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Protein

BarH-like 2 homeobox protein

Gene

Barhl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cell fate determination Source: Ensembl
  • nervous system development Source: RGD
  • neuron differentiation Source: Ensembl
  • neuron migration Source: Ensembl
  • positive regulation of translation Source: Ensembl
  • regulation of axon extension Source: Ensembl
  • regulation of neuron differentiation Source: RGD
  • regulation of transcription by RNA polymerase II Source: RGD

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Alternative name(s):
Bar-class homeodomain protein MBH1
Homeobox protein B-H1
Gene namesi
Name:Barhl2
Synonyms:Mbh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620726 Barhl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488311 – 384BarH-like 2 homeobox proteinAdd BLAST384

Proteomic databases

PaxDbiO88181

Expressioni

Tissue specificityi

Expressed in the ganglion cell layer of the retina in the eye and in the ventral zone of the dorsal thalamus of the CNS.1 Publication

Developmental stagei

Transiently expressed during embryonic development of the nervous system, detected at 11.5 days old (E11.5) and declining after E15.5.1 Publication

Gene expression databases

BgeeiENSRNOG00000002117
GenevisibleiO88181 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002887

Structurei

3D structure databases

ProteinModelPortaliO88181
SMRiO88181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 91His-rich7
Compositional biasi95 – 98Pro-rich4
Compositional biasi128 – 131Ala-rich4
Compositional biasi327 – 331Ala-rich5

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143987
HOGENOMiHOG000231533
HOVERGENiHBG050663
InParanoidiO88181
KOiK09360
OMAiMEPPEPH
OrthoDBiEOG091G13SM
PhylomeDBiO88181
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP
60 70 80 90 100
SPCSEIDTVG TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HGQQPPPPSA
110 120 130 140 150
PPAQSLQPSP QQQPPPQPQS AAQQLGSAAA APRTSTSSFL IKDILGDSKP
160 170 180 190 200
LAACAPYSTS VSSPHHTPKQ ECNAAHESFR PKLEQEDSKT KLDKREDSQS
210 220 230 240 250
DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ LNQLERSFER
260 270 280 290 300
QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
310 320 330 340 350
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ
360 370 380
RPLVPRVLIH GLGPGGQPAL NPLSNPIPGT PHPR
Length:384
Mass (Da):41,463
Last modified:November 1, 1998 - v1
Checksum:i0C6CB022ECA1F92F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004056 mRNA Translation: BAA32474.1
RefSeqiNP_075245.1, NM_022956.2
UniGeneiRn.30005

Genome annotation databases

EnsembliENSRNOT00000002887; ENSRNOP00000002887; ENSRNOG00000002117
GeneIDi65050
KEGGirno:65050
UCSCiRGD:620726 rat

Similar proteinsi

Entry informationi

Entry nameiBARH2_RAT
AccessioniPrimary (citable) accession number: O88181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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