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Protein

BarH-like 2 homeobox protein

Gene

Barhl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Alternative name(s):
Bar-class homeodomain protein MBH1
Homeobox protein B-H1
Gene namesi
Name:Barhl2
Synonyms:Mbh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620726. Barhl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488311 – 384BarH-like 2 homeobox proteinAdd BLAST384

Proteomic databases

PaxDbiO88181.

Expressioni

Tissue specificityi

Expressed in the ganglion cell layer of the retina in the eye and in the ventral zone of the dorsal thalamus of the CNS.1 Publication

Developmental stagei

Transiently expressed during embryonic development of the nervous system, detected at 11.5 days old (E11.5) and declining after E15.5.1 Publication

Gene expression databases

GenevisibleiO88181. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002887.

Structurei

3D structure databases

ProteinModelPortaliO88181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 91His-rich7
Compositional biasi95 – 98Pro-rich4
Compositional biasi128 – 131Ala-rich4
Compositional biasi327 – 331Ala-rich5

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiO88181.
KOiK09360.
OMAiDFRNQAT.
OrthoDBiEOG091G13SM.
PhylomeDBiO88181.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP
60 70 80 90 100
SPCSEIDTVG TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HGQQPPPPSA
110 120 130 140 150
PPAQSLQPSP QQQPPPQPQS AAQQLGSAAA APRTSTSSFL IKDILGDSKP
160 170 180 190 200
LAACAPYSTS VSSPHHTPKQ ECNAAHESFR PKLEQEDSKT KLDKREDSQS
210 220 230 240 250
DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ LNQLERSFER
260 270 280 290 300
QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
310 320 330 340 350
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ
360 370 380
RPLVPRVLIH GLGPGGQPAL NPLSNPIPGT PHPR
Length:384
Mass (Da):41,463
Last modified:November 1, 1998 - v1
Checksum:i0C6CB022ECA1F92F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004056 mRNA. Translation: BAA32474.1.
RefSeqiNP_075245.1. NM_022956.2.
UniGeneiRn.30005.

Genome annotation databases

EnsembliENSRNOT00000002887; ENSRNOP00000002887; ENSRNOG00000002117.
GeneIDi65050.
KEGGirno:65050.
UCSCiRGD:620726. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004056 mRNA. Translation: BAA32474.1.
RefSeqiNP_075245.1. NM_022956.2.
UniGeneiRn.30005.

3D structure databases

ProteinModelPortaliO88181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002887.

Proteomic databases

PaxDbiO88181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002887; ENSRNOP00000002887; ENSRNOG00000002117.
GeneIDi65050.
KEGGirno:65050.
UCSCiRGD:620726. rat.

Organism-specific databases

CTDi343472.
RGDi620726. Barhl2.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiO88181.
KOiK09360.
OMAiDFRNQAT.
OrthoDBiEOG091G13SM.
PhylomeDBiO88181.
TreeFamiTF316128.

Miscellaneous databases

PROiO88181.

Gene expression databases

GenevisibleiO88181. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBARH2_RAT
AccessioniPrimary (citable) accession number: O88181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.