation of ER to Golgi vesicle-mediated transport Source: Alzheimers_University_of_Toronto
  17. positive regulation of choline O-acetyltransferase activity Source: Alzheimers_University_of_Toronto
  18. positive regulation of early endosome to recycling endosome transport Source: Alzheimers_University_of_Toronto
  19. positive regulation of endocytic recycling Source: Alzheimers_University_of_Toronto
  20. positive regulation of protein catabolic process Source: Alzheimers_University_of_Toronto
  21. positive regulation of protein exit from endoplasmic reticulum Source: Alzheimers_University_of_Toronto
  22. positive regulation of protein localization to early endosome Source: Alzheimers_University_of_Toronto
  23. post-Golgi vesicle-mediated transport Source: Alzheimers_University_of_Toronto
  24. protein maturation Source: Alzheimers_University_of_Toronto
  25. protein retention in Golgi apparatus Source: Alzheimers_University_of_Toronto
  26. protein targeting Source: Alzheimers_University_of_Toronto
  27. protein targeting to Golgi Source: Alzheimers_University_of_Toronto
  28. protein targeting to lysosome Source: Alzheimers_University_of_Toronto
  29. regulation of smooth muscle cell migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sortilin-related receptor
Alternative name(s):
Gp250
Low-density lipoprotein receptor relative with 11 ligand-binding repeats
Short name:
LDLR relative with 11 ligand-binding repeats
Short name:
LR11
SorLA-1
Sorting protein-related receptor containing LDLR class A repeats
Short name:
mSorLA
Gene namesi
Name:Sorl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1202296. Sorl1.

Subcellular locationi

Membrane; Single-pass type I membrane protein Reviewed prediction. Golgi apparatus By similarity. Endosome By similarity. Secreted By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini82 – 21382057Extracellular Reviewed prediction
Add
BLAST
Transmembranei2139 – 215921Helical; Reviewed prediction
Add
BLAST
Topological domaini2160 – 221556Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi cisterna Source: Alzheimers_University_of_Toronto
  2. early endosome Source: Alzheimers_University_of_Toronto
  3. endoplasmic reticulum Source: Alzheimers_University_of_Toronto
  4. integral component of membrane Source: UniProtKB-KW
  5. low-density lipoprotein particle Source: UniProtKB-KW
  6. multivesicular body Source: Ensembl
  7. neuronal cell body Source: Ensembl
  8. nuclear envelope lumen Source: Alzheimers_University_of_Toronto
  9. perinuclear region of cytoplasm Source: MGI
  10. recycling endosome Source: Alzheimers_University_of_Toronto
  11. trans-Golgi network Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, LDL, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Propeptidei29 – 8153Removed in mature form By similarity
PRO_0000033166Add
BLAST
Chaini82 – 22152134Sortilin-related receptor
PRO_0000033167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Modified residuei114 – 1141Phosphoserine By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi367 – 3671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi616 – 6161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi674 – 6741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi818 – 8181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi871 – 8711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1035 – 10351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1068 – 10681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1078 ↔ 1090 By similarity
Disulfide bondi1085 ↔ 1103 By similarity
Disulfide bondi1097 ↔ 1112 By similarity
Disulfide bondi1117 ↔ 1131 By similarity
Disulfide bondi1125 ↔ 1144 By similarity
Disulfide bondi1138 ↔ 1153 By similarity
Disulfide bondi1158 ↔ 1170 By similarity
Glycosylationi1164 – 11641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1165 ↔ 1183 By similarity
Disulfide bondi1177 ↔ 1192 By similarity
Glycosylationi1191 – 11911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1199 ↔ 1211 By similarity
Disulfide bondi1206 ↔ 1224 By similarity
Disulfide bondi1218 ↔ 1235 By similarity
Disulfide bondi1239 ↔ 1249 By similarity
Disulfide bondi1244 ↔ 1262 By similarity
Glycosylationi1246 – 12461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1256 ↔ 1271 By similarity
Disulfide bondi1275 ↔ 1289 By similarity
Disulfide bondi1283 ↔ 1302 By similarity
Disulfide bondi1296 ↔ 1315 By similarity
Disulfide bondi1325 ↔ 1337 By similarity
Disulfide bondi1332 ↔ 1350 By similarity
Disulfide bondi1344 ↔ 1359 By similarity
Glycosylationi1367 – 13671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1368 ↔ 1381 By similarity
Disulfide bondi1376 ↔ 1394 By similarity
Disulfide bondi1388 ↔ 1403 By similarity
Disulfide bondi1419 ↔ 1431 By similarity
Disulfide bondi1426 ↔ 1444 By similarity
Disulfide bondi1438 ↔ 1453 By similarity
Glycosylationi1458 – 14581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1471 ↔ 1484 By similarity
Disulfide bondi1478 ↔ 1497 By similarity
Disulfide bondi1491 ↔ 1506 By similarity
Disulfide bondi1514 ↔ 1527 By similarity
Disulfide bondi1521 ↔ 1540 By similarity
Disulfide bondi1534 ↔ 1549 By similarity
Glycosylationi1608 – 16081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1706 – 17061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1733 – 17331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1810 – 18101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1855 – 18551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1895 – 18951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1987 – 19871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2011 – 20111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2055 – 20551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2070 – 20701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2077 – 20771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2093 – 20931N-linked (GlcNAc...) Reviewed prediction
Modified residuei2207 – 22071Phosphoserine; by ROCK2 By similarity

