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Protein

Blood group Rh(D) polypeptide

Gene

Rhd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
Erythrocyte membrane glycoprotein Rh30
CD_antigen: CD240D
Gene namesi
Name:Rhd
Synonyms:Rh30, Rhced
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620451. Rhd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13523HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15923HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26623HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 422421Blood group Rh(D) polypeptidePRO_0000383327Add
BLAST

Proteomic databases

PaxDbiO88298.
PRIDEiO88298.

Expressioni

Gene expression databases

GenevisibleiO88298. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023187.

Structurei

3D structure databases

ProteinModelPortaliO88298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
InParanoidiO88298.
KOiK06579.
OMAiFAMLXVC.
OrthoDBiEOG73NG3C.
PhylomeDBiO88298.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKYPRSLR CCLPLWAFGL QVTFILLFYF LIGQDPIQAD HKFMAIYQVI
60 70 80 90 100
QDLTLVAALG FGFLSSSFRR HGWSSVAFSF FMLALGVQGT ILLDYFLNWV
110 120 130 140 150
LDWNMIKNPF SPFLSIQRAT ISTLPLLISA GAVLGKVNLV QLAVMVLVEA
160 170 180 190 200
MTFGAIRVAD KKVFRIEDHI IMMYGHVFGA YFGLTVAWWL SKSLPRRRHE
210 220 230 240 250
NAQTEKVQMT TSSSLFAMLG TLFLWIFWPS INSALLEGTK KKNAVFNTYY
260 270 280 290 300
ALAVSTVTAT SMSALSHPKG KINMVHIHNA VLAGGVAVGA PSCLISSPWI
310 320 330 340 350
AMVLGLTAGL ISIWGAKCPQ VCLSDLLLNP SGIHYTFGLP GLLGALTYYC
360 370 380 390 400
LHIIAESRPS NLWIVTQTIT DVGALSFAMA MGMVTGLLTG CLLSVKVWRA
410 420
PHAVKYFDDQ AFWEFPHLAV EF
Length:422
Mass (Da):46,583
Last modified:November 1, 1998 - v1
Checksum:i3039E4C72464E66A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015191 mRNA. Translation: BAA32440.1.
AF531096 mRNA. Translation: AAQ10013.1.
BC127471 mRNA. Translation: AAI27472.1.
RefSeqiNP_071950.1. NM_022505.2.
UniGeneiRn.1943.

Genome annotation databases

EnsembliENSRNOT00000023187; ENSRNOP00000023187; ENSRNOG00000017130.
GeneIDi60414.
KEGGirno:60414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015191 mRNA. Translation: BAA32440.1.
AF531096 mRNA. Translation: AAQ10013.1.
BC127471 mRNA. Translation: AAI27472.1.
RefSeqiNP_071950.1. NM_022505.2.
UniGeneiRn.1943.

3D structure databases

ProteinModelPortaliO88298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023187.

Proteomic databases

PaxDbiO88298.
PRIDEiO88298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023187; ENSRNOP00000023187; ENSRNOG00000017130.
GeneIDi60414.
KEGGirno:60414.

Organism-specific databases

CTDi6007.
RGDi620451. Rhd.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
InParanoidiO88298.
KOiK06579.
OMAiFAMLXVC.
OrthoDBiEOG73NG3C.
PhylomeDBiO88298.
TreeFamiTF314450.

Miscellaneous databases

PROiO88298.

Gene expression databases

GenevisibleiO88298. RN.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene."
    Kitano T., Sumiyama K., Shiroishi T., Saitou N.
    Biochem. Biophys. Res. Commun. 249:78-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. "Evolutionary conservation and diversification of Rh family genes and proteins."
    Huang C.-H., Peng J.
    Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiRHD_RAT
AccessioniPrimary (citable) accession number: O88298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.