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Protein

Interleukin-2

Gene

IL2

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotation
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500903141221 – 152Interleukin-2UniRule annotationAdd BLAST132

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO88210
SMRiO88210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 94Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
HOGENOMiHOG000048727
HOVERGENiHBG007496

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

O88210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTLLLSCL ALTLALLTSS APTSSSPKQT QDRLELLLRD LQTLLEGVTS
60 70 80 90 100
NPRLPKMLKL KLYPPKMVSE LQHLQCLEEE LRAVEQVLNL AEHKNFPLIH
110 120 130 140 150
TKDFISNINV TVLSLKGSET AFVCDLEDES VNIVEFLKRW TAFCQKIMSR

LT
Length:152
Mass (Da):17,271
Last modified:November 1, 1998 - v1
Checksum:iCA7AC08C1B8DD1FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010093 mRNA Translation: BAA31346.1
RefSeqiNP_001166308.1, NM_001172837.1

Genome annotation databases

GeneIDi100379540

Similar proteinsi

Entry informationi

Entry nameiO88210_CAVPO
AccessioniPrimary (citable) accession number: O88210
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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