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O88281 (MEGF6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multiple epidermal growth factor-like domains protein 6

Short name=Multiple EGF-like domains protein 6
Alternative name(s):
Epidermal growth factor-like protein 3
Short name=EGF-like protein 3
Gene names
Name:Megf6
Synonyms:Egfl3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1574 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in lung. Ref.1

Sequence similarities

Contains 32 EGF-like domains.

Contains 1 EMI domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 15741547Multiple epidermal growth factor-like domains protein 6
PRO_0000007525

Regions

Domain40 – 12283EMI
Domain123 – 16341EGF-like 1; calcium-binding Potential
Domain164 – 20441EGF-like 2; calcium-binding Potential
Domain205 – 24642EGF-like 3
Domain247 – 28741EGF-like 4
Domain288 – 32841EGF-like 5; calcium-binding Potential
Domain334 – 37441EGF-like 6
Domain375 – 41238EGF-like 7
Domain415 – 45541EGF-like 8; calcium-binding Potential
Domain520 – 55637EGF-like 9
Domain564 – 59936EGF-like 10
Domain607 – 64236EGF-like 11
Domain650 – 68738EGF-like 12
Domain695 – 73238EGF-like 13
Domain740 – 77435EGF-like 14
Domain782 – 81837EGF-like 15
Domain826 – 86136EGF-like 16
Domain869 – 90537EGF-like 17
Domain913 – 94836EGF-like 18
Domain956 – 99136EGF-like 19
Domain999 – 103436EGF-like 20
Domain1042 – 107736EGF-like 21
Domain1085 – 112036EGF-like 22
Domain1128 – 116336EGF-like 23
Domain1171 – 120636EGF-like 24
Domain1214 – 125037EGF-like 25
Domain1258 – 129336EGF-like 26
Domain1301 – 133636EGF-like 27
Domain1344 – 137936EGF-like 28
Domain1387 – 142236EGF-like 29
Domain1430 – 146536EGF-like 30
Domain1473 – 150836EGF-like 31
Domain1516 – 155136EGF-like 32

