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O88281

- MEGF6_RAT

UniProt

O88281 - MEGF6_RAT

Protein

Multiple epidermal growth factor-like domains protein 6

Gene

Megf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multiple epidermal growth factor-like domains protein 6
    Short name:
    Multiple EGF-like domains protein 6
    Alternative name(s):
    Epidermal growth factor-like protein 3
    Short name:
    EGF-like protein 3
    Gene namesi
    Name:Megf6
    Synonyms:Egfl3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621188. Megf6.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 15741547Multiple epidermal growth factor-like domains protein 6PRO_0000007525Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 108By similarity
    Disulfide bondi74 ↔ 80By similarity
    Disulfide bondi107 ↔ 120By similarity
    Disulfide bondi127 ↔ 138By similarity
    Disulfide bondi134 ↔ 147By similarity
    Disulfide bondi149 ↔ 162By similarity
    Disulfide bondi168 ↔ 179By similarity
    Disulfide bondi175 ↔ 188By similarity
    Disulfide bondi190 ↔ 203By similarity
    Disulfide bondi209 ↔ 220By similarity
    Disulfide bondi216 ↔ 230By similarity
    Disulfide bondi232 ↔ 245By similarity
    Disulfide bondi251 ↔ 262By similarity
    Disulfide bondi258 ↔ 271By similarity
    Disulfide bondi273 ↔ 286By similarity
    Disulfide bondi292 ↔ 303By similarity
    Disulfide bondi299 ↔ 312By similarity
    Disulfide bondi314 ↔ 327By similarity
    Disulfide bondi338 ↔ 349By similarity
    Disulfide bondi345 ↔ 358By similarity
    Disulfide bondi360 ↔ 373By similarity
    Disulfide bondi379 ↔ 389By similarity
    Disulfide bondi385 ↔ 398By similarity
    Disulfide bondi400 ↔ 411By similarity
    Disulfide bondi419 ↔ 430By similarity
    Disulfide bondi426 ↔ 439By similarity
    Disulfide bondi441 ↔ 454By similarity
    Disulfide bondi524 ↔ 537By similarity
    Disulfide bondi531 ↔ 544By similarity
    Disulfide bondi546 ↔ 555By similarity
    Disulfide bondi568 ↔ 580By similarity
    Disulfide bondi574 ↔ 587By similarity
    Disulfide bondi589 ↔ 598By similarity
    Disulfide bondi611 ↔ 623By similarity
    Disulfide bondi617 ↔ 630By similarity
    Disulfide bondi632 ↔ 641By similarity
    Disulfide bondi654 ↔ 668By similarity
    Disulfide bondi660 ↔ 675By similarity
    Disulfide bondi677 ↔ 686By similarity
    Disulfide bondi699 ↔ 711By similarity
    Disulfide bondi705 ↔ 718By similarity
    Disulfide bondi722 ↔ 731By similarity
    Disulfide bondi744 ↔ 755By similarity
    Disulfide bondi750 ↔ 762By similarity
    Disulfide bondi764 ↔ 773By similarity
    Disulfide bondi786 ↔ 799By similarity
    Disulfide bondi793 ↔ 806By similarity
    Disulfide bondi808 ↔ 817By similarity
    Disulfide bondi830 ↔ 842By similarity
    Disulfide bondi836 ↔ 849By similarity
    Disulfide bondi851 ↔ 860By similarity
    Disulfide bondi873 ↔ 886By similarity
    Disulfide bondi879 ↔ 893By similarity
    Disulfide bondi895 ↔ 904By similarity
    Disulfide bondi917 ↔ 929By similarity
    Disulfide bondi923 ↔ 936By similarity
    Disulfide bondi938 ↔ 947By similarity
    Disulfide bondi960 ↔ 972By similarity
    Disulfide bondi966 ↔ 979By similarity
    Disulfide bondi981 ↔ 990By similarity
    Disulfide bondi1003 ↔ 1015By similarity
    Disulfide bondi1009 ↔ 1022By similarity
    Disulfide bondi1024 ↔ 1033By similarity
    Disulfide bondi1046 ↔ 1058By similarity
    Disulfide bondi1052 ↔ 1065By similarity
    Disulfide bondi1067 ↔ 1076By similarity
    Disulfide bondi1089 ↔ 1101By similarity
    Disulfide bondi1095 ↔ 1108By similarity
    Disulfide bondi1110 ↔ 1119By similarity
    Disulfide bondi1132 ↔ 1144By similarity
    Disulfide bondi1138 ↔ 1151By similarity
    Disulfide bondi1153 ↔ 1162By similarity
    Disulfide bondi1175 ↔ 1187By similarity
    Disulfide bondi1181 ↔ 1194By similarity
    Disulfide bondi1196 ↔ 1205By similarity
    Disulfide bondi1218 ↔ 1231By similarity
    Disulfide bondi1224 ↔ 1238By similarity
    Disulfide bondi1240 ↔ 1249By similarity
    Disulfide bondi1262 ↔ 1274By similarity
    Disulfide bondi1268 ↔ 1281By similarity
    Disulfide bondi1283 ↔ 1292By similarity
    Disulfide bondi1305 ↔ 1317By similarity
    Disulfide bondi1311 ↔ 1324By similarity
    Disulfide bondi1326 ↔ 1335By similarity
    Disulfide bondi1348 ↔ 1360By similarity
    Disulfide bondi1354 ↔ 1367By similarity
    Disulfide bondi1369 ↔ 1378By similarity
    Disulfide bondi1391 ↔ 1403By similarity
    Disulfide bondi1397 ↔ 1410By similarity
    Disulfide bondi1412 ↔ 1421By similarity
    Disulfide bondi1434 ↔ 1446By similarity
    Disulfide bondi1440 ↔ 1453By similarity
    Disulfide bondi1455 ↔ 1464By similarity
    Disulfide bondi1477 ↔ 1489By similarity
    Disulfide bondi1483 ↔ 1496By similarity
    Disulfide bondi1498 ↔ 1507By similarity
    Disulfide bondi1520 ↔ 1532By similarity
    Disulfide bondi1526 ↔ 1539By similarity
    Disulfide bondi1541 ↔ 1550By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO88281.

