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Protein
Submitted name:

Leukemia inhibitory factor

Gene

Lif

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Gene namesi
Name:LifImported
ORF Names:rCG_35765Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620865. Lif.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501120860623 – 202Sequence analysisAdd BLAST180

Expressioni

Gene expression databases

BgeeiENSRNOG00000007002.

Interactioni

GO - Molecular functioni

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410ITBQ. Eukaryota.
ENOG410YVPP. LUCA.
GeneTreeiENSGT00390000000059.
HOVERGENiHBG006267.
KOiK05419.
OMAiKYHVAHV.
OrthoDBiEOG091G0HWD.
TreeFamiTF336245.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiView protein in Pfam
PF01291. LIF_OSM. 1 hit.
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiView protein in SMART
SM00080. LIF_OSM. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00590. LIF_OSM. 1 hit.

Sequencei

Sequence statusi: Complete.

O88211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLATGIVP LLLILHWKHG AGSPLPITPV NATCAIRHPC HGNLMNQIKS
60 70 80 90 100
QLAQLNGSAN ALFISYYTAQ GEPFPNNVDK LCAPNMTDFP PFHANGTEKT
110 120 130 140 150
KLVELYRMVA YLGASLTNIT WDQKNLNPTA VSLQIKLNAT TDVMRGLLSN
160 170 180 190 200
VLCRLCNKYH VGHVDVPCVP DNSSKEAFQR KKLGCQLLGT YKQVISAVVQ

AF
Length:202
Mass (Da):22,126
Last modified:November 1, 1998 - v1
Checksum:i4EEE69272578C22D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119662 Genomic DNA. No translation available.
AB010275 mRNA. Translation: BAA31357.1.
CH473963 Genomic DNA. Translation: EDM00223.1.
PIRiJE0224.
RefSeqiNP_071532.2. NM_022196.2.
XP_006251426.1. XM_006251364.3.
XP_017454854.1. XM_017599365.1.
UniGeneiRn.44379.

Genome annotation databases

EnsembliENSRNOT00000009313; ENSRNOP00000009313; ENSRNOG00000007002.
GeneIDi60584.
KEGGirno:60584.

Similar proteinsi

Entry informationi

Entry nameiO88211_RAT
AccessioniPrimary (citable) accession number: O88211
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported