O88281 (MEGF6_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 83.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Multiple epidermal growth factor-like domains protein 6 Short name=Multiple EGF-like domains protein 6 Alternative name(s): Epidermal growth factor-like protein 3 Short name=EGF-like protein 3 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 1574 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location | Secreted Potential. |
| Tissue specificity | Expressed in lung. Ref.1 |
| Sequence similarities | Contains 32 EGF-like domains. Contains 1 EMI domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | EGF-like domain Repeat Signal |
| PTM | Disulfide bond |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | calcium ion binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | Potential | ||||||||
| Chain | 28 – 1574 | 1547 | Multiple epidermal growth factor-like domains protein 6 | PRO_0000007525 | |||||||
Regions | |||||||||||
| Domain | 40 – 122 | 83 | EMI | ||||||||
| Domain | 123 – 163 | 41 | EGF-like 1; calcium-binding Potential | ||||||||
| Domain | 164 – 204 | 41 | EGF-like 2; calcium-binding Potential | ||||||||
| Domain | 205 – 246 | 42 | EGF-like 3 | ||||||||
| Domain | 247 – 287 | 41 | EGF-like 4 | ||||||||
| Domain | 288 – 328 | 41 | EGF-like 5; calcium-binding Potential | ||||||||
| Domain | 334 – 374 | 41 | EGF-like 6 | ||||||||
| Domain | 375 – 412 | 38 | EGF-like 7 | ||||||||
| Domain | 415 – 455 | 41 | EGF-like 8; calcium-binding Potential | ||||||||
| Domain | 520 – 556 | 37 | EGF-like 9 | ||||||||
| Domain | 564 – 599 | 36 | EGF-like 10 | ||||||||
| Domain | 607 – 642 | 36 | EGF-like 11 | ||||||||
| Domain | 650 – 687 | 38 | EGF-like 12 | ||||||||
| Domain | 695 – 732 | 38 | EGF-like 13 | ||||||||
| Domain | 740 – 774 | 35 | EGF-like 14 | ||||||||
| Domain | 782 – 818 | 37 | EGF-like 15 | ||||||||
| Domain | 826 – 861 | 36 | EGF-like 16 | ||||||||
| Domain | 869 – 905 | 37 | EGF-like 17 | ||||||||
| Domain | 913 – 948 | 36 | EGF-like 18 | ||||||||
| Domain | 956 – 991 | 36 | EGF-like 19 | ||||||||
| Domain | 999 – 1034 | 36 | EGF-like 20 | ||||||||
| Domain | 1042 – 1077 | 36 | EGF-like 21 | ||||||||
| Domain | 1085 – 1120 | 36 | EGF-like 22 | ||||||||
| Domain | 1128 – 1163 | 36 | EGF-like 23 | ||||||||
| Domain | 1171 – 1206 | 36 | EGF-like 24 | ||||||||
| Domain | 1214 – 1250 | 37 | EGF-like 25 | ||||||||
| Domain | 1258 – 1293 | 36 | EGF-like 26 | ||||||||
| Domain | 1301 – 1336 | 36 | EGF-like 27 | ||||||||
| Domain | 1344 – 1379 | 36 | EGF-like 28 | ||||||||
| Domain | 1387 – 1422 | 36 | EGF-like 29 | ||||||||
| Domain | 1430 – 1465 | 36 | EGF-like 30 | ||||||||
| Domain | 1473 – 1508 | 36 | EGF-like 31 | ||||||||
| Domain | 1516 – 1551 | 36 | EGF-like 32 | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 44 ↔ 108 | By similarity | |||||||||
| Disulfide bond | 74 ↔ 80 | By similarity | |||||||||
| Disulfide bond | 107 ↔ 120 | By similarity | |||||||||
| Disulfide bond | 127 ↔ 138 | By similarity | |||||||||
| Disulfide bond | 134 ↔ 147 | By similarity | |||||||||
| Disulfide bond | 149 ↔ 162 | By similarity | |||||||||
| Disulfide bond | 168 ↔ 179 | By similarity | |||||||||
| Disulfide bond | 175 ↔ 188 | By similarity | |||||||||
| Disulfide bond | 190 ↔ 203 | By similarity | |||||||||
| Disulfide bond | 209 ↔ 220 | By similarity | |||||||||
| Disulfide bond | 216 ↔ 230 | By similarity | |||||||||
