Wiz

Functionⁱ

May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization.1 Publication

Regions

Feature key	Position(s)	Length	Description	Actions
Zinc fingerⁱ	308 – 330	23	C2H2-type 1PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	345 – 367	23	C2H2-type 2PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	454 – 477	24	C2H2-type 3PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	734 – 756	23	C2H2-type 4PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	802 – 824	23	C2H2-type 5PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	903 – 925	23	C2H2-type 6PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1076 – 1098	23	C2H2-type 7PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1260 – 1282	23	C2H2-type 8PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1430 – 1452	23	C2H2-type 9PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1629 – 1655	27	C2H2-type 10PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
SET domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16702210

GO - Biological processⁱ

positive regulation of nuclear cell cycle DNA replication Source: MGI
protein heterotrimerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16702210
protein stabilization
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 16702210

Complete GO annotation...

Keywords - Ligandⁱ

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Wiz Alternative name(s): Widely-interspaced zinc finger-containing protein
Gene namesⁱ	Name:Wiz
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1332638. Wiz.

Subcellular locationⁱ

Nucleus
1 Publication
Manual assertion based on experiment inⁱ
- Ref.2
  "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."
  Ueda J., Tachibana M., Ikura T., Shinkai Y.
  J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM S), FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EHMT1; EHMT2; CTBP1 AND CTBP2, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-1631 AND HIS-1651.

GO - Cellular componentⁱ

extracellular exosome Source: MGI
nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 16702210

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Mutagenesisⁱ	1631 – 1631	1	C → A: Impairs interaction with EHMT1 and EHMT2. 1 Publication Manual assertion based on experiment inⁱ Ref.2 "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP." Ueda J., Tachibana M., Ikura T., Shinkai Y. J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM S), FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EHMT1; EHMT2; CTBP1 AND CTBP2, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-1631 AND HIS-1651.
Mutagenesisⁱ	1651 – 1651	1	H → A: Impairs interaction with EHMT1 and EHMT2. 1 Publication Manual assertion based on experiment inⁱ Ref.2 "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP." Ueda J., Tachibana M., Ikura T., Shinkai Y. J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM S), FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EHMT1; EHMT2; CTBP1 AND CTBP2, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-1631 AND HIS-1651.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 1684	1684	Protein Wiz		PRO_0000286055	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Cross-linkⁱ	972 – 972		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1021 – 1021		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1029 – 1029	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1031 – 1031	1	PhosphothreonineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1039 – 1039	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039; SER-1045; THR-1049; SER-1050; SER-1179 AND SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	1045 – 1045	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045 AND THR-1049, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039; SER-1045; THR-1049; SER-1050; SER-1179 AND SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	1049 – 1049	1	PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045 AND THR-1049, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039; SER-1045; THR-1049; SER-1050; SER-1179 AND SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	1050 – 1050	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039; SER-1045; THR-1049; SER-1050; SER-1179 AND SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	1058 – 1058	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1112 – 1112	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1139 – 1139	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1141 – 1141		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1145 – 1145		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1155 – 1155	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1160 – 1160	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1167 – 1167	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1179 – 1179	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039; SER-1045; THR-1049; SER-1050; SER-1179 AND SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	1184 – 1184	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039; SER-1045; THR-1049; SER-1050; SER-1179 AND SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	1195 – 1195	1	N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity
Modified residueⁱ	1195 – 1195	1	N6,N6-dimethyllysine; by EHMT2; alternateBy similarity
Cross-linkⁱ	1210 – 1210		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1296 – 1296	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1315 – 1315		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1342 – 1342	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1347 – 1347	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1376 – 1376		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1389 – 1389		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1403 – 1403		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1405 – 1405		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1415 – 1415		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1481 – 1481		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1510 – 1510		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Modified residueⁱ	1550 – 1550	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1556 – 1556		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)
Cross-linkⁱ	1556 – 1556		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O95785 (WIZ_HUMAN)

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O88286.
MaxQBⁱ	O88286.
PaxDbⁱ	O88286.
PeptideAtlasⁱ	O88286.
PRIDEⁱ	O88286.

