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Protein

C-type lectin domain family 11 member A

Gene

Clec11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone.By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • growth factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
Biological processOsteogenesis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 11 member A
Alternative name(s):
Lymphocyte secreted C-type lectin
OsteolectinBy similarity
Stem cell growth factor
Gene namesi
Name:Clec11a
Synonyms:Scgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3627 Clec11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001747022 – 328C-type lectin domain family 11 member AAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi209 ↔ 324PROSITE-ProRule annotation
Disulfide bondi301 ↔ 316PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated. Probably sulfated on the O-glycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88201
PRIDEiO88201

PTM databases

PhosphoSitePlusiO88201

Expressioni

Gene expression databases

BgeeiENSRNOG00000019138
GenevisibleiO88201 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025949

Structurei

3D structure databases

ProteinModelPortaliO88201
SMRiO88201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 325C-type lectinPROSITE-ProRule annotationAdd BLAST138

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3S Eukaryota
ENOG410YHP3 LUCA
GeneTreeiENSGT00610000086061
HOGENOMiHOG000273889
HOVERGENiHBG052365
InParanoidiO88201
KOiK17521
OMAiYNWPVWL
OrthoDBiEOG091G0D5T
PhylomeDBiO88201
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAAWLLGAL LVPHLLSFGH GARGHGKEWE GVWGGALEEE RDRESLMLKN
60 70 80 90 100
LQEALGLPTG VGNKDNLAEN SEGKEVWEAT ETQGEEEEEE TTTTPSSSPT
110 120 130 140 150
PFPSPSPTSE DTVTYILGRL ASLDAGLHQL HIRLHVLDTR VVELTQGLRR
160 170 180 190 200
LRDAASDTRD SVQALKEVQV RSEQEHGRLE GCLKGLRLGH KCFLLSRDFE
210 220 230 240 250
TQAAAQARCK ARGGSLAQPA DRQQMDALSR YLRAALAPYN WPVWLGVHDR
260 270 280 290 300
RSEGLYLFEN GQRVSFFAWH RALSPESGAQ PSAASHPLSP DQPNGGILEN
310 320
CVAQASDDGS WWDHDCERRL YFVCEFPF
Length:328
Mass (Da):36,388
Last modified:November 1, 1998 - v1
Checksum:iC115188AC23D6257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009246 mRNA Translation: BAA32406.1
BC090344 mRNA Translation: AAH90344.1
RefSeqiNP_001012477.1, NM_001012459.1
UniGeneiRn.162423

Genome annotation databases

EnsembliENSRNOT00000025949; ENSRNOP00000025949; ENSRNOG00000019138
GeneIDi29313
KEGGirno:29313
UCSCiRGD:3627 rat

Similar proteinsi

Entry informationi

Entry nameiCLC11_RAT
AccessioniPrimary (citable) accession number: O88201
Secondary accession number(s): Q5EAN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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