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Protein

Slit homolog 1 protein

Gene

Slit1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • brain development Source: RGD
  • negative regulation of axon extension involved in axon guidance Source: RGD
  • negative regulation of synapse assembly Source: UniProtKB
  • Roundabout signaling pathway Source: GO_Central
  • spinal cord development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 1 protein
Short name:
Slit-1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name:
Multiple EGF-like domains protein 4
Gene namesi
Name:Slit1
Synonyms:Megf4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69307. Slit1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 15311498Slit homolog 1 proteinPRO_0000007724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi286 ↔ 295By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi443 ↔ 466By similarity
Disulfide bondi445 ↔ 487By similarity
Disulfide bondi513 ↔ 519By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi675 ↔ 698By similarity
Disulfide bondi677 ↔ 719By similarity
Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence analysis
Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence analysis
Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi929 ↔ 940By similarity
Disulfide bondi934 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 991By similarity
Disulfide bondi993 ↔ 1002By similarity
Disulfide bondi1009 ↔ 1020By similarity
Disulfide bondi1014 ↔ 1029By similarity
Glycosylationi1026 – 10261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1047 ↔ 1060By similarity
Disulfide bondi1054 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1107By similarity
Disulfide bondi1109 ↔ 1118By similarity
Disulfide bondi1128 ↔ 1139By similarity
Disulfide bondi1133 ↔ 1148By similarity
Disulfide bondi1150 ↔ 1159By similarity
Glycosylationi1186 – 11861N-linked (GlcNAc...)Sequence analysis
Glycosylationi1256 – 12561N-linked (GlcNAc...)Sequence analysis
Glycosylationi1303 – 13031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1310 ↔ 1336By similarity
Disulfide bondi1339 ↔ 1349By similarity
Disulfide bondi1344 ↔ 1359By similarity
Disulfide bondi1361 ↔ 1370By similarity
Disulfide bondi1378 ↔ 1388By similarity
Disulfide bondi1383 ↔ 1398By similarity
Disulfide bondi1400 ↔ 1409By similarity
Disulfide bondi1419 ↔ 1429By similarity
Disulfide bondi1424 ↔ 1439By similarity
Disulfide bondi1441 ↔ 1450By similarity
Disulfide bondi1456 ↔ 1495By similarity
Disulfide bondi1474 ↔ 1509By similarity
Disulfide bondi1485 ↔ 1525By similarity
Disulfide bondi1489 ↔ 1527By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88279.
PRIDEiO88279.

PTM databases

iPTMnetiO88279.
PhosphoSiteiO88279.

Expressioni

Tissue specificityi

In adult brains expressed in the hippocampus, cerebral cortex, and olfactory bulb but not in the cerebellum. In embryo expressed in cerebral cortex.1 Publication

Developmental stagei

Detected between E15 and E20, between P0 and P10, and in adult in different regions of the telencephalon and diencephalon.1 Publication

Gene expression databases

BgeeiENSRNOG00000026065.

Interactioni

Subunit structurei

Interacts with ROBO1 (By similarity) and GREM1.By similarity1 Publication

GO - Molecular functioni

  • heparan sulfate proteoglycan binding Source: RGD
  • Roundabout binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035315.