    Expressioni

    Tissue specificityi

    Expressed in lung.1 Publication

    Gene expression databases

    GenevestigatoriO88281.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000169.

    Structurei

    3D structure databases

    ProteinModelPortaliO88281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 12283EMIPROSITE-ProRule annotationAdd
    BLAST
    Domaini123 – 16341EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 20441EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini205 – 24642EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 28741EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini288 – 32841EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini334 – 37441EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini375 – 41238EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini415 – 45541EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini520 – 55637EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini564 – 59936EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini607 – 64236EGF-like 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini650 – 68738EGF-like 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini695 – 73238EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini740 – 77435EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini782 – 81837EGF-like 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini826 – 86136EGF-like 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini869 – 90537EGF-like 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini913 – 94836EGF-like 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini956 – 99136EGF-like 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini999 – 103436EGF-like 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini1042 – 107736EGF-like 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini1085 – 112036EGF-like 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini1128 – 116336EGF-like 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini1171 – 120636EGF-like 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini1214 – 125037EGF-like 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini1258 – 129336EGF-like 26PROSITE-ProRule annotationAdd
    BLAST
    Domaini1301 – 133636EGF-like 27PROSITE-ProRule annotationAdd
    BLAST
    Domaini1344 – 137936EGF-like 28PROSITE-ProRule annotationAdd
    BLAST
    Domaini1387 – 142236EGF-like 29PROSITE-ProRule annotationAdd
    BLAST
    Domaini1430 – 146536EGF-like 30PROSITE-ProRule annotationAdd
    BLAST
    Domaini1473 – 150836EGF-like 31PROSITE-ProRule annotationAdd
    BLAST
    Domaini1516 – 155136EGF-like 32PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 32 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 EMI domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000097840.
    HOVERGENiHBG079790.
    InParanoidiO88281.
    PhylomeDBiO88281.

    Family and domain databases

    InterProiIPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR002049. EGF_laminin.
    IPR011489. EMI_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF00053. Laminin_EGF. 9 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 13 hits.
    SM00179. EGF_CA. 4 hits.
    SM00180. EGF_Lam. 11 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
    PS00022. EGF_1. 23 hits.
    PS01186. EGF_2. 23 hits.
    PS50026. EGF_3. 21 hits.
    PS01187. EGF_CA. 5 hits.
    PS51041. EMI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88281-1 [UniParc]FASTAAdd to Basket

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    MPVRAEARAA WRVVALALLL LPAMPAASPP LTPRPLQPSM PHVCAEQKLT     50
    LVGHRQPCVQ AFSRIVPVWR RTGCAQQAWC IGQERRTVYY MSYRQVYATE 100
    ARTVFRCCPG WSQKPGQEGC LSDVDECASA NGGCEGPCCN TVGGFYCRCP 150
    PGYQLQGDGK TCQDVDECRA HNGGCQHRCV NTPGSYLCEC KPGFRLHTDG 200
    RTCLAISSCT LGNGGCQHQC VQLTVTQHRC QCRPQYQLQE DGRRCVRRSP 250
    CAEGNGGCMH ICQELRGLAH CGCHPGYQLA ADRKTCEDVD ECALGLAQCA 300
    HGCLNTQGSF KCVCHAGYEL GADGRQCYRI EMEIVNSCEA GNGGCSHGCS 350
    HTSTGPLCTC PRGYELDEDQ KTCIDIDDCA NSPCCQQACA NTPGGYECSC 400
    FAGYRLNTDG CGCEDVDECA SGHGGCEHHC SNLAGSFQCF CEAGYRLDED 450
    RRGCTSLEES VVDLDGRLPF VRPLPHIAVL RDELPRLFQD DYGAEEEAAA 500
    AELRGEHTLT EKFVCLDHSF GHDCSLTCDD CRNGGTCFPG QDGCDCPEGW 550
    TGIICNETCP PDTFGKNCSS PCTCQNGGTC DPVLGACRCP PGVSGAHCED 600
    GCPKGFYGKH CRKKCHCANR GRCHRLYGAC LCDPGLYGRF CHLACPPWAF 650
    GPGCSEDCLC EQSHTRSCNP KDGSCSCKAG FQGERCQAEC ESGFFGPGCR 700
    HRCTCQPGVA CDPVSGECRT QCPPGYQGED CGQECPVGTF GVNCSGSCSC 750
    VGAPCHRVTG ECLCPPGKTG EDCGADCPEG RWGLGCQEIC PACEHGASCN 800
    PETGTCLCLP GFVGSRCQDT CSAGWYGTGC QIRCACANDG HCDPTTGRCS 850
    CAPGWTGLSC QRACDSGHWG PDCIHPCNCS AGHGNCDAVS GLCLCEAGYE 900
    GPRCEQSCRQ GYYGPSCEQK CRCEHGAACD HVSGACTCPA GWRGSFCEHA 950
    CPAGFFGLDC DSACNCSAGA PCDAVTGSCI CPAGRWGPRC AQSCPPLTFG 1000
    LNCSQICTCF NGASCDSVTG QCHCAPGWMG PTCLQACPPG LYGKNCQHSC 1050
    LCRNGGRCDP ILGQCTCPEG WTGLACENEC LPGHYAAGCQ LNCSCLHGGI 1100
    CDRLTGHCLC PAGWTGDKCQ SSCVSGTFGV HCEEHCACRK GASCHHVTGA 1150
    CFCPPGWRGP HCEQACPRGW FGEACAQRCL CPTNASCHHV TGECRCPPGF 1200
    TGLSCEQACQ PGTFGKDCEH LCQCPGETWA CDPASGVCTC AAGYHGTGCL 1250
    QRCPSGRYGP GCEHICKCLN GGTCDPATGA CYCPAGFLGA DCSLACPQGR 1300
    FGPSCAHVCA CRQGAACDPV SGACICSPGK TGVRCEHGCP QDRFGKGCEL 1350
    KCACRNGGLC HATNGSCSCP LGWMGPHCEH ACPAGRYGAA CLLECFCQNN 1400
    GSCEPTTGAC LCGPGFYGQA CEHSCPSGFH GPGCQRVCEC QQGAPCDPVS 1450
    GQCLCPAGFH GQFCEKGCES GSFGDGCLQQ CNCHTGVPCD PISGLCLCPP 1500
    GRTGAACDLD CRRGRFGPGC ALRCDCGGGA DCDPISGQCH CVDSYMGPTC 1550
    REVPTQISSS RPAPQHPSSR AMKH 1574
    Length:1,574
    Mass (Da):165,447
    Last modified:November 1, 1998 - v1
    Checksum:i2B48533D8F77F6E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011532 mRNA. Translation: BAA32462.1.
    PIRiT13954.
    RefSeqiNP_075244.1. NM_022955.1.
    UniGeneiRn.195598.

    Genome annotation databases

    GeneIDi65049.
    KEGGirno:65049.
    UCSCiRGD:621188. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011532 mRNA. Translation: BAA32462.1 .
    PIRi T13954.
    RefSeqi NP_075244.1. NM_022955.1.
    UniGenei Rn.195598.

    3D structure databases

    ProteinModelPortali O88281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000169.

    Proteomic databases

    PRIDEi O88281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 65049.
    KEGGi rno:65049.
    UCSCi RGD:621188. rat.

    Organism-specific databases

    CTDi 1953.
    RGDi 621188. Megf6.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000097840.
    HOVERGENi HBG079790.
    InParanoidi O88281.
    PhylomeDBi O88281.

    Miscellaneous databases

    NextBioi 613892.

    Gene expression databases

    Genevestigatori O88281.

    Family and domain databases

    InterProi IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR002049. EGF_laminin.
    IPR011489. EMI_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF00053. Laminin_EGF. 9 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 13 hits.
    SM00179. EGF_CA. 4 hits.
    SM00180. EGF_Lam. 11 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 5 hits.
    PS00022. EGF_1. 23 hits.
    PS01186. EGF_2. 23 hits.
    PS50026. EGF_3. 21 hits.
    PS01187. EGF_CA. 5 hits.
    PS51041. EMI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Lubec G., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 482-486, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiMEGF6_RAT
    AccessioniPrimary (citable) accession number: O88281
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3