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O88282

- BCL6B_MOUSE

UniProt

O88282 - BCL6B_MOUSE

Protein

B-cell CLL/lymphoma 6 member B protein

Gene

Bcl6b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri323 – 34523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 45824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Alternative name(s):
    Bcl6-associated zinc finger protein
    Gene namesi
    Name:Bcl6b
    Synonyms:Bazf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1278332. Bcl6b.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474B-cell CLL/lymphoma 6 member B proteinPRO_0000047101Add
    BLAST

    Proteomic databases

    PRIDEiO88282.

    PTM databases

    PhosphoSiteiO88282.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with higher expression found in heart and lung.1 Publication

    Inductioni

    Induced in activated lymphocytes.1 Publication

    Gene expression databases

    ArrayExpressiO88282.
    BgeeiO88282.
    CleanExiMM_BCL6B.
    GenevestigatoriO88282.

    Interactioni

    Subunit structurei

    Associates with BCL6 through the BTB domain.

    Protein-protein interaction databases

    BioGridi198305. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO88282.
    SMRiO88282. Positions 16-134, 295-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 10568BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 18946Pro-richAdd
    BLAST
    Compositional biasi234 – 2396Poly-Ser

    Domaini

    Amino acids 178-210 are essential for repression activity.

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri323 – 34523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 45824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000001556.
    HOVERGENiHBG004831.
    InParanoidiO88282.
    OMAiSCSQGSP.
    OrthoDBiEOG7KQ22S.
    PhylomeDBiO88282.
    TreeFamiTF330912.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88282-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR    50
    AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR 100
    LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP 150
    RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI 200
    VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR 250
    LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN 300
    CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP 350
    YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI 400
    HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL 450
    RLHLRQKHGA ATNTKVRYHI LGGP 474
    Length:474
    Mass (Da):51,339
    Last modified:November 1, 1998 - v1
    Checksum:i94886AB265B018D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011665 mRNA. Translation: BAA31223.1.
    AK032647 mRNA. Translation: BAC27970.1.
    CCDSiCCDS24939.1.
    RefSeqiNP_031554.1. NM_007528.3.
    UniGeneiMm.12930.

    Genome annotation databases

    EnsembliENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317.
    GeneIDi12029.
    KEGGimmu:12029.
    UCSCiuc007juc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011665 mRNA. Translation: BAA31223.1 .
    AK032647 mRNA. Translation: BAC27970.1 .
    CCDSi CCDS24939.1.
    RefSeqi NP_031554.1. NM_007528.3.
    UniGenei Mm.12930.

    3D structure databases

    ProteinModelPortali O88282.
    SMRi O88282. Positions 16-134, 295-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198305. 1 interaction.

    PTM databases

    PhosphoSitei O88282.

    Proteomic databases

    PRIDEi O88282.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000326 ; ENSMUSP00000000326 ; ENSMUSG00000000317 .
    GeneIDi 12029.
    KEGGi mmu:12029.
    UCSCi uc007juc.2. mouse.

    Organism-specific databases

    CTDi 255877.
    MGIi MGI:1278332. Bcl6b.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000001556.
    HOVERGENi HBG004831.
    InParanoidi O88282.
    OMAi SCSQGSP.
    OrthoDBi EOG7KQ22S.
    PhylomeDBi O88282.
    TreeFami TF330912.

    Miscellaneous databases

    NextBioi 280263.
    PROi O88282.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88282.
    Bgeei O88282.
    CleanExi MM_BCL6B.
    Genevestigatori O88282.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor."
      Okabe S., Fukuda T., Ishibashi K., Kojima S., Okada S., Hatano M., Ebara M., Saisho H., Tokuhisa T.
      Mol. Cell. Biol. 18:4235-4244(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH BCL6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-474.
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    3. "BAZF is required for activation of naive CD4 T cells by TCR triggering."
      Takamori M., Hatano M., Arima M., Sakamoto A., Fujimura L., Hartatik T., Kuriyama T., Tokuhisa T.
      Int. Immunol. 16:1439-1449(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiBCL6B_MOUSE
    AccessioniPrimary (citable) accession number: O88282
    Secondary accession number(s): Q8CCJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3