UniProtKB - O88286 (WIZ_MOUSE)
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Protein
Protein Wiz
Gene
Wiz
Organism
Mus musculus (Mouse)
Status
Functioni
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 308 – 330 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 454 – 477 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 734 – 756 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 802 – 824 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 903 – 925 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1076 – 1098 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1260 – 1282 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1430 – 1452 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1629 – 1655 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
- SET domain binding Source: UniProtKB
GO - Biological processi
- positive regulation of nuclear cell cycle DNA replication Source: MGI
- protein heterotrimerization Source: UniProtKB
- protein stabilization Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein WizAlternative name(s): Widely-interspaced zinc finger-containing protein |
Gene namesi | Name:Wiz |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1332638. Wiz. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1631 | C → A: Impairs interaction with EHMT1 and EHMT2. 1 Publication | 1 | |
Mutagenesisi | 1651 | H → A: Impairs interaction with EHMT1 and EHMT2. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286055 | 1 – 1684 | Protein WizAdd BLAST | 1684 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 916 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 972 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 988 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1000 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1021 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1029 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1031 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 1033 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1038 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1039 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1045 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1049 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1050 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1058 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1089 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1112 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1139 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1141 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1145 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1155 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1160 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1167 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1171 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1172 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1179 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1184 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1195 | N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity | 1 | |
Modified residuei | 1195 | N6,N6-dimethyllysine; by EHMT2; alternateBy similarity | 1 | |
Cross-linki | 1210 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1273 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1296 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1315 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1342 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1347 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1376 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1389 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1403 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1405 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1415 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1481 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1497 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1510 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1550 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1556 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 1556 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 1567 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1593 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1663 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O88286. |
MaxQBi | O88286. |
PaxDbi | O88286. |
PeptideAtlasi | O88286. |
PRIDEi | O88286. |
PTM databases
iPTMneti | O88286. |
PhosphoSitePlusi | O88286. |
Expressioni
Tissue specificityi
According to PubMed:9795207, isoform L and isoform S are brain-specific. According to PubMed:16702210, isoform S is ubiquitously expressed.2 Publications
Developmental stagei
Isoform L and isoform S are expressed in brain from E14 to adulthood, with highest levels in the perinatal period. At embryonic stages, isoform L seems to be excluded from cerebellum.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000024050. |
CleanExi | MM_WIZ. |
ExpressionAtlasi | O88286. baseline and differential. |
Genevisiblei | O88286. MM. |
Interactioni
Subunit structurei
Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Interacts with EHMT1, EHMT2, CTBP1 and CTBP2.By similarity1 Publication
GO - Molecular functioni
- SET domain binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 204563. 29 interactors. |
IntActi | O88286. 27 interactors. |
MINTi | O88286. |
STRINGi | 10090.ENSMUSP00000069443. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1063 – 1067 | Interaction with CTBP1 and CTBP2 11 Publication | 5 | |
Regioni | 1247 – 1251 | Interaction with CTBP1 and CTBP2 21 Publication | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 299 – 304 | Poly-Glu | 6 | |
Compositional biasi | 601 – 608 | Poly-Glu | 8 | |
Compositional biasi | 658 – 663 | Poly-Gln | 6 | |
Compositional biasi | 786 – 790 | Poly-Lys | 5 | |
Compositional biasi | 1174 – 1177 | Poly-Pro | 4 |
Domaini
The C2H2-type zinc finger 10 mediates interaction with EHMT1 and EHMT2.