PTM databases

iPTMnetⁱ	O88286.
PhosphoSiteⁱ	O88286.

Expressionⁱ

Tissue specificityⁱ

According to PubMed:9795207, isoform L and isoform S are brain-specific. According to PubMed:16702210, isoform S is ubiquitously expressed.2 Publications

Developmental stageⁱ

Isoform L and isoform S are expressed in brain from E14 to adulthood, with highest levels in the perinatal period. At embryonic stages, isoform L seems to be excluded from cerebellum.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000024050.
CleanExⁱ	MM_WIZ.
ExpressionAtlasⁱ	O88286. baseline and differential.
Genevisibleⁱ	O88286. MM.

Interactionⁱ

Subunit structureⁱ

Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Interacts with EHMT1, EHMT2, CTBP1 and CTBP2.By similarity1 Publication

GO - Molecular functionⁱ

SET domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16702210

Protein-protein interaction databases

BioGridⁱ	204563. 28 interactions.
IntActⁱ	O88286. 26 interactions.
MINTⁱ	MINT-4105440.
STRINGⁱ	10090.ENSMUSP00000069443.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88286.
SMRⁱ	O88286. Positions 301-372, 391-425, 445-484, 730-759, 787-827.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Regionⁱ	1063 – 1067	5	Interaction with CTBP1 and CTBP2 1
Regionⁱ	1247 – 1251	5	Interaction with CTBP1 and CTBP2 2

Compositional bias

Feature key	Position(s)	Length	Description
Compositional biasⁱ	299 – 304	6	Poly-Glu
Compositional biasⁱ	601 – 608	8	Poly-Glu
Compositional biasⁱ	658 – 663	6	Poly-Gln
Compositional biasⁱ	786 – 790	5	Poly-Lys
Compositional biasⁱ	1174 – 1177	4	Poly-Pro

Domainⁱ

The C2H2-type zinc finger 10 mediates interaction with EHMT1 and EHMT2.

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	Length	Description	Actions
Zinc fingerⁱ	308 – 330	23	C2H2-type 1PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	345 – 367	23	C2H2-type 2PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	454 – 477	24	C2H2-type 3PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	734 – 756	23	C2H2-type 4PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	802 – 824	23	C2H2-type 5PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	903 – 925	23	C2H2-type 6PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1076 – 1098	23	C2H2-type 7PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1260 – 1282	23	C2H2-type 8PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1430 – 1452	23	C2H2-type 9PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	1629 – 1655	27	C2H2-type 10PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
GeneTreeⁱ	ENSGT00530000063587.
HOGENOMⁱ	HOG000154859.
HOVERGENⁱ	HBG108678.
InParanoidⁱ	O88286.
OMAⁱ	LTMPFPP.
PhylomeDBⁱ	O88286.
TreeFamⁱ	TF333705.

