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O88281

- MEGF6_RAT

UniProt

O88281 - MEGF6_RAT

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Protein

Multiple epidermal growth factor-like domains protein 6

Gene
Megf6, Egfl3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 6
Short name:
Multiple EGF-like domains protein 6
Alternative name(s):
Epidermal growth factor-like protein 3
Short name:
EGF-like protein 3
Gene namesi
Name:Megf6
Synonyms:Egfl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621188. Megf6.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 15741547Multiple epidermal growth factor-like domains protein 6PRO_0000007525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 108 By similarity
Disulfide bondi74 ↔ 80 By similarity
Disulfide bondi107 ↔ 120 By similarity
Disulfide bondi127 ↔ 138 By similarity
Disulfide bondi134 ↔ 147 By similarity
Disulfide bondi149 ↔ 162 By similarity
Disulfide bondi168 ↔ 179 By similarity
Disulfide bondi175 ↔ 188 By similarity
Disulfide bondi190 ↔ 203 By similarity
Disulfide bondi209 ↔ 220 By similarity
Disulfide bondi216 ↔ 230 By similarity
Disulfide bondi232 ↔ 245 By similarity
Disulfide bondi251 ↔ 262 By similarity
Disulfide bondi258 ↔ 271 By similarity
Disulfide bondi273 ↔ 286 By similarity
Disulfide bondi292 ↔ 303 By similarity
Disulfide bondi299 ↔ 312 By similarity
Disulfide bondi314 ↔ 327 By similarity
Disulfide bondi338 ↔ 349 By similarity
Disulfide bondi345 ↔ 358 By similarity
Disulfide bondi360 ↔ 373 By similarity
Disulfide bondi379 ↔ 389 By similarity
Disulfide bondi385 ↔ 398 By similarity
Disulfide bondi400 ↔ 411 By similarity
Disulfide bondi419 ↔ 430 By similarity
Disulfide bondi426 ↔ 439 By similarity
Disulfide bondi441 ↔ 454 By similarity
Disulfide bondi524 ↔ 537 By similarity
Disulfide bondi531 ↔ 544 By similarity
Disulfide bondi546 ↔ 555 By similarity
Disulfide bondi568 ↔ 580 By similarity
Disulfide bondi574 ↔ 587 By similarity
Disulfide bondi589 ↔ 598 By similarity
Disulfide bondi611 ↔ 623 By similarity
Disulfide bondi617 ↔ 630 By similarity
Disulfide bondi632 ↔ 641 By similarity
Disulfide bondi654 ↔ 668 By similarity
Disulfide bondi660 ↔ 675 By similarity
Disulfide bondi677 ↔ 686 By similarity
Disulfide bondi699 ↔ 711 By similarity
Disulfide bondi705 ↔ 718 By similarity
Disulfide bondi722 ↔ 731 By similarity
Disulfide bondi744 ↔ 755 By similarity
Disulfide bondi750 ↔ 762 By similarity
Disulfide bondi764 ↔ 773 By similarity
Disulfide bondi786 ↔ 799 By similarity
Disulfide bondi793 ↔ 806 By similarity
Disulfide bondi808 ↔ 817 By similarity
Disulfide bondi830 ↔ 842 By similarity
Disulfide bondi836 ↔ 849 By similarity
Disulfide bondi851 ↔ 860 By similarity
Disulfide bondi873 ↔ 886 By similarity
Disulfide bondi879 ↔ 893 By similarity
Disulfide bondi895 ↔ 904 By similarity
Disulfide bondi917 ↔ 929 By similarity
Disulfide bondi923 ↔ 936 By similarity
Disulfide bondi938 ↔ 947 By similarity
Disulfide bondi960 ↔ 972 By similarity
Disulfide bondi966 ↔ 979 By similarity
Disulfide bondi981 ↔ 990 By similarity
Disulfide bondi1003 ↔ 1015 By similarity
Disulfide bondi1009 ↔ 1022 By similarity
Disulfide bondi1024 ↔ 1033 By similarity
Disulfide bondi1046 ↔ 1058 By similarity
Disulfide bondi1052 ↔ 1065 By similarity
Disulfide bondi1067 ↔ 1076 By similarity
Disulfide bondi1089 ↔ 1101 By similarity
Disulfide bondi1095 ↔ 1108 By similarity
Disulfide bondi1110 ↔ 1119 By similarity
Disulfide bondi1132 ↔ 1144 By similarity
Disulfide bondi1138 ↔ 1151 By similarity
Disulfide bondi1153 ↔ 1162 By similarity
Disulfide bondi1175 ↔ 1187 By similarity
Disulfide bondi1181 ↔ 1194 By similarity
Disulfide bondi1196 ↔ 1205 By similarity
Disulfide bondi1218 ↔ 1231 By similarity
Disulfide bondi1224 ↔ 1238 By similarity
Disulfide bondi1240 ↔ 1249 By similarity
Disulfide bondi1262 ↔ 1274 By similarity
Disulfide bondi1268 ↔ 1281 By similarity
Disulfide bondi1283 ↔ 1292 By similarity
Disulfide bondi1305 ↔ 1317 By similarity
Disulfide bondi1311 ↔ 1324 By similarity
Disulfide bondi1326 ↔ 1335 By similarity
Disulfide bondi1348 ↔ 1360 By similarity
Disulfide bondi1354 ↔ 1367 By similarity
Disulfide bondi1369 ↔ 1378 By similarity
Disulfide bondi1391 ↔ 1403 By similarity
Disulfide bondi1397 ↔ 1410 By similarity
Disulfide bondi1412 ↔ 1421 By similarity
Disulfide bondi1434 ↔ 1446 By similarity
Disulfide bondi1440 ↔ 1453 By similarity
Disulfide bondi1455 ↔ 1464 By similarity
Disulfide bondi1477 ↔ 1489 By similarity
Disulfide bondi1483 ↔ 1496 By similarity
Disulfide bondi1498 ↔ 1507 By similarity
Disulfide bondi1520 ↔ 1532 By similarity
Disulfide bondi1526 ↔ 1539 By similarity
Disulfide bondi1541 ↔ 1550 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO88281.