| Disulfide bond | 232 ↔ 245 | By similarity | |||||||||
| Disulfide bond | 251 ↔ 262 | By similarity | |||||||||
| Disulfide bond | 258 ↔ 271 | By similarity | |||||||||
| Disulfide bond | 273 ↔ 286 | By similarity | |||||||||
| Disulfide bond | 292 ↔ 303 | By similarity | |||||||||
| Disulfide bond | 299 ↔ 312 | By similarity | |||||||||
| Disulfide bond | 314 ↔ 327 | By similarity | |||||||||
| Disulfide bond | 338 ↔ 349 | By similarity | |||||||||
| Disulfide bond | 345 ↔ 358 | By similarity | |||||||||
| Disulfide bond | 360 ↔ 373 | By similarity | |||||||||
| Disulfide bond | 379 ↔ 389 | By similarity | |||||||||
| Disulfide bond | 385 ↔ 398 | By similarity | |||||||||
| Disulfide bond | 400 ↔ 411 | By similarity | |||||||||
| Disulfide bond | 419 ↔ 430 | By similarity | |||||||||
| Disulfide bond | 426 ↔ 439 | By similarity | |||||||||
| Disulfide bond | 441 ↔ 454 | By similarity | |||||||||
| Disulfide bond | 524 ↔ 537 | By similarity | |||||||||
| Disulfide bond | 531 ↔ 544 | By similarity | |||||||||
| Disulfide bond | 546 ↔ 555 | By similarity | |||||||||
| Disulfide bond | 568 ↔ 580 | By similarity | |||||||||
| Disulfide bond | 574 ↔ 587 | By similarity | |||||||||
| Disulfide bond | 589 ↔ 598 | By similarity | |||||||||
| Disulfide bond | 611 ↔ 623 | By similarity | |||||||||
| Disulfide bond | 617 ↔ 630 | By similarity | |||||||||
| Disulfide bond | 632 ↔ 641 | By similarity | |||||||||
| Disulfide bond | 654 ↔ 668 | By similarity | |||||||||
| Disulfide bond | 660 ↔ 675 | By similarity | |||||||||
| Disulfide bond | 677 ↔ 686 | By similarity | |||||||||
| Disulfide bond | 699 ↔ 711 | By similarity | |||||||||
| Disulfide bond | 705 ↔ 718 | By similarity | |||||||||
| Disulfide bond | 722 ↔ 731 | By similarity | |||||||||
| Disulfide bond | 744 ↔ 755 | By similarity | |||||||||
| Disulfide bond | 750 ↔ 762 | By similarity | |||||||||
| Disulfide bond | 764 ↔ 773 | By similarity | |||||||||
| Disulfide bond | 786 ↔ 799 | By similarity | |||||||||
| Disulfide bond | 793 ↔ 806 | By similarity | |||||||||
| Disulfide bond | 808 ↔ 817 | By similarity | |||||||||
| Disulfide bond | 830 ↔ 842 | By similarity | |||||||||
| Disulfide bond | 836 ↔ 849 | By similarity | |||||||||
| Disulfide bond | 851 ↔ 860 | By similarity | |||||||||
| Disulfide bond | 873 ↔ 886 | By similarity | |||||||||
| Disulfide bond | 879 ↔ 893 | By similarity | |||||||||
| Disulfide bond | 895 ↔ 904 | By similarity | |||||||||
| Disulfide bond | 917 ↔ 929 | By similarity | |||||||||
| Disulfide bond | 923 ↔ 936 | By similarity | |||||||||
| Disulfide bond | 938 ↔ 947 | By similarity | |||||||||
| Disulfide bond | 960 ↔ 972 | By similarity | |||||||||
| Disulfide bond | 966 ↔ 979 | By similarity | |||||||||
| Disulfide bond | 981 ↔ 990 | By similarity | |||||||||
| Disulfide bond | 1003 ↔ 1015 | By similarity | |||||||||
| Disulfide bond | 1009 ↔ 1022 | By similarity | |||||||||
| Disulfide bond | 1024 ↔ 1033 | By similarity | |||||||||
| Disulfide bond | 1046 ↔ 1058 | By similarity | |||||||||
| Disulfide bond | 1052 ↔ 1065 | By similarity | |||||||||
| Disulfide bond | 1067 ↔ 1076 | By similarity | |||||||||
| Disulfide bond | 1089 ↔ 1101 | By similarity | |||||||||
| Disulfide bond | 1095 ↔ 1108 | By similarity | |||||||||
| Disulfide bond | 1110 ↔ 1119 | By similarity | |||||||||
| Disulfide bond | 1132 ↔ 1144 | By similarity | |||||||||