Family and domain databases

InterProⁱ	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
SMARTⁱ	SM00355. ZnF_C2H2. 11 hits. [Graphical view]
PROSITEⁱ	PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform L (identifier: O88286-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG 
        60         70         80         90        100
PRDILDGRSG ISDGQPHPGL SEALPRATSA THRISSCYWD GDSLDFQPGS 
       110        120        130        140        150
PPPHLLGPFP ASLDVQGSWE HPMVQEAREG TPSEQRFKDS VIVRTMKPYA 
       160        170        180        190        200
KLKGSRKFLH HQGEVKFLEK YSPSHHKFDW LQDTDEQGPL KDTGLHLDLP 
       210        220        230        240        250
AQPPTVTSFR RVIVPVDNTP KTLDMEVMGT REDLEDFGQV AQPSEWGLHT 
       260        270        280        290        300
SASEVATQTW TVNSEASVER LQPLLSPVQT GPYLCELLQE VAGGVDSNEE 
       310        320        330        340        350
EEEEPAVFPC IECSIYFKHK EHLLEHMSQH RRAPGQEPPA DLAPLACSEC 
       360        370        380        390        400
GWAFTEPTAL EQHWQLHQAS REKIIEEIQK LKQFPGDEGR EARLQCSKCV 
       410        420        430        440        450
FGTNSSRAFM QHAKLHVRGS LPSRQATEPF RGGSPVLDVS TLVYPSYGDS 
       460        470        480        490        500
SGLNTCVHCG FTAPSKSLLR EHTRLVHAHH AHWEEVGEAF EDLTSQPCTS 
       510        520        530        540        550
QDAYTHSPDT ATVDYFSKSE PLLASVWQEN PSGYDPDLAF GPDYQQPGMR 
       560        570        580        590        600
NFPLLNSGQQ SLGKLAFPSP MASASYSIQR NRNKSTVHLQ RMEDKSHLWS 
       610        620        630        640        650
EEEEEEDEDV VLTSERDFTP ENGAFPPLAI PSLIPQPALE LKQTFQDALQ 
       660        670        680        690        700
AVDASETQQQ QLQGMVPIVL MAKLRPQVIA ATTRASPQLP PEEPELRSTH 
       710        720        730        740        750
PLDFLLLDAP LGGSLGLNTL LEGDPAMALK HEERKCPYCP DRFHYGIGLA 
       760        770        780        790        800
NHVRGHLNRV GVSYNVRHFI SAEEVKAIER RFSFQKKKKK VANFDPGTFS 
       810        820        830        840        850
LMRCDFCGAG FDTRAGLSSH ARAHLRDFGI TNWELTISPI NILQELLATS 
       860        870        880        890        900
AAELPPSPLG REPGGPPRSF LTSRRPRLPL TMPFPPTWAE DPGPIYGDAQ 
       910        920        930        940        950
SLTTCEVCGA CFETRKGLSS HARSHLRQLG VAESESSGAP IDLLYELVKQ 
       960        970        980        990       1000
KGLPDAPLGL TPSLTKKSNS PKEFLAGAAR PGLLTLAKPM DAPAVNKAIK 
      1010       1020       1030       1040       1050
SPPGFSAKGL THPSSSPLLK KAPLTLAGSP TPKNPEDKSP QLSLSPRPTS 
      1060       1070       1080       1090       1100
PKAQWPQSED EGPLNLTSGP EPTRDIRCEF CGEFFENRKG LSSHARSHLR 
      1110       1120       1130       1140       1150
QMGVTEWYVN GSPIDTLREI LKRRTQSRPG GHLHPPGPSP KALAKVLSTG 
      1160       1170       1180       1190       1200
GPGSSLEARS PSDLHISPLT KKLPPPPGSP LGHSPTASPP PTARKMFSGL 
      1210       1220       1230       1240       1250
ATPSLPKKLK PEHMRVEIKR EMLPGTLHGE PHPSEGPWGT PREDMAPLNL 
      1260       1270       1280       1290       1300
SARAEPVRDI RCEFCGEFFE NRKGLSSHAR SHLRQMGVTE WSVNGSPIDT 
      1310       1320       1330       1340       1350
LREILKKKSK LCLIKKEPPA GDLAPALTED GSPTAAPGAL HSPLPLSPLA 
      1360       1370       1380       1390       1400
SRPGKPGAGP TQVPRELSLS PITGSKPSAA SYLGPVATKR PLQEDRFLPA 
      1410       1420       1430       1440       1450
EVKAKTYIQT ELPFKAKTLH EKTSHSSTEA CCELCGLYFE NRKALASHAR 
      1460       1470       1480       1490       1500
AHLRQFGVTE WCVNGSPIET LSEWIKHRPQ KVGAYRSYIQ GGRPFTKKFR 
      1510       1520       1530       1540       1550
SAGHGRDSDK RPPLGLAPGG LSLVGRSAGG EPGLEAGRAA DSGERPLATS 
      1560       1570       1580       1590       1600
PPGTVKSEEH QRQNINKFER RQARPSDASA ARGGEEVNDL QQKLEEVRQP 
      1610       1620       1630       1640       1650
PPRVRPVPSL VPRPPQTSLV KFVGNIYTLK CRFCEVEFQG PLSIQEEWVR 
      1660       1670       1680 
HLQRHILEMN FSKADPPPEE PQAPQAQTAA VEAP

Length:1,684

Mass (Da):184,291

Last modified:May 1, 2007 - v2

Checksum:ⁱ67BA8AC25A97DDEB

GO

Isoform S (identifier: O88286-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
63-790: Missing.

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        10         20         30         40         50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG 
        60         70         80         90        100
PRDILDGRSG ISVANFDPGT FSLMRCDFCG AGFDTRAGLS SHARAHLRDF 
       110        120        130        140        150
GITNWELTIS PINILQELLA TSAAELPPSP LGREPGGPPR SFLTSRRPRL 
       160        170        180        190        200
PLTMPFPPTW AEDPGPIYGD AQSLTTCEVC GACFETRKGL SSHARSHLRQ 
       210        220        230        240        250
LGVAESESSG APIDLLYELV KQKGLPDAPL GLTPSLTKKS NSPKEFLAGA 
       260        270        280        290        300
ARPGLLTLAK PMDAPAVNKA IKSPPGFSAK GLTHPSSSPL LKKAPLTLAG 
       310        320        330        340        350
SPTPKNPEDK SPQLSLSPRP TSPKAQWPQS EDEGPLNLTS GPEPTRDIRC 
       360        370        380        390        400
EFCGEFFENR KGLSSHARSH LRQMGVTEWY VNGSPIDTLR EILKRRTQSR 
       410        420        430        440        450
PGGHLHPPGP SPKALAKVLS TGGPGSSLEA RSPSDLHISP LTKKLPPPPG 
       460        470        480        490        500
SPLGHSPTAS PPPTARKMFS GLATPSLPKK LKPEHMRVEI KREMLPGTLH 
       510        520        530        540        550
GEPHPSEGPW GTPREDMAPL NLSARAEPVR DIRCEFCGEF FENRKGLSSH 
       560        570        580        590        600
ARSHLRQMGV TEWSVNGSPI DTLREILKKK SKLCLIKKEP PAGDLAPALT 
       610        620        630        640        650
EDGSPTAAPG ALHSPLPLSP LASRPGKPGA GPTQVPRELS LSPITGSKPS 
       660        670        680        690        700
AASYLGPVAT KRPLQEDRFL PAEVKAKTYI QTELPFKAKT LHEKTSHSST 
       710        720        730        740        750
EACCELCGLY FENRKALASH ARAHLRQFGV TEWCVNGSPI ETLSEWIKHR 
       760        770        780        790        800
PQKVGAYRSY IQGGRPFTKK FRSAGHGRDS DKRPPLGLAP GGLSLVGRSA 
       810        820        830        840        850
GGEPGLEAGR AADSGERPLA TSPPGTVKSE EHQRQNINKF ERRQARPSDA 
       860        870        880        890        900
SAARGGEEVN DLQQKLEEVR QPPPRVRPVP SLVPRPPQTS LVKFVGNIYT 
       910        920        930        940        950
LKCRFCEVEF QGPLSIQEEW VRHLQRHILE MNFSKADPPP EEPQAPQAQT 

AAVEAP

Show »

Length:956

Mass (Da):103,003

Checksum:ⁱ4DDE4A816FC04D65

GO

Isoform 2 (identifier: O88286-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-759: Missing.
     760-789: VGVSYNVRHFISAEEVKAIERRFSFQKKKK → MAEVAFLMGSPILASAKPSPVPPPPPIGSA
     898-898: D → DGLCSEENTMVAMDLGSPLLPKKSLPVSGTLEQVASRLSSKVAAEVPHGSKQELPDLK