Post-translational modificationi

The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO88307.
PaxDbiO88307.
PRIDEiO88307.

PTM databases

PhosphoSiteiO88307.

Expressioni

Tissue specificityi

Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver.

Developmental stagei

Expressed as early as embryonic day 6.5 (E6.5) and peaks at E11, the main location is in the CNS during development. At early stages, it is abundant in a subpopulation of neurons in the cerebral cortex, in the hippocampus, and granular and Purkinje cell layers in the cerebellum, whereas in the adult, expression in cerebellar granular cells and in the cerebral cortex is low. Expression occurs also in a variety of glands and organs during organogenesis.

Gene expression databases

ArrayExpressiO88307.
BgeeiO88307.
GenevestigatoriO88307.

Interactioni

Subunit structurei

Interacts with GGA1 and ROCK2 By similarity. Interacts with APP. Interacts with PLAUR By similarity.1 Publication

Protein-protein interaction databases

DIPiDIP-42439N.
MINTiMINT-1342356.

Structurei

3D structure databases

ProteinModelPortaliO88307.
SMRiO88307. Positions 1156-1193, 1651-1745.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati136 – 14712BNR 1
Add
BLAST
Repeati232 – 24312BNR 2
Add
BLAST
Repeati441 – 45212BNR 3
Add
BLAST
Repeati521 – 53212BNR 4
Add
BLAST
Repeati562 – 57312BNR 5
Add
BLAST
Repeati800 – 84344LDL-receptor class B 1
Add
BLAST
Repeati844 – 88744LDL-receptor class B 2
Add
BLAST
Repeati888 – 93245LDL-receptor class B 3
Add
BLAST
Repeati933 – 97240LDL-receptor class B 4
Add
BLAST
Repeati973 – 101341LDL-receptor class B 5
Add
BLAST
Domaini1026 – 107247EGF-like
Add
BLAST
Domaini1076 – 111439LDL-receptor class A 1
Add
BLAST
Domaini1115 – 115541LDL-receptor class A 2
Add
BLAST
Domaini1156 – 119439LDL-receptor class A 3
Add
BLAST
Domaini1198 – 123639LDL-receptor class A 4
Add
BLAST
Domaini1238 – 127235LDL-receptor class A 5
Add
BLAST
Domaini1273 – 131745LDL-receptor class A 6
Add
BLAST
Domaini1323 – 136139LDL-receptor class A 7
Add
BLAST
Domaini1366 – 140540LDL-receptor class A 8
Add
BLAST
Domaini1417 – 145539LDL-receptor class A 9
Add
BLAST
Domaini1469 – 150840LDL-receptor class A 10
Add
BLAST
Domaini1512 – 155140LDL-receptor class A 11
Add
BLAST
Domaini1557 – 164993Fibronectin type-III 1
Add
BLAST
Domaini1653 – 174593Fibronectin type-III 2
Add
BLAST
Domaini1747 – 1846100Fibronectin type-III 3
Add
BLAST
Domaini1844 – 192885Fibronectin type-III 4
Add
BLAST
Domaini1935 – 203096Fibronectin type-III 5
Add
BLAST
Domaini2031 – 211989Fibronectin type-III 6
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2173 – 21786Endocytosis signal Reviewed prediction

