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Protein

Low-density lipoprotein receptor-related protein 3

Gene

Lrp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 3
Short name:
LRP-3
Alternative name(s):
105 kDa low-density lipoprotein receptor-related protein
Short name:
rLRp105
Gene namesi
Name:Lrp3
Synonyms:Lrp105
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619729. Lrp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini37 – 496460ExtracellularSequence analysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence analysisAdd
BLAST
Topological domaini518 – 770253CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence analysisAdd
BLAST
Chaini37 – 770734Low-density lipoprotein receptor-related protein 3PRO_0000017324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 72By similarity
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 120By similarity
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi212 ↔ 227By similarity
Disulfide bondi219 ↔ 240By similarity
Disulfide bondi234 ↔ 249By similarity
Disulfide bondi254 ↔ 282By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi416 ↔ 430By similarity
Disulfide bondi423 ↔ 443By similarity
Disulfide bondi437 ↔ 452By similarity
Disulfide bondi455 ↔ 467By similarity
Disulfide bondi462 ↔ 480By similarity
Disulfide bondi474 ↔ 489By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88204.
PRIDEiO88204.

Expressioni

Gene expression databases

GenevisibleiO88204. RN.

Interactioni

Subunit structurei

Binds GGA1 and GGA2.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015384.

Structurei

3D structure databases

ProteinModelPortaliO88204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 159117CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini165 – 20137LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 25040LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini254 – 365112CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini415 – 45339LDL-receptor class A 3PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 49037LDL-receptor class A 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi682 – 6854Poly-Pro

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 4 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG049162.
InParanoidiO88204.
OMAiEPCSAQD.
OrthoDBiEOG7PCJG4.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRAAAGPE GAPGARAPLA VVCLVNLFLT GRLSSAVPAL AACSGKLEQH
60 70 80 90 100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS
110 120 130 140 150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ
160 170 180 190 200
GFRLSYIRGK LGQASCQTDE FRCDNGKCLP GPWQCNMVDE CGDGSDEGNC
210 220 230 240 250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGTQDC GDGSDEAGCP
260 270 280 290 300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD PRRVLLQLEL
310 320 330 340 350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR
360 370 380 390 400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSE GDDGSTGEQG CFSEPQRCDG
410 420 430 440 450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YAPADRCNNQ KSCPDGADEK
460 470 480 490 500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA
510 520 530 540 550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
560 570 580 590 600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
610 620 630 640 650
RRRLGRLWNR LFHRPRAPRG QIPLLTAART SQTVLGDGLL QAAPGPVPDP
660 670 680 690 700
PVPNTDTGSP REAGDGPPSG SGHAPEVGPS VPPPPLNLRD PEYRPEDKER
710 720 730 740 750
KACVDPLEDS PAPVDTPPEP CLAQDPHPQT PTASGIQDPH SAEPLGVCRS
760 770
PPPTCSPILE ASDDEALLVC
Length:770
Mass (Da):83,017
Last modified:November 1, 1998 - v1
Checksum:i9ECF3F8642FEB7C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009463 mRNA. Translation: BAA32331.1.
PIRiT00203.
RefSeqiNP_445993.1. NM_053541.1.
XP_008757424.1. XM_008759202.1.
UniGeneiRn.145216.
Rn.87059.

Genome annotation databases

EnsembliENSRNOT00000015384; ENSRNOP00000015384; ENSRNOG00000011451.
GeneIDi89787.
KEGGirno:89787.
UCSCiRGD:619729. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009463 mRNA. Translation: BAA32331.1.
PIRiT00203.
RefSeqiNP_445993.1. NM_053541.1.
XP_008757424.1. XM_008759202.1.
UniGeneiRn.145216.
Rn.87059.

3D structure databases

ProteinModelPortaliO88204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015384.

Proteomic databases

PaxDbiO88204.
PRIDEiO88204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015384; ENSRNOP00000015384; ENSRNOG00000011451.
GeneIDi89787.
KEGGirno:89787.
UCSCiRGD:619729. rat.

Organism-specific databases

CTDi4037.
RGDi619729. Lrp3.

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG049162.
InParanoidiO88204.
OMAiEPCSAQD.
OrthoDBiEOG7PCJG4.

Miscellaneous databases

NextBioi617622.
PROiO88204.

Gene expression databases

GenevisibleiO88204. RN.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2."
    Ishii H., Kim D.-H., Fujita T., Endo Y., Saeki S., Yamamoto T.T.
    Genomics 51:132-135(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains."
    Takatsu H., Katoh Y., Shiba Y., Nakayama K.
    J. Biol. Chem. 276:28541-28545(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GGA1 AND GGA2.

Entry informationi

Entry nameiLRP3_RAT
AccessioniPrimary (citable) accession number: O88204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.