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        10         20         30         40         50
MAEVAFLMGS PILASAKPSP VPPPPPIGSA KVANFDPGTF SLMRCDFCGA 
        60         70         80         90        100
GFDTRAGLSS HARAHLRDFG ITNWELTISP INILQELLAT SAAELPPSPL 
       110        120        130        140        150
GREPGGPPRS FLTSRRPRLP LTMPFPPTWA EDPGPIYGDG LCSEENTMVA 
       160        170        180        190        200
MDLGSPLLPK KSLPVSGTLE QVASRLSSKV AAEVPHGSKQ ELPDLKAQSL 
       210        220        230        240        250
TTCEVCGACF ETRKGLSSHA RSHLRQLGVA ESESSGAPID LLYELVKQKG 
       260        270        280        290        300
LPDAPLGLTP SLTKKSNSPK EFLAGAARPG LLTLAKPMDA PAVNKAIKSP 
       310        320        330        340        350
PGFSAKGLTH PSSSPLLKKA PLTLAGSPTP KNPEDKSPQL SLSPRPTSPK 
       360        370        380        390        400
AQWPQSEDEG PLNLTSGPEP TRDIRCEFCG EFFENRKGLS SHARSHLRQM 
       410        420        430        440        450
GVTEWYVNGS PIDTLREILK RRTQSRPGGH LHPPGPSPKA LAKVLSTGGP 
       460        470        480        490        500
GSSLEARSPS DLHISPLTKK LPPPPGSPLG HSPTASPPPT ARKMFSGLAT 
       510        520        530        540        550
PSLPKKLKPE HMRVEIKREM LPGTLHGEPH PSEGPWGTPR EDMAPLNLSA 
       560        570        580        590        600
RAEPVRDIRC EFCGEFFENR KGLSSHARSH LRQMGVTEWS VNGSPIDTLR 
       610        620        630        640        650
EILKKKSKLC LIKKEPPAGD LAPALTEDGS PTAAPGALHS PLPLSPLASR 
       660        670        680        690        700
PGKPGAGPTQ VPRELSLSPI TGSKPSAASY LGPVATKRPL QEDRFLPAEV 
       710        720        730        740        750
KAKTYIQTEL PFKAKTLHEK TSHSSTEACC ELCGLYFENR KALASHARAH 
       760        770        780        790        800
LRQFGVTEWC VNGSPIETLS EWIKHRPQKV GAYRSYIQGG RPFTKKFRSA 
       810        820        830        840        850
GHGRDSDKRP PLGLAPGGLS LVGRSAGGEP GLEAGRAADS GERPLATSPP 
       860        870        880        890        900
GTVKSEEHQR QNINKFERRQ ARPSDASAAR GGEEVNDLQQ KLEEVRQPPP 
       910        920        930        940        950
RVRPVPSLVP RPPQTSLVKF VGNIYTLKCR FCEVEFQGPL SIQEEWVRHL 
       960        970        980 
QRHILEMNFS KADPPPEEPQ APQAQTAAVE AP

Note: No experimental confirmation available.

Show »

Length:982

Mass (Da):105,637

Checksum:ⁱ1304FDF9672338FC

GO

Isoform 3 (identifier: O88286-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
745-798: YGIGLANHVR...KKVANFDPGT → NGIVLRPPAA...AQILLLRHQL
799-1684: Missing.

« Hide

        10         20         30         40         50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG 
        60         70         80         90        100
PRDILDGRSG ISDGQPHPGL SEALPRATSA THRISSCYWD GDSLDFQPGS 
       110        120        130        140        150
PPPHLLGPFP ASLDVQGSWE HPMVQEAREG TPSEQRFKDS VIVRTMKPYA 
       160        170        180        190        200
KLKGSRKFLH HQGEVKFLEK YSPSHHKFDW LQDTDEQGPL KDTGLHLDLP 
       210        220        230        240        250
AQPPTVTSFR RVIVPVDNTP KTLDMEVMGT REDLEDFGQV AQPSEWGLHT 
       260        270        280        290        300
SASEVATQTW TVNSEASVER LQPLLSPVQT GPYLCELLQE VAGGVDSNEE 
       310        320        330        340        350
EEEEPAVFPC IECSIYFKHK EHLLEHMSQH RRAPGQEPPA DLAPLACSEC 
       360        370        380        390        400
GWAFTEPTAL EQHWQLHQAS REKIIEEIQK LKQFPGDEGR EARLQCSKCV 
       410        420        430        440        450
FGTNSSRAFM QHAKLHVRGS LPSRQATEPF RGGSPVLDVS TLVYPSYGDS 
       460        470        480        490        500
SGLNTCVHCG FTAPSKSLLR EHTRLVHAHH AHWEEVGEAF EDLTSQPCTS 
       510        520        530        540        550
QDAYTHSPDT ATVDYFSKSE PLLASVWQEN PSGYDPDLAF GPDYQQPGMR 
       560        570        580        590        600
NFPLLNSGQQ SLGKLAFPSP MASASYSIQR NRNKSTVHLQ RMEDKSHLWS 
       610        620        630        640        650
EEEEEEDEDV VLTSERDFTP ENGAFPPLAI PSLIPQPALE LKQTFQDALQ 
       660        670        680        690        700
AVDASETQQQ QLQGMVPIVL MAKLRPQVIA ATTRASPQLP PEEPELRSTH 
       710        720        730        740        750
PLDFLLLDAP LGGSLGLNTL LEGDPAMALK HEERKCPYCP DRFHNGIVLR 
       760        770        780        790 
PPAARNVNGS TEKAARAVRE ESRRGKRRNV AKTVTLIKAQ ILLLRHQL

