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O88282

- BCL6B_MOUSE

UniProt

O88282 - BCL6B_MOUSE

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Protein
B-cell CLL/lymphoma 6 member B protein
Gene
Bcl6b, Bazf
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri323 – 34523C2H2-type 1
Add
BLAST
Zinc fingeri351 – 37323C2H2-type 2
Add
BLAST
Zinc fingeri379 – 40123C2H2-type 3
Add
BLAST
Zinc fingeri407 – 42923C2H2-type 4
Add
BLAST
Zinc fingeri435 – 45824C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 6 member B protein
Alternative name(s):
Bcl6-associated zinc finger protein
Gene namesi
Name:Bcl6b
Synonyms:Bazf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1278332. Bcl6b.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474B-cell CLL/lymphoma 6 member B protein
PRO_0000047101Add
BLAST

Proteomic databases

PRIDEiO88282.

PTM databases

PhosphoSiteiO88282.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression found in heart and lung.1 Publication

Inductioni

Induced in activated lymphocytes.1 Publication

Gene expression databases

ArrayExpressiO88282.
BgeeiO88282.
CleanExiMM_BCL6B.
GenevestigatoriO88282.

Interactioni

Subunit structurei

Associates with BCL6 through the BTB domain.

Protein-protein interaction databases

BioGridi198305. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO88282.
SMRiO88282. Positions 16-134, 295-455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 10568BTB
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi144 – 18946Pro-rich
Add
BLAST
Compositional biasi234 – 2396Poly-Ser

Domaini

Amino acids 178-210 are essential for repression activity.

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000001556.
HOVERGENiHBG004831.
InParanoidiO88282.
OMAiSCSQGSP.
OrthoDBiEOG7KQ22S.
PhylomeDBiO88282.
TreeFamiTF330912.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88282-1 [UniParc]FASTAAdd to Basket

« Hide

MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR    50
AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR 100
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP 150
RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI 200
VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR 250
LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN 300
CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP 350
YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI 400
HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL 450
RLHLRQKHGA ATNTKVRYHI LGGP 474
Length:474
Mass (Da):51,339
Last modified:November 1, 1998 - v1
Checksum:i94886AB265B018D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011665 mRNA. Translation: BAA31223.1.
AK032647 mRNA. Translation: BAC27970.1.
CCDSiCCDS24939.1.
RefSeqiNP_031554.1. NM_007528.3.
UniGeneiMm.12930.

Genome annotation databases

EnsembliENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317.
GeneIDi12029.
KEGGimmu:12029.
UCSCiuc007juc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011665 mRNA. Translation: BAA31223.1 .
AK032647 mRNA. Translation: BAC27970.1 .
CCDSi CCDS24939.1.
RefSeqi NP_031554.1. NM_007528.3.
UniGenei Mm.12930.

3D structure databases

ProteinModelPortali O88282.
SMRi O88282. Positions 16-134, 295-455.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198305. 1 interaction.

PTM databases

PhosphoSitei O88282.

Proteomic databases

PRIDEi O88282.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000326 ; ENSMUSP00000000326 ; ENSMUSG00000000317 .
GeneIDi 12029.
KEGGi mmu:12029.
UCSCi uc007juc.2. mouse.

Organism-specific databases

CTDi 255877.
MGIi MGI:1278332. Bcl6b.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000001556.
HOVERGENi HBG004831.
InParanoidi O88282.
OMAi SCSQGSP.
OrthoDBi EOG7KQ22S.
PhylomeDBi O88282.
TreeFami TF330912.

Miscellaneous databases

NextBioi 280263.
PROi O88282.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88282.
Bgeei O88282.
CleanExi MM_BCL6B.
Genevestigatori O88282.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor."
    Okabe S., Fukuda T., Ishibashi K., Kojima S., Okada S., Hatano M., Ebara M., Saisho H., Tokuhisa T.
    Mol. Cell. Biol. 18:4235-4244(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH BCL6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-474.
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. "BAZF is required for activation of naive CD4 T cells by TCR triggering."
    Takamori M., Hatano M., Arima M., Sakamoto A., Fujimura L., Hartatik T., Kuriyama T., Tokuhisa T.
    Int. Immunol. 16:1439-1449(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiBCL6B_MOUSE
AccessioniPrimary (citable) accession number: O88282
Secondary accession number(s): Q8CCJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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