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 308 – 330 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 454 – 477 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 734 – 756 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 802 – 824 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 903 – 925 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1076 – 1098 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1260 – 1282 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1430 – 1452 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1629 – 1655 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721. Eukaryota. COG5048. LUCA. |
GeneTreei | ENSGT00530000063587. |
HOGENOMi | HOG000154859. |
HOVERGENi | HBG108678. |
InParanoidi | O88286. |
OMAi | HFGLECS. |
PhylomeDBi | O88286. |
TreeFami | TF333705. |
Family and domain databases
InterProi | View protein in InterPro IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type. |
SMARTi | View protein in SMART SM00355. ZnF_C2H2. 11 hits. |
SUPFAMi | SSF57667. SSF57667. 5 hits. |
PROSITEi | View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform L (identifier: O88286-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG
60 70 80 90 100
PRDILDGRSG ISDGQPHPGL SEALPRATSA THRISSCYWD GDSLDFQPGS
110 120 130 140 150
PPPHLLGPFP ASLDVQGSWE HPMVQEAREG TPSEQRFKDS VIVRTMKPYA
160 170 180 190 200
KLKGSRKFLH HQGEVKFLEK YSPSHHKFDW LQDTDEQGPL KDTGLHLDLP
210 220 230 240 250
AQPPTVTSFR RVIVPVDNTP KTLDMEVMGT REDLEDFGQV AQPSEWGLHT
260 270 280 290 300
SASEVATQTW TVNSEASVER LQPLLSPVQT GPYLCELLQE VAGGVDSNEE
310 320 330 340 350
EEEEPAVFPC IECSIYFKHK EHLLEHMSQH RRAPGQEPPA DLAPLACSEC
360 370 380 390 400
GWAFTEPTAL EQHWQLHQAS REKIIEEIQK LKQFPGDEGR EARLQCSKCV
410 420 430 440 450
FGTNSSRAFM QHAKLHVRGS LPSRQATEPF RGGSPVLDVS TLVYPSYGDS
460 470 480 490 500
SGLNTCVHCG FTAPSKSLLR EHTRLVHAHH AHWEEVGEAF EDLTSQPCTS
510 520 530 540 550
QDAYTHSPDT ATVDYFSKSE PLLASVWQEN PSGYDPDLAF GPDYQQPGMR
560 570 580 590 600
NFPLLNSGQQ SLGKLAFPSP MASASYSIQR NRNKSTVHLQ RMEDKSHLWS
610 620 630 640 650
EEEEEEDEDV VLTSERDFTP ENGAFPPLAI PSLIPQPALE LKQTFQDALQ
660 670 680 690 700
AVDASETQQQ QLQGMVPIVL MAKLRPQVIA ATTRASPQLP PEEPELRSTH
710 720 730 740 750
PLDFLLLDAP LGGSLGLNTL LEGDPAMALK HEERKCPYCP DRFHYGIGLA
760 770 780 790 800
NHVRGHLNRV GVSYNVRHFI SAEEVKAIER RFSFQKKKKK VANFDPGTFS
810 820 830 840 850
LMRCDFCGAG FDTRAGLSSH ARAHLRDFGI TNWELTISPI NILQELLATS
860 870 880 890 900
AAELPPSPLG REPGGPPRSF LTSRRPRLPL TMPFPPTWAE DPGPIYGDAQ
910 920 930 940 950
SLTTCEVCGA CFETRKGLSS HARSHLRQLG VAESESSGAP IDLLYELVKQ
960 970 980 990 1000
KGLPDAPLGL TPSLTKKSNS PKEFLAGAAR PGLLTLAKPM DAPAVNKAIK
1010 1020 1030 1040 1050
SPPGFSAKGL THPSSSPLLK KAPLTLAGSP TPKNPEDKSP QLSLSPRPTS
1060 1070 1080 1090 1100
PKAQWPQSED EGPLNLTSGP EPTRDIRCEF CGEFFENRKG LSSHARSHLR
1110 1120 1130 1140 1150
QMGVTEWYVN GSPIDTLREI LKRRTQSRPG GHLHPPGPSP KALAKVLSTG
1160 1170 1180 1190 1200
GPGSSLEARS PSDLHISPLT KKLPPPPGSP LGHSPTASPP PTARKMFSGL
1210 1220 1230 1240 1250
ATPSLPKKLK PEHMRVEIKR EMLPGTLHGE PHPSEGPWGT PREDMAPLNL
1260 1270 1280 1290 1300
SARAEPVRDI RCEFCGEFFE NRKGLSSHAR SHLRQMGVTE WSVNGSPIDT
1310 1320 1330 1340 1350
LREILKKKSK LCLIKKEPPA GDLAPALTED GSPTAAPGAL HSPLPLSPLA
1360 1370 1380 1390 1400
SRPGKPGAGP TQVPRELSLS PITGSKPSAA SYLGPVATKR PLQEDRFLPA
1410 1420 1430 1440 1450
EVKAKTYIQT ELPFKAKTLH EKTSHSSTEA CCELCGLYFE NRKALASHAR
1460 1470 1480 1490 1500
AHLRQFGVTE WCVNGSPIET LSEWIKHRPQ KVGAYRSYIQ GGRPFTKKFR
1510 1520 1530 1540 1550
SAGHGRDSDK RPPLGLAPGG LSLVGRSAGG EPGLEAGRAA DSGERPLATS
1560 1570 1580 1590 1600
PPGTVKSEEH QRQNINKFER RQARPSDASA ARGGEEVNDL QQKLEEVRQP
1610 1620 1630 1640 1650
PPRVRPVPSL VPRPPQTSLV KFVGNIYTLK CRFCEVEFQG PLSIQEEWVR
1660 1670 1680
HLQRHILEMN FSKADPPPEE PQAPQAQTAA VEAP
Isoform 2 (identifier: O88286-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-759: Missing.
