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Protein

Guanine nucleotide-binding protein subunit alpha-15

Gene

Gna15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561MagnesiumBy similarity
Metal bindingi189 – 1891MagnesiumBy similarity
Binding sitei346 – 3461GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 568GTPBy similarity
Nucleotide bindingi183 – 1897GTPBy similarity
Nucleotide bindingi208 – 2125GTPBy similarity
Nucleotide bindingi277 – 2804GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • signal transducer activity Source: RGD

GO - Biological processi

  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-15
Short name:
G alpha-15
Short name:
G-protein subunit alpha-15
Gene namesi
Name:Gna15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619751. Gna15.

Subcellular locationi

GO - Cellular componenti

  • heterotrimeric G-protein complex Source: RGD
  • membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Guanine nucleotide-binding protein subunit alpha-15PRO_0000203758Add
BLAST

Proteomic databases

PaxDbiO88302.
PRIDEiO88302.

PTM databases

iPTMnetiO88302.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007202.

Structurei

3D structure databases

ProteinModelPortaliO88302.
SMRiO88302. Positions 42-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0085. Eukaryota.
ENOG410XNVQ. LUCA.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiO88302.
KOiK04637.
PhylomeDBiO88302.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

O88302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSLTWGCC PWCLTEEEKT AARIDQEINK ILLEQKKQER GELKLLLLGP
60 70 80 90 100
GESGKSTFIK QMRIIHGAGY SEEDRRAFRL LVYQNIFVSM QAMIEAMDRL
110 120 130 140 150
QIPFSRPDSK QHASLVMTQD PYKVSSFEKP YAVAMQYLWR DAGIRACYER
160 170 180 190 200
RREFHLLDSA VYYLSHLERI AEDDYIPTAQ DVLRSRMPTT GINEYCFSVQ
210 220 230 240 250
KTKLRIVDAG GQKSERKKWI HCFENVIALI YLASLSEYDQ CLEENSQENR
260 270 280 290 300
MKESLALFST ILELPWFKST SVILFLNKTD ILEDKIHTSH LASYFPSFQG
310 320 330 340 350
PRRDAEAAKR FILDMYARVY ASCAEPHDGG RKGSRARRLF AHFTCATDTH
360 370
SVRSVFKDVR DSVLARYLDE INLL
Length:374
Mass (Da):43,332
Last modified:November 1, 1998 - v1
Checksum:iE5E65D32D41EC0EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015308 mRNA. Translation: BAA28827.1.
RefSeqiNP_445994.1. NM_053542.1.
UniGeneiRn.3574.

Genome annotation databases

GeneIDi89788.
KEGGirno:89788.
UCSCiRGD:619751. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015308 mRNA. Translation: BAA28827.1.
RefSeqiNP_445994.1. NM_053542.1.
UniGeneiRn.3574.

3D structure databases

ProteinModelPortaliO88302.
SMRiO88302. Positions 42-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007202.

PTM databases

iPTMnetiO88302.

Proteomic databases

PaxDbiO88302.
PRIDEiO88302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi89788.
KEGGirno:89788.
UCSCiRGD:619751. rat.

Organism-specific databases

CTDi2769.
RGDi619751. Gna15.

Phylogenomic databases

eggNOGiKOG0085. Eukaryota.
ENOG410XNVQ. LUCA.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiO88302.
KOiK04637.
PhylomeDBiO88302.

Miscellaneous databases

PROiO88302.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Identification of two alpha-subunit species of GTP-binding proteins, G alpha 15 and G alpha q, expressed in rat taste buds."
    Kusakabe Y., Yamaguchi E., Tanemura K., Kameyama K., Chiba N., Arai S., Emori Y., Abe K.
    Biochim. Biophys. Acta 1403:265-272(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGNA15_RAT
AccessioniPrimary (citable) accession number: O88302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.