Note: No experimental confirmation available.

Show »

Length:798

Mass (Da):88,329

Checksum:ⁱCD980D3BFAD521B6

GO

Experimental Info

Feature key	Position(s)	Length	Description
Sequence conflictⁱ	492 – 492	1	D → G in BAA32790 (PubMed:9795207).Curated
Sequence conflictⁱ	868 – 868	1	R → G in BAA32790 (PubMed:9795207).Curated
Sequence conflictⁱ	868 – 868	1	R → G in BAA32791 (PubMed:9795207).Curated
Sequence conflictⁱ	1020 – 1020	1	K → N in AAH53035 (PubMed:16141072).Curated
Sequence conflictⁱ	1052 – 1052	1	K → R in BAA32790 (PubMed:9795207).Curated
Sequence conflictⁱ	1052 – 1052	1	K → R in BAA32791 (PubMed:9795207).Curated
Sequence conflictⁱ	1055 – 1055	1	W → C in BAA32790 (PubMed:9795207).Curated
Sequence conflictⁱ	1055 – 1055	1	W → C in BAA32791 (PubMed:9795207).Curated
Sequence conflictⁱ	1252 – 1252	1	Missing in BAA32790 (PubMed:9795207).Curated
Sequence conflictⁱ	1252 – 1252	1	Missing in BAA32791 (PubMed:9795207).Curated

Polymorphismⁱ

C57BL/6J and C57BR/cdJ mice specifically present an insertion of a type II early transposon in the opposite orientation into exon 6. This results in a strong reduction in the protein levels of isoform L.1 Publication

Alternative sequence

Feature key	Position(s)	Length	Description	Feature identifier	Actions
Alternative sequenceⁱ	1 – 759	759	Missing in isoform 2. 1 Publication Manual assertion based on opinion inⁱ Ref.4 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).	VSP_024953	Add BLAST
Alternative sequenceⁱ	63 – 790	728	Missing in isoform S. 2 Publications Manual assertion based on opinion inⁱ Ref.1 "Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum." Matsumoto K., Ishii N., Yoshida S., Shiosaka S., Wanaka A., Tohyama M. Brain Res. Mol. Brain Res. 61:179-189(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS L AND S), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Ref.2 "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP." Ueda J., Tachibana M., Ikura T., Shinkai Y. J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM S), FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EHMT1; EHMT2; CTBP1 AND CTBP2, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-1631 AND HIS-1651.	VSP_024954	Add BLAST
Alternative sequenceⁱ	745 – 798	54	YGIGL…FDPGT → NGIVLRPPAARNVNGSTEKA ARAVREESRRGKRRNVAKTV TLIKAQILLLRHQL in isoform 3. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1525-1684 (ISOFORM L).	VSP_024955	Add BLAST
Alternative sequenceⁱ	760 – 789	30	VGVSY…QKKKK → MAEVAFLMGSPILASAKPSP VPPPPPIGSA in isoform 2. 1 Publication Manual assertion based on opinion inⁱ Ref.4 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).	VSP_024956	Add BLAST
Alternative sequenceⁱ	799 – 1684	886	Missing in isoform 3. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1525-1684 (ISOFORM L).	VSP_024957	Add BLAST
Alternative sequenceⁱ	898 – 898	1	D → DGLCSEENTMVAMDLGSPLL PKKSLPVSGTLEQVASRLSS KVAAEVPHGSKQELPDLK in isoform 2. 1 Publication Manual assertion based on opinion inⁱ Ref.4 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).	VSP_024958

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012265 mRNA. Translation: BAA32790.1. AB012266 mRNA. Translation: BAA32791.1. AB255388 mRNA. Translation: BAE93139.1. AK004274 mRNA. Translation: BAB23245.1. AK133564 mRNA. Translation: BAE21728.1. BC053035 mRNA. Translation: AAH53035.1.
CCDSⁱ	CCDS28617.2. [O88286-2]
PIRⁱ	T00247. T00248.
RefSeqⁱ	NP_035847.2. NM_011717.4. NP_997603.3. NM_212438.3. [O88286-2] XP_006524131.1. XM_006524068.2. [O88286-2] XP_006524132.1. XM_006524069.1. [O88286-4]
UniGeneⁱ	Mm.274948.

Genome annotation databases

Ensemblⁱ	ENSMUST00000064694; ENSMUSP00000069443; ENSMUSG00000024050. [O88286-2]
GeneIDⁱ	22404.
KEGGⁱ	mmu:22404.
UCSCⁱ	uc008bwn.2. mouse. [O88286-2] uc008bwq.2. mouse. [O88286-3] uc008bwt.2. mouse. [O88286-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012265 mRNA. Translation: BAA32790.1. AB012266 mRNA. Translation: BAA32791.1. AB255388 mRNA. Translation: BAE93139.1. AK004274 mRNA. Translation: BAB23245.1. AK133564 mRNA. Translation: BAE21728.1. BC053035 mRNA. Translation: AAH53035.1.
CCDSⁱ	CCDS28617.2. [O88286-2]
PIRⁱ	T00247. T00248.
RefSeqⁱ	NP_035847.2. NM_011717.4. NP_997603.3. NM_212438.3. [O88286-2] XP_006524131.1. XM_006524068.2. [O88286-2] XP_006524132.1. XM_006524069.1. [O88286-4]
UniGeneⁱ	Mm.274948.

3D structure databases

ProteinModelPortalⁱ	O88286.
SMRⁱ	O88286. Positions 301-372, 391-425, 445-484, 730-759, 787-827.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204563. 28 interactions.
IntActⁱ	O88286. 26 interactions.
MINTⁱ	MINT-4105440.
STRINGⁱ	10090.ENSMUSP00000069443.

PTM databases

iPTMnetⁱ	O88286.
PhosphoSiteⁱ	O88286.

Proteomic databases

EPDⁱ	O88286.
MaxQBⁱ	O88286.
PaxDbⁱ	O88286.
PeptideAtlasⁱ	O88286.
PRIDEⁱ	O88286.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000064694; ENSMUSP00000069443; ENSMUSG00000024050. [O88286-2]
GeneIDⁱ	22404.
KEGGⁱ	mmu:22404.
UCSCⁱ	uc008bwn.2. mouse. [O88286-2] uc008bwq.2. mouse. [O88286-3] uc008bwt.2. mouse. [O88286-4]

Organism-specific databases

CTDⁱ	58525.
MGIⁱ	MGI:1332638. Wiz.

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
GeneTreeⁱ	ENSGT00530000063587.
HOGENOMⁱ	HOG000154859.
HOVERGENⁱ	HBG108678.
InParanoidⁱ	O88286.
OMAⁱ	LTMPFPP.
PhylomeDBⁱ	O88286.
TreeFamⁱ	TF333705.

Miscellaneous databases

PROⁱ	O88286.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024050.
CleanExⁱ	MM_WIZ.
ExpressionAtlasⁱ	O88286. baseline and differential.
Genevisibleⁱ	O88286. MM.

Family and domain databases

InterProⁱ	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
SMARTⁱ	SM00355. ZnF_C2H2. 11 hits. [Graphical view]
PROSITEⁱ	PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

WIZ_MOUSE

Accessionⁱ

Primary (citable) accession number: O88286
Secondary accession number(s): O88287

Q9CT89

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88286 (WIZ_MOUSE)

UniProt

O88286 - WIZ_MOUSE

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Protein Wiz

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequences (4)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (4)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