Expressioni

Tissue specificityi

Expressed in lung.1 Publication

Gene expression databases

GenevestigatoriO88281.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000169.

Structurei

3D structure databases

ProteinModelPortaliO88281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 12283EMIAdd
BLAST
Domaini123 – 16341EGF-like 1; calcium-binding Reviewed predictionAdd
BLAST
Domaini164 – 20441EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini205 – 24642EGF-like 3Add
BLAST
Domaini247 – 28741EGF-like 4Add
BLAST
Domaini288 – 32841EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini334 – 37441EGF-like 6Add
BLAST
Domaini375 – 41238EGF-like 7Add
BLAST
Domaini415 – 45541EGF-like 8; calcium-binding Reviewed predictionAdd
BLAST
Domaini520 – 55637EGF-like 9Add
BLAST
Domaini564 – 59936EGF-like 10Add
BLAST
Domaini607 – 64236EGF-like 11Add
BLAST
Domaini650 – 68738EGF-like 12Add
BLAST
Domaini695 – 73238EGF-like 13Add
BLAST
Domaini740 – 77435EGF-like 14Add
BLAST
Domaini782 – 81837EGF-like 15Add
BLAST
Domaini826 – 86136EGF-like 16Add
BLAST
Domaini869 – 90537EGF-like 17Add
BLAST
Domaini913 – 94836EGF-like 18Add
BLAST
Domaini956 – 99136EGF-like 19Add
BLAST
Domaini999 – 103436EGF-like 20Add
BLAST
Domaini1042 – 107736EGF-like 21Add
BLAST
Domaini1085 – 112036EGF-like 22Add
BLAST
Domaini1128 – 116336EGF-like 23Add
BLAST
Domaini1171 – 120636EGF-like 24Add
BLAST
Domaini1214 – 125037EGF-like 25Add
BLAST
Domaini1258 – 129336EGF-like 26Add
BLAST
Domaini1301 – 133636EGF-like 27Add
BLAST
Domaini1344 – 137936EGF-like 28Add
BLAST
Domaini1387 – 142236EGF-like 29Add
BLAST
Domaini1430 – 146536EGF-like 30Add
BLAST
Domaini1473 – 150836EGF-like 31Add
BLAST
Domaini1516 – 155136EGF-like 32Add
BLAST

Sequence similaritiesi

Contains 32 EGF-like domains.
Contains 1 EMI domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000097840.
HOVERGENiHBG079790.
InParanoidiO88281.
PhylomeDBiO88281.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00053. Laminin_EGF. 9 hits.
[Graphical view]
SMARTiSM00181. EGF. 13 hits.
SM00179. EGF_CA. 4 hits.
SM00180. EGF_Lam. 11 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 21 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88281-1 [UniParc]FASTAAdd to Basket