Structurei

3D structure databases

ProteinModelPortaliO88279.
SMRiO88279. Positions 282-487, 512-721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Domaini215 – 26551LRRCT 1Add
BLAST
Domaini273 – 30937LRRNT 2Add
BLAST
Repeati310 – 33122LRR 7Add
BLAST
Repeati334 – 35522LRR 8Add
BLAST
Repeati358 – 37922LRR 9Add
BLAST
Repeati382 – 40322LRR 10Add
BLAST
Repeati406 – 42722LRR 11Add
BLAST
Domaini439 – 48951LRRCT 2Add
BLAST
Domaini504 – 54037LRRNT 3Add
BLAST
Repeati541 – 56222LRR 12Add
BLAST
Repeati566 – 58722LRR 13Add
BLAST
Repeati590 – 61122LRR 14Add
BLAST
Repeati614 – 63522LRR 15Add
BLAST
Repeati638 – 65922LRR 16Add
BLAST
Domaini671 – 72151LRRCT 3Add
BLAST
Domaini725 – 76137LRRNT 4Add
BLAST
Repeati762 – 78322LRR 17Add
BLAST
Repeati785 – 80622LRR 18Add
BLAST
Repeati809 – 83022LRR 19Add
BLAST
Repeati833 – 85422LRR 20Add
BLAST
Domaini866 – 91651LRRCT 4Add
BLAST
Domaini927 – 96236EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini964 – 100340EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1005 – 104137EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1043 – 108139EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini1083 – 111937EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1124 – 116037EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini1163 – 1336174Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini1337 – 137135EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini1374 – 141037EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini1415 – 145137EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini1456 – 153176CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated
Contains 4 LRRCT domains.Curated
Contains 4 LRRNT domains.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO88279.
KOiK06838.
PhylomeDBiO88279.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 4 hits.
PF12661. hEGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF13855. LRR_8. 6 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 7 hits.
SM00274. FOLN. 3 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 18 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52058. SSF52058. 4 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTPQRGSS SGLSRPELWL LLWAAAWRLG ATACPALCTC TGTTVDCHGT
60 70 80 90 100
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV
110 120 130 140 150
ERGAFDDMKE LERLRLNRNQ LQVLPELLFQ NNQALSRLDL SENSLQAVPR
160 170 180 190 200
KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS
210 220 230 240 250
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG
260 270 280 290 300
LNVAEVQKSE FSCSGQGEAA QVPACTLSSG SCPAMCSCSN GIVDCRGKGL
310 320 330 340 350
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP
360 370 380 390 400
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA
410 420 430 440 450
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL
460 470 480 490 500
ADFLRTNPIE TTGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED
510 520 530 540 550
YHLNSECTSD VACPHKCRCE ASVVECSGLK LSKIPERIPQ STTELRLNNN
560 570 580 590 600
EISILEATGL FKKLSHLKKI NLSNNKVSEI EDGTFEGATS VSELHLTANQ
610 620 630 640 650
LESVRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNHIT
660 670 680 690 700
TISPGAFDTL QALSTLNLLA NPFNCNCQLA WLGDWLRKRK IVTGNPRCQN
710 720 730 740 750
PDFLRQIPLQ DVAFPDFRCE EGQEEVGCLP RPQCPQECAC LDTVVRCSNK
760 770 780 790 800
HLQALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS
810 820 830 840 850
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDVSTLQEG
860 870 880 890 900
IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPPEME
910 920 930 940 950
GKLLLTTPAK KFECQGPPSL AVQAKCDPCL SSPCQNQGTC HNDPLEVYRC
960 970 980 990 1000
TCPSGYKGRN CEVSLDSCSS NPCGNGGTCH AQEGEDAGFT CSCPSGFEGL
1010 1020 1030 1040 1050
TCGMNTDDCV KHDCVNGGVC VDGIGNYTCQ CPLQYTGRAC EQLVDFCSPD
1060 1070 1080 1090 1100
LNPCQHEAQC VGTPEGPRCE CVPGYTGDNC SKNQDDCKDH QCQNGAQCVD
1110 1120 1130 1140 1150
EINSYACLCA EGYSGQLCEI PPAPRNSCEG TECQNGANCV DQGSRPVCQC
1160 1170 1180 1190 1200
LPGFGGPECE KLLSVNFVDR DTYLQFTDLQ NWPRANITLQ VSTAEDNGIL
1210 1220 1230 1240 1250
LYNGDNDHIA VELYQGHVRV SYDPGSYPSS AIYSAETIND GQFHTVELVT
1260 1270 1280 1290 1300
FDQMVNLSID GGSPMTMDNF GKHYTLNSEA PLYVGGMPVD VNSAAFRLWQ
1310 1320 1330 1340 1350
ILNGTSFHGC IRNLYINNEL QDFTKTQMKP GVVPGCEPCR KLYCLHGICQ
1360 1370 1380 1390 1400
PNATPGPVCH CEAGWGGLHC DQPVDGPCHG HKCVHGKCVP LDALAYSCQC
1410 1420 1430 1440 1450
QDGYSGALCN QVGAVAEPCG GLQCLHGHCQ ASATRGAHCV CSPGFSGELC
1460 1470 1480 1490 1500
EQESECRGDP VRDFHRVQRG YAICQTTRPL SWVECRGACP GQGCCQGLRL
1510 1520 1530
KRRKLTFECS DGTSFAEEVE KPTKCGCAPC A
Length:1,531
Mass (Da):167,499
Last modified:November 1, 1998 - v1
Checksum:iDFC4B60CCBC5529A
GO
Isoform 2 (identifier: O88279-2) [UniParc]FASTAAdd to basket
Also known as: Sb

The sequence of this isoform differs from the canonical sequence as follows:
     1412-1474: VGAVAEPCGG...HRVQRGYAIC → SPSAGGTLSG...LRVQRWDLVC
     1475-1531: Missing.

Show »
Length:1,474
Mass (Da):161,215
Checksum:iB725C10B6A4E3A56
GO
Isoform 3 (identifier: O88279-3) [UniParc]FASTAAdd to basket
Also known as: La

The sequence of this isoform differs from the canonical sequence as follows:
     1453-1458: ESECRG → GQGAPS
     1459-1531: Missing.

Show »
Length:1,458
Mass (Da):159,243
Checksum:i0E2C7E457FB74B93
GO
Isoform 4 (identifier: O88279-4) [UniParc]FASTAAdd to basket
Also known as: Sa

The sequence of this isoform differs from the canonical sequence as follows:
     113-136: Missing.

Show »
Length:1,507
Mass (Da):164,638
Checksum:i42A671CC99C19EA0
GO

Sequence cautioni

The sequence BAC21664 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751R → W in AAD25540 (PubMed:10102268).Curated
Sequence conflicti96 – 961Q → P in AAD25540 (PubMed:10102268).Curated
Sequence conflicti100 – 1001V → A in BAC21666 (Ref. 3) Curated
Sequence conflicti102 – 1021R → P in AAD25540 (PubMed:10102268).Curated
Sequence conflicti108 – 1081M → V in BAC21665 (Ref. 3) Curated
Sequence conflicti113 – 1153RLR → PFQ in AAD25540 (PubMed:10102268).Curated
Sequence conflicti123 – 1231V → M in AAD25540 (PubMed:10102268).Curated
Sequence conflicti171 – 1711C → R in BAC21664 (Ref. 3) Curated
Sequence conflicti264 – 2641S → T in BAC21665 (Ref. 3) Curated
Sequence conflicti408 – 4081S → P in BAC21665 (Ref. 3) Curated
Sequence conflicti442 – 4432IC → TW in BAC21665 (Ref. 3) Curated
Sequence conflicti468 – 4681S → T in BAC21666 (Ref. 3) Curated
Sequence conflicti523 – 5231V → A in BAC21666 (Ref. 3) Curated
Sequence conflicti616 – 6172RT → WS in AAD25540 (PubMed:10102268).Curated
Sequence conflicti652 – 6521I → T in BAC21665 (Ref. 3) Curated
Sequence conflicti699 – 6991Q → H in BAC21666 (Ref. 3) Curated
Sequence conflicti703 – 7031F → L in BAC21665 (Ref. 3) Curated
Sequence conflicti739 – 7391A → T in BAC21665 (Ref. 3) Curated
Sequence conflicti739 – 7391A → T in BAC21666 (Ref. 3) Curated
Sequence conflicti754 – 7563ALP → LL in AAD25540 (PubMed:10102268).Curated
Sequence conflicti921 – 9211A → T in BAC21666 (Ref. 3) Curated
Sequence conflicti932 – 9321S → N in AAD25540 (PubMed:10102268).Curated
Sequence conflicti1008 – 10081D → N in BAC21665 (Ref. 3) Curated
Sequence conflicti1078 – 10781D → A in BAC21666 (Ref. 3) Curated
Sequence conflicti1094 – 10941N → T in BAC21666 (Ref. 3) Curated
Sequence conflicti1159 – 11591C → R in BAC21665 (Ref. 3) Curated
Sequence conflicti1247 – 12471E → K in AAD25540 (PubMed:10102268).Curated
Sequence conflicti1256 – 12561N → D in BAC21665 (Ref. 3) Curated
Sequence conflicti1258 – 12581S → F in AAD25540 (PubMed:10102268).Curated
Sequence conflicti1280 – 12834APLY → GPPS in AAD25540 (PubMed:10102268).Curated
Sequence conflicti1433 – 14331A → V in AAD25540 (PubMed:10102268).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 13624Missing in isoform 4. 1 PublicationVSP_009709Add
BLAST
Alternative sequencei1412 – 147463VGAVA…GYAIC → SPSAGGTLSGTFTGSRGAMP SARPRAHCHGWNAGARARAR AAARAAAEAEEAHLRVQRWD LVC in isoform 2. 1 PublicationVSP_009710Add
BLAST
Alternative sequencei1453 – 14586ESECRG → GQGAPS in isoform 3. 1 PublicationVSP_009712
Alternative sequencei1459 – 153173Missing in isoform 3. 1 PublicationVSP_009713Add
BLAST
Alternative sequencei1475 – 153157Missing in isoform 2. 1 PublicationVSP_009711Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011530 mRNA. Translation: BAA32460.1.
AF133730 mRNA. Translation: AAD25540.1.
AB073213 mRNA. Translation: BAC21664.1. Different initiation.
AB073214 mRNA. Translation: BAC21665.1.
AB073215 mRNA. Translation: BAC21666.1.
AB017170 mRNA. Translation: BAA35187.1.
PIRiT42218.
RefSeqiNP_075242.1. NM_022953.2. [O88279-1]
UniGeneiRn.30002.

Genome annotation databases

GeneIDi65047.
KEGGirno:65047.
UCSCiRGD:69307. rat. [O88279-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011530 mRNA. Translation: BAA32460.1.
AF133730 mRNA. Translation: AAD25540.1.
AB073213 mRNA. Translation: BAC21664.1. Different initiation.
AB073214 mRNA. Translation: BAC21665.1.
AB073215 mRNA. Translation: BAC21666.1.
AB017170 mRNA. Translation: BAA35187.1.
PIRiT42218.
RefSeqiNP_075242.1. NM_022953.2. [O88279-1]
UniGeneiRn.30002.

3D structure databases

ProteinModelPortaliO88279.
SMRiO88279. Positions 282-487, 512-721.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035315.

PTM databases

iPTMnetiO88279.
PhosphoSiteiO88279.

Proteomic databases

PaxDbiO88279.
PRIDEiO88279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65047.
KEGGirno:65047.
UCSCiRGD:69307. rat. [O88279-1]

Organism-specific databases

CTDi6585.
RGDi69307. Slit1.

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO88279.
KOiK06838.
PhylomeDBiO88279.

Miscellaneous databases

PROiO88279.

Gene expression databases

BgeeiENSRNOG00000026065.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 4 hits.
PF12661. hEGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF13855. LRR_8. 6 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 7 hits.
SM00274. FOLN. 3 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 18 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52058. SSF52058. 4 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIT1_RAT
AccessioniPrimary (citable) accession number: O88279
Secondary accession number(s): Q8CJG8
, Q8CJG9, Q8CJH0, Q9QWL1, Q9WUG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.