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History
Entry version 140 (30 Aug 2017)
Sequence version 2 (01 May 2007)
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Protein

Protein Wiz

Gene

Wiz

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	308 – 330	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	345 – 367	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	454 – 477	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	734 – 756	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	802 – 824	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	903 – 925	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1076 – 1098	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1260 – 1282	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1430 – 1452	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1629 – 1655	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	27

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro
SET domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16702210

Complete GO annotation...

GO - Biological processⁱ

positive regulation of nuclear cell cycle DNA replication Source: MGI
protein heterotrimerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16702210
protein stabilization
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 16702210

Complete GO annotation...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Wiz Alternative name(s): Widely-interspaced zinc finger-containing protein
Gene namesⁱ	Name:Wiz
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1332638. Wiz.

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1631	C → A: Impairs interaction with EHMT1 and EHMT2. 1 Publication		1
Mutagenesisⁱ	1651	H → A: Impairs interaction with EHMT1 and EHMT2. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286055	1 – 1684	Protein WizAdd BLAST		1684

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	916	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	972	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	988	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1000	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1021	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1029	PhosphoserineBy similarity	1
Modified residueⁱ	1031	PhosphothreonineBy similarity	1
Cross-linkⁱ	1033	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1038	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1039	PhosphoserineCombined sources	1
Modified residueⁱ	1045	PhosphoserineCombined sources	1
Modified residueⁱ	1049	PhosphothreonineCombined sources	1
Modified residueⁱ	1050	PhosphoserineCombined sources	1
Modified residueⁱ	1058	PhosphoserineBy similarity	1
Cross-linkⁱ	1089	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1112	PhosphoserineBy similarity	1
Modified residueⁱ	1139	PhosphoserineBy similarity	1
Cross-linkⁱ	1141	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1145	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1155	PhosphoserineBy similarity	1
Modified residueⁱ	1160	PhosphoserineBy similarity	1
Modified residueⁱ	1167	PhosphoserineBy similarity	1
Cross-linkⁱ	1171	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1172	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1179	PhosphoserineCombined sources	1
Modified residueⁱ	1184	PhosphoserineCombined sources	1
Modified residueⁱ	1195	N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity	1
Modified residueⁱ	1195	N6,N6-dimethyllysine; by EHMT2; alternateBy similarity	1
Cross-linkⁱ	1210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1273	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1296	PhosphoserineBy similarity	1
Cross-linkⁱ	1315	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1342	PhosphoserineBy similarity	1
Modified residueⁱ	1347	PhosphoserineBy similarity	1
Cross-linkⁱ	1376	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1389	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1403	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1405	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1415	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1481	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1497	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1510	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1550	PhosphoserineBy similarity	1
Cross-linkⁱ	1556	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linkⁱ	1556	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1567	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1593	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1663	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O88286.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O88286.
PaxDbⁱ	O88286.
PeptideAtlas More...PeptideAtlasⁱ	O88286.
PRIDEⁱ	O88286.

PTM databases

iPTMnetⁱ	O88286.
PhosphoSitePlusⁱ	O88286.

Expressionⁱ

Tissue specificityⁱ

According to PubMed:9795207, isoform L and isoform S are brain-specific. According to PubMed:16702210, isoform S is ubiquitously expressed.2 Publications

Developmental stageⁱ

Isoform L and isoform S are expressed in brain from E14 to adulthood, with highest levels in the perinatal period. At embryonic stages, isoform L seems to be excluded from cerebellum.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000024050.
CleanExⁱ	MM_WIZ.
ExpressionAtlasⁱ	O88286. baseline and differential.
Genevisibleⁱ	O88286. MM.