Amino acid modifications

Disulfide bond44 ↔ 108 By similarity
Disulfide bond74 ↔ 80 By similarity
Disulfide bond107 ↔ 120 By similarity
Disulfide bond127 ↔ 138 By similarity
Disulfide bond134 ↔ 147 By similarity
Disulfide bond149 ↔ 162 By similarity
Disulfide bond168 ↔ 179 By similarity
Disulfide bond175 ↔ 188 By similarity
Disulfide bond190 ↔ 203 By similarity
Disulfide bond209 ↔ 220 By similarity
Disulfide bond216 ↔ 230 By similarity
Disulfide bond232 ↔ 245 By similarity
Disulfide bond251 ↔ 262 By similarity
Disulfide bond258 ↔ 271 By similarity
Disulfide bond273 ↔ 286 By similarity
Disulfide bond292 ↔ 303 By similarity
Disulfide bond299 ↔ 312 By similarity
Disulfide bond314 ↔ 327 By similarity
Disulfide bond338 ↔ 349 By similarity
Disulfide bond345 ↔ 358 By similarity
Disulfide bond360 ↔ 373 By similarity
Disulfide bond379 ↔ 389 By similarity
Disulfide bond385 ↔ 398 By similarity
Disulfide bond400 ↔ 411 By similarity
Disulfide bond419 ↔ 430 By similarity
Disulfide bond426 ↔ 439 By similarity
Disulfide bond441 ↔ 454 By similarity
Disulfide bond524 ↔ 537 By similarity
Disulfide bond531 ↔ 544 By similarity
Disulfide bond546 ↔ 555 By similarity
Disulfide bond568 ↔ 580 By similarity
Disulfide bond574 ↔ 587 By similarity
Disulfide bond589 ↔ 598 By similarity
Disulfide bond611 ↔ 623 By similarity
Disulfide bond617 ↔ 630 By similarity
Disulfide bond632 ↔ 641 By similarity
Disulfide bond654 ↔ 668 By similarity
Disulfide bond660 ↔ 675 By similarity
Disulfide bond677 ↔ 686 By similarity
Disulfide bond699 ↔ 711 By similarity
Disulfide bond705 ↔ 718 By similarity
Disulfide bond722 ↔ 731 By similarity
Disulfide bond744 ↔ 755 By similarity
Disulfide bond750 ↔ 762 By similarity
Disulfide bond764 ↔ 773 By similarity
Disulfide bond786 ↔ 799 By similarity
Disulfide bond793 ↔ 806 By similarity
Disulfide bond808 ↔ 817 By similarity
Disulfide bond830 ↔ 842 By similarity
Disulfide bond836 ↔ 849 By similarity
Disulfide bond851 ↔ 860 By similarity
Disulfide bond873 ↔ 886 By similarity
Disulfide bond879 ↔ 893 By similarity
Disulfide bond895 ↔ 904 By similarity
Disulfide bond917 ↔ 929 By similarity
Disulfide bond923 ↔ 936 By similarity
Disulfide bond938 ↔ 947 By similarity
Disulfide bond960 ↔ 972 By similarity
Disulfide bond966 ↔ 979 By similarity
Disulfide bond981 ↔ 990 By similarity
Disulfide bond1003 ↔ 1015 By similarity
Disulfide bond1009 ↔ 1022 By similarity
Disulfide bond1024 ↔ 1033 By similarity
Disulfide bond1046 ↔ 1058 By similarity
Disulfide bond1052 ↔ 1065 By similarity
Disulfide bond1067 ↔ 1076 By similarity
Disulfide bond1089 ↔ 1101 By similarity
Disulfide bond1095 ↔ 1108 By similarity
Disulfide bond1110 ↔ 1119 By similarity
Disulfide bond1132 ↔ 1144 By similarity
Disulfide bond1138 ↔ 1151 By similarity
Disulfide bond1153 ↔ 1162 By similarity
Disulfide bond1175 ↔ 1187 By similarity
Disulfide bond1181 ↔ 1194 By similarity
Disulfide bond1196 ↔ 1205 By similarity
Disulfide bond1218 ↔ 1231 By similarity
Disulfide bond1224 ↔ 1238 By similarity
Disulfide bond1240 ↔ 1249 By similarity
Disulfide bond1262 ↔ 1274 By similarity
Disulfide bond1268 ↔ 1281 By similarity
Disulfide bond1283 ↔ 1292 By similarity
Disulfide bond1305 ↔ 1317 By similarity
Disulfide bond1311 ↔ 1324 By similarity
Disulfide bond1326 ↔ 1335 By similarity
Disulfide bond1348 ↔ 1360 By similarity
Disulfide bond1354 ↔ 1367 By similarity
Disulfide bond1369 ↔ 1378 By similarity
Disulfide bond1391 ↔ 1403 By similarity
Disulfide bond1397 ↔ 1410 By similarity
Disulfide bond1412 ↔ 1421 By similarity
Disulfide bond1434 ↔ 1446 By similarity
Disulfide bond1440 ↔ 1453 By similarity
Disulfide bond1455 ↔ 1464 By similarity
Disulfide bond1477 ↔ 1489 By similarity
Disulfide bond1483 ↔ 1496 By similarity
Disulfide bond1498 ↔ 1507 By similarity
Disulfide bond1520 ↔ 1532 By similarity
Disulfide bond1526 ↔ 1539 By similarity
Disulfide bond1541 ↔ 1550 By similarity

Sequences

Sequence LengthMass (Da)Tools
O88281 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 2B48533D8F77F6E7

FASTA1,574165,447
        10         20         30         40         50         60 
MPVRAEARAA WRVVALALLL LPAMPAASPP LTPRPLQPSM PHVCAEQKLT LVGHRQPCVQ 

        70         80         90        100        110        120 
AFSRIVPVWR RTGCAQQAWC IGQERRTVYY MSYRQVYATE ARTVFRCCPG WSQKPGQEGC 

       130        140        150        160        170        180 
LSDVDECASA NGGCEGPCCN TVGGFYCRCP PGYQLQGDGK TCQDVDECRA HNGGCQHRCV 

       190        200        210        220        230        240 
NTPGSYLCEC KPGFRLHTDG RTCLAISSCT LGNGGCQHQC VQLTVTQHRC QCRPQYQLQE 

       250        260        270        280        290        300 
DGRRCVRRSP CAEGNGGCMH ICQELRGLAH CGCHPGYQLA ADRKTCEDVD ECALGLAQCA 

       310        320        330        340        350        360 
HGCLNTQGSF KCVCHAGYEL GADGRQCYRI EMEIVNSCEA GNGGCSHGCS HTSTGPLCTC 

       370        380        390        400        410        420 
PRGYELDEDQ KTCIDIDDCA NSPCCQQACA NTPGGYECSC FAGYRLNTDG CGCEDVDECA 

       430        440        450        460        470        480 
SGHGGCEHHC SNLAGSFQCF CEAGYRLDED RRGCTSLEES VVDLDGRLPF VRPLPHIAVL 

