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Protein

Multidrug resistance-associated protein 6

Gene

Abcc6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi661 – 6688ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1298 – 13058ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: RGD
  • ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  • ATP binding Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
MRP-like protein 1
Short name:
MLP-1
Gene namesi
Name:Abcc6
Synonyms:Mlp1, Mrp6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620268. Abcc6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini5 – 3733ExtracellularBy similarityAdd
BLAST
Transmembranei38 – 5821Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini59 – 7820CytoplasmicBy similarityAdd
BLAST
Transmembranei79 – 9921Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini100 – 1045ExtracellularBy similarity
Transmembranei105 – 12521Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini126 – 13712CytoplasmicBy similarityAdd
BLAST
Transmembranei138 – 15518Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini156 – 17318ExtracellularBy similarityAdd
BLAST
Transmembranei174 – 19421Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini195 – 300106CytoplasmicBy similarityAdd
BLAST
Transmembranei301 – 32121Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini322 – 34726ExtracellularBy similarityAdd
BLAST
Transmembranei348 – 36821Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini369 – 42456CytoplasmicBy similarityAdd
BLAST
Transmembranei425 – 44521Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini446 – 4483ExtracellularBy similarity
Transmembranei449 – 46921Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini470 – 53162CytoplasmicBy similarityAdd
BLAST
Transmembranei532 – 55221Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini553 – 57422ExtracellularBy similarityAdd
BLAST
Transmembranei575 – 59521Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini596 – 938343CytoplasmicBy similarityAdd
BLAST
Transmembranei939 – 95921Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini960 – 99637ExtracellularBy similarityAdd
BLAST
Transmembranei997 – 101721Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1018 – 106043CytoplasmicBy similarityAdd
BLAST
Transmembranei1061 – 108121Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1082 – 10821ExtracellularBy similarity
Transmembranei1083 – 110321Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1104 – 117471CytoplasmicBy similarityAdd
BLAST
Transmembranei1175 – 119521Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Topological domaini1196 – 11972ExtracellularBy similarity
Transmembranei1198 – 121821Helical; Name=17PROSITE-ProRule annotationAdd
BLAST
Topological domaini1219 – 1502284CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: RGD
  • membrane Source: RGD
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073712.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15021502Multidrug resistance-associated protein 6PRO_0000093368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Modified residuei891 – 8911PhosphoserineCombined sources
Modified residuei1285 – 12851PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO88269.
PRIDEiO88269.

PTM databases

PhosphoSiteiO88269.

Expressioni

Tissue specificityi

High in liver and lower in duodenum and kidney.

Gene expression databases

GenevisibleiO88269. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051412.

Structurei

3D structure databases

ProteinModelPortaliO88269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 592284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini627 – 851225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini946 – 1227282ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1264 – 1498235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00840000129727.
HOVERGENiHBG108314.
InParanoidiO88269.
KOiK05669.
OMAiLWADDPT.
OrthoDBiEOG7MWGW0.
PhylomeDBiO88269.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030239. ABCC6.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF226. PTHR24223:SF226. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGEHSMATP GESCAGLRVW NQTEQEPVAY HLLNLCFLRA AGSWVPPMYL
60 70 80 90 100
WVLGPIYLLY IHRHGCCYLR MSRLFKIKMV LGFALILLYT FNAAVPLWRI
110 120 130 140 150
HRGMPQAPEL LIHPTVWLTT MSFATFLIHM ERKKGVRASG LLFGYWLLCC
160 170 180 190 200
LVPAIDTVQQ ASAGSFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS
210 220 230 240 250
EDSKPLNPCP EAEASFPSKA MFWWASGLLW KGYRKLLGPK DLWSLERENS
260 270 280 290 300
SEELVSQLER EWRRNFSELP GHKGHSGMGT PETEAFLQPE RSQRGPLLRA
310 320 330 340 350
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDL ESSAWTGWLL
360 370 380 390 400
AVLMFLSACL QTLFEQQYMY RVKVLQMRLR TAITGLVYRK VLVLSSGSRK
410 420 430 440 450
SSAAGDVVNL VSVDVQRLVE SILHLNGLWL LFLWIIVCFV YLWQLLGPSA
460 470 480 490 500
LTAVAVFLSL LPLNFFITKK RSFHQEEQMR QKASRARLTS SMLRTVRTIK
510 520 530 540 550
SHGWECAFLE RLLHIRGQEL GALKTSAFLF SVSLVSFQVS TFLVALVVFA
560 570 580 590 600
VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCL VQARVSFDRL
610 620 630 640 650
AAFLCLEEVD PNGMVLSPSR CSSKDRISIH NGTFAWSQES PPCLHGINLT
660 670 680 690 700
VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV
710 720 730 740 750
QNTSVVENVC FRQELDLPWL QEVLEACALG SDVASFPAGV HTPVGEQGMN
760 770 780 790 800
LSGGQKQRLS LARAVYRRAA VYLMDDPLAA LDAHVSQEVF KQVIGPSGLL
810 820 830 840 850
QGTTRILVTH TLHVLPQADQ ILVLANGTIA EMGSYQDLLH RNGALVGLLD
860 870 880 890 900
GARQPAGEGE GEAHAAATSD DLGGFSGGGT PTRRPERPRP SDAAPVKGST
910 920 930 940 950
SEAQMEPSLD DVEVTGLTAG EDSVQYGRVK SATYLSYLRA VGTPLCTYTL
960 970 980 990 1000
FLFLCQQVAS FCQGYWLSLW ADDPVVDGKQ MHSALRGSIF GLLGCLQAIG
1010 1020 1030 1040 1050
LFASMAAVFL GGARASCLLF RSLLWDVARS PIGFFERTPV GNLLNRFSKE
1060 1070 1080 1090 1100
TDIVDVDIPD KMRTLLTYAF GLLEVGLAVS MATPLAIVAI LPLMLLYAGF
1110 1120 1130 1140 1150
QSLYVATCCQ LRRLESASYS SVCSHLAETF QGSQVVRAFQ AQGPFTAQHD
1160 1170 1180 1190 1200
ALMDENQRIS FPRLVADRWL AANLELLGNG LVFVAATCAV LSKAHLSAGL
1210 1220 1230 1240 1250
AGFSVSAALQ VTQTLQWVVR SWTDLENSMV AVERVQDYVH TPKEAPWRLP
1260 1270 1280 1290 1300
SSAAQPLWPC GGQIEFRDFG LRHRPELPMA VQGVSLKIHA GEKVGIVGRT
1310 1320 1330 1340 1350
GAGKSSLTWG LLRLQEATEG GIWIDGVPIT DMGLHTLRSR ITIIPQDPVL
1360 1370 1380 1390 1400
FPGSLRMNLD LLQENTDEGI WAALETVQLK AFVTSLPGQL QYECSGQGDD
1410 1420 1430 1440 1450
LSVGQKQLLC LARALLRKTQ ILILDEATAS VDPGTEIQMQ AALERWFAQC
1460 1470 1480 1490 1500
TVLLIAHRLR SVMNCARVLV MDEGQVAESG SPAQLLAQKG LFYRLAQESG

LA
Length:1,502
Mass (Da):164,995
Last modified:November 1, 1998 - v1
Checksum:i539901B674A74A28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010466 mRNA. Translation: BAA28954.1.
U73038 mRNA. Translation: AAD12747.1.
PIRiT42216.
RefSeqiNP_112275.1. NM_031013.1.
UniGeneiRn.29976.

Genome annotation databases

EnsembliENSRNOT00000042115; ENSRNOP00000051412; ENSRNOG00000028781.
GeneIDi81642.
KEGGirno:81642.
UCSCiRGD:620268. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010466 mRNA. Translation: BAA28954.1.
U73038 mRNA. Translation: AAD12747.1.
PIRiT42216.
RefSeqiNP_112275.1. NM_031013.1.
UniGeneiRn.29976.

3D structure databases

ProteinModelPortaliO88269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051412.

Chemistry

ChEMBLiCHEMBL2073712.

Protein family/group databases

TCDBi3.A.1.208.1. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteiO88269.

Proteomic databases

PaxDbiO88269.
PRIDEiO88269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042115; ENSRNOP00000051412; ENSRNOG00000028781.
GeneIDi81642.
KEGGirno:81642.
UCSCiRGD:620268. rat.

Organism-specific databases

CTDi368.
RGDi620268. Abcc6.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00840000129727.
HOVERGENiHBG108314.
InParanoidiO88269.
KOiK05669.
OMAiLWADDPT.
OrthoDBiEOG7MWGW0.
PhylomeDBiO88269.
TreeFamiTF105199.

Enzyme and pathway databases

ReactomeiR-RNO-382556. ABC-family proteins mediated transport.

Miscellaneous databases

NextBioi615148.
PROiO88269.

Gene expression databases

GenevisibleiO88269. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030239. ABCC6.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF226. PTHR24223:SF226. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats."
    Hirohashi T., Suzuki H., Ito K., Ogawa K., Kume K., Shimizu T., Sugiyama Y.
    Mol. Pharmacol. 53:1068-1075(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Transport function and hepatocellular localization of mrp6 in rat liver."
    Madon J., Hagenbuch B., Landmann L., Meier P.J., Stieger B.
    Mol. Pharmacol. 57:634-641(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-891, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMRP6_RAT
AccessioniPrimary (citable) accession number: O88269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.