Reviewed, UniProtKB/Swiss-Prot O88201 (CLC11_RAT)

Names and origin

Protein names

Recommended name:
    C-type lectin domain family 11 member A
Alternative name(s):
    Stem cell growth factor
    Lymphocyte secreted C-type lectin

Gene names

Name:	Clec11a
Synonyms:	Scgf

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation By similarity. UniProtKB Q9Y240
Subcellular location	Cytoplasm By similarity. Secreted By similarity.
Post-translational modification	O-glycosylated. Probably sulfated on the O-glycans By similarity. UniProtKB Q9Y240
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Cytoplasm Secreted
Domain	Signal
Ligand	Lectin
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	positive regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	growth factor activity Inferred from sequence or structural similarity. Source: UniProtKB sugar binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity UniProtKB Q9Y240
	Chain	22 – 328	307	C-type lectin domain family 11 member A UniProtKB Q9Y240		PRO_0000017470
Regions
	Domain	188 – 325	138	C-type lectin
Amino acid modifications
	Disulfide bond	209 ↔ 324		By similarity
	Disulfide bond	301 ↔ 316		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O88201-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: C115188AC23D6257	FASTA	328	36,388
	10 20 30 40 50 60 MQAAWLLGAL LVPHLLSFGH GARGHGKEWE GVWGGALEEE RDRESLMLKN LQEALGLPTG 70 80 90 100 110 120 VGNKDNLAEN SEGKEVWEAT ETQGEEEEEE TTTTPSSSPT PFPSPSPTSE DTVTYILGRL 130 140 150 160 170 180 ASLDAGLHQL HIRLHVLDTR VVELTQGLRR LRDAASDTRD SVQALKEVQV RSEQEHGRLE 190 200 210 220 230 240 GCLKGLRLGH KCFLLSRDFE TQAAAQARCK ARGGSLAQPA DRQQMDALSR YLRAALAPYN 250 260 270 280 290 300 WPVWLGVHDR RSEGLYLFEN GQRVSFFAWH RALSPESGAQ PSAASHPLSP DQPNGGILEN 310 320 CVAQASDDGS WWDHDCERRL YFVCEFPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily." Mio H., Kagami N., Yokokawa S., Kawai H., Nakagawa S., Takeuchi K., Sekine S., Hiraoka A. Biochem. Biophys. Res. Commun. 249:124-130(1998) [PubMed: 9705843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB009246 mRNA. Translation: BAA32406.1. BC090344 mRNA. Translation: AAH90344.1.
IPI	IPI00199368.
RefSeq	NP_001012477.1.
UniGene	Rn.162423
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O88201.
Genome annotation databases
Ensembl	ENSRNOT00000025949; ENSRNOP00000025949; ENSRNOG00000019138; Rattus norvegicus. [Genome view]
GeneID	29313.
KEGG	rno:29313.
UCSC	NM_001012459. rat.
Organism-specific databases
CTD	29313.
RGD	3627. Clec11a.
Phylogenomic databases
HOVERGEN	O88201.
OMA	GCLKGLR
OrthoDB	EOG96T5N3
Gene expression databases
ArrayExpress	O88201.
Genevestigator	O88201.
GermOnline	ENSRNOG00000019138. Rattus norvegicus.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
PROSITE	PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	608754.

Entry information

Entry name

CLC11_RAT

Accession

Primary (citable) accession number: O88201
Secondary accession number(s): Q5EAN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	November 1, 1998
Last modified:	November 24, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)