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Protein
Submitted name:

Leukemia inhibitory factor

Gene

Lif

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Gene namesi
Name:LifImported
ORF Names:rCG_35765Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620865 Lif

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501410209123 – 202Sequence analysisAdd BLAST180

Expressioni

Gene expression databases

BgeeiENSRNOG00000007002

Interactioni

GO - Molecular functioni

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410ITBQ Eukaryota
ENOG410YVPP LUCA
GeneTreeiENSGT00390000000059
HOVERGENiHBG006267
KOiK05419
OMAiKYHVAHV
OrthoDBiEOG091G0HWD
TreeFamiTF336245

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003624 Leukemia_IF
IPR001581 Leukemia_IF/oncostatin
IPR019827 Leukemia_IF/oncostatin_CS
PANTHERiPTHR10633 PTHR10633, 1 hit
PfamiView protein in Pfam
PF01291 LIF_OSM, 1 hit
PRINTSiPR01883 LEUKAEMIAIF
SMARTiView protein in SMART
SM00080 LIF_OSM, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00590 LIF_OSM, 1 hit

Sequencei

Sequence statusi: Complete.

O88211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLATGIVP LLLILHWKHG AGSPLPITPV NATCAIRHPC HGNLMNQIKS
60 70 80 90 100
QLAQLNGSAN ALFISYYTAQ GEPFPNNVDK LCAPNMTDFP PFHANGTEKT
110 120 130 140 150
KLVELYRMVA YLGASLTNIT WDQKNLNPTA VSLQIKLNAT TDVMRGLLSN
160 170 180 190 200
VLCRLCNKYH VGHVDVPCVP DNSSKEAFQR KKLGCQLLGT YKQVISAVVQ

AF
Length:202
Mass (Da):22,126
Last modified:November 1, 1998 - v1
Checksum:i4EEE69272578C22D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119662 Genomic DNA No translation available.
AB010275 mRNA Translation: BAA31357.1
CH473963 Genomic DNA Translation: EDM00223.1
PIRiJE0224
RefSeqiNP_071532.2, NM_022196.2
XP_006251426.1, XM_006251364.3
XP_017454854.1, XM_017599365.1
UniGeneiRn.44379

Genome annotation databases

EnsembliENSRNOT00000009313; ENSRNOP00000009313; ENSRNOG00000007002
GeneIDi60584
KEGGirno:60584

Similar proteinsi

Entry informationi

Entry nameiO88211_RAT
AccessioniPrimary (citable) accession number: O88211
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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