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Protein

Lymphocyte antigen 86

Gene

Ly86

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 86
Short name:
Ly-86
Alternative name(s):
Protein MD-1
Gene namesi
Name:Ly86
Synonyms:Md1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1321404. Ly86.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001861520 – 162Lymphocyte antigen 86Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 58
Disulfide bondi45 ↔ 154
Glycosylationi96N-linked (GlcNAc...)1 Publication1
Disulfide bondi102 ↔ 112
Glycosylationi156N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88188.
PaxDbiO88188.
PeptideAtlasiO88188.
PRIDEiO88188.

PTM databases

PhosphoSitePlusiO88188.

Expressioni

Tissue specificityi

Highly expressed in spleen, liver, brain and thymus, and at lower levels in kidney.

Gene expression databases

BgeeiENSMUSG00000021423.
CleanExiMM_LY86.
GenevisibleiO88188. MM.

Interactioni

Subunit structurei

M-shaped tetramer of two CD180-LY86 heterodimers.2 Publications

Protein-protein interaction databases

DIPiDIP-30960N.
IntActiO88188. 2 interactors.
MINTiMINT-4100785.
STRINGi10090.ENSMUSP00000021860.

Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi38 – 44Combined sources7
Beta strandi52 – 57Combined sources6
Beta strandi60 – 62Combined sources3
Beta strandi67 – 73Combined sources7
Beta strandi79 – 89Combined sources11
Beta strandi92 – 103Combined sources12
Beta strandi106 – 111Combined sources6
Beta strandi119 – 125Combined sources7
Beta strandi130 – 132Combined sources3
Beta strandi135 – 146Combined sources12
Beta strandi151 – 161Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M7OX-ray1.65A/B/C/D1-162[»]
3T6QX-ray1.90C/D20-162[»]
ProteinModelPortaliO88188.
SMRiO88188.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88188.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWHW. Eukaryota.
ENOG410YWD5. LUCA.
GeneTreeiENSGT00390000018605.
HOGENOMiHOG000261640.
HOVERGENiHBG019056.
InParanoidiO88188.
OMAiINIRFGI.
OrthoDBiEOG091G0QGP.
PhylomeDBiO88188.
TreeFamiTF335876.

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGVAAALLV WILTSPSSSD HGSENGWPKH TACNSGGLEV VYQSCDPLQD
60 70 80 90 100
FGLSIDQCSK QIQSNLNIRF GIILRQDIRK LFLDITLMAK GSSILNYSYP
110 120 130 140 150
LCEEDQPKFS FCGRRKGEQI YYAGPVNNPG LDVPQGEYQL LLELYNENRA
160
TVACANATVT SS
Length:162
Mass (Da):17,811
Last modified:November 1, 1998 - v1
Checksum:iEED25DEA64A9372E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007599 mRNA. Translation: BAA32399.1.
AK027929 mRNA. Translation: BAC25670.1.
CH466546 Genomic DNA. Translation: EDL40921.1.
BC065783 mRNA. Translation: AAH65783.1.
BC096414 mRNA. Translation: AAH96414.1.
CCDSiCCDS26457.1.
RefSeqiNP_034875.1. NM_010745.2.
UniGeneiMm.2639.

Genome annotation databases

EnsembliENSMUST00000021860; ENSMUSP00000021860; ENSMUSG00000021423.
GeneIDi17084.
KEGGimmu:17084.
UCSCiuc007qcr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007599 mRNA. Translation: BAA32399.1.
AK027929 mRNA. Translation: BAC25670.1.
CH466546 Genomic DNA. Translation: EDL40921.1.
BC065783 mRNA. Translation: AAH65783.1.
BC096414 mRNA. Translation: AAH96414.1.
CCDSiCCDS26457.1.
RefSeqiNP_034875.1. NM_010745.2.
UniGeneiMm.2639.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M7OX-ray1.65A/B/C/D1-162[»]
3T6QX-ray1.90C/D20-162[»]
ProteinModelPortaliO88188.
SMRiO88188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-30960N.
IntActiO88188. 2 interactors.
MINTiMINT-4100785.
STRINGi10090.ENSMUSP00000021860.

PTM databases

PhosphoSitePlusiO88188.

Proteomic databases

MaxQBiO88188.
PaxDbiO88188.
PeptideAtlasiO88188.
PRIDEiO88188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021860; ENSMUSP00000021860; ENSMUSG00000021423.
GeneIDi17084.
KEGGimmu:17084.
UCSCiuc007qcr.2. mouse.

Organism-specific databases

CTDi9450.
MGIiMGI:1321404. Ly86.

Phylogenomic databases

eggNOGiENOG410IWHW. Eukaryota.
ENOG410YWD5. LUCA.
GeneTreeiENSGT00390000018605.
HOGENOMiHOG000261640.
HOVERGENiHBG019056.
InParanoidiO88188.
OMAiINIRFGI.
OrthoDBiEOG091G0QGP.
PhylomeDBiO88188.
TreeFamiTF335876.

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.

Miscellaneous databases

EvolutionaryTraceiO88188.
PROiO88188.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021423.
CleanExiMM_LY86.
GenevisibleiO88188. MM.

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLY86_MOUSE
AccessioniPrimary (citable) accession number: O88188
Secondary accession number(s): Q4VAF1, Q5D046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.