| Disulfide bond | 1138 ↔ 1151 | By similarity | |||||||||
| Disulfide bond | 1153 ↔ 1162 | By similarity | |||||||||
| Disulfide bond | 1175 ↔ 1187 | By similarity | |||||||||
| Disulfide bond | 1181 ↔ 1194 | By similarity | |||||||||
| Disulfide bond | 1196 ↔ 1205 | By similarity | |||||||||
| Disulfide bond | 1218 ↔ 1231 | By similarity | |||||||||
| Disulfide bond | 1224 ↔ 1238 | By similarity | |||||||||
| Disulfide bond | 1240 ↔ 1249 | By similarity | |||||||||
| Disulfide bond | 1262 ↔ 1274 | By similarity | |||||||||
| Disulfide bond | 1268 ↔ 1281 | By similarity | |||||||||
| Disulfide bond | 1283 ↔ 1292 | By similarity | |||||||||
| Disulfide bond | 1305 ↔ 1317 | By similarity | |||||||||
| Disulfide bond | 1311 ↔ 1324 | By similarity | |||||||||
| Disulfide bond | 1326 ↔ 1335 | By similarity | |||||||||
| Disulfide bond | 1348 ↔ 1360 | By similarity | |||||||||
| Disulfide bond | 1354 ↔ 1367 | By similarity | |||||||||
| Disulfide bond | 1369 ↔ 1378 | By similarity | |||||||||
| Disulfide bond | 1391 ↔ 1403 | By similarity | |||||||||
| Disulfide bond | 1397 ↔ 1410 | By similarity | |||||||||
| Disulfide bond | 1412 ↔ 1421 | By similarity | |||||||||
| Disulfide bond | 1434 ↔ 1446 | By similarity | |||||||||
| Disulfide bond | 1440 ↔ 1453 | By similarity | |||||||||
| Disulfide bond | 1455 ↔ 1464 | By similarity | |||||||||
| Disulfide bond | 1477 ↔ 1489 | By similarity | |||||||||
| Disulfide bond | 1483 ↔ 1496 | By similarity | |||||||||
| Disulfide bond | 1498 ↔ 1507 | By similarity | |||||||||
| Disulfide bond | 1520 ↔ 1532 | By similarity | |||||||||
| Disulfide bond | 1526 ↔ 1539 | By similarity | |||||||||
| Disulfide bond | 1541 ↔ 1550 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening." Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O. Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Brain. |
| [2] | Lubec G., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 482-486, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB011532 mRNA. Translation: BAA32462.1. |
| IPI | IPI00207575. |
| PIR | T13954. |
| RefSeq | NP_075244.1. NM_022955.1. |
| UniGene | Rn.195598. |
3D structure databases | |
| ProteinModelPortal | O88281. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | O88281. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 65049. |
| KEGG | rno:65049. |
| UCSC | RGD:621188. rat. |
Organism-specific databases | |
| CTD | 1953. |
| RGD | 621188. Megf6. |
Phylogenomic databases | |
| eggNOG | NOG12793. |
| HOGENOM | HOG000097840. |
| HOVERGEN | HBG079790. |
| InParanoid | O88281. |
Gene expression databases | |
| Genevestigator | O88281. |
Family and domain databases | |
| InterPro | IPR026823. cEGF. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR002049. EGF_laminin. IPR011489. EMI_domain. [Graphical view] |
| Pfam | PF12662. cEGF. 1 hit. PF07645. EGF_CA. 2 hits. PF00053. Laminin_EGF. 8 hits. [Graphical view] |
| SMART | SM00181. EGF. 13 hits. SM00179. EGF_CA. 4 hits. SM00180. EGF_Lam. 11 hits. [Graphical view] |
| PROSITE | PS00010. ASX_HYDROXYL. 5 hits. PS00022. EGF_1. 23 hits. PS01186. EGF_2. 23 hits. PS50026. EGF_3. 21 hits. PS01187. EGF_CA. 5 hits. PS51041. EMI. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 613892. |
Entry information
| Entry name | MEGF6_RAT | ||||||||
| Accession | Primary (citable) accession number: O88281 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |