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O88281

- MEGF6_RAT

UniProt

O88281 - MEGF6_RAT

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Protein

Multiple epidermal growth factor-like domains protein 6

Gene

Megf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 6
Short name:
Multiple EGF-like domains protein 6
Alternative name(s):
Epidermal growth factor-like protein 3
Short name:
EGF-like protein 3
Gene namesi
Name:Megf6
Synonyms:Egfl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621188. Megf6.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 15741547Multiple epidermal growth factor-like domains protein 6PRO_0000007525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 108By similarity
Disulfide bondi74 ↔ 80By similarity
Disulfide bondi107 ↔ 120By similarity
Disulfide bondi127 ↔ 138By similarity
Disulfide bondi134 ↔ 147By similarity
Disulfide bondi149 ↔ 162By similarity
Disulfide bondi168 ↔ 179By similarity
Disulfide bondi175 ↔ 188By similarity
Disulfide bondi190 ↔ 203By similarity
Disulfide bondi209 ↔ 220By similarity
Disulfide bondi216 ↔ 230By similarity
Disulfide bondi232 ↔ 245By similarity
Disulfide bondi251 ↔ 262By similarity
Disulfide bondi258 ↔ 271By similarity
Disulfide bondi273 ↔ 286By similarity
Disulfide bondi292 ↔ 303By similarity
Disulfide bondi299 ↔ 312By similarity
Disulfide bondi314 ↔ 327By similarity
Disulfide bondi338 ↔ 349By similarity
Disulfide bondi345 ↔ 358By similarity
Disulfide bondi360 ↔ 373By similarity
Disulfide bondi379 ↔ 389By similarity
Disulfide bondi385 ↔ 398By similarity
Disulfide bondi400 ↔ 411By similarity
Disulfide bondi419 ↔ 430By similarity
Disulfide bondi426 ↔ 439By similarity
Disulfide bondi441 ↔ 454By similarity
Disulfide bondi524 ↔ 537By similarity
Disulfide bondi531 ↔ 544By similarity
Disulfide bondi546 ↔ 555By similarity
Disulfide bondi568 ↔ 580By similarity
Disulfide bondi574 ↔ 587By similarity
Disulfide bondi589 ↔ 598By similarity
Disulfide bondi611 ↔ 623By similarity
Disulfide bondi617 ↔ 630By similarity
Disulfide bondi632 ↔ 641By similarity
Disulfide bondi654 ↔ 668By similarity
Disulfide bondi660 ↔ 675By similarity
Disulfide bondi677 ↔ 686By similarity
Disulfide bondi699 ↔ 711By similarity
Disulfide bondi705 ↔ 718By similarity
Disulfide bondi722 ↔ 731By similarity
Disulfide bondi744 ↔ 755By similarity
Disulfide bondi750 ↔ 762By similarity
Disulfide bondi764 ↔ 773By similarity
Disulfide bondi786 ↔ 799By similarity
Disulfide bondi793 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Disulfide bondi830 ↔ 842By similarity
Disulfide bondi836 ↔ 849By similarity
Disulfide bondi851 ↔ 860By similarity
Disulfide bondi873 ↔ 886By similarity
Disulfide bondi879 ↔ 893By similarity
Disulfide bondi895 ↔ 904By similarity
Disulfide bondi917 ↔ 929By similarity
Disulfide bondi923 ↔ 936By similarity
Disulfide bondi938 ↔ 947By similarity
Disulfide bondi960 ↔ 972By similarity
Disulfide bondi966 ↔ 979By similarity
Disulfide bondi981 ↔ 990By similarity
Disulfide bondi1003 ↔ 1015By similarity
Disulfide bondi1009 ↔ 1022By similarity
Disulfide bondi1024 ↔ 1033By similarity
Disulfide bondi1046 ↔ 1058By similarity
Disulfide bondi1052 ↔ 1065By similarity
Disulfide bondi1067 ↔ 1076By similarity
Disulfide bondi1089 ↔ 1101By similarity
Disulfide bondi1095 ↔ 1108By similarity
Disulfide bondi1110 ↔ 1119By similarity
Disulfide bondi1132 ↔ 1144By similarity
Disulfide bondi1138 ↔ 1151By similarity
Disulfide bondi1153 ↔ 1162By similarity
Disulfide bondi1175 ↔ 1187By similarity
Disulfide bondi1181 ↔ 1194By similarity
Disulfide bondi1196 ↔ 1205By similarity
Disulfide bondi1218 ↔ 1231By similarity
Disulfide bondi1224 ↔ 1238By similarity
Disulfide bondi1240 ↔ 1249By similarity
Disulfide bondi1262 ↔ 1274By similarity
Disulfide bondi1268 ↔ 1281By similarity
Disulfide bondi1283 ↔ 1292By similarity
Disulfide bondi1305 ↔ 1317By similarity
Disulfide bondi1311 ↔ 1324By similarity
Disulfide bondi1326 ↔ 1335By similarity
Disulfide bondi1348 ↔ 1360By similarity
Disulfide bondi1354 ↔ 1367By similarity
Disulfide bondi1369 ↔ 1378By similarity
Disulfide bondi1391 ↔ 1403By similarity
Disulfide bondi1397 ↔ 1410By similarity
Disulfide bondi1412 ↔ 1421By similarity
Disulfide bondi1434 ↔ 1446By similarity
Disulfide bondi1440 ↔ 1453By similarity
Disulfide bondi1455 ↔ 1464By similarity
Disulfide bondi1477 ↔ 1489By similarity
Disulfide bondi1483 ↔ 1496By similarity
Disulfide bondi1498 ↔ 1507By similarity
Disulfide bondi1520 ↔ 1532By similarity
Disulfide bondi1526 ↔ 1539By similarity
Disulfide bondi1541 ↔ 1550By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO88281.

Expressioni

Tissue specificityi

Expressed in lung.1 Publication

Gene expression databases

GenevestigatoriO88281.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000169.

Structurei

3D structure databases

ProteinModelPortaliO88281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 12283EMIPROSITE-ProRule annotationAdd
BLAST
Domaini123 – 16341EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini164 – 20441EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini205 – 24642EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 28741EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini288 – 32841EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini334 – 37441EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini375 – 41238EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini415 – 45541EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini520 – 55637EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini564 – 59936EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini607 – 64236EGF-like 11PROSITE-ProRule annotationAdd
BLAST
Domaini650 – 68738EGF-like 12PROSITE-ProRule annotationAdd
BLAST
Domaini695 – 73238EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini740 – 77435EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 81837EGF-like 15PROSITE-ProRule annotationAdd
BLAST
Domaini826 – 86136EGF-like 16PROSITE-ProRule annotationAdd
BLAST
Domaini869 – 90537EGF-like 17PROSITE-ProRule annotationAdd
BLAST
Domaini913 – 94836EGF-like 18PROSITE-ProRule annotationAdd
BLAST
Domaini956 – 99136EGF-like 19PROSITE-ProRule annotationAdd
BLAST
Domaini999 – 103436EGF-like 20PROSITE-ProRule annotationAdd
BLAST
Domaini1042 – 107736EGF-like 21PROSITE-ProRule annotationAdd
BLAST
Domaini1085 – 112036EGF-like 22PROSITE-ProRule annotationAdd
BLAST
Domaini1128 – 116336EGF-like 23PROSITE-ProRule annotationAdd
BLAST
Domaini1171 – 120636EGF-like 24PROSITE-ProRule annotationAdd
BLAST
Domaini1214 – 125037EGF-like 25PROSITE-ProRule annotationAdd
BLAST
Domaini1258 – 129336EGF-like 26PROSITE-ProRule annotationAdd
BLAST
Domaini1301 – 133636EGF-like 27PROSITE-ProRule annotationAdd
BLAST
Domaini1344 – 137936EGF-like 28PROSITE-ProRule annotationAdd
BLAST
Domaini1387 – 142236EGF-like 29PROSITE-ProRule annotationAdd
BLAST
Domaini1430 – 146536EGF-like 30PROSITE-ProRule annotationAdd
BLAST
Domaini1473 – 150836EGF-like 31PROSITE-ProRule annotationAdd
BLAST
Domaini1516 – 155136EGF-like 32PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 32 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000097840.
HOVERGENiHBG079790.
InParanoidiO88281.
PhylomeDBiO88281.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00053. Laminin_EGF. 9 hits.
[Graphical view]
SMARTiSM00181. EGF. 13 hits.
SM00179. EGF_CA. 4 hits.
SM00180. EGF_Lam. 11 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 21 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88281-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVRAEARAA WRVVALALLL LPAMPAASPP LTPRPLQPSM PHVCAEQKLT
60 70 80 90 100
LVGHRQPCVQ AFSRIVPVWR RTGCAQQAWC IGQERRTVYY MSYRQVYATE
110 120 130 140 150
ARTVFRCCPG WSQKPGQEGC LSDVDECASA NGGCEGPCCN TVGGFYCRCP
160 170 180 190 200
PGYQLQGDGK TCQDVDECRA HNGGCQHRCV NTPGSYLCEC KPGFRLHTDG
210 220 230 240 250
RTCLAISSCT LGNGGCQHQC VQLTVTQHRC QCRPQYQLQE DGRRCVRRSP
260 270 280 290 300
CAEGNGGCMH ICQELRGLAH CGCHPGYQLA ADRKTCEDVD ECALGLAQCA
310 320 330 340 350
HGCLNTQGSF KCVCHAGYEL GADGRQCYRI EMEIVNSCEA GNGGCSHGCS
360 370 380 390 400
HTSTGPLCTC PRGYELDEDQ KTCIDIDDCA NSPCCQQACA NTPGGYECSC
410 420 430 440 450
FAGYRLNTDG CGCEDVDECA SGHGGCEHHC SNLAGSFQCF CEAGYRLDED
460 470 480 490 500
RRGCTSLEES VVDLDGRLPF VRPLPHIAVL RDELPRLFQD DYGAEEEAAA
510 520 530 540 550
AELRGEHTLT EKFVCLDHSF GHDCSLTCDD CRNGGTCFPG QDGCDCPEGW
560 570 580 590 600
TGIICNETCP PDTFGKNCSS PCTCQNGGTC DPVLGACRCP PGVSGAHCED
610 620 630 640 650
GCPKGFYGKH CRKKCHCANR GRCHRLYGAC LCDPGLYGRF CHLACPPWAF
660 670 680 690 700
GPGCSEDCLC EQSHTRSCNP KDGSCSCKAG FQGERCQAEC ESGFFGPGCR
710 720 730 740 750
HRCTCQPGVA CDPVSGECRT QCPPGYQGED CGQECPVGTF GVNCSGSCSC
760 770 780 790 800
VGAPCHRVTG ECLCPPGKTG EDCGADCPEG RWGLGCQEIC PACEHGASCN
810 820 830 840 850
PETGTCLCLP GFVGSRCQDT CSAGWYGTGC QIRCACANDG HCDPTTGRCS
860 870 880 890 900
CAPGWTGLSC QRACDSGHWG PDCIHPCNCS AGHGNCDAVS GLCLCEAGYE
910 920 930 940 950
GPRCEQSCRQ GYYGPSCEQK CRCEHGAACD HVSGACTCPA GWRGSFCEHA
960 970 980 990 1000
CPAGFFGLDC DSACNCSAGA PCDAVTGSCI CPAGRWGPRC AQSCPPLTFG
1010 1020 1030 1040 1050
LNCSQICTCF NGASCDSVTG QCHCAPGWMG PTCLQACPPG LYGKNCQHSC
1060 1070 1080 1090 1100
LCRNGGRCDP ILGQCTCPEG WTGLACENEC LPGHYAAGCQ LNCSCLHGGI
1110 1120 1130 1140 1150
CDRLTGHCLC PAGWTGDKCQ SSCVSGTFGV HCEEHCACRK GASCHHVTGA
1160 1170 1180 1190 1200
CFCPPGWRGP HCEQACPRGW FGEACAQRCL CPTNASCHHV TGECRCPPGF
1210 1220 1230 1240 1250
TGLSCEQACQ PGTFGKDCEH LCQCPGETWA CDPASGVCTC AAGYHGTGCL
1260 1270 1280 1290 1300
QRCPSGRYGP GCEHICKCLN GGTCDPATGA CYCPAGFLGA DCSLACPQGR
1310 1320 1330 1340 1350
FGPSCAHVCA CRQGAACDPV SGACICSPGK TGVRCEHGCP QDRFGKGCEL
1360 1370 1380 1390 1400
KCACRNGGLC HATNGSCSCP LGWMGPHCEH ACPAGRYGAA CLLECFCQNN
1410 1420 1430 1440 1450
GSCEPTTGAC LCGPGFYGQA CEHSCPSGFH GPGCQRVCEC QQGAPCDPVS
1460 1470 1480 1490 1500
GQCLCPAGFH GQFCEKGCES GSFGDGCLQQ CNCHTGVPCD PISGLCLCPP
1510 1520 1530 1540 1550
GRTGAACDLD CRRGRFGPGC ALRCDCGGGA DCDPISGQCH CVDSYMGPTC
1560 1570
REVPTQISSS RPAPQHPSSR AMKH
Length:1,574
Mass (Da):165,447
Last modified:November 1, 1998 - v1
Checksum:i2B48533D8F77F6E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011532 mRNA. Translation: BAA32462.1.
PIRiT13954.
RefSeqiNP_075244.1. NM_022955.1.
UniGeneiRn.195598.

Genome annotation databases

GeneIDi65049.
KEGGirno:65049.
UCSCiRGD:621188. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011532 mRNA. Translation: BAA32462.1 .
PIRi T13954.
RefSeqi NP_075244.1. NM_022955.1.
UniGenei Rn.195598.

3D structure databases

ProteinModelPortali O88281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000169.

Proteomic databases

PRIDEi O88281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 65049.
KEGGi rno:65049.
UCSCi RGD:621188. rat.

Organism-specific databases

CTDi 1953.
RGDi 621188. Megf6.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000097840.
HOVERGENi HBG079790.
InParanoidi O88281.
PhylomeDBi O88281.

Miscellaneous databases

NextBioi 613892.

Gene expression databases

Genevestigatori O88281.

Family and domain databases

InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00053. Laminin_EGF. 9 hits.
[Graphical view ]
SMARTi SM00181. EGF. 13 hits.
SM00179. EGF_CA. 4 hits.
SM00180. EGF_Lam. 11 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 21 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Lubec G., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 482-486, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMEGF6_RAT
AccessioniPrimary (citable) accession number: O88281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3