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Protein

B-cell CLL/lymphoma 6 member B protein

Gene

Bcl6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 458C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 6 member B protein
Alternative name(s):
Bcl6-associated zinc finger protein
Gene namesi
Name:Bcl6b
Synonyms:Bazf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1278332 Bcl6b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471011 – 474B-cell CLL/lymphoma 6 member B proteinAdd BLAST474

Proteomic databases

PaxDbiO88282
PRIDEiO88282

PTM databases

iPTMnetiO88282
PhosphoSitePlusiO88282

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression found in heart and lung.1 Publication

Inductioni

Induced in activated lymphocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000000317
CleanExiMM_BCL6B
ExpressionAtlasiO88282 baseline and differential
GenevisibleiO88282 MM

Interactioni

Subunit structurei

Associates with BCL6 through the BTB domain.

Protein-protein interaction databases

BioGridi198305, 2 interactors
STRINGi10090.ENSMUSP00000000326

Structurei

3D structure databases

ProteinModelPortaliO88282
SMRiO88282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 105BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 189Pro-richAdd BLAST46
Compositional biasi234 – 239Poly-Ser6

Domaini

Amino acids 178-210 are essential for repression activity.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 458C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139443
HOGENOMiHOG000001556
HOVERGENiHBG004831
InParanoidiO88282
OMAiKVHYHIL
OrthoDBiEOG091G025U
PhylomeDBiO88282
TreeFamiTF330912

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

O88282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR
60 70 80 90 100
AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR
110 120 130 140 150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP
160 170 180 190 200
RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI
210 220 230 240 250
VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR
260 270 280 290 300
LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN
310 320 330 340 350
CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP
360 370 380 390 400
YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI
410 420 430 440 450
HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL
460 470
RLHLRQKHGA ATNTKVRYHI LGGP
Length:474
Mass (Da):51,339
Last modified:November 1, 1998 - v1
Checksum:i94886AB265B018D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011665 mRNA Translation: BAA31223.1
AK032647 mRNA Translation: BAC27970.1
CCDSiCCDS24939.1
RefSeqiNP_031554.1, NM_007528.3
UniGeneiMm.12930

Genome annotation databases

EnsembliENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317
GeneIDi12029
KEGGimmu:12029
UCSCiuc007juc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBCL6B_MOUSE
AccessioniPrimary (citable) accession number: O88282
Secondary accession number(s): Q8CCJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health