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Protein

Fibroblast growth factor 18

Gene

Fgf18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: RGD

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • nervous system development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 18
Short name:
FGF-18
Gene namesi
Name:Fgf18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2608. Fgf18.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 207180Fibroblast growth factor 18PRO_0000008992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi109 ↔ 127By similarity
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88182.
PRIDEiO88182.

Expressioni

Tissue specificityi

Mainly expressed in the lung. Not detected in brain, heart, liver, kidney and small intestine.

Developmental stagei

Expressed in several discrete regions at embryonic days 14.5 and 19.5 but not 10.5. At E14.5, expressed in isthmus, pituitary, spinal cord, tongue, intervertebral disk, dorsal root ganglion and pelvis. At E19.5, expressed in lung and anterior pituitary.

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064983.

Structurei

3D structure databases

ProteinModelPortaliO88182.
SMRiO88182. Positions 33-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOVERGENiHBG005659.
InParanoidiO88182.
KOiK04358.
PhylomeDBiO88182.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK
60 70 80 90 100
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK
110 120 130 140 150
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY
160 170 180 190 200
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQTELQKPFK YTTVTKRSRR

IRPTHPG
Length:207
Mass (Da):23,951
Last modified:November 1, 1998 - v1
Checksum:iD90EDD7B271628B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004638 mRNA. Translation: BAA31979.1.
RefSeqiNP_062072.1. NM_019199.1.
UniGeneiRn.44478.

Genome annotation databases

GeneIDi29369.
KEGGirno:29369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004638 mRNA. Translation: BAA31979.1.
RefSeqiNP_062072.1. NM_019199.1.
UniGeneiRn.44478.

3D structure databases

ProteinModelPortaliO88182.
SMRiO88182. Positions 33-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064983.

Proteomic databases

PaxDbiO88182.
PRIDEiO88182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29369.
KEGGirno:29369.

Organism-specific databases

CTDi8817.
RGDi2608. Fgf18.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOVERGENiHBG005659.
InParanoidiO88182.
KOiK04358.
PhylomeDBiO88182.

Miscellaneous databases

NextBioi608922.
PROiO88182.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
    Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
    J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Embryo.

Entry informationi

Entry nameiFGF18_RAT
AccessioniPrimary (citable) accession number: O88182
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.