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O88277

- FAT2_RAT

UniProt

O88277 - FAT2_RAT

Protein

Protocadherin Fat 2

Gene

Fat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May modulate the extracellular space surronding parallel fibers of cerebellar during development. Plays a role in the migration of epidermal cells By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. epithelial cell migration Source: UniProtKB
    2. homophilic cell adhesion Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin Fat 2
    Alternative name(s):
    Multiple epidermal growth factor-like domains protein 1
    Short name:
    Multiple EGF-like domains protein 1
    Gene namesi
    Name:Fat2
    Synonyms:Fath2, Megf1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620656. Fat2.

    Subcellular locationi

    Cell membrane Curated; Single-pass membrane protein Curated. Cell junction By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cell-cell adherens junction Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 43514333Protocadherin Fat 2PRO_0000004019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi996 – 9961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1175 – 11751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1276 – 12761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1417 – 14171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1899 – 18991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1998 – 19981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2007 – 20071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2102 – 21021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2165 – 21651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2183 – 21831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2325 – 23251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2368 – 23681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2387 – 23871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2430 – 24301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2470 – 24701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2547 – 25471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2597 – 25971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3127 – 31271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3278 – 32781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3312 – 33121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3432 – 34321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3603 – 36031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3770 – 37701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3774 – 37741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3815 – 38151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3842 – 38421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3875 – 38751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3906 – 39061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3914 ↔ 3946By similarity
    Disulfide bondi3953 ↔ 3964By similarity
    Disulfide bondi3958 ↔ 3974By similarity
    Disulfide bondi3976 ↔ 3985By similarity
    Glycosylationi3991 – 39911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3992 ↔ 4003By similarity
    Disulfide bondi3997 ↔ 4012By similarity
    Disulfide bondi4014 ↔ 4023By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO88277.
    PRIDEiO88277.

    PTM databases

    PhosphoSiteiO88277.

    Expressioni

    Tissue specificityi

    Cerebellum-specific expression. Expressed in thin parallel fibers of cerebellar granule cells.2 Publications

    Developmental stagei

    In the developing cerebellum, expressed in granule cells in the inner external germinal layer and in migrating granule cells whereas proliferating cells in the outer extessornal germinal layer did not shown expression. Expression levels in the internal granule cell layer peak during the third postnatal week and remain considerably high in the adult cerebellum.1 Publication

    Gene expression databases

    GenevestigatoriO88277.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi249241. 1 interaction.
    STRINGi10116.ENSRNOP00000017106.

    Structurei

    3D structure databases

    ProteinModelPortaliO88277.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 40504032ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini4072 – 4351280CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4051 – 407121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 148115Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 256108Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini363 – 45896Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini459 – 564106Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini565 – 669105Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini716 – 820105Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini821 – 925105Cadherin 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini926 – 1032107Cadherin 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1033 – 1142110Cadherin 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1138 – 1242105Cadherin 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1243 – 1346104Cadherin 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1350 – 144899Cadherin 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1449 – 1555107Cadherin 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1556 – 1660105Cadherin 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1661 – 175898Cadherin 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1759 – 1872114Cadherin 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1873 – 196896Cadherin 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1969 – 2070102Cadherin 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini2071 – 2171101Cadherin 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini2172 – 2272101Cadherin 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini2273 – 2379107Cadherin 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini2380 – 2481102Cadherin 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini2482 – 2585104Cadherin 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini2586 – 2692107Cadherin 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini2693 – 2799107Cadherin 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini2800 – 2908109Cadherin 26PROSITE-ProRule annotationAdd
    BLAST
    Domaini2909 – 3013105Cadherin 27PROSITE-ProRule annotationAdd
    BLAST
    Domaini3014 – 3115102Cadherin 28PROSITE-ProRule annotationAdd
    BLAST
    Domaini3116 – 3220105Cadherin 29PROSITE-ProRule annotationAdd
    BLAST
    Domaini3221 – 3323103Cadherin 30PROSITE-ProRule annotationAdd
    BLAST
    Domaini3324 – 3428105Cadherin 31PROSITE-ProRule annotationAdd
    BLAST
    Domaini3429 – 3533105Cadherin 32PROSITE-ProRule annotationAdd
    BLAST
    Domaini3534 – 363198Cadherin 33PROSITE-ProRule annotationAdd
    BLAST
    Domaini3775 – 3946172Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini3949 – 398638EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini3988 – 402437EGF-like 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 33 cadherin domains.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000046499.
    HOVERGENiHBG005641.
    KOiK16506.
    PhylomeDBiO88277.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    2.60.40.60. 33 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00028. Cadherin. 27 hits.
    PF00008. EGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 33 hits.
    SM00181. EGF. 2 hits.
    SM00282. LamG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 33 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS00232. CADHERIN_1. 14 hits.
    PS50268. CADHERIN_2. 33 hits.
    PS00022. EGF_1. 2 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88277-1 [UniParc]FASTAAdd to Basket

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    MTLVLLGLAI LLLHRAACEK SLEETIPPLS WRFTHSLYNA TIYENSAPKT     50
    YVESPVKMGM YLAEPHWVVK YRIISGDAAG VFKTEEHVVG NFCFLRIRTK 100
    SSNTALLNRE VRDSYTLIVQ ASDKSLEFEA LTQVVVHILD QNDLKPLFSP 150
    PSYRVTISED RPLKSPICKV TATDADLGQN AEFYYAFNAR SEVFAIHPTS 200
    GVVTVAGKLN VTRRGKYELQ VLAVDRMRKI SEGNGFGNLA SLVIRVEPVH 250
    RKPPAINLVV LNPPEGDEGD IYAIVTVDTN GSGAEVDSLE VVGGDPGKYF 300
    KVLRSYAQGN EFNLVAVRDI NWAEHPHGFN ISLQTHSWSR FPPHSIIRAF 350
    HLPSWKLANL RFEKAVYRVK LSEFSPPGSR VALVKVTTAL PNLRYSLKPS 400
    SRNTAFKLNA RTGLITTTKL VDFHEQNQYQ LHVKTSLGQA TTTVIIDIVD 450
    CNNHAPVFNR SSYEGTLDEN IPPGTSVLTV TATDQDHGDN GHITYSIAGP 500
    KAVPFSIDPL LGVISTTKPM DYELMKRIYT FRVRASDWGS PFRQEKEVSV 550
    SLRLKNLNDN QPMFEEVNCT VSLRQDVPVG KSIMAVSAID MDELQNLKYE 600
    IVSGNEQDYF HLNHFSGVIS LKRSFMNLTA VRPTIYSLKI TASDGKNYAS 650
    PTTLKVTVVK DPHSEVPVQC DKTGVLTHIT KTILQSAGLQ SQELGEEEFT 700
    SLSNYQINHH SPQFEDHFPQ SIDILEQVPI NTPLARLAAT DPDTGFHGKL 750
    VYVISDGNEE GCFDIELETG LLMVAAALDY ETTSFYVLNV TVYDLGTPPK 800
    SSWKLLTVTV KDWNDNPPRF PPGGYQLTIS EDTEVGTTIA ELKTEDADSE 850
    DNRRVRYTLL TPTEKFSLHP FTGELVVTGH LDRESESQYI LKAEARDQPT 900
    KGHQLFSVTD LIVTLEDIND NPPQCITEHR RLKVPEDMPL GTVLTFLDAS 950
    DPDLGPAGEV KYILVEDAHG TFQVHPMTGA LSLEKELDFE RRAGYNLSFW 1000
    ASDSGKPLSR RTLCHVEVLV MDVNENLHSP HFSSFVYQGQ VQENSPAGTP 1050
    VMVVTAQDDD SGLDGELQYF LRAGTGLETF SINQDTGMLE TLAPLDREFT 1100
    PYYWLTVLAV DRGSVPLSAV TEVYIEVTDI NDNIPSMSRP VFYPSVLEDA 1150
    PLGTSVLQLE AWDPDSSSQG KLTFNLTSGN HLGHFIVHPF TGLLTTAKQL 1200
    DRENKDEYVL EVTVQDNGDP SLRSTSRVVV CILDVNDNPP MFSHKLFNVR 1250
    LSERLSPLSP EPVYRLVASD PDEGLNGSVT YSIEESDEES FRIDPVTGVV 1300
    SSSSTFAAGE YNILTIKATD SGQPALSTSV RLHIEWIPQP RPSSIPLSFD 1350
    ESYYSFTVME TDPVNHMVGV ISVEGRPGLF WFHISDGDKD MDFDIEKTTG 1400
    SIVIARPLDT RRKSSYNLTV EVTDGFHTIA TQVHIFMIAN INHHRPQFLQ 1450
    DHYEIRVPQD TLPGVELLRV QATDQDHGKG LIYTILSSQD PGSANLFQLD 1500
    PSSGVLVTVG TLELHSGPSQ HILTVMVRDQ EMPIKRNFVW VTIHVEDGNL 1550
    HSPHFTQLRY EANVPDTTAP GTELLQVRAV DADRGANAEI HYSFLKGNSD 1600
    GFFNIDSLLG IITVAQRLYH VHLTRHALTV KAEDQGSPRR HDLALVVIHV 1650
    HPSDSSAPVF SKDEYFIEIP ESVPIGSPIL LLSAGSSSEV TYELREGNKD 1700
    SVFSMNSYSG LISTQKRLDH EKVPSYRLRI RGSNMAGVFT EVVALVYIID 1750
    ENDNPPAFGK PTFLGHISEA APLHSLILGE DNSPLVVRAS DSDREANSLL 1800
    VYKILEPEAL KFFKIDPSMG TLTTTSELDF EDTPLFQFNI YVHDQGTPIL 1850
    FAPRSAKVII HVRDVNDSPP RFSEQIYEVA VVEPIHPGMG LLTVQAEDND 1900
    SRVTYSIKTS NADEAVTIHP TTGQISVVNP ATLRLFQKFS IRASDGLYHD 1950
    TAVVKISLTQ VLDKSLQFDQ DVYRARVTEN TPHRKALVIL GVHGNHLNDT 2000
    LSYFLLNGTD LFHMIESAGV LQTRGGTFDR EQQDTHEVAV EVRDNRVPQR 2050
    VAQALVRVSV EDVNDNIPEF QHLPYYTVIQ DGTEPGDVLF QVSATDKDLG 2100
    ANGSVTYGFA EDYAYFRIDP YVGDISLKKP FDYQALNKYH LRVIARDSGI 2150
    PPLQTEVEVH VTVRNKSNPL FQSPYYKVKV PENITLYTPI LHTQARSPEG 2200
    LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKNKHV FTVRATDTAL 2250