760-789: VGVSYNVRHFISAEEVKAIERRFSFQKKKK → MAEVAFLMGSPILASAKPSPVPPPPPIGSA
898-898: D → DGLCSEENTMVAMDLGSPLLPKKSLPVSGTLEQVASRLSSKVAAEVPHGSKQELPDLK
Note: No experimental confirmation available.
Show »Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 492 | D → G in BAA32790 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 868 | R → G in BAA32790 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 868 | R → G in BAA32791 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 1020 | K → N in AAH53035 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1052 | K → R in BAA32790 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 1052 | K → R in BAA32791 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 1055 | W → C in BAA32790 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 1055 | W → C in BAA32791 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 1252 | Missing in BAA32790 (PubMed:9795207).Curated | 1 | |
Sequence conflicti | 1252 | Missing in BAA32791 (PubMed:9795207).Curated | 1 |
Polymorphismi
C57BL/6J and C57BR/cdJ mice specifically present an insertion of a type II early transposon in the opposite orientation into exon 6. This results in a strong reduction in the protein levels of isoform L.1 Publication
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024953 | 1 – 759 | Missing in isoform 2. 1 PublicationAdd BLAST | 759 | |
Alternative sequenceiVSP_024954 | 63 – 790 | Missing in isoform S. 2 PublicationsAdd BLAST | 728 | |
Alternative sequenceiVSP_024955 | 745 – 798 | YGIGL…FDPGT → NGIVLRPPAARNVNGSTEKA ARAVREESRRGKRRNVAKTV TLIKAQILLLRHQL in isoform 3. 1 PublicationAdd BLAST | 54 | |
Alternative sequenceiVSP_024956 | 760 – 789 | VGVSY…QKKKK → MAEVAFLMGSPILASAKPSP VPPPPPIGSA in isoform 2. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_024957 | 799 – 1684 | Missing in isoform 3. 1 PublicationAdd BLAST | 886 | |
Alternative sequenceiVSP_024958 | 898 | D → DGLCSEENTMVAMDLGSPLL PKKSLPVSGTLEQVASRLSS KVAAEVPHGSKQELPDLK in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012265 mRNA. Translation: BAA32790.1. AB012266 mRNA. Translation: BAA32791.1. AB255388 mRNA. Translation: BAE93139.1. AK004274 mRNA. Translation: BAB23245.1. AK133564 mRNA. Translation: BAE21728.1. BC053035 mRNA. Translation: AAH53035.1. |
CCDSi | CCDS28617.2. [O88286-2] |
PIRi | T00247. T00248. |
RefSeqi | NP_035847.2. NM_011717.4. NP_997603.3. NM_212438.3. [O88286-2] XP_017172890.1. XM_017317401.1. [O88286-2] |
UniGenei | Mm.274948. |
Genome annotation databases
Ensembli | ENSMUST00000064694; ENSMUSP00000069443; ENSMUSG00000024050. [O88286-2] |
GeneIDi | 22404. |
KEGGi | mmu:22404. |
UCSCi | uc008bwn.2. mouse. [O88286-2] uc008bwq.2. mouse. [O88286-3] uc008bwt.2. mouse. [O88286-4] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | WIZ_MOUSE | |
Accessioni | O88286Primary (citable) accession number: O88286 Secondary accession number(s): O88287 Q9CT89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | March 28, 2018 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |