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Protein

Interleukin-2

Gene

IL2

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotation
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500903141221 – 152Interleukin-2UniRule annotationAdd BLAST132

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007430.

Structurei

3D structure databases

ProteinModelPortaliO88210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

O88210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTLLLSCL ALTLALLTSS APTSSSPKQT QDRLELLLRD LQTLLEGVTS
60 70 80 90 100
NPRLPKMLKL KLYPPKMVSE LQHLQCLEEE LRAVEQVLNL AEHKNFPLIH
110 120 130 140 150
TKDFISNINV TVLSLKGSET AFVCDLEDES VNIVEFLKRW TAFCQKIMSR

LT
Length:152
Mass (Da):17,271
Last modified:November 1, 1998 - v1
Checksum:iCA7AC08C1B8DD1FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010093 mRNA. Translation: BAA31346.1.
RefSeqiNP_001166308.1. NM_001172837.1.

Genome annotation databases

GeneIDi100379540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010093 mRNA. Translation: BAA31346.1.
RefSeqiNP_001166308.1. NM_001172837.1.

3D structure databases

ProteinModelPortaliO88210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100379540.

Organism-specific databases

CTDi3558.

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO88210_CAVPO
AccessioniPrimary (citable) accession number: O88210
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 10, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.