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Protein

Platelet glycoprotein IX

Gene

Gp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_296516. Platelet Aggregation (Plug Formation).
REACT_304203. GP1b-IX-V activation signalling.
REACT_340184. Intrinsic Pathway of Fibrin Clot Formation.
REACT_344422. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein IX
Short name:
GP-IX
Short name:
GPIX
Alternative name(s):
Glycoprotein 9
CD_antigen: CD42a
Gene namesi
Name:Gp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1860137. Gp9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 147131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Topological domaini169 – 1779CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616By similarityAdd
BLAST
Chaini17 – 177161Platelet glycoprotein IXPRO_0000378456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88186.
PaxDbiO88186.
PRIDEiO88186.

Expressioni

Gene expression databases

BgeeiO88186.
GenevisibleiO88186. MM.

Interactioni

Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032133.

Structurei

3D structure databases

ProteinModelPortaliO88186.
SMRiO88186. Positions 20-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 5135LRRNTAdd
BLAST
Repeati60 – 8324LRRAdd
BLAST
Domaini85 – 13753LRRCTAdd
BLAST

Sequence similaritiesi

Contains 1 LRR (leucine-rich) repeat.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307904.
GeneTreeiENSGT00530000064244.
HOGENOMiHOG000089943.
InParanoidiO88186.
KOiK06263.
OMAiCTCQALE.
OrthoDBiEOG7X6M1H.
PhylomeDBiO88186.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTWGLLFLL WPATTDTQAC PRPCTCQSLE TMGLKVNCEG QGLTALPVIP
60 70 80 90 100
AHTRQLLLAN NSLRSVPPGA FDHLPQLWDL DVTHNPWHCD CSLTYLRLWL
110 120 130 140 150
EDHMPEALMH VYCASPDLAT RRPLGQLTGY ELGSCGWKLP PSWAYPGVWW
160 170
DVSLVAVAVL GLILLAGLLN TFTESRN
Length:177
Mass (Da):19,664
Last modified:November 1, 1998 - v1
Checksum:iEB82B952BD3DD7C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007464 mRNA. Translation: BAA31694.1.
CH466523 Genomic DNA. Translation: EDK99218.1.
BC111106 mRNA. Translation: AAI11107.1.
CCDSiCCDS20328.1.
RefSeqiNP_061232.1. NM_018762.1.
UniGeneiMm.12897.

Genome annotation databases

EnsembliENSMUST00000032133; ENSMUSP00000032133; ENSMUSG00000030054.
GeneIDi54368.
KEGGimmu:54368.
UCSCiuc009ctv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007464 mRNA. Translation: BAA31694.1.
CH466523 Genomic DNA. Translation: EDK99218.1.
BC111106 mRNA. Translation: AAI11107.1.
CCDSiCCDS20328.1.
RefSeqiNP_061232.1. NM_018762.1.
UniGeneiMm.12897.

3D structure databases

ProteinModelPortaliO88186.
SMRiO88186. Positions 20-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032133.

Proteomic databases

MaxQBiO88186.
PaxDbiO88186.
PRIDEiO88186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032133; ENSMUSP00000032133; ENSMUSG00000030054.
GeneIDi54368.
KEGGimmu:54368.
UCSCiuc009ctv.1. mouse.

Organism-specific databases

CTDi2815.
MGIiMGI:1860137. Gp9.

Phylogenomic databases

eggNOGiNOG307904.
GeneTreeiENSGT00530000064244.
HOGENOMiHOG000089943.
InParanoidiO88186.
KOiK06263.
OMAiCTCQALE.
OrthoDBiEOG7X6M1H.
PhylomeDBiO88186.

Enzyme and pathway databases

ReactomeiREACT_296516. Platelet Aggregation (Plug Formation).
REACT_304203. GP1b-IX-V activation signalling.
REACT_340184. Intrinsic Pathway of Fibrin Clot Formation.
REACT_344422. Platelet Adhesion to exposed collagen.

Miscellaneous databases

NextBioi311166.
PROiO88186.
SOURCEiSearch...

Gene expression databases

BgeeiO88186.
GenevisibleiO88186. MM.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA encoding full-length mouse platelet glycoprotein IX."
    Kitaguchi T., Murata M., Ambo H., Ikeda Y.
    Blood Coagul. Fibrinolysis 9:381-385(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPIX_MOUSE
AccessioniPrimary (citable) accession number: O88186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.