Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-type lectin domain family 11 member A

Gene

Clec11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • growth factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 11 member A
Alternative name(s):
Lymphocyte secreted C-type lectin
Stem cell growth factor
Gene namesi
Name:Clec11a
Synonyms:Scgf
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1298219. Clec11a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 328307C-type lectin domain family 11 member APRO_0000017469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi209 ↔ 324PROSITE-ProRule annotation
Disulfide bondi301 ↔ 316PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated. Probably sulfated on the O-glycans (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88200.
PaxDbiO88200.
PeptideAtlasiO88200.
PRIDEiO88200.

PTM databases

PhosphoSiteiO88200.

Expressioni

Gene expression databases

BgeeiO88200.
CleanExiMM_CLEC11A.
GenevisibleiO88200. MM.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO88200.
SMRiO88200. Positions 129-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 325138C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3S. Eukaryota.
ENOG410YHP3. LUCA.
GeneTreeiENSGT00610000086061.
HOGENOMiHOG000273889.
HOVERGENiHBG052365.
InParanoidiO88200.
KOiK17521.
OMAiFAWHRSP.
OrthoDBiEOG754HQT.
PhylomeDBiO88200.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAAWLLGAL VVPQLLSFGH GARGPGREWE GGWGGALEEE RERESQMLKN
60 70 80 90 100
LQEALGLPTG VGNEDNLAEN PEDKEVWETT ETQGEEEEEE ITTAPSSSPN
110 120 130 140 150
PFPSPSPTPE DTVTYILGRL ASLDAGLHQL HVRLHVLDTR VVELTQGLRQ
160 170 180 190 200
LRDAASDTRD SVQALKEVQD RAEQEHGRLE GCLKGLRLGH KCFLLSRDFE
210 220 230 240 250
TQAAAQARCK ARGGSLAQPA DRQQMDALSR YLRAALAPYN WPVWLGVHDR
260 270 280 290 300
RSEGLYLFEN GQRVSFFAWH RAFSLESGAQ PSAATHPLSP DQPNGGVLEN
310 320
CVAQASDDGS WWDHDCERRL YFVCEFPF
Length:328
Mass (Da):36,451
Last modified:November 1, 1998 - v1
Checksum:i309C17A861EE135C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1174TYIL → FFTV in BAC31421 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009245 mRNA. Translation: BAA32405.1.
BC002001 mRNA. Translation: AAH02001.3.
AK042963 mRNA. Translation: BAC31421.1.
AK003813 mRNA. Translation: BAB23010.1.
CCDSiCCDS21203.1.
RefSeqiNP_033157.1. NM_009131.3.
UniGeneiMm.20428.

Genome annotation databases

EnsembliENSMUST00000004587; ENSMUSP00000004587; ENSMUSG00000004473.
GeneIDi20256.
KEGGimmu:20256.
UCSCiuc009gpb.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Stem cell growth factor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009245 mRNA. Translation: BAA32405.1.
BC002001 mRNA. Translation: AAH02001.3.
AK042963 mRNA. Translation: BAC31421.1.
AK003813 mRNA. Translation: BAB23010.1.
CCDSiCCDS21203.1.
RefSeqiNP_033157.1. NM_009131.3.
UniGeneiMm.20428.

3D structure databases

ProteinModelPortaliO88200.
SMRiO88200. Positions 129-326.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO88200.

Proteomic databases

MaxQBiO88200.
PaxDbiO88200.
PeptideAtlasiO88200.
PRIDEiO88200.

Protocols and materials databases

DNASUi20256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004587; ENSMUSP00000004587; ENSMUSG00000004473.
GeneIDi20256.
KEGGimmu:20256.
UCSCiuc009gpb.2. mouse.

Organism-specific databases

CTDi6320.
MGIiMGI:1298219. Clec11a.

Phylogenomic databases

eggNOGiENOG410IS3S. Eukaryota.
ENOG410YHP3. LUCA.
GeneTreeiENSGT00610000086061.
HOGENOMiHOG000273889.
HOVERGENiHBG052365.
InParanoidiO88200.
KOiK17521.
OMAiFAWHRSP.
OrthoDBiEOG754HQT.
PhylomeDBiO88200.
TreeFamiTF330481.

Miscellaneous databases

PROiO88200.
SOURCEiSearch...

Gene expression databases

BgeeiO88200.
CleanExiMM_CLEC11A.
GenevisibleiO88200. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily."
    Mio H., Kagami N., Yokokawa S., Kawai H., Nakagawa S., Takeuchi K., Sekine S., Hiraoka A.
    Biochem. Biophys. Res. Commun. 249:124-130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: CalvariaImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-328.
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryo.

Entry informationi

Entry nameiCLC11_MOUSE
AccessioniPrimary (citable) accession number: O88200
Secondary accession number(s): Q8C946, Q9CTF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.