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Protein

Fibroblast growth factor 18

Gene

Fgf18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: RGD
  • growth factor activity Source: UniProtKB-KW

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • nervous system development Source: RGD

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 18
Short name:
FGF-18
Gene namesi
Name:Fgf18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2608. Fgf18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000899228 – 207Fibroblast growth factor 18Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 127By similarity
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88182.
PRIDEiO88182.

Expressioni

Tissue specificityi

Mainly expressed in the lung. Not detected in brain, heart, liver, kidney and small intestine.

Developmental stagei

Expressed in several discrete regions at embryonic days 14.5 and 19.5 but not 10.5. At E14.5, expressed in isthmus, pituitary, spinal cord, tongue, intervertebral disk, dorsal root ganglion and pelvis. At E19.5, expressed in lung and anterior pituitary.

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: RGD
  • growth factor activity Source: UniProtKB-KW

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064983.

Structurei

3D structure databases

ProteinModelPortaliO88182.
SMRiO88182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOVERGENiHBG005659.
InParanoidiO88182.
KOiK04358.
PhylomeDBiO88182.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF99. PTHR11486:SF99. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK
60 70 80 90 100
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK
110 120 130 140 150
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY
160 170 180 190 200
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQTELQKPFK YTTVTKRSRR

IRPTHPG
Length:207
Mass (Da):23,951
Last modified:November 1, 1998 - v1
Checksum:iD90EDD7B271628B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004638 mRNA. Translation: BAA31979.1.
RefSeqiNP_062072.1. NM_019199.1.
UniGeneiRn.44478.

Genome annotation databases

GeneIDi29369.
KEGGirno:29369.

Similar proteinsi

Entry informationi

Entry nameiFGF18_RAT
AccessioniPrimary (citable) accession number: O88182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families