    GSFSEATVEV LVEDINDNPP TFSQLVYTTS VSEGSPAQTP VIQLLASDQD 2300
    SGQNQDVSYQ IVEDGSDVSK FFRINGSTGE IFTIQELDYE THQHFRVKVR 2350
    AMDKGDPPLT GETLVVVNVS DINDNPPKFR EPQYEANVSE LATCGHLVLK 2400
    VQALDPDIGD TSRLEYLILS GNQDRHFSIN STSGIISMFN LCKKQLDSSY 2450
    NLRVGASDGV FRATVPVYIN TTNANKYSPE FQQNVYEAEL AENAKVGTKV 2500
    IELLAIDKDS GPYGTVDYTI INKLAGERFF INPRGQITTL QKLDRENSTE 2550
    RVIAIKVMAR DGGGKVAFCT VKIILTDEND NAPQFKASGY TVSIPSNVSR 2600
    DSPIIQVLAY DADEGRNADV TYSVDSTEDL AEEIIEVNPT TGVVKVKESL 2650
    VGLENRAVDF NIKAQDGGPP HWDSLVPVRL QVVPNEIPLP KFSEPLYTFS 2700
    APEDLPEGSE IGSVKAVAAQ DPIIYSLVQG TTPESNSDDV FSLDQDTGVL 2750
    KVRKAMDHES TKWYQIDLMA HCPHEDTDLV SLVSVSIQVE DVNDNRPVFE 2800
    ADPYKAFLTE NMPGGTTVIQ VTANDQDTGS DGQVSYRLSV EPGSNIHELF 2850
    AVDSESGWIT TLQELDCETQ QTYRFYVVAF DHGQTIQLSS QALVEVSITD 2900
    ENDNPPRFAS EDYRGSVVEN NEPGELVATL KTLDADVSDQ NRQVTCYITE 2950
    GDPLGQFSIS QVGDEWRISS RKTLDREHIA KYLLRVTASD GKFQASVPVE 3000
    VFVVDINDNS PQCSQLLYTG KVREDVTPGH FILKVSAIDV DMDTNAQITY 3050
    SLHGPGAQEF KLDPHTGELT TLTVLDRERK DVYNLVAKAT DGGGQSCQAE 3100
    VTLHIEDVND NAPRFFPSHC DVAVFDNTTV KTPVAVVFAR DPDQGANAQV 3150
    VYSLTDSADG QFSIDATSGV IRLEKPLQVR ASSAVELTVR ASDLGTPIPL 3200
    STLGTVTVSV VGLEDYLPIF LNAEHSTQVP EDAPIDMEVL HLATLTRPGS 3250
    EKTGYHITGG NEQGKFRLDA HTGILYVNGS LDFETNPKYF LSIECSRKSS 3300
    SSLSDVTTIV INVTDVNEHH PRFTHDLYTV RVLENAVVGD VILTVSASDD 3350
    DGPVNSAITY SLVGGNQLGH FTINPKKGKL QVAKALDWEQ TPSYSLRLRA 3400
    TDSGQPPLHE DTEVAVEVVD VNDNPPRFFQ LNYSTSVQEN SPIGIKVLQL 3450
    ILDDPDSPQN GPPYFFRITE GNTGSVFRVT PDGWLVTAAS LSKKAREWYQ 3500
    LHIEVSDSGL PPLSSSTLVR VQVTEQSRYP PSTLPLEISI TKGEEEFQGG 3550
    MIGKIHATDR DPQDTLTYSL EQEGGLDRYF TVGASDGKII ASQGLPHGRY 3600
    SFNVTVSDGT FTTTTGVHVH VWHMEPEVPQ QAVWLGFHQL TPEELVSDHW 3650
    RNLQRFLSNL LDVKRANIHL ASLQPAEVTA GVDVLLVFER HSGTSYDLQE 3700
    LASAIAHSVR EIEHSVGIRM RSALPVVPCQ GQSCQDQTCQ ETVSLEPRVG 3750
    PSYSTARLSI LTPRHHLGRN CSCNGTTLRF SGQSYVQYRP LEAQNWQIHF 3800
    YLKTLQPWAL LMFTNETASI SLKLANGFSH LEYHCPGGFY GNLSSRYPVN 3850
    DGQWHSMLLE ERDTSVHLLV DITDNASLVI PEECQGLRTE RQLLLGGLVP 3900
    SNPSSNVSLG FEGCLDAVVV NGERLELLGR EKKMEGRLET WALSQCCWPG 3950
    TACSQSPCLN GGSCSPALGS GYLCRCPPPF SGRNCELGRE NCTSAPCQEG 4000
    GTCVSSPEGT SCNCPHPYTG DRCEMEARGC SGGHCLITPE IKRGDWGQQE 4050
    FLVITVALPL VIIATVGLLL YCRRRKSHKP VTMEDPDLLA RSIGVDTQAS 4100
    PAIELDPLNT SSCNNLNQPE PSKTSVPNEL VTFGPSSKQR PMVCSVPPRL 4150
    PPAAVSSHPG HEPIIKRTWS GEELVYPSGA AVWPPTYSRK KHWEYPHPET 4200
    MQGTLPPSPR RHVGPAVMPD PTGLYGGFPF PLELENKRAP LPPRYSNQNL 4250
    EDLMPPRPPS PREHLLAPCL NEYTAISYYH SQFRQGGGGP CLAEGGYKGV 4300
    SMRLSRAGPS YADCEVNGGP ATGRSQPRAP PNYEGSDMVE SDYGSCEEVM 4350
    F 4351
    Length:4,351
    Mass (Da):480,654
    Last modified:November 1, 1998 - v1
    Checksum:iC564E7F98EBB3888
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011527 mRNA. Translation: BAA32458.1.
    PIRiT00252.
    RefSeqiNP_075243.1. NM_022954.1.
    UniGeneiRn.137161.

    Genome annotation databases

    GeneIDi65048.
    KEGGirno:65048.
    UCSCiRGD:620656. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011527 mRNA. Translation: BAA32458.1 .
    PIRi T00252.
    RefSeqi NP_075243.1. NM_022954.1.
    UniGenei Rn.137161.

    3D structure databases

    ProteinModelPortali O88277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249241. 1 interaction.
    STRINGi 10116.ENSRNOP00000017106.

    PTM databases

    PhosphoSitei O88277.

    Proteomic databases

    PaxDbi O88277.
    PRIDEi O88277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 65048.
    KEGGi rno:65048.
    UCSCi RGD:620656. rat.

    Organism-specific databases

    CTDi 2196.
    RGDi 620656. Fat2.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000046499.
    HOVERGENi HBG005641.
    KOi K16506.
    PhylomeDBi O88277.

    Miscellaneous databases

    NextBioi 613888.
    PROi O88277.

    Gene expression databases

    Genevestigatori O88277.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    2.60.40.60. 33 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00028. Cadherin. 27 hits.
    PF00008. EGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 33 hits.
    SM00181. EGF. 2 hits.
    SM00282. LamG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 33 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS00232. CADHERIN_1. 14 hits.
    PS50268. CADHERIN_2. 33 hits.
    PS00022. EGF_1. 2 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 673-681; 2566-2572; 2968-2976 AND 3081-3088, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    3. "MEGF1/fat2 proteins containing extraordinarily large extracellular domains are localized to thin parallel fibers of cerebellar granule cells."
      Nakayama M., Nakajima D., Yoshimura R., Endo Y., Ohara O.
      Mol. Cell. Neurosci. 20:563-578(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBUNIT, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiFAT2_RAT
    AccessioniPrimary (citable) accession number: O88277
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3