Sequence similaritiesi

Contains 5 BNR repeats.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281049.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000007009.
HOVERGENiHBG017830.
InParanoidiQ3UHM3.
OMAiTNVYISS.
OrthoDBiEOG7FV3PK.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.60.40.10. 4 hits.
4.10.400.10. 11 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR006581. VPS10.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00057. Ldl_recept_a. 10 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00060. FN3. 6 hits.
SM00192. LDLa. 11 hits.
SM00135. LY. 5 hits.
SM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
SSF57424. SSF57424. 11 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50853. FN3. 4 hits.
PS01209. LDLRA_1. 10 hits.
PS50068. LDLRA_2. 11 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88307-1 [UniParc]FASTAAdd to Basket

« Hide

MATRSSRRES RLPFLFALVA LLPRGALGGG WTQRLHGGPA PLPQDRGFFV     50
VQGDPRDLRL GTHGDAPGAS PAARKPLRTR RSAALQPQPI QVYGQVSLND 100
SHNQMVVHWA GEKSNVIVAL ARDSLALARP KSSDVYVSYD YGKSFSKISE 150
KLNFGVGNNS EAVISQFYHS PADNKRYIFV DAYAQYLWIT FDFCSTIHGF 200
SIPFRAADLL LHSKASNLLL GFDRSHPNKQ LWKSDDFGQT WIMIQEHVKS 250
FSWGIDPYDQ PNAIYIERHE PFGFSTVLRS TDFFQSRENQ EVILEEVRDF 300
QLRDKYMFAT KVVHLPGSQQ QSSVQLWVSF GRKPMRAAQF VTKHPINEYY 350
IADAAEDQVF VCVSHSNNST NLYISEAEGL KFSLSLENVL YYSPGGAGSD 400
TLVRYFANEP FADFHRVEGL QGVYIATLIN GSMNEENMRS VITFDKGGTW 450
EFLQAPAFTG YGEKINCELS QGCSLHLAQR LSQLLNLQLR RMPILSKESA 500
PGLIIATGSV GKNLASKTNV YISSSAGARW REALPGPHYY TWGDHGGIIM 550
AIAQGMETNE LKYSTNEGET WKTFVFSEKP VFVYGLLTEP GEKSTVFTIF 600
GSNKESVHSW LILQVNATDA LGVPCTENDY KLWSPSDERG NECLLGHKTV 650
FKRRTPHATC FNGEDFDRPV VVSNCSCTRE DYECDFGFKM SEDLSLEVCV 700
PDPEFSGKPY SPPVPCPVGS SYRRTRGYRK ISGDTCSGGD VEARLEGELV 750
PCPLAEENEF ILYAMRKSIY RYDLASGATE QLPLSGLRAA VALDFDYERN 800
CLYWSDLALD TIQRLCLNGS TGQEVIINSG LETVEALAFE PLSQLLYWVD 850
AGFKKIEVAN PDGDFRLTIV NSSVLDRPRA LVLVPQEGVM FWTDWGDLKP 900
GIYRSYMDGS AAYRLVSEDV KWPNGISVDS QWIYWTDAYL DCIERITFSG 950
QQRSVILDSL PHPYAIAVFK NEIYWDDWSQ LSIFRASKHS RSQVEILASQ 1000
LTGLMDMKVF YKGKNAGSNA CVPQPCSLLC LPKANNSKSC RCPEGVASSV 1050
LPSGDLMCDC PQGYQRKNNT CVKEENTCLR NQYRCSNGNC INSIWWCDFD 1100
NDCGDMSDER NCPTTVCDAD TQFRCQESGT CIPLSYKCDL EDDCGDNSDE 1150
SHCEMHQCRS DEFNCSSGMC IRSSWVCDGD NDCRDWSDEA NCTAIYHTCE 1200
ASNFQCHNGH CIPQRWACDG DADCQDGSDE DPVSCEKKCN GFHCPNGTCI 1250
PSSKHCDGLR DCPDGSDEQH CEPFCTRFMD FVCKNRQQCL FHSMVCDGIV 1300
QCRDGSDEDA AFAGCSQDPE FHKECDEFGF QCQNGVCISL IWKCDGMDDC 1350
GDYSDEANCE NPTEAPNCSR YFQFHCENGH CIPNRWKCDR ENDCGDWSDE 1400
KDCGDSHVLP SPTPGPSTCL PNYFHCSSGA CVMGTWVCDG YRDCADGSDE 1450
EACPSLANST AASTPTQFGQ CDRFEFECHQ PKKCIPNWKR CDGHQDCQDG 1500
QDEANCPTHS TLTCTSREFK CEDGEACIVL SERCDGFLDC SDESDEKACS 1550
DELTVYKVQN LQWTADFSGD VTLTWMRPKK MPSASCVYNV YYRVVGESIW 1600
KTLETHSNKT STVLKVLKPD TTYQVKVQVH CLNKVHNTND FVTLRTPEGL 1650
PDAPRNLQLS LNSEEEGVIL GHWAPPVHTH GLIREYIVEY SRSGSKMWAS 1700
QRAASNSTEI KNLLLNALYT VRVAAVTSRG IGNWSDSKSI TTIKGKVIQA 1750
PNIHIDSYDE NSLSFTLTMD GDIKVNGYVV NLFWSFDAHK QEKKTLSFRG 1800
GSALSHRVSN LTAHTSYEIS AWAKTDLGDS PLAFEHILTR GSSPPAPSLK 1850
AKAINQTAVE CIWTGPKNVV YGIFYATSFL DLYRNPKSVT TSLHNKTVIV 1900
SKDEQYLFLV RVLIPYQGPS SDYVVVKMIP DSRLPPRHLH AVHIGKTSAL 1950
IKWESPYDSP DQDLFYAIAV KDLIRKTDRS YKVRSRNSTV EYSLSKLEPG 2000
GKYHIIVQLG NMSKDSSIKI TTVSLSAPDA LKIITENDHV LLFWKSLALK 2050
EKQFNETRGY EIHMSDSAVN LTAYLGNTTD NFFKVSNLKM GHNYTFTVQA 2100
RCLFGSQICG EPAVLLYDEL SSGADAAVIQ AARSTDVAAV VVPILFLILL 2150
SLGVGFAILY TKHRRLQSSF SAFANSHYSS RLGSAIFSSG DDLGEDDEDA 2200
PMITGFSDDV PMVIA 2215
Length:2,215
Mass (Da):247,086
Last modified:July 27, 2011 - v3
Checksum:i5D7F53806EFE2CB0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti706 – 7061S → F in AAC16739. 1 Publication
Sequence conflicti768 – 7681S → F in AAC16739. 1 Publication
Sequence conflicti785 – 7851S → W in BAA31219. 1 Publication
Sequence conflicti796 – 7961D → G in AAC16739. 1 Publication
Sequence conflicti953 – 9531R → G in BAA31219. 1 Publication
Sequence conflicti1268 – 12692EQ → DE in BAA31219. 1 Publication
Sequence conflicti1425 – 14251H → A in BAA31219. 1 Publication
Sequence conflicti1425 – 14251H → R in AAC16739. 1 Publication
Sequence conflicti1425 – 14251H → R in CAA72732. 1 Publication
Sequence conflicti1468 – 14681F → L in BAA31219. 1 Publication
Sequence conflicti1468 – 14681F → L in AAC16739. 1 Publication
Sequence conflicti1468 – 14681F → L in CAA72732. 1 Publication
Sequence conflicti1663 – 16631S → R in BAA31219. 1 Publication
Sequence conflicti1663 – 16631S → R in AAC16739. 1 Publication
Sequence conflicti1663 – 16631S → R in CAA72732. 1 Publication
Sequence conflicti1709 – 17135EIKNL → KKKKK in CAA72732. 1 Publication
Sequence conflicti1807 – 18071R → K in BAA31219. 1 Publication
Sequence conflicti1807 – 18071R → K in AAC16739. 1 Publication
Sequence conflicti2130 – 21301Q → H in BAA31219. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015790 mRNA. Translation: BAA31219.1.
AK147303 mRNA. Translation: BAE27834.1.
AF031816 mRNA. Translation: AAC16739.1.
Y12004 mRNA. Translation: CAA72732.1.
CCDSiCCDS40594.1.
PIRiT00348.
RefSeqiNP_035566.2. NM_011436.3.
UniGeneiMm.121920.

