O88186 (GPIX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Platelet glycoprotein IX
Short name=GP-IX
Short name=GPIX

Alternative name(s):
Glycoprotein 9
CD_antigen=CD42a

Gene names

Name:

Gp9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib By similarity.
Subunit structure	Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 1 LRR (leucine-rich) repeat. Contains 1 LRRCT domain. Contains 1 LRRNT domain.

Ontologies

Keywords
Biological process	Blood coagulation Cell adhesion Hemostasis
Cellular component	Membrane
Domain	Leucine-rich repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	By similarity
	Chain	17 – 177	161	Platelet glycoprotein IX		PRO_0000378456
Regions
	Topological domain	17 – 147	131	Extracellular Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Topological domain	169 – 177	9	Cytoplasmic Potential
	Domain	17 – 51	35	LRRNT
	Repeat	60 – 83	24	LRR
	Domain	85 – 137	53	LRRCT
Amino acid modifications
	Glycosylation	60	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O88186 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: EB82B952BD3DD7C4	FASTA	177	19,664
	10 20 30 40 50 60 MTTWGLLFLL WPATTDTQAC PRPCTCQSLE TMGLKVNCEG QGLTALPVIP AHTRQLLLAN 70 80 90 100 110 120 NSLRSVPPGA FDHLPQLWDL DVTHNPWHCD CSLTYLRLWL EDHMPEALMH VYCASPDLAT 130 140 150 160 170 RRPLGQLTGY ELGSCGWKLP PSWAYPGVWW DVSLVAVAVL GLILLAGLLN TFTESRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of cDNA encoding full-length mouse platelet glycoprotein IX." Kitaguchi T., Murata M., Ambo H., Ikeda Y. Blood Coagul. Fibrinolysis 9:381-385(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB007464 mRNA. Translation: BAA31694.1. CH466523 Genomic DNA. Translation: EDK99218.1. BC111106 mRNA. Translation: AAI11107.1.
IPI	IPI00128024.
RefSeq	NP_061232.1. NM_018762.1.
UniGene	Mm.12897.
3D structure databases
HSSP	HSSP built from PDB template 1W8A based on UniProtKB P24014.
ProteinModelPortal	O88186.
SMR	O88186. Positions 20-132.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000032133.
Proteomic databases
PaxDb	O88186.
PRIDE	O88186.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032133; ENSMUSP00000032133; ENSMUSG00000030054.
GeneID	54368.
KEGG	mmu:54368.
UCSC	uc009ctv.1. mouse.
Organism-specific databases
CTD	2815.
MGI	MGI:1860137. Gp9.
Phylogenomic databases
eggNOG	NOG307904.
GeneTree	ENSGT00530000064244.
HOGENOM	HOG000089943.
InParanoid	O88186.
KO	K06263.
OMA	PPGAFDH.
OrthoDB	EOG4SBF03.
Gene expression databases
Bgee	O88186.
Genevestigator	O88186.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF01462. LRRNT. 1 hit. [Graphical view]
SMART	SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311166.
SOURCE	Search...

Entry information

Entry name

GPIX_MOUSE

Accession

Primary (citable) accession number: O88186

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program