Interactionⁱ

Subunit structureⁱ

Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Interacts with EHMT1, EHMT2, CTBP1 and CTBP2.By similarity1 Publication

GO - Molecular functionⁱ

SET domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16702210

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	204563. 28 interactors.
IntActⁱ	O88286. 26 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4105440.
STRINGⁱ	10090.ENSMUSP00000069443.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88286.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1063 – 1067	Interaction with CTBP1 and CTBP2 11 Publication		5
Regionⁱ	1247 – 1251	Interaction with CTBP1 and CTBP2 21 Publication		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	299 – 304	Poly-Glu	6
Compositional biasⁱ	601 – 608	Poly-Glu	8
Compositional biasⁱ	658 – 663	Poly-Gln	6
Compositional biasⁱ	786 – 790	Poly-Lys	5
Compositional biasⁱ	1174 – 1177	Poly-Pro	4

Domainⁱ

The C2H2-type zinc finger 10 mediates interaction with EHMT1 and EHMT2.

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	308 – 330	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	345 – 367	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	454 – 477	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	734 – 756	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	802 – 824	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	903 – 925	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1076 – 1098	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1260 – 1282	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1430 – 1452	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1629 – 1655	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	27

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063587.
HOGENOMⁱ	HOG000154859.
HOVERGENⁱ	HBG108678.
InParanoidⁱ	O88286.
OMAⁱ	HFGLECS.
PhylomeDBⁱ	O88286.
TreeFamⁱ	TF333705.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR013087. Znf_C2H2_type. IPR013083. Znf_RING/FYVE/PHD.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 11 hits.
SUPFAMⁱ	SSF57667. SSF57667. 5 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform L (identifier: O88286-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG 
        60         70         80         90        100
PRDILDGRSG ISDGQPHPGL SEALPRATSA THRISSCYWD GDSLDFQPGS 
       110        120        130        140        150
PPPHLLGPFP ASLDVQGSWE HPMVQEAREG TPSEQRFKDS VIVRTMKPYA 
       160        170        180        190        200
KLKGSRKFLH HQGEVKFLEK YSPSHHKFDW LQDTDEQGPL KDTGLHLDLP 
       210        220        230        240        250
AQPPTVTSFR RVIVPVDNTP KTLDMEVMGT REDLEDFGQV AQPSEWGLHT 
       260        270        280        290        300
SASEVATQTW TVNSEASVER LQPLLSPVQT GPYLCELLQE VAGGVDSNEE 
       310        320        330        340        350
EEEEPAVFPC IECSIYFKHK EHLLEHMSQH RRAPGQEPPA DLAPLACSEC 
       360        370        380        390        400
GWAFTEPTAL EQHWQLHQAS REKIIEEIQK LKQFPGDEGR EARLQCSKCV 
       410        420        430        440        450
FGTNSSRAFM QHAKLHVRGS LPSRQATEPF RGGSPVLDVS TLVYPSYGDS 
       460        470        480        490        500
SGLNTCVHCG FTAPSKSLLR EHTRLVHAHH AHWEEVGEAF EDLTSQPCTS 
       510        520        530        540        550
QDAYTHSPDT ATVDYFSKSE PLLASVWQEN PSGYDPDLAF GPDYQQPGMR 
       560        570        580        590        600
NFPLLNSGQQ SLGKLAFPSP MASASYSIQR NRNKSTVHLQ RMEDKSHLWS 
       610        620        630        640        650
EEEEEEDEDV VLTSERDFTP ENGAFPPLAI PSLIPQPALE LKQTFQDALQ 
       660        670        680        690        700
AVDASETQQQ QLQGMVPIVL MAKLRPQVIA ATTRASPQLP PEEPELRSTH 
       710        720        730        740        750
PLDFLLLDAP LGGSLGLNTL LEGDPAMALK HEERKCPYCP DRFHYGIGLA 
       760        770        780        790        800
NHVRGHLNRV GVSYNVRHFI SAEEVKAIER RFSFQKKKKK VANFDPGTFS 
       810        820        830        840        850
LMRCDFCGAG FDTRAGLSSH ARAHLRDFGI TNWELTISPI NILQELLATS 
       860        870        880        890        900
AAELPPSPLG REPGGPPRSF LTSRRPRLPL TMPFPPTWAE DPGPIYGDAQ 
       910        920        930        940        950
SLTTCEVCGA CFETRKGLSS HARSHLRQLG VAESESSGAP IDLLYELVKQ 
       960        970        980        990       1000
KGLPDAPLGL TPSLTKKSNS PKEFLAGAAR PGLLTLAKPM DAPAVNKAIK 
      1010       1020       1030       1040       1050
SPPGFSAKGL THPSSSPLLK KAPLTLAGSP TPKNPEDKSP QLSLSPRPTS 
      1060       1070       1080       1090       1100
PKAQWPQSED EGPLNLTSGP EPTRDIRCEF CGEFFENRKG LSSHARSHLR 
      1110       1120       1130       1140       1150
QMGVTEWYVN GSPIDTLREI LKRRTQSRPG GHLHPPGPSP KALAKVLSTG 
      1160       1170       1180       1190       1200
GPGSSLEARS PSDLHISPLT KKLPPPPGSP LGHSPTASPP PTARKMFSGL 
      1210       1220       1230       1240       1250
ATPSLPKKLK PEHMRVEIKR EMLPGTLHGE PHPSEGPWGT PREDMAPLNL 
      1260       1270       1280       1290       1300
SARAEPVRDI RCEFCGEFFE NRKGLSSHAR SHLRQMGVTE WSVNGSPIDT 
      1310       1320       1330       1340       1350
LREILKKKSK LCLIKKEPPA GDLAPALTED GSPTAAPGAL HSPLPLSPLA 
      1360       1370       1380       1390       1400
SRPGKPGAGP TQVPRELSLS PITGSKPSAA SYLGPVATKR PLQEDRFLPA 
      1410       1420       1430       1440       1450
EVKAKTYIQT ELPFKAKTLH EKTSHSSTEA CCELCGLYFE NRKALASHAR 
      1460       1470       1480       1490       1500
AHLRQFGVTE WCVNGSPIET LSEWIKHRPQ KVGAYRSYIQ GGRPFTKKFR 
      1510       1520       1530       1540       1550
SAGHGRDSDK RPPLGLAPGG LSLVGRSAGG EPGLEAGRAA DSGERPLATS 
      1560       1570       1580       1590       1600
PPGTVKSEEH QRQNINKFER RQARPSDASA ARGGEEVNDL QQKLEEVRQP 
      1610       1620       1630       1640       1650
PPRVRPVPSL VPRPPQTSLV KFVGNIYTLK CRFCEVEFQG PLSIQEEWVR 
      1660       1670       1680 
HLQRHILEMN FSKADPPPEE PQAPQAQTAA VEAP