Genome annotation databases

EnsembliENSMUST00000060989; ENSMUSP00000058613; ENSMUSG00000049313.
GeneIDi20660.
KEGGimmu:20660.
UCSCiuc009pap.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015790 mRNA. Translation: BAA31219.1 .
AK147303 mRNA. Translation: BAE27834.1 .
AF031816 mRNA. Translation: AAC16739.1 .
Y12004 mRNA. Translation: CAA72732.1 .
CCDSi CCDS40594.1.
PIRi T00348.
RefSeqi NP_035566.2. NM_011436.3.
UniGenei Mm.121920.

3D structure databases

ProteinModelPortali O88307.
SMRi O88307. Positions 1156-1193, 1651-1745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-42439N.
MINTi MINT-1342356.

PTM databases

PhosphoSitei O88307.

Proteomic databases

MaxQBi O88307.
PaxDbi O88307.
PRIDEi O88307.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060989 ; ENSMUSP00000058613 ; ENSMUSG00000049313 .
GeneIDi 20660.
KEGGi mmu:20660.
UCSCi uc009pap.1. mouse.

Organism-specific databases

CTDi 6653.
MGIi MGI:1202296. Sorl1.

Phylogenomic databases

eggNOGi NOG281049.
GeneTreei ENSGT00510000046443.
HOGENOMi HOG000007009.
HOVERGENi HBG017830.
InParanoidi Q3UHM3.
OMAi TNVYISS.
OrthoDBi EOG7FV3PK.
TreeFami TF324918.

Miscellaneous databases

NextBioi 299101.
PROi O88307.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88307.
Bgeei O88307.
Genevestigatori O88307.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
2.60.40.10. 4 hits.
4.10.400.10. 11 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR006581. VPS10.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00057. Ldl_recept_a. 10 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00060. FN3. 6 hits.
SM00192. LDLa. 11 hits.
SM00135. LY. 5 hits.
SM00602. VPS10. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
SSF57424. SSF57424. 11 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50853. FN3. 4 hits.
PS01209. LDLRA_1. 10 hits.
PS50068. LDLRA_2. 11 hits.
PS51120. LDLRB. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex."
    Hermans-Borgmeyer I., Hampe W., Schinke B., Methner A., Nykjaer A., Suesens U., Fenger U., Herbarth B., Schaller H.C.
    Mech. Dev. 70:65-76(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-2215.
    Tissue: Brain.
  4. Boehmelt G., Antonio L., Iscove N.N.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1119-1713.
    Strain: Swiss Webster.
  5. "LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration."
    Zhu Y., Bujo H., Yamazaki H., Ohwaki K., Jiang M., Hirayama S., Kanaki T., Shibasaki M., Takahashi K., Schneider W.J., Saito Y.
    Circ. Res. 94:752-758(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: INTERACTION WITH APP.

Entry informationi

Entry nameiSORL_MOUSE
AccessioniPrimary (citable) accession number: O88307
Secondary accession number(s): O54711, O70581, Q3UHM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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