       490        500        510        520        530        540 
RDELPRLFQD DYGAEEEAAA AELRGEHTLT EKFVCLDHSF GHDCSLTCDD CRNGGTCFPG 

       550        560        570        580        590        600 
QDGCDCPEGW TGIICNETCP PDTFGKNCSS PCTCQNGGTC DPVLGACRCP PGVSGAHCED 

       610        620        630        640        650        660 
GCPKGFYGKH CRKKCHCANR GRCHRLYGAC LCDPGLYGRF CHLACPPWAF GPGCSEDCLC 

       670        680        690        700        710        720 
EQSHTRSCNP KDGSCSCKAG FQGERCQAEC ESGFFGPGCR HRCTCQPGVA CDPVSGECRT 

       730        740        750        760        770        780 
QCPPGYQGED CGQECPVGTF GVNCSGSCSC VGAPCHRVTG ECLCPPGKTG EDCGADCPEG 

       790        800        810        820        830        840 
RWGLGCQEIC PACEHGASCN PETGTCLCLP GFVGSRCQDT CSAGWYGTGC QIRCACANDG 

       850        860        870        880        890        900 
HCDPTTGRCS CAPGWTGLSC QRACDSGHWG PDCIHPCNCS AGHGNCDAVS GLCLCEAGYE 

       910        920        930        940        950        960 
GPRCEQSCRQ GYYGPSCEQK CRCEHGAACD HVSGACTCPA GWRGSFCEHA CPAGFFGLDC 

       970        980        990       1000       1010       1020 
DSACNCSAGA PCDAVTGSCI CPAGRWGPRC AQSCPPLTFG LNCSQICTCF NGASCDSVTG 

      1030       1040       1050       1060       1070       1080 
QCHCAPGWMG PTCLQACPPG LYGKNCQHSC LCRNGGRCDP ILGQCTCPEG WTGLACENEC 

      1090       1100       1110       1120       1130       1140 
LPGHYAAGCQ LNCSCLHGGI CDRLTGHCLC PAGWTGDKCQ SSCVSGTFGV HCEEHCACRK 

      1150       1160       1170       1180       1190       1200 
GASCHHVTGA CFCPPGWRGP HCEQACPRGW FGEACAQRCL CPTNASCHHV TGECRCPPGF 

      1210       1220       1230       1240       1250       1260 
TGLSCEQACQ PGTFGKDCEH LCQCPGETWA CDPASGVCTC AAGYHGTGCL QRCPSGRYGP 

      1270       1280       1290       1300       1310       1320 
GCEHICKCLN GGTCDPATGA CYCPAGFLGA DCSLACPQGR FGPSCAHVCA CRQGAACDPV 

      1330       1340       1350       1360       1370       1380 
SGACICSPGK TGVRCEHGCP QDRFGKGCEL KCACRNGGLC HATNGSCSCP LGWMGPHCEH 

      1390       1400       1410       1420       1430       1440 
ACPAGRYGAA CLLECFCQNN GSCEPTTGAC LCGPGFYGQA CEHSCPSGFH GPGCQRVCEC 

      1450       1460       1470       1480       1490       1500 
QQGAPCDPVS GQCLCPAGFH GQFCEKGCES GSFGDGCLQQ CNCHTGVPCD PISGLCLCPP 

      1510       1520       1530       1540       1550       1560 
GRTGAACDLD CRRGRFGPGC ALRCDCGGGA DCDPISGQCH CVDSYMGPTC REVPTQISSS 

      1570 
RPAPQHPSSR AMKH 

« Hide

References

[1]"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Brain.
[2]Lubec G., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 482-486, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011532 mRNA. Translation: BAA32462.1.
PIRT13954.
RefSeqNP_075244.1. NM_022955.1.
UniGeneRn.195598.

3D structure databases

ProteinModelPortalO88281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000169.

Proteomic databases

PRIDEO88281.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65049.
KEGGrno:65049.
UCSCRGD:621188. rat.

Organism-specific databases

CTD1953.
RGD621188. Megf6.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000097840.
HOVERGENHBG079790.
InParanoidO88281.
PhylomeDBO88281.

Gene expression databases

GenevestigatorO88281.

Family and domain databases

InterProIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00053. Laminin_EGF. 9 hits.
[Graphical view]
SMARTSM00181. EGF. 13 hits.
SM00179. EGF_CA. 4 hits.
SM00180. EGF_Lam. 11 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 23 hits.
PS01186. EGF_2. 23 hits.
PS50026. EGF_3. 21 hits.
PS01187. EGF_CA. 5 hits.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613892.

Entry information

Entry nameMEGF6_RAT
AccessionPrimary (citable) accession number: O88281
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families