Length:1,684

Mass (Da):184,291

Last modified:May 1, 2007 - v2

Checksum:ⁱ67BA8AC25A97DDEB

Isoform S (identifier: O88286-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
63-790: Missing.

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        10         20         30         40         50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG 
        60         70         80         90        100
PRDILDGRSG ISVANFDPGT FSLMRCDFCG AGFDTRAGLS SHARAHLRDF 
       110        120        130        140        150
GITNWELTIS PINILQELLA TSAAELPPSP LGREPGGPPR SFLTSRRPRL 
       160        170        180        190        200
PLTMPFPPTW AEDPGPIYGD AQSLTTCEVC GACFETRKGL SSHARSHLRQ 
       210        220        230        240        250
LGVAESESSG APIDLLYELV KQKGLPDAPL GLTPSLTKKS NSPKEFLAGA 
       260        270        280        290        300
ARPGLLTLAK PMDAPAVNKA IKSPPGFSAK GLTHPSSSPL LKKAPLTLAG 
       310        320        330        340        350
SPTPKNPEDK SPQLSLSPRP TSPKAQWPQS EDEGPLNLTS GPEPTRDIRC 
       360        370        380        390        400
EFCGEFFENR KGLSSHARSH LRQMGVTEWY VNGSPIDTLR EILKRRTQSR 
       410        420        430        440        450
PGGHLHPPGP SPKALAKVLS TGGPGSSLEA RSPSDLHISP LTKKLPPPPG 
       460        470        480        490        500
SPLGHSPTAS PPPTARKMFS GLATPSLPKK LKPEHMRVEI KREMLPGTLH 
       510        520        530        540        550
GEPHPSEGPW GTPREDMAPL NLSARAEPVR DIRCEFCGEF FENRKGLSSH 
       560        570        580        590        600
ARSHLRQMGV TEWSVNGSPI DTLREILKKK SKLCLIKKEP PAGDLAPALT 
       610        620        630        640        650
EDGSPTAAPG ALHSPLPLSP LASRPGKPGA GPTQVPRELS LSPITGSKPS 
       660        670        680        690        700
AASYLGPVAT KRPLQEDRFL PAEVKAKTYI QTELPFKAKT LHEKTSHSST 
       710        720        730        740        750
EACCELCGLY FENRKALASH ARAHLRQFGV TEWCVNGSPI ETLSEWIKHR 
       760        770        780        790        800
PQKVGAYRSY IQGGRPFTKK FRSAGHGRDS DKRPPLGLAP GGLSLVGRSA 
       810        820        830        840        850
GGEPGLEAGR AADSGERPLA TSPPGTVKSE EHQRQNINKF ERRQARPSDA 
       860        870        880        890        900
SAARGGEEVN DLQQKLEEVR QPPPRVRPVP SLVPRPPQTS LVKFVGNIYT 
       910        920        930        940        950
LKCRFCEVEF QGPLSIQEEW VRHLQRHILE MNFSKADPPP EEPQAPQAQT 

AAVEAP

Show »

Length:956

Mass (Da):103,003

Checksum:ⁱ4DDE4A816FC04D65

Isoform 2 (identifier: O88286-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-759: Missing.
     760-789: VGVSYNVRHFISAEEVKAIERRFSFQKKKK → MAEVAFLMGSPILASAKPSPVPPPPPIGSA
     898-898: D → DGLCSEENTMVAMDLGSPLLPKKSLPVSGTLEQVASRLSSKVAAEVPHGSKQELPDLK

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        10         20         30         40         50
MAEVAFLMGS PILASAKPSP VPPPPPIGSA KVANFDPGTF SLMRCDFCGA 
        60         70         80         90        100
GFDTRAGLSS HARAHLRDFG ITNWELTISP INILQELLAT SAAELPPSPL 
       110        120        130        140        150
GREPGGPPRS FLTSRRPRLP LTMPFPPTWA EDPGPIYGDG LCSEENTMVA 
       160        170        180        190        200
MDLGSPLLPK KSLPVSGTLE QVASRLSSKV AAEVPHGSKQ ELPDLKAQSL 
       210        220        230        240        250
TTCEVCGACF ETRKGLSSHA RSHLRQLGVA ESESSGAPID LLYELVKQKG 
       260        270        280        290        300
LPDAPLGLTP SLTKKSNSPK EFLAGAARPG LLTLAKPMDA PAVNKAIKSP 
       310        320        330        340        350
PGFSAKGLTH PSSSPLLKKA PLTLAGSPTP KNPEDKSPQL SLSPRPTSPK 
       360        370        380        390        400
AQWPQSEDEG PLNLTSGPEP TRDIRCEFCG EFFENRKGLS SHARSHLRQM 
       410        420        430        440        450
GVTEWYVNGS PIDTLREILK RRTQSRPGGH LHPPGPSPKA LAKVLSTGGP 
       460        470        480        490        500
GSSLEARSPS DLHISPLTKK LPPPPGSPLG HSPTASPPPT ARKMFSGLAT 
       510        520        530        540        550
PSLPKKLKPE HMRVEIKREM LPGTLHGEPH PSEGPWGTPR EDMAPLNLSA 
       560        570        580        590        600
RAEPVRDIRC EFCGEFFENR KGLSSHARSH LRQMGVTEWS VNGSPIDTLR 
       610        620        630        640        650
EILKKKSKLC LIKKEPPAGD LAPALTEDGS PTAAPGALHS PLPLSPLASR 
       660        670        680        690        700
PGKPGAGPTQ VPRELSLSPI TGSKPSAASY LGPVATKRPL QEDRFLPAEV 
       710        720        730        740        750
KAKTYIQTEL PFKAKTLHEK TSHSSTEACC ELCGLYFENR KALASHARAH 
       760        770        780        790        800
LRQFGVTEWC VNGSPIETLS EWIKHRPQKV GAYRSYIQGG RPFTKKFRSA 
       810        820        830        840        850
GHGRDSDKRP PLGLAPGGLS LVGRSAGGEP GLEAGRAADS GERPLATSPP 
       860        870        880        890        900
GTVKSEEHQR QNINKFERRQ ARPSDASAAR GGEEVNDLQQ KLEEVRQPPP 
       910        920        930        940        950
RVRPVPSLVP RPPQTSLVKF VGNIYTLKCR FCEVEFQGPL SIQEEWVRHL 
       960        970        980 
QRHILEMNFS KADPPPEEPQ APQAQTAAVE AP

Note: No experimental confirmation available.

Show »

Length:982

Mass (Da):105,637

Checksum:ⁱ1304FDF9672338FC

Isoform 3 (identifier: O88286-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
745-798: YGIGLANHVR...KKVANFDPGT → NGIVLRPPAA...AQILLLRHQL
799-1684: Missing.

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        10         20         30         40         50
MEGLLAGGLA APDHPRGPAP REDIESGAEA AEGEGDIFPS SHYLPITKEG 
        60         70         80         90        100
PRDILDGRSG ISDGQPHPGL SEALPRATSA THRISSCYWD GDSLDFQPGS 
       110        120        130        140        150
PPPHLLGPFP ASLDVQGSWE HPMVQEAREG TPSEQRFKDS VIVRTMKPYA 
       160        170        180        190        200
KLKGSRKFLH HQGEVKFLEK YSPSHHKFDW LQDTDEQGPL KDTGLHLDLP 
       210        220        230        240        250
AQPPTVTSFR RVIVPVDNTP KTLDMEVMGT REDLEDFGQV AQPSEWGLHT 
       260        270        280        290        300
SASEVATQTW TVNSEASVER LQPLLSPVQT GPYLCELLQE VAGGVDSNEE 
       310        320        330        340        350
EEEEPAVFPC IECSIYFKHK EHLLEHMSQH RRAPGQEPPA DLAPLACSEC 
       360        370        380        390        400
GWAFTEPTAL EQHWQLHQAS REKIIEEIQK LKQFPGDEGR EARLQCSKCV 
       410        420        430        440        450
FGTNSSRAFM QHAKLHVRGS LPSRQATEPF RGGSPVLDVS TLVYPSYGDS 
       460        470        480        490        500
SGLNTCVHCG FTAPSKSLLR EHTRLVHAHH AHWEEVGEAF EDLTSQPCTS 
       510        520        530        540        550
QDAYTHSPDT ATVDYFSKSE PLLASVWQEN PSGYDPDLAF GPDYQQPGMR 
       560        570        580        590        600
NFPLLNSGQQ SLGKLAFPSP MASASYSIQR NRNKSTVHLQ RMEDKSHLWS 
       610        620        630        640        650
EEEEEEDEDV VLTSERDFTP ENGAFPPLAI PSLIPQPALE LKQTFQDALQ 
       660        670        680        690        700
AVDASETQQQ QLQGMVPIVL MAKLRPQVIA ATTRASPQLP PEEPELRSTH 
       710        720        730        740        750
PLDFLLLDAP LGGSLGLNTL LEGDPAMALK HEERKCPYCP DRFHNGIVLR 
       760        770        780        790 
PPAARNVNGS TEKAARAVRE ESRRGKRRNV AKTVTLIKAQ ILLLRHQL

Note: No experimental confirmation available.

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Length:798

Mass (Da):88,329

Checksum:ⁱCD980D3BFAD521B6

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	492	D → G in BAA32790 (PubMed:9795207).Curated	1
Sequence conflictⁱ	868	R → G in BAA32790 (PubMed:9795207).Curated	1
Sequence conflictⁱ	868	R → G in BAA32791 (PubMed:9795207).Curated	1
Sequence conflictⁱ	1020	K → N in AAH53035 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1052	K → R in BAA32790 (PubMed:9795207).Curated	1
Sequence conflictⁱ	1052	K → R in BAA32791 (PubMed:9795207).Curated	1
Sequence conflictⁱ	1055	W → C in BAA32790 (PubMed:9795207).Curated	1
Sequence conflictⁱ	1055	W → C in BAA32791 (PubMed:9795207).Curated	1
Sequence conflictⁱ	1252	Missing in BAA32790 (PubMed:9795207).Curated	1
Sequence conflictⁱ	1252	Missing in BAA32791 (PubMed:9795207).Curated	1

Polymorphismⁱ

C57BL/6J and C57BR/cdJ mice specifically present an insertion of a type II early transposon in the opposite orientation into exon 6. This results in a strong reduction in the protein levels of isoform L.1 Publication

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024953	1 – 759	Missing in isoform 2. 1 PublicationAdd BLAST	759
Alternative sequenceⁱVSP_024954	63 – 790	Missing in isoform S. 2 PublicationsAdd BLAST	728
Alternative sequenceⁱVSP_024955	745 – 798	YGIGL…FDPGT → NGIVLRPPAARNVNGSTEKA ARAVREESRRGKRRNVAKTV TLIKAQILLLRHQL in isoform 3. 1 PublicationAdd BLAST	54
Alternative sequenceⁱVSP_024956	760 – 789	VGVSY…QKKKK → MAEVAFLMGSPILASAKPSP VPPPPPIGSA in isoform 2. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_024957	799 – 1684	Missing in isoform 3. 1 PublicationAdd BLAST	886
Alternative sequenceⁱVSP_024958	898	D → DGLCSEENTMVAMDLGSPLL PKKSLPVSGTLEQVASRLSS KVAAEVPHGSKQELPDLK in isoform 2. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012265 mRNA. Translation: BAA32790.1. AB012266 mRNA. Translation: BAA32791.1. AB255388 mRNA. Translation: BAE93139.1. AK004274 mRNA. Translation: BAB23245.1. AK133564 mRNA. Translation: BAE21728.1. BC053035 mRNA. Translation: AAH53035.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28617.2. [O88286-2]
PIRⁱ	T00247. T00248.
NCBI Reference Sequences More...RefSeqⁱ	NP_035847.2. NM_011717.4. NP_997603.3. NM_212438.3. [O88286-2] XP_017172890.1. XM_017317401.1. [O88286-2]
UniGeneⁱ	Mm.274948.

Genome annotation databases

Ensemblⁱ	ENSMUST00000064694; ENSMUSP00000069443; ENSMUSG00000024050. [O88286-2]
GeneIDⁱ	22404.
KEGGⁱ	mmu:22404.
UCSC genome browser More...UCSCⁱ	uc008bwn.2. mouse. [O88286-2] uc008bwq.2. mouse. [O88286-3] uc008bwt.2. mouse. [O88286-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O88286	E9Q5R9 UPI0007EDA188	Mus musculus (Mouse)	1,684	UniRef100_O88286	Cluster: Protein Wiz	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O88286	E9Q5R9 UPI0007EDA188 UPI00077DDABE A0A1U8CJ24 UPI00045417C2 UPI0008102C54	Mus musculus (Mouse) Peromyscus maniculatus bairdii (prairie deer mouse) Mesocricetus auratus (Golden hamster) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Rattus norvegicus (Rat)	1,684	UniRef90_O88286	Cluster: Protein Wiz	7
O88286-2	UPI0003337FBF D3ZQQ2 A0A1U7RB34 UPI0000F3292A UPI00022F4FA8 UPI000298B26E UPI000387AE42 UPI00038C5209 UPI0003AB8CEC UPI0003BBF714 +29	Octodon degus (Degu) (Sciurus degus) Rattus norvegicus (Rat) Mesocricetus auratus (Golden hamster) Bos taurus (Bovine) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Felis catus (Cat) (Felis silvestris catus) Homo sapiens (Human) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Myotis brandtii (Brandt's bat) And more	956	UniRef90_O88286-2	Cluster: Isoform S of Protein Wiz	40
O88286-3	UPI0003F1AB63 UPI00076290CC UPI000B4F0148 UPI00093D2083 UPI000A308DA8 UPI000333E855 UPI0002BCF735 UPI0003C460C7 UPI000441DDAF UPI00046BDF10 +13	Felis catus (Cat) (Felis silvestris catus) Marmota marmota marmota (Alpine marmot) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Hipposideros armiger (great roundleaf bat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Octodon degus (Degu) (Sciurus degus) Orcinus orca (Killer whale) Myotis lucifugus (Little brown bat) Lipotes vexillifer (Yangtze river dolphin) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) And more	982	UniRef90_O88286-3	Cluster: Isoform 2 of Protein Wiz	24
O88286-4	UPI0000D63884 UPI0003D6E3E6 Q3TLM6	Mus musculus (Mouse)	798	UniRef90_O88286-4	Cluster: Isoform 3 of Protein Wiz	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O88286	E9Q5R9 UPI0007EDA188 UPI00077DDABE A0A1U8CJ24 UPI00045417C2 UPI0008102C54 UPI000A335959 UPI000B5431D5 UPI00053F2DBC UPI00093F91BE +86	Mus musculus (Mouse) Peromyscus maniculatus bairdii (prairie deer mouse) Mesocricetus auratus (Golden hamster) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Rattus norvegicus (Rat) Heterocephalus glaber (Naked mole rat) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Hipposideros armiger (great roundleaf bat) Rhinolophus sinicus (Chinese rufous horseshoe bat) And more	1,684	UniRef50_O88286	Cluster: Protein Wiz	97
O88286-2	UPI0003337FBF UPI0005FB8F6A UPI0007196A16 UPI00038C5209 UPI00022F4FA8 UPI000847D193 UPI0004D07D4A UPI0003C45084 UPI00045E4F8D UPI000786B697 +104	Octodon degus (Degu) (Sciurus degus) Ovis aries musimon (Mouflon) Ceratotherium simum simum (southern white rhinoceros) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Capra hircus (Goat) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Myotis lucifugus (Little brown bat) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) And more	956	UniRef50_O88286-2	Cluster: Isoform S of Protein Wiz	115
O88286-3	UPI0003F1AB63 UPI00076290CC UPI000B4F0148 UPI00093D2083 UPI000A308DA8 UPI000333E855 UPI0005335869 UPI0008F51A4C UPI000981A052 F6RZM7 +20	Felis catus (Cat) (Felis silvestris catus) Marmota marmota marmota (Alpine marmot) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Hipposideros armiger (great roundleaf bat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Octodon degus (Degu) (Sciurus degus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Gorilla gorilla gorilla (Western lowland gorilla) Castor canadensis (Beaver) Callithrix jacchus (White-tufted-ear marmoset) And more	982	UniRef50_O88286-3	Cluster: Isoform 2 of Protein Wiz	31
O88286-4	UPI0000D63884 UPI0003D6E3E6 Q3TLM6 L5JWT6 UPI0006548AE1	Mus musculus (Mouse) Pteropus alecto (Black flying fox) Mustela putorius furo (European domestic ferret) (Mustela furo)	798	UniRef50_O88286-4	Cluster: Isoform 3 of Protein Wiz	6

Structural Biology Knowledgebase	Search...

CTDⁱ	58525.
MGIⁱ	MGI:1332638. Wiz.

Protein Ontology More...PROⁱ	PR:O88286.
SOURCEⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WIZ_MOUSE
Accessionⁱ	O88286Primary (citable) accession number: O88286 Secondary accession number(s): O88287 , Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	May 1, 2007
	Last modified:	August 30, 2017
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - O88286 (WIZ_MOUSE)

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Wiz

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

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<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

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Functionⁱ

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Sequences (4)ⁱ

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