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MPVRAEARAA WRVVALALLL LPAMPAASPP LTPRPLQPSM PHVCAEQKLT     50
LVGHRQPCVQ AFSRIVPVWR RTGCAQQAWC IGQERRTVYY MSYRQVYATE 100
ARTVFRCCPG WSQKPGQEGC LSDVDECASA NGGCEGPCCN TVGGFYCRCP 150
PGYQLQGDGK TCQDVDECRA HNGGCQHRCV NTPGSYLCEC KPGFRLHTDG 200
RTCLAISSCT LGNGGCQHQC VQLTVTQHRC QCRPQYQLQE DGRRCVRRSP 250
CAEGNGGCMH ICQELRGLAH CGCHPGYQLA ADRKTCEDVD ECALGLAQCA 300
HGCLNTQGSF KCVCHAGYEL GADGRQCYRI EMEIVNSCEA GNGGCSHGCS 350
HTSTGPLCTC PRGYELDEDQ KTCIDIDDCA NSPCCQQACA NTPGGYECSC 400
FAGYRLNTDG CGCEDVDECA SGHGGCEHHC SNLAGSFQCF CEAGYRLDED 450
RRGCTSLEES VVDLDGRLPF VRPLPHIAVL RDELPRLFQD DYGAEEEAAA 500
AELRGEHTLT EKFVCLDHSF GHDCSLTCDD CRNGGTCFPG QDGCDCPEGW 550
TGIICNETCP PDTFGKNCSS PCTCQNGGTC DPVLGACRCP PGVSGAHCED 600
GCPKGFYGKH CRKKCHCANR GRCHRLYGAC LCDPGLYGRF CHLACPPWAF 650
GPGCSEDCLC EQSHTRSCNP KDGSCSCKAG FQGERCQAEC ESGFFGPGCR 700
HRCTCQPGVA CDPVSGECRT QCPPGYQGED CGQECPVGTF GVNCSGSCSC 750
VGAPCHRVTG ECLCPPGKTG EDCGADCPEG RWGLGCQEIC PACEHGASCN 800
PETGTCLCLP GFVGSRCQDT CSAGWYGTGC QIRCACANDG HCDPTTGRCS 850
CAPGWTGLSC QRACDSGHWG PDCIHPCNCS AGHGNCDAVS GLCLCEAGYE 900
GPRCEQSCRQ GYYGPSCEQK CRCEHGAACD HVSGACTCPA GWRGSFCEHA 950
CPAGFFGLDC DSACNCSAGA PCDAVTGSCI CPAGRWGPRC AQSCPPLTFG 1000
LNCSQICTCF NGASCDSVTG QCHCAPGWMG PTCLQACPPG LYGKNCQHSC 1050
LCRNGGRCDP ILGQCTCPEG WTGLACENEC LPGHYAAGCQ LNCSCLHGGI 1100
CDRLTGHCLC PAGWTGDKCQ SSCVSGTFGV HCEEHCACRK GASCHHVTGA 1150
CFCPPGWRGP HCEQACPRGW FGEACAQRCL CPTNASCHHV TGECRCPPGF 1200
TGLSCEQACQ PGTFGKDCEH LCQCPGETWA CDPASGVCTC AAGYHGTGCL 1250
QRCPSGRYGP GCEHICKCLN GGTCDPATGA CYCPAGFLGA DCSLACPQGR 1300
FGPSCAHVCA CRQGAACDPV SGACICSPGK TGVRCEHGCP QDRFGKGCEL 1350
KCACRNGGLC HATNGSCSCP LGWMGPHCEH ACPAGRYGAA CLLECFCQNN 1400
GSCEPTTGAC LCGPGFYGQA CEHSCPSGFH GPGCQRVCEC QQGAPCDPVS 1450
GQCLCPAGFH GQFCEKGCES GSFGDGCLQQ CNCHTGVPCD PISGLCLCPP 1500
GRTGAACDLD CRRGRFGPGC ALRCDCGGGA DCDPISGQCH CVDSYMGPTC 1550
REVPTQISSS RPAPQHPSSR AMKH 1574
Length:1,574
Mass (Da):165,447
Last modified:November 1, 1998 - v1
Checksum:i2B48533D8F77F6E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011532 mRNA. Translation: BAA32462.1.
PIRiT13954.
RefSeqiNP_075244.1. NM_022955.1.
UniGeneiRn.195598.

Genome annotation databases

GeneIDi65049.
KEGGirno:65049.
UCSCiRGD:621188. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011532 mRNA. Translation: BAA32462.1 .
PIRi T13954.
RefSeqi NP_075244.1. NM_022955.1.
UniGenei Rn.195598.

3D structure databases

ProteinModelPortali O88281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000169.

Proteomic databases

PRIDEi O88281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 65049.
KEGGi rno:65049.
UCSCi RGD:621188. rat.

Organism-specific databases

CTDi 1953.
RGDi 621188. Megf6.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000097840.
HOVERGENi HBG079790.
InParanoidi O88281.
PhylomeDBi O88281.

Miscellaneous databases

NextBioi 613892.

Gene expression databases

Genevestigatori O88281.

Family and domain databases

InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00053. Laminin_EGF. 9 hits.
[Graphical view ]
SMARTi SM00181. EGF. 13 hits.
SM00179. EGF_CA. 4 hits.
SM00180. EGF_Lam. 11 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 21 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Lubec G., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 482-486, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMEGF6_RAT
AccessioniPrimary (citable) accession number: O88281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi